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  1. Article: An overview of transanal irrigation devices: an update.

    Harris, Gemma

    British journal of nursing (Mark Allen Publishing)

    2022  Volume 31, Issue 12, Page(s) 612–618

    Abstract: Transanal irrigation (TAI) is safe and effective treatment for constipation and faecal incontinence, but it should not be carried out before less invasive options have been tried. A thorough patient assessment and consideration of their preferences and ... ...

    Abstract Transanal irrigation (TAI) is safe and effective treatment for constipation and faecal incontinence, but it should not be carried out before less invasive options have been tried. A thorough patient assessment and consideration of their preferences and tolerance should determine suitability and system choice. The range of available TAI equipment can be overwhelming. Therefore, to aid health professionals, this article presents a summary of the latest available devices on the market, as well as guidance on how to select a suitable device. TAI devices can be categorised into low-or high-volume; cones, catheters or balloon inflating devices; manual, electric pump or gravity-fed systems; and bed systems. Determining whether a low or high volume of water is required is a good starting point for device selection. Nurses should be aware of available devices and select one most suitable for a patient, as well as adequately train them in its usage and provide follow-up support. Nurses should communicate the potential improvement to quality of life TAI can offer and encourage adherence to avoid premature discontinuation.
    MeSH term(s) Anal Canal ; Constipation/therapy ; Fecal Incontinence/therapy ; Humans ; Quality of Life ; Therapeutic Irrigation ; Treatment Outcome
    Language English
    Publishing date 2022-06-23
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1119191-0
    ISSN 0966-0461
    ISSN 0966-0461
    DOI 10.12968/bjon.2022.31.12.612
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3449: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Book: High dimensional single cell analysis

    Fienberg, Harris G. / Nolan, Garry P.

    mass cytometry, multi-parametric flow cytometry and bioinformatic techniques

    (Current topics in microbiology and immunology ; 377)

    2014  

    Title variant High-dimensional single cell analysis
    Author's details Harris G. Fienberg ; Garry P. Nolan ed
    Series title Current topics in microbiology and immunology ; 377
    Collection
    Keywords Cytometrie ; Einzelzellanalyse ; Immuncytochemie ; Bioinformatik
    Subject Immunhistochemie ; Immunocytochemie ; Immunzytochemie ; Immunozytochemie ; Single Cell Analysis ; Einzelzell-Analyse ; SCA ; Zytometrie
    Language English
    Size X, 215 S. : Ill., graph. Darst., 235 mm x 155 mm
    Publisher Springer
    Publishing place Heidelberg u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT018265657
    ISBN 978-3-642-54826-0 ; 3-642-54826-1 ; 9783642548277 ; 364254827X
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Ud II Zs 24 -377- verfügbar in Königswinter Königswinter

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  3. Book: Seeking sustainability in an age of complexity

    Harris, Graham

    2007  

    Author's details Graham Harris
    Keywords Sustainable development ; Natural resources/Management
    Subject code 333.7
    Language English
    Size VIII, 366 S.
    Publisher Cambridge Univ. Press
    Publishing place Cambridge u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT015239928
    ISBN 0-521-87349-5 ; 0-521-69532-5 ; 978-0-521-87349-9 ; 978-0-521-69532-9
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    074/516 available for loan (reading room) Freihandmagazin (U1)

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  4. Article ; Online: Beyond the bulge: parastomal seromas and ileostomy dysfunction.

    Yeung, Trevor M / Harris, Guy

    ANZ journal of surgery

    2023  Volume 93, Issue 11, Page(s) 2762–2763

    MeSH term(s) Humans ; Ileostomy/adverse effects ; Seroma ; Surgical Stomas/adverse effects ; Colostomy/adverse effects ; Hernia, Ventral ; Surgical Mesh
    Language English
    Publishing date 2023-07-24
    Publishing country Australia
    Document type Case Reports
    ZDB-ID 2050749-5
    ISSN 1445-2197 ; 1445-1433 ; 0004-8682
    ISSN (online) 1445-2197
    ISSN 1445-1433 ; 0004-8682
    DOI 10.1111/ans.18627
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 180: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: High Comorbidity of Gastrointestinal Disorders Among Those Seeking Care for Dyspareunia.

    Silvernale, Casey / Harris, Grace / Staller, Kyle

    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

    2024  

    Abstract: Dyspareunia, defined as genital pain that occurs before, during, or after sexual intercourse, is the most commonly diagnosed form of female sexual dysfunction. As high as 43% of women experience some form of sexual dysfunction, but the etiology of these ... ...

    Abstract Dyspareunia, defined as genital pain that occurs before, during, or after sexual intercourse, is the most commonly diagnosed form of female sexual dysfunction. As high as 43% of women experience some form of sexual dysfunction, but the etiology of these conditions is not well understood.
    Language English
    Publishing date 2024-01-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2119789-1
    ISSN 1542-7714 ; 1542-3565
    ISSN (online) 1542-7714
    ISSN 1542-3565
    DOI 10.1016/j.cgh.2024.01.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5836: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Absence of a robust mitotic timer mechanism in early preimplantation mouse embryos leads to chromosome instability.

    Allais, Adélaïde / FitzHarris, Greg

    Development (Cambridge, England)

    2022  Volume 149, Issue 13

    Abstract: Preimplantation embryos often consist of a combination of euploid and aneuploid cells, suggesting that safeguards preventing the generation and propagation of aneuploid cells in somatic cells might be deficient in embryos. In somatic cells, a mitotic ... ...

    Abstract Preimplantation embryos often consist of a combination of euploid and aneuploid cells, suggesting that safeguards preventing the generation and propagation of aneuploid cells in somatic cells might be deficient in embryos. In somatic cells, a mitotic timer mechanism has been described, in which even a small increase in the duration of M phase can cause a cell cycle arrest in the subsequent interphase, preventing further propagation of cells that have undergone a potentially hazardously long M phase. Here, we report that cell divisions in the mouse embryo and embryonic development continue even after a mitotic prolongation of several hours. However, similar M-phase extensions caused cohesion fatigue, resulting in prematurely separated sister chromatids and the production of micronuclei. Only extreme prolongation of M phase caused a subsequent interphase arrest, through a mechanism involving DNA damage. Our data suggest that the simultaneous absence of a robust mitotic timer and susceptibility of the embryo to cohesion fatigue could contribute to chromosome instability in mammalian embryos. This article has an associated 'The people behind the papers' interview.
    MeSH term(s) Aneuploidy ; Animals ; Blastocyst/metabolism ; Chromosomal Instability ; Embryonic Development/genetics ; Fatigue/metabolism ; Female ; Humans ; Mammals ; Mice ; Pregnancy
    Language English
    Publishing date 2022-06-30
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 90607-4
    ISSN 1477-9129 ; 0950-1991
    ISSN (online) 1477-9129
    ISSN 0950-1991
    DOI 10.1242/dev.200391
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ub I Zs.183: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 91: Show issues

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  7. Article ; Online: Automated detection, delineation and quantification of whole-body bone metastasis using FDG-PET/CT images.

    Nigam, R / Field, M / Harris, G / Barton, M / Carolan, M / Metcalfe, P / Holloway, L

    Physical and engineering sciences in medicine

    2023  Volume 46, Issue 2, Page(s) 851–863

    Abstract: Non-small cell lung cancer (NSCLC) patients with the metastatic spread of disease to the bone have high morbidity and mortality. Stereotactic ablative body radiotherapy increases the progression free survival and overall survival of these patients with ... ...

    Abstract Non-small cell lung cancer (NSCLC) patients with the metastatic spread of disease to the bone have high morbidity and mortality. Stereotactic ablative body radiotherapy increases the progression free survival and overall survival of these patients with oligometastases. FDG-PET/CT, a functional imaging technique combining positron emission tomography (PET) with 18 F-fluorodeoxyglucose (FDG) and computer tomography (CT) provides improved staging and identification of treatment response. It is also associated with reduction in size of the radiotherapy tumour volume delineation compared with CT based contouring in radiotherapy, thus allowing for dose escalation to the target volume with lower doses to the surrounding organs at risk. FDG-PET/CT is increasingly being used for the clinical management of NSCLC patients undergoing radiotherapy and has shown high sensitivity and specificity for the detection of bone metastases in these patients. Here, we present a software tool for detection, delineation and quantification of bone metastases using FDG-PET/CT images. The tool extracts standardised uptake values (SUV) from FDG-PET images for auto-segmentation of bone lesions and calculates volume of each lesion and associated mean and maximum SUV. The tool also allows automatic statistical validation of the auto-segmented bone lesions against the manual contours of a radiation oncologist. A retrospective review of FDG-PET/CT scans of more than 30 candidate NSCLC patients was performed and nine patients with one or more metastatic bone lesions were selected for the present study. The SUV threshold prediction model was designed by splitting the cohort of patients into a subset of 'development' and 'validation' cohorts. The development cohort yielded an optimum SUV threshold of 3.0 for automatic detection of bone metastases using FDG-PET/CT images. The validity of the derived optimum SUV threshold on the validation cohort demonstrated that auto-segmented and manually contoured bone lesions showed strong concordance for volume of bone lesion (r = 0.993) and number of detected lesions (r = 0.996). The tool has various applications in radiotherapy, including but not limited to studies determining optimum SUV threshold for accurate and standardised delineation of bone lesions and in scientific studies utilising large patient populations for instance for investigation of the number of metastatic lesions that can be treated safety with an ablative dose of radiotherapy without exceeding the normal tissue toxicity.
    MeSH term(s) Humans ; Carcinoma, Non-Small-Cell Lung/diagnostic imaging ; Carcinoma, Non-Small-Cell Lung/pathology ; Carcinoma, Non-Small-Cell Lung/radiotherapy ; Fluorodeoxyglucose F18 ; Positron Emission Tomography Computed Tomography ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/radiotherapy ; Tomography, X-Ray Computed/methods ; Positron-Emission Tomography/methods ; Computers
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2023-05-01
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2662-4737
    ISSN (online) 2662-4737
    DOI 10.1007/s13246-023-01258-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: How can we tackle malnutrition in patients discharged from hospital?

    Harris, Gemma

    British Journal of Healthcare Management

    Abstract: The UK is facing a malnutrition emergency in hospitals that will place further strain on the NHS if action is not taken and guidelines are not followed The coronavirus pandemic is increasing the pressure to take action Effectively identifying and ... ...

    Abstract The UK is facing a malnutrition emergency in hospitals that will place further strain on the NHS if action is not taken and guidelines are not followed The coronavirus pandemic is increasing the pressure to take action Effectively identifying and managing malnutrition can improve lives and save money
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #648080
    Database COVID19

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  9. Book ; Online: Improving Constraint Satisfaction Algorithm Efficiency for the AllDifferent Constraint

    Harris, Geoff

    2020  

    Abstract: Combinatorial problems stated as Constraint Satisfaction Problems (CSP) are examined. It is shown by example that any algorithm designed for the original CSP, and involving the AllDifferent constraint, has at least the same level of efficacy when ... ...

    Abstract Combinatorial problems stated as Constraint Satisfaction Problems (CSP) are examined. It is shown by example that any algorithm designed for the original CSP, and involving the AllDifferent constraint, has at least the same level of efficacy when simultaneously applied to both the original and its complementary problem. The 1-to-1 mapping employed to transform a CSP to its complementary problem, which is also a CSP, is introduced. This "Dual CSP" method and its application are outlined. The analysis of several random problem instances demonstrate the benefits of this method for variable domain reduction compared to the standard approach to CSP. Extensions to additional constraints other than AllDifferent, as well as the use of hybrid algorithms, are proposed as candidates for this Dual CSP method.

    Comment: *sigh* - it has been gently and kindly pointed out to me that I have simply re-discovered the channelling of constraints across alternate problem specifications. Gosh this is oddly amusing albeit embarrassing!
    Keywords Computer Science - Artificial Intelligence
    Subject code 006
    Publishing date 2020-12-07
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Book ; Online: PROCESS IMPROVEMENT FOR EMERGENCY DEPARTMENT FAST TRACK

    Harris, Gwen

    2020  

    Abstract: A modification within triage was created to assist with the differentiation of fast track and non-fast track patients in an urban, nontrauma center emergency department. The process improvement project intended to have fast track appropriate patients ... ...

    Abstract A modification within triage was created to assist with the differentiation of fast track and non-fast track patients in an urban, nontrauma center emergency department. The process improvement project intended to have fast track appropriate patients ready for provider evaluation in a decrease time frame. The triage modification reduced the number of questions asked to fast track patients to four. Overall, the goal was to demonstrate that earlier provider evaluation decreased total patient length of stay for fast track patients. However, the process improvement project was terminated early due to the outbreak of COVID-19 in the winter/early spring of 2020. There was minimal data collection specific to fast track, but overall departmental data suggests that when providers evaluate patients in a timely manner, the total patient length of stay time decreases.

    D.N.P.
    Keywords Emergency department ; fast track ; triage ; covid19
    Language English
    Publishing date 2020-08-02
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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