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  1. Article ; Online: Hospital admission for symptomatic COVID-19 and impact of vaccination: analysis of linked data from the Coronavirus Clinical Information Network and the National Immunisation Management Service.

    Egan, C / Turtle, L / Thorpe, M / Harrison, E M / Semple, M G / Docherty, A B

    Anaesthesia

    2022  Volume 77, Issue 5, Page(s) 605–608

    MeSH term(s) COVID-19/prevention & control ; Hospitals ; Humans ; Information Services ; Semantic Web ; Vaccination
    Language English
    Publishing date 2022-02-18
    Publishing country England
    Document type Letter
    ZDB-ID 80033-8
    ISSN 1365-2044 ; 0003-2409
    ISSN (online) 1365-2044
    ISSN 0003-2409
    DOI 10.1111/anae.15677
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Correspondence.

    Harrison, E M / Thomas, H S / Weiser, T G

    The British journal of surgery

    2019  Volume 106, Issue 6, Page(s) 802–803

    MeSH term(s) Checklist ; Laparotomy
    Language English
    Publishing date 2019-04-07
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2985-3
    ISSN 1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
    ISSN (online) 1365-2168
    ISSN 0263-1202 ; 0007-1323 ; 1355-7688
    DOI 10.1002/bjs.11194
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Counting the cost of cancelled surgery: a system wide approach is needed.

    Gillies, M A / Wijeysundera, D N / Harrison, E M

    British journal of anaesthesia

    2018  Volume 121, Issue 4, Page(s) 691–694

    MeSH term(s) Cohort Studies ; Hospitals ; Inpatients ; National Health Programs ; United Kingdom
    Keywords covid19
    Language English
    Publishing date 2018-09-07
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 80074-0
    ISSN 1471-6771 ; 0007-0912
    ISSN (online) 1471-6771
    ISSN 0007-0912
    DOI 10.1016/j.bja.2018.08.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Twelve-month risk of thromboembolic events in COVID-19 hospital survivors in Scotland.

    Farrell, J / Docherty, A B / Thorpe, M G / Shaw, C A / Harrison, E M / Lone, N I

    Anaesthesia

    2022  Volume 77, Issue 12, Page(s) 1445–1447

    MeSH term(s) Humans ; COVID-19 ; Thromboembolism/epidemiology ; Thromboembolism/etiology ; Survivors ; Hospitals ; Scotland/epidemiology
    Language English
    Publishing date 2022-08-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 80033-8
    ISSN 1365-2044 ; 0003-2409
    ISSN (online) 1365-2044
    ISSN 0003-2409
    DOI 10.1111/anae.15826
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Perioperative mortality in bariatric surgery: meta-analysis.

    Robertson, A G N / Wiggins, T / Robertson, F P / Huppler, L / Doleman, B / Harrison, E M / Hollyman, M / Welbourn, R

    The British journal of surgery

    2021  Volume 108, Issue 8, Page(s) 892–897

    Abstract: Background: Bariatric surgery is an established treatment for severe obesity; however, fewer than 1 per cent of eligible patients undergo surgery. The perceived risk of surgery may contribute to the low uptake. The aim of this study was to determine ... ...

    Abstract Background: Bariatric surgery is an established treatment for severe obesity; however, fewer than 1 per cent of eligible patients undergo surgery. The perceived risk of surgery may contribute to the low uptake. The aim of this study was to determine perioperative mortality associated with bariatric surgery, comparing different operation types and data sources.
    Methods: A literature search of Ovid MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials was conducted to identify studies published between 1 January 2014 and 31 July 2020. Inclusion criteria were studies of at least 1000 patients reporting short-term mortality after bariatric surgery. Data were collected on RCTs. Meta-analysis was performed to establish overall mortality rates across different study types. The primary outcome measure was perioperative mortality. Different operation types were compared, along with study type, in subgroup analyses. The study was registered at PROSPERO (2019: CRD 42019131632).
    Results: Some 4356 articles were identified and 58 met the inclusion criteria. Data were available on over 3.6 million patients. There were 4707 deaths. Pooled analysis showed an overall mortality rate of 0.08 (95 per cent c.i. 0.06 to 0.10; 95 per cent prediction interval 0 to 0.21) per cent. In subgroup analysis, there was no statistically significant difference between overall, 30-day, 90-day or in-hospital mortality (P = 0.29). There was no significant difference in reported mortality for RCTs, large studies, national databases or registries (P = 0.60). The pooled mortality rates by procedure type in ascending order were: 0.03 per cent for gastric band, 0.05 per cent for sleeve gastrectomy, 0.09 per cent for one-anastomosis gastric bypass, 0.09 per cent for Roux-en-Y gastric bypass, and 0.41 per cent for duodenal switch (P < 0.001 between operations).
    Conclusion: Bariatric surgery is safe, with low reported perioperative mortality rates.
    MeSH term(s) Bariatric Surgery/methods ; Bariatric Surgery/mortality ; Global Health ; Humans ; Laparoscopy/mortality ; Obesity, Morbid/mortality ; Obesity, Morbid/physiopathology ; Obesity, Morbid/surgery ; Perioperative Period ; Survival Rate/trends ; Weight Loss/physiology
    Language English
    Publishing date 2021-07-23
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 2985-3
    ISSN 1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
    ISSN (online) 1365-2168
    ISSN 0263-1202 ; 0007-1323 ; 1355-7688
    DOI 10.1093/bjs/znab245
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Systematic review of the use of big data to improve surgery in low- and middle-income countries.

    Knight, S R / Ots, R / Maimbo, M / Drake, T M / Fairfield, C J / Harrison, E M

    The British journal of surgery

    2019  Volume 106, Issue 2, Page(s) e62–e72

    Abstract: Background: Technological advances have led to the generation of large amounts of data, both in surgical research and practice. Despite this, it is unclear how much originates in low- and middle-income countries (LMICs) and what barriers exist to the ... ...

    Abstract Background: Technological advances have led to the generation of large amounts of data, both in surgical research and practice. Despite this, it is unclear how much originates in low- and middle-income countries (LMICs) and what barriers exist to the use of such data in improving surgical care. The aim of this review was to capture the extent and impact of programmes that use large volumes of patient data on surgical care in LMICs.
    Methods: A PRISMA-compliant systematic literature review of PubMed, Embase and Google Scholar was performed in August 2018. Prospective studies collecting large volumes of patient-level data within LMIC settings were included and evaluated qualitatively.
    Results: A total of 68 studies were included from 71 LMICs, involving 708 032 patients. The number of patients in included studies varied widely (from 335 to 428 346), with 25 reporting data on 3000 or more LMIC patients. Patient inclusion in large-data studies in LMICs has increased dramatically since 2015. Studies predominantly involved Brazil, China, India and Thailand, with low patient numbers from Africa and Latin America. Outcomes after surgery were commonly the focus (33 studies); very few large studies looked at access to surgical care or patient expenditure. The use of large data sets specifically to improve surgical outcomes in LMICs is currently limited.
    Conclusion: Large volumes of data are becoming more common and provide a strong foundation for continuing investigation. Future studies should address questions more specific to surgery.
    MeSH term(s) Big Data ; Developing Countries ; General Surgery/standards ; General Surgery/statistics & numerical data ; Humans ; Outcome Assessment (Health Care) ; Quality Improvement/statistics & numerical data
    Language English
    Publishing date 2019-01-07
    Publishing country England
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 2985-3
    ISSN 1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
    ISSN (online) 1365-2168
    ISSN 0263-1202 ; 0007-1323 ; 1355-7688
    DOI 10.1002/bjs.11052
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Transparency in surgical randomized clinical trials: cross-sectional observational study.

    Helliwell, J A / Shelton, B / Mahmood, H / Blanco-Colino, R / Fitzgerald, J E / Harrison, E M / Bhangu, A / Chapman, S J

    BJS open

    2020  Volume 4, Issue 5, Page(s) 977–984

    Abstract: Background: RCTs provide the scientific basis upon which treatment decisions are made. To facilitate critical review, it is important that methods and results are reported transparently. The aim of this study was to explore transparency in surgical RCTs ...

    Abstract Background: RCTs provide the scientific basis upon which treatment decisions are made. To facilitate critical review, it is important that methods and results are reported transparently. The aim of this study was to explore transparency in surgical RCTs with respect to trial registration, disclosure of funding sources, declarations of investigator conflicts and data-sharing.
    Methods: This was a cross-sectional review of published surgical RCTs. Ten high-impact journals were searched systematically for RCTs published in years 2009, 2012, 2015 and 2018. Four domains of transparency were explored: trial registration, disclosure of funding, disclosure of investigator conflicts, and a statement relating to data-sharing.
    Results: Of 611 RCTs, 475 were eligible for analysis. Some 397 RCTs (83.6 per cent) were registered on a trial database, of which 190 (47·9 per cent) had been registered prospectively. Prospective registration increased over time (26 per cent in 2009, 33·0 per cent in 2012, 54 per cent in 2015, and 72·7 per cent in 2018). Funding disclosure was present in 55·0, 65·0, 69·4 and 75·4 per cent of manuscripts respectively. Conflict of interest disclosure was present in 49·5, 89·1, 94·6 and 98·3 per cent of manuscripts across the same time periods. Data-sharing statements were present in only 15 RCTs (3·2 per cent), 11 of which were published in 2018.
    Conclusion: Trial registration, disclosure of funding and disclosure of investigator conflicts in surgical RCTs have improved markedly over the past 10 years. Disclosure of data-sharing plans is exceptionally low. This may contribute to research waste and represents a target for improvement.
    MeSH term(s) Conflict of Interest ; Cross-Sectional Studies ; Disclosure ; Editorial Policies ; General Surgery ; Humans ; Journal Impact Factor ; Periodicals as Topic/standards ; Periodicals as Topic/statistics & numerical data ; Randomized Controlled Trials as Topic/economics ; Randomized Controlled Trials as Topic/ethics ; Research Support as Topic
    Language English
    Publishing date 2020-08-15
    Publishing country England
    Document type Journal Article ; Observational Study
    ISSN 2474-9842
    ISSN (online) 2474-9842
    DOI 10.1002/bjs5.50333
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Staphylococcus pseudoxylosus sp. nov., isolated from bovine mastitis.

    MacFadyen, A C / Leroy, S / Harrison, E M / Parkhill, J / Holmes, M A / Paterson, G K

    International journal of systematic and evolutionary microbiology

    2019  Volume 69, Issue 8, Page(s) 2208–2213

    Abstract: ... Strain ... ...

    Abstract Strain S04009
    MeSH term(s) Animals ; Bacterial Typing Techniques ; Base Composition ; Cattle/microbiology ; DNA, Bacterial/genetics ; Fatty Acids/chemistry ; Female ; France ; Mastitis, Bovine/microbiology ; Nucleic Acid Hybridization ; Phylogeny ; RNA, Ribosomal, 16S/genetics ; Sequence Analysis, DNA ; Staphylococcus/classification ; Staphylococcus/isolation & purification
    Chemical Substances DNA, Bacterial ; Fatty Acids ; RNA, Ribosomal, 16S
    Language English
    Publishing date 2019-06-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2002336-4
    ISSN 1466-5034 ; 1466-5026
    ISSN (online) 1466-5034
    ISSN 1466-5026
    DOI 10.1099/ijsem.0.003416
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Patient experience and overall satisfaction after emergency abdominal surgery.

    Jones, C H / O'Neill, S / McLean, K A / Wigmore, S J / Harrison, E M

    BMC surgery

    2017  Volume 17, Issue 1, Page(s) 76

    Abstract: Background: There is a growing recognition of the importance of patient experience in healthcare, however little is known in the context of emergency abdominal surgery. This study sought to quantify the association between patient experience and overall ...

    Abstract Background: There is a growing recognition of the importance of patient experience in healthcare, however little is known in the context of emergency abdominal surgery. This study sought to quantify the association between patient experience and overall satisfaction.
    Methods: Patient demographics, operation details and 30-day clinical outcome data of consecutive patients undergoing emergency abdominal surgery were collected. Data was collected using validated Patient Reported Experience Measures (PREMs) questionnaires. Categorical data were tested using Mann Whitney U test. Multivariable regression was used to determine independent factors associated with satisfaction.
    Results: In a well-fitting multivariable analysis (R
    Conclusions: Overall patient satisfaction was strongly associated with perceptions of good communication and transfer of information. Confidence and trust in the clinical team is an important determinant of patient experience. Improving the ward environment by reducing noise at night may also improve the overall experience and satisfaction in emergency surgery.
    Language English
    Publishing date 2017-07-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2050442-1
    ISSN 1471-2482 ; 1471-2482
    ISSN (online) 1471-2482
    ISSN 1471-2482
    DOI 10.1186/s12893-017-0271-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Conjugative transfer frequencies of mef(A)-containing Tn1207.3 to macrolide-susceptible Streptococcus pyogenes belonging to different emm types.

    Hadjirin, N F / Harrison, E M / Holmes, M A / Paterson, G K

    Letters in applied microbiology

    2014  Volume 58, Issue 4, Page(s) 299–302

    Abstract: Unlabelled: The aim of this study was to examine the gene transfer potential of mef(A)-containing Tn120.3 to macrolide-susceptible Streptococcus pyogenes belonging to different emm types. Using the filter mating technique, Tn1207.3 was transferred by ... ...

    Abstract Unlabelled: The aim of this study was to examine the gene transfer potential of mef(A)-containing Tn120.3 to macrolide-susceptible Streptococcus pyogenes belonging to different emm types. Using the filter mating technique, Tn1207.3 was transferred by conjugation to 23 macrolide-susceptible recipients representing 11 emm types. PCR analysis confirmed the presence of the mef(A) gene and the comEC junction regions of the Tn1207.3 insertion in resultant transconjugants. Significant variation was found in the transfer frequency of Tn1207.3 to different Strep. pyogenes strains, and this phenomenon may contribute to the differences in mef(A) frequency observed among clinical isolates.
    Significance and impact of the study: The spread of antimicrobial resistance among pathogenic bacteria is an important problem, but the mechanisms of horizontal transfer between strains and species are often poorly understood. For instance, little is known on how macrolide resistance spreads between strains of the human pathogen Strep. pyogenes and why certain strains more commonly display resistance than others. Here, we show that Strep. pyogenes strains vary greatly in their ability to acquire a transposon encoding macrolide resistance by horizontal gene transfer in vitro. These data provide a novel insight into the transfer of antibiotic resistance between bacterial strains and offer an explanation for the differences in the frequency of resistance determinates and resistance seen among clinical isolates.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Bacterial Proteins/genetics ; Conjugation, Genetic ; DNA Transposable Elements ; Drug Resistance, Bacterial/genetics ; Gene Transfer, Horizontal ; Macrolides/pharmacology ; Membrane Proteins/genetics ; Streptococcus pyogenes/classification ; Streptococcus pyogenes/drug effects ; Streptococcus pyogenes/genetics
    Chemical Substances Anti-Bacterial Agents ; Bacterial Proteins ; DNA Transposable Elements ; Macrolides ; MefA protein, Streptococcus ; Membrane Proteins
    Language English
    Publishing date 2014-01-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 632584-1
    ISSN 1472-765X ; 0266-8254
    ISSN (online) 1472-765X
    ISSN 0266-8254
    DOI 10.1111/lam.12213
    Database MEDical Literature Analysis and Retrieval System OnLINE

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