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  1. Article: A rude awakening. Interview by Caroline Swinburne.

    Harrison, Clare / Myerson, Keith / Dunne, Madge

    Nursing standard (Royal College of Nursing (Great Britain) : 1987)

    2008  Volume 22, Issue 37, Page(s) 18–19

    Abstract: A recent film highlighted the possibility of awareness under anaesthetic. While a rare occurrence, it is invariably distressing. ...

    Abstract A recent film highlighted the possibility of awareness under anaesthetic. While a rare occurrence, it is invariably distressing.
    MeSH term(s) Anesthesia, General/adverse effects ; Anesthesia, General/psychology ; Attitude to Health ; Awareness ; Humans ; Literature, Modern ; Medicine in Literature ; Motion Pictures ; Pain/etiology ; Pain/psychology ; Stress, Psychological/etiology ; Stress, Psychological/psychology ; Wakefulness
    Language English
    Publishing date 2008-05
    Publishing country England
    Document type Interview
    ZDB-ID 645016-7
    ISSN 2047-9018 ; 0029-6570
    ISSN (online) 2047-9018
    ISSN 0029-6570
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Cycling to work in London and inhaled dose of black carbon.

    Nwokoro, Chinedu / Ewin, Clare / Harrison, Clare / Ibrahim, Mubin / Dundas, Isobel / Dickson, Iain / Mushtaq, Naseem / Grigg, Jonathan

    The European respiratory journal

    2012  Volume 40, Issue 5, Page(s) 1091–1097

    Abstract: Modelling studies suggest that urban cycling is associated with an increased inhaled dose of fossil fuel-derived black carbon (BC). Using the amount of black material in airway macrophages as a marker of long-term inhaled BC, we sought to compare inhaled ...

    Abstract Modelling studies suggest that urban cycling is associated with an increased inhaled dose of fossil fuel-derived black carbon (BC). Using the amount of black material in airway macrophages as a marker of long-term inhaled BC, we sought to compare inhaled BC dose in London (UK) cyclists and non-cyclists. Airway macrophage carbon was assessed in 28 (58%) out of 48 healthy adults (14 cyclists and 14 non-cyclists) who attended for induced sputum. Short-term (24 h) exposure to BC was assessed on a representative working day in 27 out of 28 subjects. Serum interleukin (IL)-1β, IL-2, IL-6, IL-8, granulocyte-macrophage colony-stimulating factor and tumour necrosis factor (TNF)-α were assessed in 26 out of the 28 subjects. Cyclists were found to have increased airway macrophage carbon when compared with non-cyclists (mean ± se 1.81 ± 0.21 versus 1.11 ± 0.07 μm(2); p<0.01). Short-term monitoring showed no difference in 24 h BC exposure between the two groups. However, cyclists were exposed to higher concentrations of BC during commuting (p<0.01). Airway macrophage carbon was associated with monitored commute BC (n=28; r=0.47, p<0.05). TNF-α was found to be increased in cyclists (p<0.05), but no other cytokines were increased. Commuting to work by bicycle in London is associated with increased long-term inhaled dose of BC. Whether cycling per se increases inhaled BC dose remains unclear.
    MeSH term(s) Adult ; Air Pollution ; Bicycling ; Female ; Humans ; Inhalation ; London ; Macrophages, Alveolar/chemistry ; Male ; Soot/analysis ; Work ; Young Adult
    Chemical Substances Soot
    Language English
    Publishing date 2012-02-23
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/09031936.00195711
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: SCF(Pof1)-ubiquitin and its target Zip1 transcription factor mediate cadmium response in fission yeast.

    Harrison, Clare / Katayama, Satoshi / Dhut, Susheela / Chen, Dongrong / Jones, Nic / Bähler, Jürg / Toda, Takashi

    The EMBO journal

    2005  Volume 24, Issue 3, Page(s) 599–610

    Abstract: Ubiquitin-dependent proteolysis regulates gene expression in many eukaryotic systems. Pof1 is an essential fission yeast F-box protein that is homologous to budding yeast Met30. Temperature-sensitive pof1 mutants display acute growth arrest with small ... ...

    Abstract Ubiquitin-dependent proteolysis regulates gene expression in many eukaryotic systems. Pof1 is an essential fission yeast F-box protein that is homologous to budding yeast Met30. Temperature-sensitive pof1 mutants display acute growth arrest with small cell size. Extragenic suppressor analysis identified Zip1, a bZIP (basic leucine zipper) transcription factor, as a target for Pof1. We show Zip1 is stabilized in pof1 mutants, Pof1 binds only phosphorylated forms of Zip1, and Zip1 is ubiquitylated in vivo, indicating that Zip1 is a substrate of SCF(Pof1). Genome-wide DNA microarray assay shows that many cadmium-induced genes are under the control of Zip1, suggesting Zip1 plays a role in cadmium response. Consistently, zip1 mutants are hypersensitive to cadmium and unlike wild type, lose cell viability under this stress. Intriguingly, cadmium exposure results in upregulation of Zip1 levels and leads wild-type cells to growth arrest with reduced cell size, reminiscent of pof1 phenotypes. Our results indicate that Zip1 mediates growth arrest in cadmium response, which is essential to maintain viability. Normally growing cells prevent this response through constitutive ubiquitylation and degradation of Zip1 via SCF(Pof1).
    MeSH term(s) Basic-Leucine Zipper Transcription Factors ; Cadmium/pharmacology ; Carrier Proteins/genetics ; Carrier Proteins/metabolism ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; F-Box Proteins/genetics ; F-Box Proteins/metabolism ; G-Box Binding Factors ; Genes, Fungal/drug effects ; Models, Biological ; Mutation ; Phosphorylation ; Protein Binding ; SKP Cullin F-Box Protein Ligases/genetics ; SKP Cullin F-Box Protein Ligases/metabolism ; Schizosaccharomyces/drug effects ; Schizosaccharomyces/genetics ; Schizosaccharomyces/metabolism ; Schizosaccharomyces pombe Proteins/genetics ; Schizosaccharomyces pombe Proteins/metabolism ; Suppression, Genetic ; Temperature ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Ubiquitin/metabolism ; Up-Regulation/drug effects
    Chemical Substances Basic-Leucine Zipper Transcription Factors ; Carrier Proteins ; DNA-Binding Proteins ; F-Box Proteins ; G-Box Binding Factors ; Schizosaccharomyces pombe Proteins ; Transcription Factors ; Ubiquitin ; Cadmium (00BH33GNGH) ; SKP Cullin F-Box Protein Ligases (EC 2.3.2.27)
    Language English
    Publishing date 2005-01-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 586044-1
    ISSN 1460-2075 ; 0261-4189
    ISSN (online) 1460-2075
    ISSN 0261-4189
    DOI 10.1038/sj.emboj.7600536
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Requirement of the SCFPop1/Pop2 Ubiquitin Ligase for Degradation of the Fission Yeast S Phase Cyclin Cig2.

    Yamano, Hiroyuki / Kominami, Kin-Ichiro / Harrison, Clare / Kitamura, Kenji / Katayama, Satoshi / Dhut, Susheela / Hunt, Tim / Toda, Takashi

    The Journal of biological chemistry

    2004  Volume 279, Issue 18, Page(s) 18974–18980

    Abstract: Two multiprotein E3 (ubiquitin-protein ligase) ubiquitin ligases, the SCF (Skp1-Cullin-1-F-box) and the APC/C (anaphase promoting complex/cyclosome), are vital in ensuring the temporal order of the cell cycle. Particularly, timely destruction of cyclins ... ...

    Abstract Two multiprotein E3 (ubiquitin-protein ligase) ubiquitin ligases, the SCF (Skp1-Cullin-1-F-box) and the APC/C (anaphase promoting complex/cyclosome), are vital in ensuring the temporal order of the cell cycle. Particularly, timely destruction of cyclins via these two E3s is essential for down-regulation of cyclin-dependent kinase. In general, G(1) and S phase cyclins are ubiquitylated by the SCF, whereas ubiquitylation of mitotic cyclins is catalyzed by the APC/C. Here we show that fission yeast S phase cyclin Cig2 is ubiquitylated and degraded via both the SCF and the APC/C. Cig2 instability during G(2) and M phase is dependent upon the SCF complex, whereas the APC/C is responsible for Cig2 destruction during anaphase and G(1), thereby ensuring a spike pattern of Cig2 levels, peaking only at S phase. Two F-box/WD proteins Pop1 and Pop2, homologues of budding yeast Cdc4 and human Fbw7, are responsible for Cig2 instability. Pop1 binds Cig2 in vivo. An in vitro binding assay shows that an internal 93 amino acid residues comprising a part of the cyclin box are necessary and sufficient for this binding. Cig2 phosphorylation is also required for interaction with Pop1. We previously showed that transcriptional oscillation of cig2(+) requires Pop1 and Pop2 function. SCF(Pop1/Pop2) therefore regulates Cig2 levels in a dual manner, transcriptionally and post-translationally. Our results also highlight a collaborative action of the APC/C and the SCF toward the common substrate Cig2. This type of composite degradation control may be more general as the regulatory mechanism in other complex systems.
    MeSH term(s) Apoptosis Regulatory Proteins ; Binding Sites ; Carrier Proteins ; Cell Cycle Proteins/chemistry ; Cell Cycle Proteins/metabolism ; Cyclin B ; Cyclins/metabolism ; Cysteine Endopeptidases/metabolism ; Interphase ; Multienzyme Complexes/metabolism ; Phosphorylation ; Proteasome Endopeptidase Complex ; Protein Structure, Tertiary ; Proteins/metabolism ; Ribonucleases ; Ribonucleoproteins/metabolism ; S Phase ; SKP Cullin F-Box Protein Ligases/metabolism ; Saccharomyces cerevisiae Proteins ; Schizosaccharomyces pombe Proteins/chemistry ; Schizosaccharomyces pombe Proteins/metabolism ; Transcription Factors
    Chemical Substances Apoptosis Regulatory Proteins ; CNOT8 protein, human ; Carrier Proteins ; Cell Cycle Proteins ; Cig2 protein, S pombe ; Cyclin B ; Cyclins ; Multienzyme Complexes ; POP1 protein, S cerevisiae ; POP1 protein, human ; Proteins ; Ribonucleoproteins ; Saccharomyces cerevisiae Proteins ; Schizosaccharomyces pombe Proteins ; Transcription Factors ; pop1 protein, S pombe ; SKP Cullin F-Box Protein Ligases (EC 2.3.2.27) ; Ribonucleases (EC 3.1.-) ; POP2 protein, S cerevisiae (EC 3.1.13.4) ; Cysteine Endopeptidases (EC 3.4.22.-) ; Proteasome Endopeptidase Complex (EC 3.4.25.1)
    Language English
    Publishing date 2004-02-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1074/jbc.M311060200
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Molecular interactions of fission yeast Skp1 and its role in the DNA damage checkpoint.

    Lehmann, Anna / Katayama, Satoshi / Harrison, Clare / Dhut, Susheela / Kitamura, Kenji / McDonald, Neil / Toda, Takashi

    Genes to cells : devoted to molecular & cellular mechanisms

    2004  Volume 9, Issue 5, Page(s) 367–382

    Abstract: Skp1 is a central component of the E3 ubiquitin ligase SCF (Skp1-Cullin-1-F-box). It forms an adapter bridge between Cullin-1 and the substrate-determining component, the F-box protein. In order to establish the role of Skp1, a temperature sensitive (ts) ...

    Abstract Skp1 is a central component of the E3 ubiquitin ligase SCF (Skp1-Cullin-1-F-box). It forms an adapter bridge between Cullin-1 and the substrate-determining component, the F-box protein. In order to establish the role of Skp1, a temperature sensitive (ts) screen was carried out using mutagenic PCR (polymerase chain reaction) and 9 independent ts mutants were isolated. Mapping the mutated residues on the 3-D structure of human Skp1 suggested that the mutants would be compromised in binding to F-box proteins but not Cullin-1 (Pcu1). In order to assess the binding properties of ts Skp1, 12 F-box proteins and Pcu1 were epitope-tagged, and co-immunoprecipitation performed. This systematic analysis showed that ts Skp1 retains binding to Pcu1. However, binding to three specific F-box proteins, essential Pof1, Pof3 involved in maintaining genome integrity, and nonessential Pof10, was reduced. skp1ts cells exhibit a G2 cell cycle delay, which is attributable to activation of the DNA damage checkpoint. Intriguingly, contrary to pof3 mutants, in which this checkpoint is required for survival, checkpoint abrogation in skp1(ts) suppresses a G2 delay and furthermore almost rescues the ts phenotype. The activation mechanism of the DNA damage checkpoint therefore differs between pof3Delta and skp1(ts), implicating a novel role for Skp1 in the checkpoint-signalling cascade.
    MeSH term(s) Amino Acid Sequence ; Cell Cycle Proteins/metabolism ; Cullin Proteins/metabolism ; DNA Damage ; F-Box Proteins/genetics ; F-Box Proteins/metabolism ; G2 Phase ; Genes, cdc ; Genome, Fungal ; Models, Molecular ; Molecular Sequence Data ; Mutation ; Protein Binding ; SKP Cullin F-Box Protein Ligases/chemistry ; SKP Cullin F-Box Protein Ligases/genetics ; SKP Cullin F-Box Protein Ligases/metabolism ; Saccharomyces cerevisiae Proteins/genetics ; Schizosaccharomyces/genetics ; Schizosaccharomyces/metabolism ; Schizosaccharomyces pombe Proteins/chemistry ; Schizosaccharomyces pombe Proteins/genetics ; Schizosaccharomyces pombe Proteins/metabolism ; Temperature
    Chemical Substances Cell Cycle Proteins ; Cullin 1 ; Cullin Proteins ; F-Box Proteins ; Saccharomyces cerevisiae Proteins ; Schizosaccharomyces pombe Proteins ; SKP Cullin F-Box Protein Ligases (EC 2.3.2.27) ; SKP1 protein, S cerevisiae (EC 2.3.2.27) ; SKP1 protein, S pombe (EC 2.3.2.27)
    Language English
    Publishing date 2004-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1330000-3
    ISSN 1365-2443 ; 1356-9597
    ISSN (online) 1365-2443
    ISSN 1356-9597
    DOI 10.1111/j.1356-9597.2004.00730.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: The expectations, health beliefs and behaviour of patients seeking homœopathic and conventional medicine

    Harrison, Clare / Hewison, Jenny / Davies, Peter / Pietroni, Patrick

    British Homeopathic Journal

    1989  Volume 78, Issue 04, Page(s) 210–218

    Abstract: Research was carried out to determine whether or not there was a difference in the health beliefs, expectations and behaviour of a sample of 92 patients attending a dermatological or rheumatological outpatient clinic which offered either homœopathic ... ...

    Abstract Research was carried out to determine whether or not there was a difference in the health beliefs, expectations and behaviour of a sample of 92 patients attending a dermatological or rheumatological outpatient clinic which offered either homœopathic treatment (N=47) or conventional treatment (N=45). Self-administered questionnaires were used which examined patients' pathways to care, expectations, beliefs, behaviour and multidimensional health locus of control. The two key differences between those seeking homœopathic and those seeking conventional medicine were in terms of (1) their reasons for attending a homœopathic or conventional clinic, and (2) their beliefs about their presenting dermatological or rheumatological condition.
    Keywords Expectations ; Health beliefs ; Health behaviour
    Language English
    Publishing date 1989-10-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 422693-8
    ISSN 0007-0785 ; 0007-0785
    ISSN (online) 0007-0785
    ISSN 0007-0785
    DOI 10.1016/S0007-0785(89)80086-9
    Database Thieme publisher's database

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  7. Article ; Online: Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2

    Folegatti, Pedro M / Ewer, Katie J / Aley, Parvinder K / Angus, Brian / Becker, Stephan / Belij-Rammerstorfer, Sandra / Bellamy, Duncan / Bibi, Sagida / Bittaye, Mustapha / Clutterbuck, Elizabeth A / Dold, Christina / Faust, Saul N / Finn, Adam / Flaxman, Amy L / Hallis, Bassam / Heath, Paul / Jenkin, Daniel / Lazarus, Rajeka / Makinson, Rebecca /
    Minassian, Angela M / Pollock, Katrina M / Ramasamy, Maheshi / Robinson, Hannah / Snape, Matthew / Tarrant, Richard / Voysey, Merryn / Green, Catherine / Douglas, Alexander D / Hill, Adrian V S / Lambe, Teresa / Gilbert, Sarah C / Pollard, Andrew J / Aboagye, Jeremy / Adams, Kelly / Ali, Aabidah / Allen, Elizabeth / Allison, Jennifer L. / Anslow, Rachel / Arbe-Barnes, Edward H. / Babbage, Gavin / Baillie, Kenneth / Baker, Megan / Baker, Natalie / Baker, Philip / Baleanu, Ioana / Ballaminut, Juliana / Barnes, Eleanor / Barrett, Jordan / Bates, Louise / Batten, Alexander / Beadon, Kirsten / Beckley, Rebecca / Berrie, Eleanor / Berry, Lisa / Beveridge, Amy / Bewley, Kevin R. / Bijker, Else Margreet / Bingham, Tracey / Blackwell, Luke / Blundell, Caitlin L. / Bolam, Emma / Boland, Elena / Borthwick, Nicola / Bower, Thomas / Boyd, Amy / Brenner, Tanja / Bright, Philip D. / Brown-O'Sullivan, Charlie / Brunt, Emily / Burbage, Jamie / Burge, Sharon / Buttigieg, Karen R. / Byard, Nicholas / Cabera Puig, Ingrid / Calvert, Anna / Camara, Susana / Cao, Michelangelo / Cappuccini, Federica / Carr, Melanie / Carroll, Miles W. / Carter, Victoria / Cathie, Katrina / Challis, Ruth J. / Charlton, Sue / Chelysheva, Irina / Cho, Jee-Sun / Cicconi, Paola / Cifuentes, Liliana / Clark, Helen / Clark, Elizabeth / Cole, Tom / Colin-Jones, Rachel / Conlon, Christopher P. / Cook, Aislinn / Coombes, Naomi S. / Cooper, Rachel / Cosgrove, Catherine A. / Coy, Karen / Crocker, Wendy E.M. / Cunningham, Christina J. / Damratoski, Brad E. / Dando, Lynne / Datoo, Mehreen S. / Davies, Hannah / De Graaf, Hans / Demissie, Tesfaye / Di Maso, Claudio / Dietrich, Isabelle / Dong, Tao / Donnellan, Francesca R. / Douglas, Naomi / Downing, Charlotte / Drake, Jonathan / Drake-Brockman, Rachael / Drury, Ruth Elizabeth / Dunachie, Susanna Jane / Edwards, Nick J. / Edwards, Frances D.L. / Edwards, Chris J. / Elias, Sean C. / Elmore, Michael J. / Emary, Katherine R.W. / English, Marcus Rex / Fagerbrink, Susanne / Felle, Sally / Feng, Shuo / Field, Samantha / Fixmer, Carine / Fletcher, Clare / Ford, Karen J. / Fowler, Jamie / Fox, Polly / Francis, Emma / Frater, John / Furze, Julie / Fuskova, Michelle / Galiza, Eva / Gbesemete, Diane / Gilbride, Ciaran / Godwin, Kerry / Gorini, Giacomo / Goulston, Lyndsey / Grabau, Caroline / Gracie, Lara / Gray, Zoe / Guthrie, Lucy Belle / Hackett, Mark / Halwe, Sandro / Hamilton, Elizabeth / Hamlyn, Joseph / Hanumunthadu, Brama / Harding, Irasha / Harris, Stephanie A. / Harris, Andrew / Harrison, Daisy / Harrison, Clare / Hart, Thomas C. / Haskell, Louise / Hawkins, Sophia / Head, Ian / Henry, John Aaron / Hill, Jennifer / Hodgson, Susanne H.C. / Hou, Mimi M. / Howe, Elizabeth / Howell, Nicola / Hutlin, Cecilia / Ikram, Sabina / Isitt, Catherine / Iveson, Poppy / Jackson, Susan / Jackson, Frederic / James, Sir William / Jenkins, Megan / Jones, Elizabeth / Jones, Kathryn / Jones, Christine E. / Jones, Bryony / Kailath, Reshma / Karampatsas, Konstantinos / Keen, Jade / Kelly, Sarah / Kelly, Dearbhla / Kerr, David / Kerridge, Simon / Khan, Liaquat / Khan, Uzma / Killen, Annabel / Kinch, Jasmin / King, Thomas B. / King, Lloyd / King, Jade / Kingham-Page, Lucy / Klenerman, Paul / Knapper, Francesca / Knight, Julian C. / Knott, Daniel / Koleva, Stanislava / Kupke, Alexandra / Larkworthy, Colin W. / Larwood, Jessica P.J. / Laskey, Anna / Lawrie, Alison M. / Lee, Arlene / Ngan Lee, Kim Yee / Lees, Emily A / Legge, Helen / Lelliott, Alice / Lemm, Nana-Marie / Lias, Amelia M. / Linder, Aline / Lipworth, Samuel / Liu, Xinxue / Liu, Shuchang / Lopez Ramon, Raquel / Lwin, May / Mabesa, Francesca / Madhavan, Meera / Mallett, Garry / Mansatta, Kushal / Marcal, Ines / Marinou, Spyridoula / Marlow, Emma / Marshall, Julia L. / Martin, Jane / McEwan, Joanne / McInroy, Lorna / Meddaugh, Gretchen / Mentzer, Alexander J. / Mirtorabi, Neginsadat / Moore, Maria / Moran, Edward / Morey, Ella / Morgan, Victoria / Morris, Susan Jane / Morrison, Hazel / Morshead, Gertraud / Morter, Richard / Mujadidi, Yama F. / Muller, Jilly / Munera-Huertas, Tatiana / Munro, Claire / Munro, Alasdair / Murphy, Sarah / Munster, Vincent J. / Mweu, Philomena / Noé, Andrés / Nugent, Fay L. / Nuthall, Elizabeth / O'Brien, Katie / O'Connor, Daniel / Oguti, Blanché / Oliver, Jennifer L. / Oliveira, Catarina / O'Reilly, Peter John / Osborn, Mairead / Osborne, Piper / Owen, Cathy / Owens, Daniel / Owino, Nelly / Pacurar, Mihaela / Parker, Kaye / Parracho, Helena / Patrick-Smith, Maia / Payne, Victoria / Pearce, Jennifer / Peng, Yanchun / Peralta Alvarez, Marco Polo / Perring, James / Pfafferott, Katja / Pipini, Dimitra / Plested, Emma / Pluess-Hall, Helen / Pollock, Katrina / Poulton, Ian / Presland, Laura / Provstgaard-Morys, Samuel / Pulido, David / Radia, Kajal / Ramos Lopez, Fernando / Rand, Jade / Ratcliffe, Helen / Rawlinson, Thomas / Rhead, Sarah / Riddell, Amy / Ritchie, Adam John / Roberts, Hannah / Robson, Joanna / Roche, Sophie / Rohde, Cornelius / Rollier, Christine S. / Romani, Rossana / Rudiansyah, Indra / Saich, Stephen / Sajjad, Sara / Salvador, Stephannie / Sanchez Riera, Lidia / Sanders, Helen / Sanders, Katherine / Sapaun, Shari / Sayce, Chloe / Schofield, Ella / Screaton, Gavin / Selby, Beatrice / Semple, Calum / Sharpe, Hannah R. / Shaik, Imam / Shea, Adam / Shelton, Holly / Silk, Sarah / Silva-Reyes, Laura / Skelly, Donal T. / Smee, Heather / Smith, Catherine C. / Smith, David J. / Song, Rinn / Spencer, Alexandra J. / Stafford, Elizabeth / Steele, Amy / Stefanova, Elena / Stockdale, Lisa / Szigeti, Anna / Tahiri-Alaoui, Abdessamad / Tait, Moira / Talbot, Helen / Tanner, Rachel / Taylor, Iona Jennifer / Taylor, Victoria / Te Water Naude, Rebecca / Thakur, Nazia / Themistocleous, Yrene / Themistocleous, Andreas / Thomas, Merin / Thomas, Tonia M. / Thompson, Amber / Thomson-Hill, Samantha / Tomlins, Jennifer / Tonks, Susan / Towner, James / Tran, Nguyen / Tree, Julia A. / Truby, Adam / Turkentine, Kate / Turner, Cheryl / Turner, Nicola / Turner, Sally / Tuthill, Toby / Ulaszewska, Marta / Varughese, Rachel / Van Doremalen, Neeltje / Veighey, Kristin / Verheul, Marije K. / Vichos, Iason / Vitale, Elia / Walker, Laura / Watson, Marion E.E. / Welham, Benjamin / Wheat, Julie / White, Caroline / White, Rachel / Worth, Andrew T. / Wright, Danny / Wright, Suzie / Yao, Xin Li / Yau, Yasmine

    The Lancet

    a preliminary report of a phase 1/2, single-blind, randomised controlled trial

    2020  Volume 396, Issue 10249, Page(s) 467–478

    Keywords General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/s0140-6736(20)31604-4
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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