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  1. Book ; Online: Hakol Kol Yaakov : The Joel Roth Jubilee Volume

    Harris, Robert A. / Milgram, Jonathan S.

    2021  

    Keywords Judaism ; Judaism: worship, rites & ceremonies
    Size 1 electronic resource (527 pages)
    Publisher Brill
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021048764
    ISBN 9789004420458 ; 9004420452
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Glycyl-L-Histidyl-L-Lysine (GHK) Prevents Copper- and Zinc-Induced Protein Aggregation and CNS Cell Death in vitro.

    Min, Jin-Hong / Sarlus, Heela / Harris, Robert A

    Metallomics : integrated biometal science

    2024  

    Abstract: Common features of neurodegenerative diseases are oxidative and inflammatory imbalances as well as the misfolding of proteins. An excess of free metal ions can be pathological and contribute to cell death, but only copper and zinc strongly promote ... ...

    Abstract Common features of neurodegenerative diseases are oxidative and inflammatory imbalances as well as the misfolding of proteins. An excess of free metal ions can be pathological and contribute to cell death, but only copper and zinc strongly promote protein aggregation. Herein we demonstrate that the endogenous copper binding tripeptide Glycyl-L-Histidyl-L-Lysine (GHK) has the ability to bind to and reduce copper redox activity, and to prevent copper and zinc induced cell death in vitro. In addition, GHK prevents copper- and zinc-induced BSA aggregation and reverses aggregation through resolubilizing the protein. We further demonstrate the enhanced toxicity of copper during inflammation and the ability of GHK to attenuate this toxicity. Finally, we investigated the effects of copper on enhancing paraquat toxicity and report a protective effect of GHK. We therefore conclude that GHK has potential as a cytoprotective compound with regards to copper and zinc toxicity, with positive effects on protein solubility and aggregation that warrants further investigation in the treatment of neurodegenerative diseases.
    Language English
    Publishing date 2024-04-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2474317-3
    ISSN 1756-591X ; 1756-5901
    ISSN (online) 1756-591X
    ISSN 1756-5901
    DOI 10.1093/mtomcs/mfae019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Conference proceedings: Branched chain amino acids

    Harris, Robert A.

    metabolism, physiological function, and application ; proceedings of the Symposium on Branched-Chain Amino Acids held May 23 - 24, 2005 in Versailles

    (The journal of nutrition ; 136,1,S)

    2006  

    Title variant Branched-chain amino acids
    Event/congress Symposium on Branched Chain Amino Acids (2005, Versailles)
    Author's details guest ed.: Robert A. Harris
    Series title The journal of nutrition ; 136,1,S
    Collection
    Language English
    Size S. 207S - 336S : Ill., graph. Darst.
    Publisher American Soc. for Nutritional Sciences
    Publishing place Bethesda, MD
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT014607847
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    Z 774 (136,1,S) available for loan (reading room) Freihandmagazin (U1)

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  4. Article ; Online: A critical review of the role of M

    Harris, Robert A / Fenton, Aron W

    Biochimica et biophysica acta. Reviews on cancer

    2019  Volume 1871, Issue 2, Page(s) 225–239

    Abstract: It is becoming generally accepted in recent literature that the Warburg effect in cancer depends on inhibition of ... ...

    Abstract It is becoming generally accepted in recent literature that the Warburg effect in cancer depends on inhibition of M
    MeSH term(s) Animals ; Cell Respiration/physiology ; Glycolysis/physiology ; Humans ; Neoplasms/metabolism ; Pyruvate Kinase/metabolism
    Chemical Substances Pyruvate Kinase (EC 2.7.1.40)
    Language English
    Publishing date 2019-01-29
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2918802-7
    ISSN 1879-2561 ; 0304-419X
    ISSN (online) 1879-2561
    ISSN 0304-419X
    DOI 10.1016/j.bbcan.2019.01.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7162: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: A translational concept of immuno-radiobiology.

    Lippitz, Bodo E / Harris, Robert A

    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

    2019  Volume 140, Page(s) 116–124

    Abstract: Background: Traditional concepts of radiobiology model the direct radiation-induced cellular cytotoxicity but are not focused on late and sustained effects of radiation. Recent experimental data show the close involvement of immunological processes.: ... ...

    Abstract Background: Traditional concepts of radiobiology model the direct radiation-induced cellular cytotoxicity but are not focused on late and sustained effects of radiation. Recent experimental data show the close involvement of immunological processes.
    Methods: Based on systematic PubMed searches, experimental data on immunological radiation effects are summarized and analyzed in a non-quantitative descriptive manner to provide a translational perspective on the immuno-modulatory impact of radiation in cancer.
    Results: Novel experimental findings document that sustained radiation effects are ultimately mediated through systemic factors such as cytotoxic CD8+ T cells and involve a local immuno-stimulation. Increased tumor infiltration of CD8+ T cell is a prerequisite for long-term radiation effects. CD8+ T cell depletion induces radio-resistance in experimental tumors. The proposed sequence of events involves radiation-damaged cells that release HMGB1, which activates macrophages via TLR4 to a local immuno-stimulation via TNF, which contributes to maturation of DCs. The mature DCs migrate to lymph nodes where they trigger effective CD8+ T cell responses. Radiation effects are boosted, when the physiological self-terminating negative feedback of immune reactions is antagonised via blocking of TGF-β or via checkpoint inhibition with involvement of CD8+ T cells as common denominator.
    Conclusion: The concept of immuno-radiobiology emphasizes the necessity for a functional integrity of APCs and T cells for the long-term effects of radiotherapy. Local irradiation at higher doses induces tumor infiltration of CD8+ T cells, which can be boosted by immunotherapy. More systematic research is warranted to better understand the immunological effects of escalating radiation doses.
    MeSH term(s) Animals ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/radiation effects ; Humans ; Immunomodulation/radiation effects ; Immunotherapy ; Neoplasms/immunology ; Neoplasms/radiotherapy
    Language English
    Publishing date 2019-07-01
    Publishing country Ireland
    Document type Journal Article ; Review
    ZDB-ID 605646-5
    ISSN 1879-0887 ; 0167-8140
    ISSN (online) 1879-0887
    ISSN 0167-8140
    DOI 10.1016/j.radonc.2019.06.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1926: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Chronic Immunosuppression and Potential Infection Risks in CSF1R-Related Leukoencephalopathy.

    Han, Jinming / Harris, Robert A / Karrenbauer, Virginija Danylaité

    Movement disorders : official journal of the Movement Disorder Society

    2021  Volume 36, Issue 6, Page(s) 1470–1471

    MeSH term(s) Humans ; Immunosuppression ; Leukoencephalopathies/etiology ; Magnetic Resonance Imaging
    Language English
    Publishing date 2021-06-18
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 607633-6
    ISSN 1531-8257 ; 0885-3185
    ISSN (online) 1531-8257
    ISSN 0885-3185
    DOI 10.1002/mds.28627
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2555: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 238: Show issues

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  7. Article ; Online: Phenotyping of Macrophages After Radiolabeling and Safety of Intra-arterial Transplantation Assessed by SPECT/CT and MRI.

    Friberger, Ida / Gontu, Vamsi / Harris, Robert A / Tran, Thuy A / Lundberg, Johan / Holmin, Staffan

    Cell transplantation

    2023  Volume 32, Page(s) 9636897231212780

    Abstract: Cell therapy is an integral modality of regenerative medicine. Macrophages are known for their sensitivity to activation stimuli and capability to recruit other immune cells to the sites of injury and healing. In addition, the route of administration can ...

    Abstract Cell therapy is an integral modality of regenerative medicine. Macrophages are known for their sensitivity to activation stimuli and capability to recruit other immune cells to the sites of injury and healing. In addition, the route of administration can impact engraftment and efficacy of cell therapy, and modern neuro-interventional techniques provide the possibility for selective intra-arterial (IA) delivery to the central nervous system (CNS) with very low risk. The effects of radiolabelling and catheter transport on differentially activated macrophages were evaluated. Furthermore, the safety of selective IA administration of these macrophages to the rabbit brain was assessed by single-photon emission computed tomography/computed tomography (SPECT/CT) and ultra-high-field (9.4 T) magnetic resonance imaging (MRI). Cells were successfully labeled with (
    MeSH term(s) Animals ; Rabbits ; Lipopolysaccharides/pharmacology ; Interferon-gamma ; Tomography, Emission-Computed, Single-Photon/methods ; Tomography, X-Ray Computed ; Macrophages ; Magnetic Resonance Imaging/methods
    Chemical Substances Lipopolysaccharides ; Interferon-gamma (82115-62-6)
    Language English
    Publishing date 2023-11-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1135816-6
    ISSN 1555-3892 ; 0963-6897
    ISSN (online) 1555-3892
    ISSN 0963-6897
    DOI 10.1177/09636897231212780
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3556: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Spatial, Temporal, and Functional Aspects of Macrophages during "The Good, the Bad, and the Ugly" Phases of Inflammation.

    Harris, Robert A

    Frontiers in immunology

    2014  Volume 5, Page(s) 612

    Language English
    Publishing date 2014
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 1664-3224
    ISSN (online) 1664-3224
    DOI 10.3389/fimmu.2014.00612
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Inhibition of colony stimulating factor-1 receptor (CSF-1R) as a potential therapeutic strategy for neurodegenerative diseases: opportunities and challenges.

    Han, Jinming / Chitu, Violeta / Stanley, E Richard / Wszolek, Zbigniew K / Karrenbauer, Virginija Danylaité / Harris, Robert A

    Cellular and molecular life sciences : CMLS

    2022  Volume 79, Issue 4, Page(s) 219

    Abstract: Microglia are specialized dynamic immune cells in the central nervous system (CNS) that plays a crucial role in brain homeostasis and in disease states. Persistent neuroinflammation is considered a hallmark of many neurodegenerative diseases, including ... ...

    Abstract Microglia are specialized dynamic immune cells in the central nervous system (CNS) that plays a crucial role in brain homeostasis and in disease states. Persistent neuroinflammation is considered a hallmark of many neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), amyotrophic lateral sclerosis (ALS) and primary progressive multiple sclerosis (MS). Colony stimulating factor 1-receptor (CSF-1R) is predominantly expressed on microglia and its expression is significantly increased in neurodegenerative diseases. Cumulative findings have indicated that CSF-1R inhibitors can have beneficial effects in preclinical neurodegenerative disease models. Research using CSF-1R inhibitors has now been extended into non-human primates and humans. This review article summarizes the most recent advances using CSF-1R inhibitors in different neurodegenerative conditions including AD, PD, HD, ALS and MS. Potential challenges for translating these findings into clinical practice are presented.
    MeSH term(s) Alzheimer Disease/drug therapy ; Animals ; Colony-Stimulating Factors/pharmacology ; Colony-Stimulating Factors/therapeutic use ; Microglia/metabolism ; Neurodegenerative Diseases/drug therapy ; Neurodegenerative Diseases/metabolism ; Parkinson Disease/drug therapy
    Chemical Substances Colony-Stimulating Factors
    Language English
    Publishing date 2022-04-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1358415-7
    ISSN 1420-9071 ; 1420-682X
    ISSN (online) 1420-9071
    ISSN 1420-682X
    DOI 10.1007/s00018-022-04225-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 195: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: Pyruvate Dehydrogenase Kinase 4 Deficiency Increases Tumorigenesis in a Murine Model of Bladder Cancer.

    Woolbright, Benjamin L / Rajendran, Ganeshkumar / Abbott, Erika / Martin, Austin / Didde, Ryan / Dennis, Katie / Harris, Robert A / Taylor, John A

    Cancers

    2023  Volume 15, Issue 6

    Abstract: Pyruvate dehydrogenase kinase 4 (PDK4) is a mitochondrial isozyme in the PDK family (PDK1-4) partially responsible for phosphorylation of pyruvate dehydrogenase (PDH). Phosphorylation of PDH is thought to result in a pro-proliferative shift in metabolism ...

    Abstract Pyruvate dehydrogenase kinase 4 (PDK4) is a mitochondrial isozyme in the PDK family (PDK1-4) partially responsible for phosphorylation of pyruvate dehydrogenase (PDH). Phosphorylation of PDH is thought to result in a pro-proliferative shift in metabolism that sustains growth of cancer cells. Previous data from our lab indicate the pan-PDK inhibitor dichloroacetate (DCA) or acute genetic knockdown of PDK4 blocks proliferation of bladder cancer (BCa) cells. The goal of this study was to determine the role of PDK4 in an in vivo BCa model, with the hypothesis that genetic depletion of PDK4 would impair formation of BCa. PDK4
    Language English
    Publishing date 2023-03-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15061654
    Database MEDical Literature Analysis and Retrieval System OnLINE

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