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  1. Article ; Online: Anatomical variation and its management in transplantation.

    Watson, C J E / Harper, S J F

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

    2015  Volume 15, Issue 6, Page(s) 1459–1471

    Abstract: Variant anatomy may be challenging at retrieval, with failure to identify variance being associated with organ damage, particularly vascular damage. On implantation, some variants demand nonstandard techniques of reconstruction or implantation. This ... ...

    Abstract Variant anatomy may be challenging at retrieval, with failure to identify variance being associated with organ damage, particularly vascular damage. On implantation, some variants demand nonstandard techniques of reconstruction or implantation. This review covers the common and less common anatomical variants of the liver, kidney and pancreas, and gives guidance as to how they may be managed during organ retrieval and implantation.
    MeSH term(s) Humans ; Kidney/abnormalities ; Kidney/anatomy & histology ; Kidney/blood supply ; Kidney Transplantation/methods ; Liver/abnormalities ; Liver/anatomy & histology ; Liver/blood supply ; Liver Transplantation/methods ; Organ Transplantation/methods ; Pancreas/abnormalities ; Pancreas/anatomy & histology ; Pancreas/blood supply ; Pancreas Transplantation/methods ; Tissue and Organ Harvesting/trends
    Language English
    Publishing date 2015-05-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2060594-8
    ISSN 1600-6143 ; 1600-6135
    ISSN (online) 1600-6143
    ISSN 1600-6135
    DOI 10.1111/ajt.13310
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Early derangement of INR predicts liver failure after liver resection for hepatocellular carcinoma.

    Silva, A N S / Greensmith, M / Praseedom, R K / Jah, A / Huguet, E L / Harper, S J F / Liau, S S / Basu, B / Alexander, G J / Brais, R / See, T C / Hoare, M / Gibbs, P / Balakrishnan, A

    The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland

    2022  Volume 20, Issue 5, Page(s) e288–e295

    Abstract: Background: Surgical resection, where appropriate, remains one of the best treatment options for hepatocellular carcinoma (HCC), however outcomes can be compromised by the development of liver failure. We reviewed our experience of liver resection for ... ...

    Abstract Background: Surgical resection, where appropriate, remains one of the best treatment options for hepatocellular carcinoma (HCC), however outcomes can be compromised by the development of liver failure. We reviewed our experience of liver resection for HCC patients to identify factors that may predict the development of post-hepatectomy liver failure (PHLF) and survival.
    Methods: A single centre retrospective cohort study. Data was collected between 1999 and 2017 from all patients undergoing HCC resection in a tertiary university hospital from electronic medical records. PHLF was defined as per the International Study Group for Liver Surgery criteria. Variables with p < 0.15 on univariate analysis were included in a multivariate binary logistic regression model. Kaplan-Meier analyses were used to determine correlations with overall survival (OS) and disease-free survival (DFS), and variables with p < 0.15 on univariate analysis selected for a step-down Cox proportional hazard regression model.
    Results: Overall, 120 patients underwent liver resection within the study period, of which 22 (18%) developed PHLF. Patients with normal INR ≤1.20 at day 2 did not develop PHLF whereas patients with INR >1.60 were at significant risk. Resection of multiple tumours (odds ratio 21.63, p = 0.002) and deranged postoperative day 2 INR>1.6 (odds ratio 21.05, p < 0.0001) were identified as independent prognostic markers of PHLF.
    Conclusion: The use of INR measurement at day 2 predicts PHLF and may enable us to objectively identify and stratify patients who may be eligible for enhanced recovery programs from those who will merit close monitoring in high dependency areas.
    MeSH term(s) Carcinoma, Hepatocellular ; Hepatectomy/adverse effects ; Humans ; International Normalized Ratio ; Liver Failure/etiology ; Liver Failure/surgery ; Liver Neoplasms ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Postoperative Complications/surgery ; Retrospective Studies
    Language English
    Publishing date 2022-02-07
    Publishing country Scotland
    Document type Journal Article ; Review
    ZDB-ID 2102927-1
    ISSN 1479-666X
    ISSN 1479-666X
    DOI 10.1016/j.surge.2022.01.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Arteriovenous fistula formation using transposed basilic vein: extensive single centre experience.

    Harper, S J F / Goncalves, I / Doughman, T / Nicholson, M L

    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery

    2008  Volume 36, Issue 2, Page(s) 237–241

    Abstract: Objectives: The expanding haemodialysis population has lead to increased requirement for more complex vascular access. The aim of this study is to present the results of an extensive series of brachiobasilic arteriovenous fistulae.: Methods: BBAVF ... ...

    Abstract Objectives: The expanding haemodialysis population has lead to increased requirement for more complex vascular access. The aim of this study is to present the results of an extensive series of brachiobasilic arteriovenous fistulae.
    Methods: BBAVF were performed using single-stage vein transposition. A retrospective review of case notes was performed.
    Results: One hundred and sixty eight BBAVF were created in 144 patients. This was the first access procedure in only 30 cases and the fourth or fifth in 30. At 24h, 165 fistulas (98%) were patent. One hundred and eleven fistulas (66%) were used for haemodialysis and 57 (34%) were never used, of which 39 (23%) were due to fistula failure. The cumulative secondary patency at 1, 2 and 3 years was 66%, 50% and 41% respectively. There were 201 complications in 119 patients (71%), including thrombosis (29%), arm oedema (17%), infection (13%) and arterial steal syndrome (11%). Ten angioplasties and 48 operative procedures were performed for complications. Pre-operative ipsilateral subclavian catheter had been placed in 62 cases (37%) and was associated with poor patency.
    Conclusions: BBAVF represents an important option for vascular access with acceptable patency rates, although complication rates remain significant.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Arm/blood supply ; Arteriovenous Shunt, Surgical/adverse effects ; Arteriovenous Shunt, Surgical/methods ; Brachial Artery/physiopathology ; Brachial Artery/surgery ; Female ; Humans ; Male ; Middle Aged ; Renal Dialysis ; Reoperation ; Retrospective Studies ; Time Factors ; Treatment Outcome ; Vascular Patency ; Veins/physiopathology ; Veins/surgery
    Language English
    Publishing date 2008-04-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 1225869-6
    ISSN 1532-2165 ; 1078-5884
    ISSN (online) 1532-2165
    ISSN 1078-5884
    DOI 10.1016/j.ejvs.2008.02.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Vascular clamping of calcified vessels: the peanut technique.

    Bagul, A / Brook, N R / Harper, S J F / Nicholson, M L

    Annals of the Royal College of Surgeons of England

    2006  Volume 88, Issue 1, Page(s) 77

    MeSH term(s) Anastomosis, Surgical/instrumentation ; Anastomosis, Surgical/methods ; Calcinosis/complications ; Constriction ; Humans ; Vascular Surgical Procedures/instrumentation ; Vascular Surgical Procedures/methods
    Language English
    Publishing date 2006-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 80044-2
    ISSN 1478-7083 ; 0035-8843
    ISSN (online) 1478-7083
    ISSN 0035-8843
    DOI 10.1308/rcsann.2006.88.1.77a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Postoperative CT in pancreas transplantation.

    Powell, F E / Harper, S J F / Callaghan, C J / Shaw, A / Godfrey, E M / Bradley, J A / Watson, C J E / Pettigrew, G J

    Clinical radiology

    2015  Volume 70, Issue 11, Page(s) 1220–1228

    Abstract: Aim: To examine the usage and value of computed tomography (CT) following simultaneous pancreas and kidney (SPK) transplantation.: Materials and methods: Indications for postoperative CT, key findings, and their influence on management were ... ...

    Abstract Aim: To examine the usage and value of computed tomography (CT) following simultaneous pancreas and kidney (SPK) transplantation.
    Materials and methods: Indications for postoperative CT, key findings, and their influence on management were determined by retrospective analysis.
    Results: Ninety-eight patients underwent 313 CT examinations. Common indications for the examinations included suspected intra-abdominal collection (31.1%) and elevated serum amylase/lipase (24.1%). CT findings most frequently showed non-specific mild inflammation (27.6%), a normal scan (17.1%) and fluid collections (16.3%). High capillary blood glucose (CBG) was associated with resultant CT demonstration of graft vascular abnormalities, but otherwise, particular clinical indications were not associated with specific CT findings.
    Conclusion: Clinical findings in patients with SPK transplants are non-specific. The pattern of abnormalities encountered is significantly different to those seen in native pancreatic disease and demands a tailored protocol. CT enables accurate depiction of vascular abnormalities and fluid collections, thus reducing the number of surgical interventions that might otherwise be required. Elevated CBG should prompt urgent CT to exclude potentially reversible vascular complications.
    MeSH term(s) Adult ; Allografts/diagnostic imaging ; Blood Glucose/metabolism ; Female ; Graft Survival ; Humans ; Kaplan-Meier Estimate ; Kidney Transplantation/methods ; Male ; Pancreas/diagnostic imaging ; Pancreas Transplantation/methods ; Postoperative Care/methods ; Postoperative Complications/diagnostic imaging ; Retrospective Studies ; Tomography, X-Ray Computed ; Transplantation, Homologous/methods
    Chemical Substances Blood Glucose
    Language English
    Publishing date 2015-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 391227-9
    ISSN 1365-229X ; 0009-9260
    ISSN (online) 1365-229X
    ISSN 0009-9260
    DOI 10.1016/j.crad.2015.06.086
    Database MEDical Literature Analysis and Retrieval System OnLINE

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