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  1. Article ; Online: The salivary microbiota of patients with acute lower respiratory tract infection-A multicenter cohort study.

    Rogers, Matthew B / Harner, Ashley / Buhay, Megan / Firek, Brian / Methé, Barbara / Morris, Alison / Palmer, Octavia M Peck / Promes, Susan B / Sherwin, Robert L / Southerland, Lauren / Vieira, Alexandre R / Yende, Sachin / Morowitz, Michael J / Huang, David T

    PloS one

    2024  Volume 19, Issue 1, Page(s) e0290062

    Abstract: The human microbiome contributes to health and disease, but the oral microbiota is understudied relative to the gut microbiota. The salivary microbiota is easily accessible, underexplored, and may provide insight into response to infections. We sought to ...

    Abstract The human microbiome contributes to health and disease, but the oral microbiota is understudied relative to the gut microbiota. The salivary microbiota is easily accessible, underexplored, and may provide insight into response to infections. We sought to determine the composition, association with clinical features, and heterogeneity of the salivary microbiota in patients with acute lower respiratory tract infection (LRTI). We conducted a multicenter prospective cohort study of 147 adults with acute LRTI presenting to the emergency department of seven hospitals in three states (Pennsylvania, Michigan, and Ohio) between May 2017 and November 2018. Salivary samples were collected in the emergency department, at days 2-5 if hospitalized, and at day 30, as well as fecal samples if patients were willing. We compared salivary microbiota profiles from patients to those of healthy adult volunteers by sequencing and analyzing bacterial 16-rRNA. Compared to healthy volunteers, the salivary microbiota of patients with LRTI was highly distinct and strongly enriched with intestinal anaerobes such as Bacteroidaceae, Ruminococcaceae, and Lachnospiraceae (e.g., mean 10% relative abundance of Bacteroides vs < 1% in healthy volunteers). Within the LRTI population, COPD exacerbation was associated with altered salivary microbiota composition compared to other LRTI conditions. The largest determinant of microbiota variation within the LRTI population was geography (city in which the hospital was located).
    MeSH term(s) Adult ; Humans ; Prospective Studies ; Microbiota ; Respiratory Tract Infections/microbiology ; Gastrointestinal Microbiome ; Feces/microbiology ; RNA, Ribosomal, 16S/genetics
    Chemical Substances RNA, Ribosomal, 16S
    Language English
    Publishing date 2024-01-11
    Publishing country United States
    Document type Multicenter Study ; Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0290062
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Early Cold Stored Platelet Transfusion Following Severe Injury: A Randomized Clinical Trial.

    Sperry, Jason L / Guyette, Francis X / Rosario-Rivera, Bedda L / Kutcher, Matthew E / Kornblith, Lucy Z / Cotton, Bryan A / Wilson, Chad T / Inaba, Kenji / Zadorozny, Eva V / Vincent, Laura E / Harner, Ashley M / Love, Emily T / Doherty, Joseph E / Cuschieri, Joseph / Kornblith, Aaron E / Fox, Erin E / Bai, Yu / Hoffman, Marcus K / Seger, Catherine P /
    Hudgins, Jay / Mallett-Smith, Sheila / Neal, Matthew D / Leeper, Christine M / Spinella, Philip C / Yazer, Mark H / Wisniewski, Stephen R

    Annals of surgery

    2024  

    Abstract: Objective: To determine the feasibility, efficacy, and safety of early cold stored platelet transfusion compared to standard care resuscitation in patients with hemorrhagic shock.: Summary background data: Data demonstrating the safety and efficacy ... ...

    Abstract Objective: To determine the feasibility, efficacy, and safety of early cold stored platelet transfusion compared to standard care resuscitation in patients with hemorrhagic shock.
    Summary background data: Data demonstrating the safety and efficacy of early cold stored platelet transfusion are lacking following severe injury.
    Methods: A phase 2, multicenter, randomized, open label, clinical trial was performed at five U.S. trauma centers. Injured patients at risk of large volume blood transfusion and the need for hemorrhage control procedures were enrolled and randomized. The intervention was the early transfusion of a single apheresis cold stored platelet unit, stored for up to 14 days vs. standard care resuscitation. The primary outcome was feasibility and the principal clinical outcome for efficacy and safety was 24-hour mortality.
    Results: Mortality at 24 hours was 5.9% in patients who were randomized to early cold stored platelet transfusion compared to 10.2% in the standard care arm (difference, -4.3%; 95% CI, -12.8% to 3.5%; P=0.26). No significant differences were found for any of the prespecified ancillary outcomes. Rates of arterial and/or venous thromboembolism and adverse events did not differ across treatment groups.
    Conclusions and relevance: In severely injured patients, early cold stored platelet transfusion is feasible, safe and did not result in a significant lower rate of 24-hour mortality. Early cold stored platelet transfusion did not result in a higher incidence of arterial and/or venous thrombotic complications or adverse events. The storage age of the cold stored platelet product was not associated with significant outcome differences.
    Language English
    Publishing date 2024-05-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 340-2
    ISSN 1528-1140 ; 0003-4932
    ISSN (online) 1528-1140
    ISSN 0003-4932
    DOI 10.1097/SLA.0000000000006317
    Database MEDical Literature Analysis and Retrieval System OnLINE

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