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Article ; Online: Meaning Making in Wartime Bereavement: Lessons Learned From Bereaved Parents and Siblings.

Harrington, Christina

2017 Volume 76, Issue 2, Page(s) 103–121

Abstract: Wartime deaths are traumatic and leave many grieving families in their wake. Yet, the unique, nuanced bereavement needs and experiences of those who remain are largely unknown. This Canadian, qualitative study examined the bereavement experiences of ... ...

Abstract	Wartime deaths are traumatic and leave many grieving families in their wake. Yet, the unique, nuanced bereavement needs and experiences of those who remain are largely unknown. This Canadian, qualitative study examined the bereavement experiences of family of origin, bereaved during the mission to Afghanistan. The findings provide rich data on the predominant ways in which family members found and made meaning following the death and the ways in which military culture influenced the meanings made.
MeSH term(s)	Adolescent ; Adult ; Bereavement ; Canada ; Death ; Family/psychology ; Female ; Humans ; Interviews as Topic ; Male ; Military Personnel ; Parents/psychology ; Siblings/psychology ; Social Support ; Warfare ; Young Adult
Language	English
Publishing date	2017-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	207363-8
ISSN	1541-3764 ; 0030-2228
ISSN (online)	1541-3764
ISSN	0030-2228
DOI	10.1177/0030222816643084
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Article: "It's Kind of Like Code-Switching": Black Older Adults' Experiences with a Voice Assistant for Health Information Seeking.

Harrington, Christina N / Garg, Radhika / Woodward, Amanda / Williams, Dimitri

Proceedings of the SIGCHI conference on human factors in computing systems. CHI Conference

2022 Volume 2022

Abstract: Black older adults from lower socioeconomic environments are often neglected in health technology interventions. Voice assistants have a potential to make healthcare more accessible to older adults, yet, little is known about their experiences with this ... ...

Abstract	Black older adults from lower socioeconomic environments are often neglected in health technology interventions. Voice assistants have a potential to make healthcare more accessible to older adults, yet, little is known about their experiences with this type of health information seeking, especially Black older adults. Through a three-phase exploratory study, we explored health information seeking with 30 Black older adults in lower-income environments to understand how they ask health-related questions, and their perceptions of the Google Home being used for that purpose. Through our analysis, we identified the health information needs and common search topics, and discussed the communication breakdowns and types of repair performed. We contribute an understanding of cultural code-switching that has to be done by these older adults when interacting with voice assistants, and the importance of such phenomenon when designing for historically excluded groups.
Language	English
Publishing date	2022-04-29
Publishing country	United States
Document type	Journal Article
DOI	10.1145/3491102.3501995
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Creating a Career Path for Shared Research Resources Personnel.

Fletcher, Luellen / Harrington, Christina A / Nilsen, Aaron / Petrie, Stefanie Kaech / Chitty, Andrew I

Journal of biomolecular techniques : JBT

2023 Volume 33, Issue 4

Abstract: Shared research resources are essential to academic research. A rapidly evolving workforce within a highly competitive market is making recruitment and retention of knowledgeable and technically skilled core staff more difficult. The inability to recruit ...

Abstract	Shared research resources are essential to academic research. A rapidly evolving workforce within a highly competitive market is making recruitment and retention of knowledgeable and technically skilled core staff more difficult. The inability to recruit and retain staff diminishes the resource's overall ability to provide services, which in turn affects academic research quality. Research institutions need to recognize that the roles and skills of shared research resource staff are distinguishable from those of research staff in funded investigator laboratories, and in doing so, develop a career path for shared research resource staff that will help these facilities recruit, train, and retain them. This brief focuses on the creation of a standardized career track for shared research resource staff: a career path of at least 3 to 5 tiered positions with task outlines that can be tailored to positions needed in any shared research resource. Salaries will vary for individuals within each position classification based on experience, mastered competencies, and time within the shared research resource. Besides characterizing basic task differences between shared research resource staff and other research personnel, the most compelling reason for having a well-delineated career path for shared research resource staff is to establish fairness, equity, and true opportunity in a supportive working environment, where shared research resource staff are motivated by developing a marketable skill set, gaining professional self-confidence, and earning a meaningful salary. Presented here is a case study from Oregon Health & Science University of the creation of a career path for shared research resource staff.
MeSH term(s)	Humans ; Research Personnel ; Oregon
Language	English
Publishing date	2023-01-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	2116011-9
ISSN	1943-4731 ; 1943-4731
ISSN (online)	1943-4731
ISSN	1943-4731
DOI	10.7171/3fc1f5fe.418fa1db
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Personal Narratives in Technology Design: The Value of Sharing Older Adults' Stories in the Design of Social Robots.

Ostrowski, Anastasia K / Harrington, Christina N / Breazeal, Cynthia / Park, Hae Won

Frontiers in robotics and AI

2021 Volume 8, Page(s) 716581

Abstract: The storytelling lens in human-computer interaction has primarily focused on personas, design fiction, and other stories crafted by designers, yet informal personal narratives from everyday people have not been considered meaningful data, such as ... ...

Abstract	The storytelling lens in human-computer interaction has primarily focused on personas, design fiction, and other stories crafted by designers, yet informal personal narratives from everyday people have not been considered meaningful data, such as storytelling from older adults. Storytelling may provide a clear path to conceptualize how technologies such as social robots can support the lives of older or disabled individuals. To explore this, we engaged 28 older adults in a year-long co-design process, examining informal stories told by older adults as a means of generating and expressing technology ideas and needs. This paper presents an analysis of participants' stories around their prior experience with technology, stories shaped by social context, and speculative scenarios for the future of social robots. From this analysis, we present suggestions for social robot design, considerations of older adults' values around technology design, and promotion of participant stories as sources for design knowledge and shifting perspectives of older adults and technology.
Language	English
Publishing date	2021-09-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781824-X
ISSN	2296-9144 ; 2296-9144
ISSN (online)	2296-9144
ISSN	2296-9144
DOI	10.3389/frobt.2021.716581
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Article ; Online: Molecular profiling of pre- and post-treatment pediatric high-grade astrocytomas reveals acquired increased tumor mutation burden in a subset of recurrences.

Wood, Matthew D / Beadling, Carol / Neff, Tanaya / Moore, Steve / Harrington, Christina A / Baird, Lissa / Corless, Christopher

Acta neuropathologica communications

2023 Volume 11, Issue 1, Page(s) 143

Abstract: Diffuse gliomas are a heterogeneous category of primary central nervous system tumors. Due to their infiltrative growth precluding complete surgical resection, most diffuse high-grade gliomas are treated with adjuvant chemotherapy and radiation. ... ...

Abstract	Diffuse gliomas are a heterogeneous category of primary central nervous system tumors. Due to their infiltrative growth precluding complete surgical resection, most diffuse high-grade gliomas are treated with adjuvant chemotherapy and radiation. Recurrent/progressive diffuse gliomas may show genetic differences when compared to the primary tumors, giving insight into their molecular evolution and mechanisms of treatment resistance. In adult-type diffuse gliomas with or without isocitrate dehydrogenase gene mutations, tumor recurrence/progression can be associated with mutations in genes encoding DNA mismatch repair proteins, leading to a dramatic increase in tumor mutation burden. This phenomenon is closely linked to treatment with the DNA alkylating agent temozolomide, a mainstay of adult diffuse glioma chemotherapeutic management. Post-treatment mismatch repair deficiency and acquired high tumor mutation burden is relatively unexplored in pediatric patients who have recurrent high-grade gliomas. Here, we report a molecular and histological analysis of an institutional cohort of eleven pediatric patients with paired initial and recurrent high-grade astrocytoma samples with intervening temozolomide treatment. We identified three cases with evidence for increased tumor mutation burden at recurrence, including two cases of diffuse hemispheric glioma H3 G34-mutant (one previously reported). We also show that molecular analysis by next-generation DNA sequencing and DNA methylation-based profiling enabled an integrated diagnosis per 2021 World Health Organization criteria in 10 of 11 cases (91%). Our findings indicate that increased tumor mutation burden at post-treatment recurrence is relevant in pediatric-type diffuse high-grade gliomas. Diffuse hemispheric glioma H3 G34-mutant may be particularly susceptible to this phenomenon.
MeSH term(s)	Adult ; Humans ; Child ; Temozolomide ; Neoplasm Recurrence, Local ; Astrocytoma ; Glioma ; Mutation
Chemical Substances	Temozolomide (YF1K15M17Y)
Language	English
Publishing date	2023-09-05
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2715589-4
ISSN	2051-5960 ; 2051-5960
ISSN (online)	2051-5960
ISSN	2051-5960
DOI	10.1186/s40478-023-01644-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Internet access and cardiovascular death in the United States.

Moorhead, Jeffrey B / Herbert, Brandon M / Abebe, Kaleab Z / Harrington, Christina / Miller, Elizabeth / Lindau, Stacy T / Magnani, Jared W / Johnson, Amber E

American heart journal plus : cardiology research and practice

2022 Volume 21

Abstract: As high-speed internet becomes increasingly important as a resource for cardiovascular disease (CVD) prevention and management services, gaps in digital infrastructure may have detrimental impact on health outcomes. Using national census and CDC data ... ...

Abstract	As high-speed internet becomes increasingly important as a resource for cardiovascular disease (CVD) prevention and management services, gaps in digital infrastructure may have detrimental impact on health outcomes. Using national census and CDC data from 2018 we evaluated state-level rates of household internet access and age-adjusted cardiac mortality. After adjusting for state level demographic variables, and rates of education, income, and health insurance, internet access rates were inversely associated with age adjusted CVD mortality, showing that the potential for internet access to affect CVD management deserves further study.
Language	English
Publishing date	2022-08-28
Publishing country	United States
Document type	Journal Article
ISSN	2666-6022
ISSN (online)	2666-6022
DOI	10.1016/j.ahjo.2022.100200
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Article ; Online: RNA isolation from micro-quantity of articular cartilage for quantitative gene expression by microarray analysis.

Zhang, Xiaowei / McFarland, Trevor J / Vartanian, Kristina / Zhu, Yong / Harrington, Christina A / Chu, Cong-Qiu

International journal of medical sciences

2022 Volume 19, Issue 1, Page(s) 98–104

Abstract: Isolation of quality RNA from articular cartilage has been challenging due to low cellularity and the high abundance of extracellular matrix and proteoglycan proteins. Recently developed methods for isolation of high quality RNA from cartilage are more ... ...

Abstract	Isolation of quality RNA from articular cartilage has been challenging due to low cellularity and the high abundance of extracellular matrix and proteoglycan proteins. Recently developed methods for isolation of high quality RNA from cartilage are more applicable to larger cartilage specimens typically weighing at least 25 mg. While these methods generate RNA suitable for analysis, they are less successful with smaller tissue inputs. For the study of small focal defect cartilage specimens an improved RNA extraction method is needed. Here we report a protocol for direct RNA isolation from less than 3 mg of wet weight rabbit articular cartilage for quantitative microarray gene profiling. This protocol is useful for identifying differentially expressed genes in chondrocytes following focal cartilage repair and can potentially be adopted for gene expression analysis of cartilage biopsy specimens from human joints.
MeSH term(s)	Animals ; Cartilage, Articular/metabolism ; Chondrocytes/metabolism ; Female ; Gene Expression ; Microarray Analysis ; RNA/isolation & purification ; RNA/metabolism ; Rabbits
Chemical Substances	RNA (63231-63-0)
Language	English
Publishing date	2022-01-01
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2151424-0
ISSN	1449-1907 ; 1449-1907
ISSN (online)	1449-1907
ISSN	1449-1907
DOI	10.7150/ijms.65343
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Article ; Online: Novel recruitment approaches and operational results for a statewide population Cohort for cancer research: The Healthy Oregon Project.

Zhang, Zhenzhen / Shafer, Autumn / Johnson-Camacho, Katie / Adey, Andrew / Anur, Pavana / Brown, Kim A / Conrad, Casey / Crist, Rachel / Farris, Paige E / Harrington, Christina A / Marriott, Lisa K / Mitchell, Asia / O'Roak, Brian / Serrato, Vanessa / Richards, C Sue / Spellman, Paul T / Shannon, Jackilen

Journal of clinical and translational science

2024 Volume 8, Issue 1, Page(s) e32

Abstract: Background: Cancer health research relies on large-scale cohorts to derive generalizable results for different populations. While traditional epidemiological cohorts often use costly random sampling or self-motivated, preselected groups, a shift toward ... ...

Abstract	Background: Cancer health research relies on large-scale cohorts to derive generalizable results for different populations. While traditional epidemiological cohorts often use costly random sampling or self-motivated, preselected groups, a shift toward health system-based cohorts has emerged. However, such cohorts depend on participants remaining within a single system. Recent consumer engagement models using smartphone-based communication, driving projects, and social media have begun to upend these paradigms. Methods: We initiated the Healthy Oregon Project (HOP) to support basic and clinical cancer research. HOP study employs a novel, cost-effective remote recruitment approach to effectively establish a large-scale cohort for population-based studies. The recruitment leverages the unique email account, the HOP website, and social media platforms to direct smartphone users to the study app, which facilitates saliva sample collection and survey administration. Monthly newsletters further facilitate engagement and outreach to broader communities. Results: By the end of 2022, the HOP has enrolled approximately 35,000 participants aged 18-100 years (median = 44.2 years), comprising more than 1% of the Oregon adult population. Among those who have app access, ∼87% provided consent to genetic screening. The HOP monthly email newsletters have an average open rate of 38%. Efforts continue to be made to improve survey response rates. Conclusion: This study underscores the efficacy of remote recruitment approaches in establishing large-scale cohorts for population-based cancer studies. The implementation of the study facilitates the collection of extensive survey and biological data into a repository that can be broadly shared and supports collaborative clinical and translational research.
Language	English
Publishing date	2024-01-19
Publishing country	England
Document type	Journal Article
ISSN	2059-8661
ISSN (online)	2059-8661
DOI	10.1017/cts.2024.9
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Article: Understanding older adults' perceptions of and attitudes towards exergames.

Barg-Walkow, Laura H / Harrington, Christina N / Mitzner, Tracy L / Hartley, Jordan Q / Rogers, Wendy A

Gerontechnology : international journal on the fundamental aspects of technology to serve the ageing society

2020 Volume 16, Issue 2, Page(s) 81–90

Abstract: Purpose: Maintaining physical activity is a key component of successful aging and has benefits for both physical and cognitive functioning in the older adult population. One promising method for engaging in physical activity is through exergames, which ... ...

Abstract	Purpose: Maintaining physical activity is a key component of successful aging and has benefits for both physical and cognitive functioning in the older adult population. One promising method for engaging in physical activity is through exergames, which are video games designed to promote exercise. Exergames have the potential to be used by a wide range of people, including older adults, in a variety of settings, such as at home, in community living environments, or senior centers. However, exergames have not been designed for older adults (e.g., with respect to their attitudes, needs). Thus, older adults may not adopt these systems if they perceive them as not useful or relevant to them. Method: Twenty older adults (aged 60-79) interacted with two exergames, and were then interviewed about their perceptions of the system's ease of use and usefulness, as well as their general attitudes towards the system. Results: Participants identified the potential for exergames' usefulness for various goals, such as to increase their physical activity. However, they also reported negative attitudes concerning the system, including perceiving barriers to system use. Overall, participants said they would use the system in the future and recommend it to other people at their age for improving health, despite these use challenges. Conclusion: The older adults were open to adopting exergames, which could provide opportunities to increase physical activity. Given the participants' overall positive perceptions of the usefulness of exergames, designers must address the perceived challenges of using these systems. Understanding barriers and facilitators for older adults' use of exergames can guide design, training, and adoption of these systems.
Language	English
Publishing date	2020-02-03
Publishing country	Netherlands
Document type	Journal Article
ISSN	1569-1101
ISSN	1569-1101
DOI	10.4017/gt.2017.16.2.003.00
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Article ; Online: Deciphering spatially distinct immune microenvironments in glioblastoma using ferumoxytol and gadolinium-enhanced and FLAIR hyperintense MRI phenotypes.

Stoller, Jared / Kersch, Cymon N / Muldoon, Leslie L / Ambady, Prakash / Harrington, Christina A / Fu, Rongwei / Raslan, Ahmed M / Dogan, Aclan / Neuwelt, Edward A / Barajas, Ramon F

Neuro-oncology advances

2023 Volume 5, Issue 1, Page(s) vdad148

Abstract: Background: MRI with gadolinium (Gd)-contrast agents is used to assess glioblastoma treatment response but does not specifically reveal heterogeneous biology or immune microenvironmental composition. Ferumoxytol (Fe) contrast is an iron nanoparticle ... ...

Abstract	Background: MRI with gadolinium (Gd)-contrast agents is used to assess glioblastoma treatment response but does not specifically reveal heterogeneous biology or immune microenvironmental composition. Ferumoxytol (Fe) contrast is an iron nanoparticle that localizes glioblastoma macrophages and microglia. Therefore, we hypothesized that the use of Fe contrast improves upon standard Gd-based T1-weighted and T2/FLAIR analysis by specifically delineating immune processes. Methods: In this, HIPAA-compliant institutional review board-approved prospective study, stereotactic biopsy samples were acquired from patients with treatment-naïve and recurrent glioblastoma based on MR imaging phenotypes; Gd and Fe T1 enhancement (Gd+, Fe+) or not (Gd-, Fe-), as well as T2-Flair hyperintensity (FLAIR+, FLAIR-). Analysis of genetic expression was performed with RNA microarrays. Imaging and genomic expression patterns were compared using false discovery rate statistics. Results: MR imaging phenotypes defined a variety of immune pathways and Hallmark gene sets. Gene set enrichment analysis demonstrated that Gd+, Fe+, and FLAIR+ features were individually correlated with the same 7 immune process gene sets. Fe+ tissue showed the greatest degree of immune Hallmark gene sets compared to Gd+ or Flair+ tissues and had statistically elevated M2 polarized macrophages, among others. Importantly, the FLAIR+ Gd+ and Fe- imaging phenotypes did not demonstrate expression of immune Hallmark gene sets. Conclusions: Our study demonstrates the potential of Fe and Gd-enhanced MRI phenotypes to reveal spatially distinct immune processes within glioblastoma. Fe improves upon the standard of care Gd enhancement by specifically localizing glioblastoma-associated inflammatory processes, providing valuable insights into tumor biology.
Language	English
Publishing date	2023-11-08
Publishing country	England
Document type	Journal Article
ZDB-ID	3009682-0
ISSN	2632-2498 ; 2632-2498
ISSN (online)	2632-2498
ISSN	2632-2498
DOI	10.1093/noajnl/vdad148
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