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Book ; Online: A simulation study to distinguish prompt photon from $\pi^0$ and beam halo in a granular calorimeter using deep networks

Ghosh, Shamik / Harilal, Abhirami / Sahasransu, A. R. / Singh, Ritesh Kumar / Bhattacharya, Satyaki

2018

Abstract: In a hadron collider environment identification of prompt photons originating in a hard partonic scattering process and rejection of non-prompt photons coming from hadronic jets or from beam related sources, is the first step for study of processes with ... ...

Abstract	In a hadron collider environment identification of prompt photons originating in a hard partonic scattering process and rejection of non-prompt photons coming from hadronic jets or from beam related sources, is the first step for study of processes with photons in final state. Photons coming from decay of $\pi_0$'s produced inside a hadronic jet and photons produced in catastrophic bremsstrahlung by beam halo muons are two major sources of non-prompt photons. In this paper the potential of deep learning methods for separating the prompt photons from beam halo and $\pi^0$'s in the electromagnetic calorimeter of a collider detector is investigated, using an approximate description of the CMS detector. It is shown that, using only calorimetric information as images with a Convolutional Neural Network, beam halo (and $\pi^{0}$) can be separated from photon with 99.96\% (97.7\%) background rejection for 99.00\% (90.0\%) signal efficiency which is much better than traditionally employed variables.
Keywords	Physics - Instrumentation and Detectors ; Computer Science - Machine Learning ; High Energy Physics - Experiment
Subject code	535
Publishing date	2018-08-12
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A novel in vitro three-dimensional retinoblastoma model for evaluating chemotherapeutic drugs.

Mitra, Moutushy / Mohanty, Chandana / Harilal, Anju / Maheswari, Uma K / Sahoo, Sanjeeb Kumar / Krishnakumar, Subramanian

Molecular vision

2012 Volume 18, Page(s) 1361–1378

Abstract: Purpose: Novel strategies are being applied for creating better in vitro models that simulate in vivo conditions for testing the efficacy of anticancer drugs. In the present study we developed surface-engineered, large and porous, biodegradable, ... ...

Abstract	Purpose: Novel strategies are being applied for creating better in vitro models that simulate in vivo conditions for testing the efficacy of anticancer drugs. In the present study we developed surface-engineered, large and porous, biodegradable, polymeric microparticles as a scaffold for three dimensional (3-D) growth of a Y79 retinoblastoma (RB) cell line. We evaluated the effect of three anticancer drugs in naïve and nanoparticle-loaded forms on a 3-D versus a two-dimensional (2-D) model. We also studied the influence of microparticles on extracellular matrix (ECM) synthesis and whole genome miRNA-gene expression profiling to identify 3D-responsive genes that are implicated in oncogenesis in RB cells. Methods: Poly(D,L)-lactide-co-glycolide (PLGA) microparticles were prepared by the solvent evaporation method. RB cell line Y79 was grown alone or with PLGA-gelatin microparticles. Antiproliferative activity, drug diffusion, and cellular uptake were studied by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, a yellow tetrazole (MTT) assay, fluorescent microscope, and flow cytometry. Extra cellular matrix (ECM) synthesis was observed by collagenase assay and whole genome miRNA-microarray profiling by using an Agilent chip. Results: With optimized composition of microparticles and cell culture conditions, an eightfold increase from the seeding density was achieved in 5 days of culture. The antiproliferative effect of the drugs in the 3-D model was significantly lower than in the 2-D suspension, which was evident from the 4.5 to 21.8 fold differences in their IC(50) values. Using doxorubicin, the flow cytometry data demonstrated a 4.4 fold lower drug accumulation in the cells grown in the 3-D model at 4 h. The collagen content of the cells grown in the 3-D model was 2.3 fold greater than that of the cells grown in the 2-D model, suggesting greater synthesis of the extracellular matrix in the 3-D model as the extracellular matrix acted as a barrier to drug diffusion. The microarray and miRNA analysis showed changes in several genes and miRNA expression in cells grown in the 3-D model, which could also influence the environment and drug effects. Conclusions: Our 3-D retinoblastoma model could be used in developing effective drugs based on a better understanding of the role of chemical, biologic, and physical parameters in the process of drug diffusion through the tumor mass, drug retention, and therapeutic outcome.
MeSH term(s)	Antineoplastic Agents/pharmacology ; Biocompatible Materials/chemistry ; Carboplatin/pharmacology ; Cell Culture Techniques/methods ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Diffusion ; Doxorubicin/pharmacology ; Etoposide/pharmacology ; Extracellular Matrix/drug effects ; Extracellular Matrix/metabolism ; Gene Expression Profiling ; Humans ; Inhibitory Concentration 50 ; Kinetics ; Lactic Acid/chemistry ; MicroRNAs/biosynthesis ; Nanoparticles/chemistry ; Oligonucleotide Array Sequence Analysis ; Particle Size ; Polyglycolic Acid/chemistry ; Polylactic Acid-Polyglycolic Acid Copolymer ; Porosity ; Retinoblastoma/drug therapy ; Retinoblastoma/metabolism ; Retinoblastoma/pathology ; Tissue Engineering/methods ; Tissue Scaffolds
Chemical Substances	Antineoplastic Agents ; Biocompatible Materials ; MicroRNAs ; Polylactic Acid-Polyglycolic Acid Copolymer (1SIA8062RS) ; Polyglycolic Acid (26009-03-0) ; Lactic Acid (33X04XA5AT) ; Etoposide (6PLQ3CP4P3) ; Doxorubicin (80168379AG) ; Carboplatin (BG3F62OND5)
Language	English
Publishing date	2012-05-31
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2017540-1
ISSN	1090-0535 ; 1090-0535
ISSN (online)	1090-0535
ISSN	1090-0535
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Enhanced in vitro antiproliferative effects of EpCAM antibody-functionalized paclitaxel-loaded PLGA nanoparticles in retinoblastoma cells.

Mitra, Moutushy / Misra, Ranjita / Harilal, Anju / Sahoo, Sanjeeb K / Krishnakumar, Subramanian

publication RETRACTED

Molecular vision

2011 Volume 17, Page(s) 2724–2737

Abstract: Background: To specifically deliver paclitaxel (PTX) to retinoblastoma (RB) cells, the anionic surface-charged poly(lactic-co-glycolic acid) (PLGA) NPs loaded with paclitaxel were conjugated with epithelial cell adhesion molecule (EpCAM) antibody for ... ...

Abstract	Background: To specifically deliver paclitaxel (PTX) to retinoblastoma (RB) cells, the anionic surface-charged poly(lactic-co-glycolic acid) (PLGA) NPs loaded with paclitaxel were conjugated with epithelial cell adhesion molecule (EpCAM) antibody for enhancing site-specific intracellular delivery of paclitaxel against EpCAM overexpressing RB cells. Methods: PTX-loaded PLGA NPs were prepared by the oil-in-water single emulsion solvent evaporation method, and the PTX content in NPs was estimated by the reverse phase isocratic mode of high performance liquid chromatography. Ethyl-3-[3-dimethylaminopropyl] carbodiimide hydrochloride/N-hydroxysuccinimide chemistry was employed for the covalent attachment of monoclonal EpCAM antibody onto the NP surface. In vitro cytotoxicity of native PTX, unconjugated PTX-loaded NPs (PTX-NPs), and EpCAM antibody-conjugated PTX-loaded nanoparticles (PTX-NP-EpCAM) were evaluated on a Y79 RB cell line by a dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, while cellular apoptosis, cysteinyl-aspartic acid protease (caspase)-3 activation, Poly (adenosine diphosphate-ribose) polymerase (PARP) cleavage, and cell-cycle arrest were quantified by flow cytometry. By employing flow cytometry and fluorescence image analyses, the extent of cellular uptake was comparatively evaluated. Results: PTX-NP-EpCAM had superior antiproliferation activity, increased arrested cell population at the G(2)-M phase, and increased activation of caspase-3, followed by PARP cleavage in parallel with the induction of apoptosis. Increased uptake of PTX-Np-EpCAM by the cells suggests that they were mainly taken up through EpCAM mediated endocytosis. Conclusions: EpCAM antibody-functionalized biodegradable NPs for tumor-selective drug delivery and overcoming drug resistance could be an efficient therapeutic strategy for retinoblastoma treatment.
MeSH term(s)	Antibodies/immunology ; Antibodies/metabolism ; Antigens, Neoplasm/immunology ; Antigens, Neoplasm/metabolism ; Antineoplastic Agents, Phytogenic/chemistry ; Antineoplastic Agents, Phytogenic/pharmacology ; Apoptosis/drug effects ; Caspase 3/genetics ; Caspase 3/metabolism ; Cell Adhesion Molecules/immunology ; Cell Adhesion Molecules/metabolism ; Cell Cycle Checkpoints/drug effects ; Cell Line, Tumor ; Cell Survival/drug effects ; Cross-Linking Reagents/chemistry ; Drug Carriers/chemical synthesis ; Drug Carriers/metabolism ; Drug Carriers/pharmacology ; Endocytosis ; Epithelial Cell Adhesion Molecule ; Flow Cytometry ; Humans ; Immunoconjugates/immunology ; Immunoconjugates/metabolism ; Immunoconjugates/pharmacology ; Lactic Acid/chemistry ; Nanoparticles/chemistry ; Paclitaxel/chemistry ; Paclitaxel/pharmacology ; Particle Size ; Poly(ADP-ribose) Polymerases/metabolism ; Polyglycolic Acid/chemistry ; Polylactic Acid-Polyglycolic Acid Copolymer ; Retinal Neoplasms/drug therapy ; Retinal Neoplasms/metabolism ; Retinal Neoplasms/pathology ; Retinoblastoma/drug therapy ; Retinoblastoma/metabolism ; Retinoblastoma/pathology
Chemical Substances	Antibodies ; Antigens, Neoplasm ; Antineoplastic Agents, Phytogenic ; Cell Adhesion Molecules ; Cross-Linking Reagents ; Drug Carriers ; Epithelial Cell Adhesion Molecule ; Immunoconjugates ; Polylactic Acid-Polyglycolic Acid Copolymer (1SIA8062RS) ; Polyglycolic Acid (26009-03-0) ; Lactic Acid (33X04XA5AT) ; Poly(ADP-ribose) Polymerases (EC 2.4.2.30) ; Caspase 3 (EC 3.4.22.-) ; Paclitaxel (P88XT4IS4D)
Language	English
Publishing date	2011-10-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Retracted Publication
ZDB-ID	2017540-1
ISSN	1090-0535 ; 1090-0535
ISSN (online)	1090-0535
ISSN	1090-0535
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: EpCAM is a putative stem marker in retinoblastoma and an effective target for T-cell-mediated immunotherapy.

Mitra, Moutushy / Kandalam, Mallikarjuna / Harilal, Anju / Verma, Rama Shenkar / Krishnan, Uma Maheswari / Swaminathan, Sethuraman / Krishnakumar, Subramanian

Molecular vision

2012 Volume 18, Page(s) 290–308

Abstract: Purpose: The molecular markers cluster of differentiation (CD)24, CD44, adenosine tri-phosphate (ATP) binding cassette protein G2 (ABCG2), and epithelial cell adhesion molecule (EpCAM) are widely used, individually or in combination, to characterize ... ...

Abstract	Purpose: The molecular markers cluster of differentiation (CD)24, CD44, adenosine tri-phosphate (ATP) binding cassette protein G2 (ABCG2), and epithelial cell adhesion molecule (EpCAM) are widely used, individually or in combination, to characterize some types of cancer stem cells. In this study we characterized the EpCAM+ retinoblastoma (RB) cells for their cancer stem-like properties in vitro. Additionally, we targeted RB tumor cells via redirecting T cells using bispecific EpCAM×CD3 antibody. Methods: Flow cytometry was used to study the co-expression of EpCAM with putative cancer stem cell markers, such as CD44, CD24, and ABCG2, in RB primary tumors. In vitro methyl thiazol tetrazolium (MTT) assay, invasion assay, and neurosphere formation assay were performed to characterize EpCAM+ cells for their cancer stem/progenitor cell-like properties. We assessed the in vitro efficacy of bispecific EpCAM×CD3 antibody on RB tumor cell proliferation and validated the results by evaluating effector cytokine production in the culture medium with the ELISA method. Results: EpCAM was co-expressed with all cancer stem cell markers (CD44, CD24, and ABCG2) in primary RB tumors. EpCAM+ cells showed significantly higher proliferative invasive potential and neurosphere formation in vitro compared to EpCAM⁻ Y79 cells. EpCAM+ cells showed higher β-catenin expression compared to EpCAM- cells. EpCAM×CD3 significantly retarded proliferation of RB primary tumor cells. EpCAM×CD3 effectively induced the secretion of effector cytokines, such as interferon (IFN)-γ, tumor necrosis factor (TNF)-α, interleukin (IL)-10, IL-2, and transforming growth factor (TGF)-β1, and also perforin levels by pre-activated lymphocytes. Conclusions: EpCAM might be a novel cancer stem cell marker in RB. EpCAM×CD3 antibody redirecting T cells to attack RB tumor cells may prove effective in RB management. Further preclinical studies are needed to confirm the initial findings of our study.
MeSH term(s)	ATP Binding Cassette Transporter, Subfamily G, Member 2 ; ATP-Binding Cassette Transporters/biosynthesis ; ATP-Binding Cassette Transporters/immunology ; Antibodies, Bispecific/pharmacology ; Antigens, Neoplasm/genetics ; Antigens, Neoplasm/metabolism ; Biomarkers, Tumor/biosynthesis ; Biomarkers, Tumor/immunology ; CD24 Antigen/biosynthesis ; CD24 Antigen/immunology ; Cell Adhesion Molecules/antagonists & inhibitors ; Cell Adhesion Molecules/genetics ; Cell Adhesion Molecules/metabolism ; Cell Proliferation ; Child ; Child, Preschool ; Cytokines/biosynthesis ; Cytokines/immunology ; Epithelial Cell Adhesion Molecule ; Female ; Flow Cytometry ; Humans ; Hyaluronan Receptors/biosynthesis ; Hyaluronan Receptors/immunology ; Immunotherapy ; Infant ; Male ; Neoplasm Proteins/biosynthesis ; Neoplasm Proteins/immunology ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/pathology ; Primary Cell Culture ; RNA, Small Interfering/genetics ; Retinal Neoplasms/immunology ; Retinal Neoplasms/pathology ; Retinal Neoplasms/therapy ; Retinoblastoma/immunology ; Retinoblastoma/pathology ; Retinoblastoma/therapy ; T-Lymphocytes/drug effects ; T-Lymphocytes/immunology
Chemical Substances	ABCG2 protein, human ; ATP Binding Cassette Transporter, Subfamily G, Member 2 ; ATP-Binding Cassette Transporters ; Antibodies, Bispecific ; Antigens, Neoplasm ; Biomarkers, Tumor ; CD24 Antigen ; CD24 protein, human ; CD44 protein, human ; Cell Adhesion Molecules ; Cytokines ; EPCAM protein, human ; Epithelial Cell Adhesion Molecule ; Hyaluronan Receptors ; Neoplasm Proteins ; RNA, Small Interfering
Language	English
Publishing date	2012-02-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2017540-1
ISSN	1090-0535 ; 1090-0535
ISSN (online)	1090-0535
ISSN	1090-0535
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Audio / Video: Coincident isolation of a novel homoisoflavonoid from Resnova humifusa and Eucomis montana (Hyacinthoideae: Hyacinthaceae)

Koorbanally, N.A / Crouch, N.R / Harilal, A / Pillay, B / Mulholland, D.A

Biochemical systematics and ecology. 2006 Feb., v. 34, no. 2

2006

Abstract: We report on the first phytochemical investigation of a member of the African genus Resnova (Hyacinthoideae: Hyacinthaceae). From the dichloromethane extract of the bulbs of both Resnova humifusa and Eucomis montana (Hyacinthoideae: Hyacinthaceae) a ... ...

Abstract	We report on the first phytochemical investigation of a member of the African genus Resnova (Hyacinthoideae: Hyacinthaceae). From the dichloromethane extract of the bulbs of both Resnova humifusa and Eucomis montana (Hyacinthoideae: Hyacinthaceae) a novel 3-benzyl-4-chromanone homoisoflavonoid, 5,6-dimethoxy-7-hydroxy-3-(4'-hydroxybenzyl)-4-chromanone, was isolated. A further 11 known homoisoflavonoids were also identified, the 12 in total presenting a clear biosynthetic sequence. Eight of the 12 compounds found were common to both species.
Keywords	chemical constituents of plants ; flavonoids ; chemotaxonomy
Language	English
Dates of publication	2006-02
Size	p. 114-118.
Document type	Article ; Audio / Video
ISSN	0305-1978
Database	NAL-Catalogue (AGRICOLA)

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Article: Toxicogenomics of nanoparticulate delivery of etoposide: potential impact on nanotechnology in retinoblastoma therapy.

Mitra, Moutushy / Dilnawaz, Fahima / Misra, Ranjita / Harilal, Anju / Verma, Rama Shenkar / Sahoo, Sanjeeb K / Krishnakumar, Subramanian

Cancer nanotechnology

2010 Volume 2, Issue 1-6, Page(s) 21–36

Abstract: To develop a suitable formulation with high entrapment efficiency, etoposide-loaded poly(lactide- ...

Abstract	To develop a suitable formulation with high entrapment efficiency, etoposide-loaded poly(lactide-
Language	English
Publishing date	2010-12-17
Publishing country	Austria
Document type	Journal Article
ISSN	1868-6958
ISSN	1868-6958
DOI	10.1007/s12645-010-0010-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Bufadienolides from Drimia robusta and Urginea epigea (Hyacinthaceae)

Koorbanally, N.A / Koorbanally, C / Harilal, A / Mulholland, D.A / Crouch, N.R

Phytochemistry. 2004 Dec., v. 65, no. 23

2004

Keywords	Drimia ; Liliaceae ; medicinal plants ; plant extracts ; phytochemicals ; bufadienolides ; spectral analysis ; chemical structure ; South Africa
Language	English
Dates of publication	2004-12
Size	p. 3069-3073.
Document type	Article
ZDB-ID	208884-8
ISSN	1873-3700 ; 0031-9422
ISSN (online)	1873-3700
ISSN	0031-9422
Database	NAL-Catalogue (AGRICOLA)

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Article: Bufadienolides from Drimia robusta and Urginea epigea (Hyacinthaceae).

Koorbanally, Neil A / Koorbanally, Chantal / Harilal, Avinash / Mulholland, Dulcie A / Crouch, Neil R

Phytochemistry

2004 Volume 65, Issue 23, Page(s) 3069–3073

Abstract: Two bufadienolides, 6beta-acetoxy-3beta,8beta,14beta-trihydroxy-12-oxobufa-4,20,22-trienolide and 14beta-hydroxybufa-3,5,20,22-tetraenolide were isolated from the dichloromethane extract of the bulbs of Drimia robusta and the methanol extract of the ... ...

Abstract	Two bufadienolides, 6beta-acetoxy-3beta,8beta,14beta-trihydroxy-12-oxobufa-4,20,22-trienolide and 14beta-hydroxybufa-3,5,20,22-tetraenolide were isolated from the dichloromethane extract of the bulbs of Drimia robusta and the methanol extract of the bulbs of Urginea epigea, respectively. The bulbs of Drimia robusta also yielded several known compounds, 6beta-acetoxy-3beta,8beta,12beta,14beta-tetrahydroxybufa-4,20,22-trienolide (12beta-hydroxyscillirosidin) from the dichloromethane extract and three common aromatic acids, 4-hydroxy-3-methoxybenzoic acid, 3,4-dihydroxybenzoic acid, and trans-3-(4'-hydroxyphenyl)-2-propenoic acid from the ethyl acetate extract.
MeSH term(s)	Bufanolides/chemistry ; Bufanolides/isolation & purification ; Drimia/chemistry ; Hydroxybenzoates/chemistry ; Liliaceae/chemistry ; Magnetic Resonance Spectroscopy ; Mass Spectrometry ; Molecular Structure ; Plant Roots/chemistry ; Propionates/chemistry ; Vanillic Acid/chemistry
Chemical Substances	12beta-hydroxyscillirosidin ; 14beta-hydroxybufa-3,5,20,22-tetraenolide ; 6beta-acetoxy-3beta,8beta,14beta-trihydroxy-12-oxobufa-4,20,22-trienolide ; Bufanolides ; Hydroxybenzoates ; Propionates ; protocatechuic acid (36R5QJ8L4B) ; Vanillic Acid (GM8Q3JM2Y8) ; p-coumaric acid (IBS9D1EU3J)
Language	English
Publishing date	2004-05-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	208884-8
ISSN	1873-3700 ; 0031-9422
ISSN (online)	1873-3700
ISSN	0031-9422
DOI	10.1016/j.phytochem.2004.08.051
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Online: The DAQ system of the 12,000 Channel CMS High Granularity Calorimeter Prototype

Acar, B. / Adamov, G. / Adloff, C. / Afanasiev, S. / Akchurin, N. / Akgün, B. / Alhusseini, M. / Alison, J. / Altopp, G. / Alyari, M. / An, S. / Anagul, S. / Andreev, I. / Andrews, M. / Aspell, P. / Atakisi, I. A. / Bach, O. / Baden, A. / Bakas, G. /

Bakshi, A. / Bargassa, P. / Barney, D. / Becheva, E. / Behera, P. / Belloni, A. / Bergauer, T. / Besancon, M. / Bhattacharya, S. / Bhowmik, D. / Bloch, P. / Bodek, A. / Bonanomi, M. / Bonnemaison, A. / Bonomally, S. / Borg, J. / Bouyjou, F. / Braga, D. / Brashear, J. / Brondolin, E. / Bryant, P. / Bueghly, J. / Bilki, B. / Burkle, B. / Butler-Nalin, A. / Callier, S. / Calvet, D. / Cao, X. / Caraway, B. / Caregari, S. / Ceard, L. / Cekmecelioglu, Y. C. / Cerminara, G. / Charitonidis, N. / Chatterjee, R. / Chen, Y. M. / Chen, Z. / Cheng, K. y. / Chernichenko, S. / Cheung, H. / Chien, C. H. / Choudhury, S. / Čoko, D. / Collura, G. / Couderc, F. / Dumanoglu, I. / Dannheim, D. / Dauncey, P. / David, A. / Davies, G. / Day, E. / DeBarbaro, P. / De Guio, F. / de La Taille, C. / De Silva, M. / Debbins, P. / Delagnes, E. / Deltoro, J. M. / Derylo, G. / de Almeida, P. G. Dias / Diaz, D. / Dinaucourt, P. / Dittmann, J. / Dragicevic, M. / Dugad, S. / Dutta, V. / Dutta, S. / Eckdahl, J. / Edberg, T. K. / Berni, M. El / Eno, S. C. / Ershov, Yu. / Everaerts, P. / Extier, S. / Fahim, F. / Fallon, C. / Alves, B. A. Fontana Santos / Frahm, E. / Franzoni, G. / Freeman, J. / French, T. / Guler, E. Gurpinar / Guler, Y. / Gagnan, M. / Gandhi, P. / Ganjour, S. / Garcia-Bellido, A. / Gecse, Z. / Geerebaert, Y. / Gerwig, H. / Gevin, O. / Gilbert, W. / Gilbert, A. / Gill, K. / Gingu, C. / Gninenko, S. / Golunov, A. / Golutvin, I. / Gonzalez, T. / Gorbounov, N. / Gouskos, L. / Gu, Y. / Guilloux, F. / Gülmez, E. / Hammer, M. / Harilal, A. / Hatakeyama, K. / Heering, A. / Hegde, V. / Heintz, U. / Hinger, V. / Hinton, N. / Hirschauer, J. / Hoff, J. / Hou, W. S. / Isik, C. / Incandela, J. / Jain, S. / Jheng, H. R. / Joshi, U. / Kara, O. / Kachanov, V. / Kalinin, A. / Kameshwar, R. / Kaminskiy, A. / Karneyeu, A. / Kaya, O. / Kaya, M. / Khukhunaishvili, A. / Kim, S. / Koetz, K. / Kolberg, T. / Kristić, A. / Krohn, M. / Krüger, K. / Kulagin, N. / Kulis, S. / Kunori, S. / Kuo, C. M. / Kuryatkov, V. / Kyre, S. / Köseyan, O. K. / Lai, Y. / Lamichhane, K. / Landsberg, G. / Langford, J. / Lee, M. Y. / Levin, A. / Li, A. / Li, B. / Li, J. -H. / Liao, H. / Lincoln, D. / Linssen, L. / Lipton, R. / Liu, Y. / Lobanov, A. / Lu, R. S. / Lysova, I. / Magnan, A. M. / Magniette, F. / Maier, A. A. / Malakhov, A. / Mandjavize, I. / Mannelli, M. / Mans, J. / Marchioro, A. / Martelli, A. / Masterson, P. / Meng, B. / Mengke, T. / Mestvirishvili, A. / Mirza, I. / Moccia, S. / Morrissey, I. / Mudholkar, T. / Musić, J. / Musienko, I. / Nabili, S. / Nagar, A. / Nikitenko, A. / Noonan, D. / Noy, M. / Nurdan, K. / Ochando, C. / Odegard, B. / Odell, N. / Onel, Y. / Ortez, W. / Ozegović, J. / Rodriguez, L. Pacheco / Paganis, E. / Pagenkopf, D. / Palladino, V. / Pandey, S. / Pantaleo, F. / Papageorgakis, C. / Papakrivopoulos, I. / Parshook, J. / Pastika, N. / Paulini, M. / Paulitsch, P. / Peltola, T. / Gomes, R. Pereira / Perkins, H. / Petiot, P. / Pitters, F. / Prosper, H. / Prvan, M. / Puljak, I. / Quast, T. / Quinn, R. / Quinnan, M. / Rapacz, K. / Raux, L. / Reichenbach, G. / Reinecke, M. / Revering, M. / Rodriguez, A. / Romanteau, T. / Rose, A. / Rovere, M. / Roy, A. / Rubinov, P. / Rusack, R. / Simsek, A. E. / Sozbilir, U. / Sahin, O. M. / Sanchez, A. / Saradhy, R. / Sarkar, T. / Sarkisla, M. A. / Sauvan, J. B. / Schmidt, I. / Schmitt, M. / Scott, E. / Seez, C. / Sefkow, F. / Sharma, S. / Shein, I. / Shenai, A. / Shukla, R. / Sicking, E. / Sieberer, P. / Sirois, Y. / Smirnov, V. / Spencer, E. / Steen, A. / Strait, J. / Strebler, T. / Strobbe, N. / Su, J. W. / Sukhov, E. / Sun, L. / Sun, M. / Syal, C. / Tali, B. / Tok, U. G. / Topaksu, A. Kayis / Tan, C. L. / Tastan, I. / Tatli, T. / Thaus, R. / Tekten, S. / Thienpont, D. / Pierre-Emile, T. / Tiras, E. / Titov, M. / Tlisov, D. / Troska, J. / Tsamalaidze, Z. / Tsipolitis, G. / Tsirou, A. / Tyurin, N. / Undleeb, S. / Urbanski, D. / Ustinov, V. / Uzunian, A. / van de Klundert, M. / Varela, J. / Velasco, M. / Pinto, M. Vicente Barreto / da Silva, P. M. / Virdee, T. / de Oliveira, R. Vizinho / Voelker, J. / Voirin, E. / Wang, Z. / Wang, X. / Wang, F. / Wayne, M. / Webb, S. N. / Weinberg, M. / Whitbeck, A. / White, D. / Wickwire, R. / Wilson, J. S. / Wu, H. Y. / Wu, L. / Yeh, C. H / Yohay, R. / Yu, G. B. / Yu, S. S. / Yu, D. / Yumiceva, F. / Zacharopoulou, A. / Zamiatin, N. / Zarubin, A. / Zenz, S. / Zhang, H. / Zhang, J.

2020

Abstract: The CMS experiment at the CERN LHC will be upgraded to accommodate the 5-fold increase in the instantaneous luminosity expected at the High-Luminosity LHC (HL-LHC). Concomitant with this increase will be an increase in the number of interactions in each ... ...

Abstract	The CMS experiment at the CERN LHC will be upgraded to accommodate the 5-fold increase in the instantaneous luminosity expected at the High-Luminosity LHC (HL-LHC). Concomitant with this increase will be an increase in the number of interactions in each bunch crossing and a significant increase in the total ionising dose and fluence. One part of this upgrade is the replacement of the current endcap calorimeters with a high granularity sampling calorimeter equipped with silicon sensors, designed to manage the high collision rates. As part of the development of this calorimeter, a series of beam tests have been conducted with different sampling configurations using prototype segmented silicon detectors. In the most recent of these tests, conducted in late 2018 at the CERN SPS, the performance of a prototype calorimeter equipped with ${\approx}12,000\rm{~channels}$ of silicon sensors was studied with beams of high-energy electrons, pions and muons. This paper describes the custom-built scalable data acquisition system that was built with readily available FPGA mezzanines and low-cost Raspberry PI computers.
Keywords	Physics - Instrumentation and Detectors ; High Energy Physics - Experiment
Subject code	621
Publishing date	2020-12-07
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Construction and commissioning of CMS CE prototype silicon modules

2020

Abstract: As part of its HL-LHC upgrade program, the CMS Collaboration is developing a High Granularity Calorimeter (CE) to replace the existing endcap calorimeters. The CE is a sampling calorimeter with unprecedented transverse and longitudinal readout for both ... ...

Abstract	As part of its HL-LHC upgrade program, the CMS Collaboration is developing a High Granularity Calorimeter (CE) to replace the existing endcap calorimeters. The CE is a sampling calorimeter with unprecedented transverse and longitudinal readout for both electromagnetic (CE-E) and hadronic (CE-H) compartments. The calorimeter will be built with $\sim$30,000 hexagonal silicon modules. Prototype modules have been constructed with 6-inch hexagonal silicon sensors with cell areas of 1.1~$cm^2$, and the SKIROC2-CMS readout ASIC. Beam tests of different sampling configurations were conducted with the prototype modules at DESY and CERN in 2017 and 2018. This paper describes the construction and commissioning of the CE calorimeter prototype, the silicon modules used in the construction, their basic performance, and the methods used for their calibration. Comment: 35 pages, submitted to JINST
Keywords	Physics - Instrumentation and Detectors ; High Energy Physics - Experiment
Subject code	621
Publishing date	2020-12-10
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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