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  1. Article ; Online: The Role of the Epidermal Growth Factor Receptor in Diabetic Kidney Disease.

    Harris, Raymond C

    Cells

    2022  Volume 11, Issue 21

    Abstract: The epidermal growth factor receptor (EGFR) is expressed in numerous cell types in the adult mammalian kidney and is activated by a family of EGF-like ligands. ...

    Abstract The epidermal growth factor receptor (EGFR) is expressed in numerous cell types in the adult mammalian kidney and is activated by a family of EGF-like ligands.
    MeSH term(s) Animals ; Diabetic Nephropathies/metabolism ; ErbB Receptors/metabolism ; Kidney/metabolism ; Kidney Glomerulus ; Epithelial Cells/metabolism ; Mammals/metabolism ; Diabetes Mellitus/metabolism
    Chemical Substances ErbB Receptors (EC 2.7.10.1)
    Language English
    Publishing date 2022-10-28
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells11213416
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The epidermal growth factor receptor axis and kidney fibrosis.

    Harris, Raymond C

    Current opinion in nephrology and hypertension

    2021  Volume 30, Issue 3, Page(s) 275–279

    Abstract: Purpose of review: The aim of this study was to summarize recent findings about the role of the epidermal growth factor receptor (EGFR) in acute kidney injury and in progression of chronic kidney injury.: Recent findings: There is increasing evidence ...

    Abstract Purpose of review: The aim of this study was to summarize recent findings about the role of the epidermal growth factor receptor (EGFR) in acute kidney injury and in progression of chronic kidney injury.
    Recent findings: There is increasing evidence that EGFR activation occurs as a response to either ischemic or toxic kidney injury and EGFR signalling plays an important role in recovery of epithelial integrity. However, with incomplete recovery or in conditions predisposing to progressive glomerular and tubulointerstitial injury, aberrant persistent EGFR signalling is a causal mediator of progressive fibrotic injury. New studies have implicated activation of HIPPO/YAP signalling as a component of EGFR's actions in the kidney. There is also new evidence for sex disparities in kidney EGFR expression and activation after injury, with a male predominance that is mediated by androgens.
    Summary: There is increasing evidence for an important role for EGFR signalling in mediation of kidney injury, raising the possibility that interruption of the signalling cascade could limit progression of development of progressive kidney fibrosis.
    MeSH term(s) Acute Kidney Injury ; ErbB Receptors ; Female ; Fibrosis ; Humans ; Kidney/enzymology ; Kidney/pathology ; Male ; Signal Transduction
    Chemical Substances EGFR protein, human (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1)
    Language English
    Publishing date 2021-03-24
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 1151092-4
    ISSN 1473-6543 ; 1535-3842 ; 1062-4813 ; 1062-4821
    ISSN (online) 1473-6543 ; 1535-3842
    ISSN 1062-4813 ; 1062-4821
    DOI 10.1097/MNH.0000000000000696
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3686: Show issues Location:
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  3. Article ; Online: Authors' Reply.

    Harris, Raymond C / Zhang, Ming-Zhi

    Journal of the American Society of Nephrology : JASN

    2021  Volume 32, Issue 11, Page(s) 2972

    Language English
    Publishing date 2021-10-05
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.2021070993
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    Zs.A 3344: Show issues Location:
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  4. Article ; Online: Inhibition of transcriptional coactivator YAP Impairs the expression and function of transcription factor WT1 in diabetic podocyte injury.

    Chen, Jianchun / Wang, Xiaoyong / He, Qian / Yang, Hai-Chun / Fogo, Agnes B / Harris, Raymond C

    Kidney international

    2024  

    Abstract: Podocyte injury and loss are hallmarks of diabetic nephropathy (DN). However, the molecular mechanisms underlying these phenomena remain poorly understood. YAP (Yes-associated protein) is an important transcriptional coactivator that binds with various ... ...

    Abstract Podocyte injury and loss are hallmarks of diabetic nephropathy (DN). However, the molecular mechanisms underlying these phenomena remain poorly understood. YAP (Yes-associated protein) is an important transcriptional coactivator that binds with various other transcription factors, including the TEAD family members (nuclear effectors of the Hippo pathway), that regulate cell proliferation, differentiation, and apoptosis. The present study found an increase in YAP phosphorylation at S127 of YAP and a reduction of nuclear YAP localization in podocytes of diabetic mouse and human kidneys, suggesting dysregulation of YAP may play a role in diabetic podocyte injury. Tamoxifen-inducible podocyte-specific Yap gene knockout mice (Yap
    Language English
    Publishing date 2024-02-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2024.01.038
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    Zs.A 797: Show issues Location:
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  5. Article ; Online: The authors reply.

    Yu, Pan / Harris, Raymond C / Zhang, Ming-Zhi

    Kidney international

    2022  Volume 101, Issue 5, Page(s) 1084–1085

    Language English
    Publishing date 2022-04-23
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2022.01.019
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  6. Article: The role of gender disparities in kidney injury.

    Harris, Raymond C / Zhang, Ming-Zhi

    Annals of translational medicine

    2020  Volume 8, Issue 7, Page(s) 514

    Language English
    Publishing date 2020-04-24
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm.2020.01.23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The Vanderbilt O'Brien Kidney Center.

    Pozzi, Ambra / Harris, Raymond C

    American journal of physiology. Renal physiology

    2020  Volume 320, Issue 3, Page(s) F342–F350

    Abstract: The Vanderbilt O'Brien Kidney Center (VOKC) is one of the eight National Institutes of Health P30-funded centers in the United States. The mission of these core-based centers is to provide technical and conceptual support to enhance and facilitate ... ...

    Abstract The Vanderbilt O'Brien Kidney Center (VOKC) is one of the eight National Institutes of Health P30-funded centers in the United States. The mission of these core-based centers is to provide technical and conceptual support to enhance and facilitate research in the field of kidney diseases. The goal of the VOKC is to provide support to understand mechanisms and identify potential therapies for acute and chronic kidney disease. The services provided by the VOKC are meant to help the scientific community to have the right support and tools as well as to select the right animal model, statistical analysis, and clinical study design to perform innovative research and translate discoveries into personalized care to prevent, diagnose, and cure kidney disease. To achieve these goals, the VOKC has in place a program to foster collaborative investigation into critical questions of kidney disease, to personalize diagnosis and treatment of kidney disease, and to disseminate information about kidney disease and the benefits of VOKC services and research. The VOKC is complemented by state-of-the-art cores and an education and outreach program whose goals are to provide an educational platform to enhance the study of kidney disease, to publicize information about services available through the VOKC, and to provide information about kidney disease to patients and other interested members of the community. In this review, we highlight the major services and contributions of the VOKC.
    MeSH term(s) Animals ; Biomedical Research/education ; Biomedical Research/organization & administration ; Community-Institutional Relations ; Cooperative Behavior ; Education, Professional/organization & administration ; Health Education/organization & administration ; Humans ; Interdisciplinary Communication ; Nephrology/education ; Nephrology/organization & administration ; Research Design ; Tennessee
    Language English
    Publishing date 2020-12-28
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 603837-2
    ISSN 1522-1466 ; 0363-6127
    ISSN (online) 1522-1466
    ISSN 0363-6127
    DOI 10.1152/ajprenal.00452.2020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uc I Zs.89: Show issues Location:
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  8. Article ; Online: Immunohistochemical Staining of CD8α in Diabetic Mouse Kidney.

    Zhang, Ming-Zhi / Harris, Raymond C

    Bio-protocol

    2019  Volume 9, Issue 18, Page(s) e3364

    Abstract: Immune cell infiltration, particularly cytotoxic CD8α lymphocyte infiltration, plays an important role in development of diabetic nephropathy. Although CD8α infiltration can be evaluated by its production of cytokines, its localization in the kidney is ... ...

    Abstract Immune cell infiltration, particularly cytotoxic CD8α lymphocyte infiltration, plays an important role in development of diabetic nephropathy. Although CD8α infiltration can be evaluated by its production of cytokines, its localization in the kidney is of particular importance. The current protocol describes CD8α immunostaining using a Vectastain ABC kit. This protocol works well with most commercially available antibodies, including CD8α antibodies in kidneys of diabetic mice.
    Language English
    Publishing date 2019-09-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2833269-6
    ISSN 2331-8325 ; 2331-8325
    ISSN (online) 2331-8325
    ISSN 2331-8325
    DOI 10.21769/BioProtoc.3364
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: How the Kidney Health Initiative Catalyzes Innovation in a Dynamic Environment.

    Harris, Raymond C / Cahill, Zachary

    Clinical journal of the American Society of Nephrology : CJASN

    2019  Volume 15, Issue 3, Page(s) 421–422

    MeSH term(s) Biomedical Research ; Cooperative Behavior ; Diffusion of Innovation ; Health Priorities ; Health Services Needs and Demand ; Humans ; Interdisciplinary Communication ; Nephrology ; Public-Private Sector Partnerships ; Societies, Medical ; United States ; United States Food and Drug Administration
    Language English
    Publishing date 2019-12-06
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 2226665-3
    ISSN 1555-905X ; 1555-9041
    ISSN (online) 1555-905X
    ISSN 1555-9041
    DOI 10.2215/CJN.11060919
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6584: Show issues Location:
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  10. Article ; Online: TAZ is important for maintenance of the integrity of podocytes.

    Chen, Jianchun / Wang, Xiaoyong / He, Qian / Harris, Raymond C

    American journal of physiology. Renal physiology

    2022  Volume 322, Issue 4, Page(s) F419–F428

    Abstract: The podocyte is an important component of the glomerular filtration barrier, and maintenance of the integrity of its highly specified structure and function is critical for normal kidney function. Yes-associated protein (YAP)/transcriptional coactivator ... ...

    Abstract The podocyte is an important component of the glomerular filtration barrier, and maintenance of the integrity of its highly specified structure and function is critical for normal kidney function. Yes-associated protein (YAP)/transcriptional coactivator with PDZ-binding motif (TAZ) are two crucial effectors of the Hippo signaling pathway, and recent studies have shown that podocyte-specific YAP deletion causes podocyte apoptosis and the development of focal segmental glomerulosclerosis followed by progressive renal failure. In the present study, we investigated a potential role of the YAP paralog TAZ in podocytes. TAZ was found to be constitutively active in podocytes, and mice with podocyte-specific deletion of TAZ (
    MeSH term(s) Animals ; Glomerulosclerosis, Focal Segmental/metabolism ; Kidney/metabolism ; Mice ; Podocytes/metabolism ; Proteinuria/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism
    Chemical Substances Transcription Factors
    Language English
    Publishing date 2022-02-14
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 603837-2
    ISSN 1522-1466 ; 0363-6127
    ISSN (online) 1522-1466
    ISSN 0363-6127
    DOI 10.1152/ajprenal.00426.2021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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