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  1. AU="Harry Cridge"
  2. AU="Ameriso, Sebastián"
  3. AU="Candice Czech"
  4. AU="Pargent, Florian"
  5. AU=Fausther Michel
  6. AU="Arrate, Clara"
  7. AU="Tarrach, Klaus"
  8. AU="Coburn, Bryan A"
  9. AU="Fieke Mooren"
  10. AU=Lubitz Steven A.
  11. AU=Chattopadhyay Sanchari
  12. AU=Ghanbari Behzad
  13. AU="Desmecht, Daniel"
  14. AU="Juškov, A. N"
  15. AU="Bach, Francis"
  16. AU="Afşin, Emine"
  17. AU="McLeod, Jonathan"
  18. AU=Srensen Morten Drby
  19. AU=de Noronha Lucia
  20. AU=Robinson Jennifer G
  21. AU=CHIACO JOHN MICHAEL S. CHUA
  22. AU="Simon, Benedikt"
  23. AU="Zhao, Andong"
  24. AU="Zhao, Tianshi"
  25. AU="Morris, Helen"

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  1. Artikel ; Online: Risk Factors and Clinical Presentation in Dogs with Increased Serum Pancreatic Lipase Concentrations—A Descriptive Analysis

    Harry Cridge / Nicole Scott / Jörg M. Steiner

    Animals, Vol 12, Iss 1581, p

    2022  Band 1581

    Abstract: Limited data exist regarding the full array of clinical signs seen in dogs with pancreatitis and potential risk factors for the disease. Laboratory submissions from the Gastrointestinal Laboratory at Texas A&M University were retrospectively reviewed for ...

    Abstract Limited data exist regarding the full array of clinical signs seen in dogs with pancreatitis and potential risk factors for the disease. Laboratory submissions from the Gastrointestinal Laboratory at Texas A&M University were retrospectively reviewed for dogs with an increased serum pancreatic lipase immunoreactivity (cPLI) concentration (≥400 µg/L), and an internet-based survey was distributed to the attending veterinarian and/or technician on each case. The survey contained questions related to (i) clinical signs, (ii) prior gastrointestinal upset, (iii) comorbidities, (iv) pre-existing medical therapies, and (v) dietary history. One hundred and seventy (170) survey responses were recorded. The top three clinical signs reported were inappetence (62%), diarrhea (53%), and vomiting (49%). Abdominal pain was noted in only 32% of dogs, likely associated with poor pain detection. Additionally, the majority of dogs (71%) had prior episodes of gastrointestinal upset within the past 12 months, lending support for the commonality of recurrent acute pancreatitis, or acute on chronic disease. Hepatobiliary abnormalities (24%) were the most common concurrent disease, and endocrine disorders were seen in a low proportion of respondents (5–8%). Adult maintenance diets (65%), dog treats (40%), and human foods (29%) were commonly consumed by dogs prior to the discovery of increased cPLI concentration.
    Schlagwörter canine ; pancreatitis ; cPLI ; etiology ; clinical signs ; Veterinary medicine ; SF600-1100 ; Zoology ; QL1-991
    Thema/Rubrik (Code) 610 ; 630
    Sprache Englisch
    Erscheinungsdatum 2022-06-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Evaluation of Clinicopathological Data, the Specific Feline Pancreatic Lipase Assay, and Abdominal Ultrasound as Severity Determinants in Cats with Pancreatitis

    Christy Buckley / Alison M. Lee / Robert W. Wills / Alyssa M. Sullivant / Harry Cridge

    Veterinary Sciences, Vol 10, Iss 209, p

    2023  Band 209

    Abstract: Limited data exist to predict the severity of pancreatitis in cats. In this retrospective case series, we reviewed the medical records of 45 cats with SP from June 2014 to June 2019. Case definition was based on an internist’s review of clinopathologic ... ...

    Abstract Limited data exist to predict the severity of pancreatitis in cats. In this retrospective case series, we reviewed the medical records of 45 cats with SP from June 2014 to June 2019. Case definition was based on an internist’s review of clinopathologic data, Spec fPL concentration, and AUS findings. Information extracted from the medical records included signalment, history, physical examination findings, selected clinicopathological data (total bilirubin, glucose, ALP, ALT, and total calcium), Spec fPL concentration, AUS images/clips, length of hospitalization, and survival data. Hazard ratios were used to evaluate the association between clinicopathological data, the Spec fPL assay, AUS findings, and the length of hospitalization. Clinicopathological abnormalities, the Spec fPL, and AUS abnormalities were not statistically associated with the length of hospitalization. Despite a lack of statistical significance, the hazard ratios suggest the potential that an elevated total bilirubin (hazard ratio (HR): 1.19), hypocalcemia (HR: 1.49), and an elevated Spec fPL concentration (HR: 1.54) could be associated with prolonged hospitalization, although additional studies would be needed to verify this. Additionally, hazard ratios suggest that AUS evidence of concurrent gallbladder (HR: 1.61) and gastric abnormalities (HR: 1.36) could be associated with prolonged hospitalization.
    Schlagwörter Spec fPL ; diagnostic imaging ; clinical severity ; Veterinary medicine ; SF600-1100
    Thema/Rubrik (Code) 333
    Sprache Englisch
    Erscheinungsdatum 2023-03-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: New insights into the etiology, risk factors, and pathogenesis of pancreatitis in dogs

    Harry Cridge / Sue Yee Lim / Hana Algül / Jörg M. Steiner

    Journal of Veterinary Internal Medicine, Vol 36, Iss 3, Pp 847-

    Potential impacts on clinical practice

    2022  Band 864

    Abstract: Abstract While most cases of pancreatitis in dogs are thought to be idiopathic, potential risk factors are identified. In this article we provide a state‐of‐the‐art overview of suspected risk factors for pancreatitis in dogs, allowing for improved ... ...

    Abstract Abstract While most cases of pancreatitis in dogs are thought to be idiopathic, potential risk factors are identified. In this article we provide a state‐of‐the‐art overview of suspected risk factors for pancreatitis in dogs, allowing for improved awareness and detection of potential dog‐specific risk factors, which might guide the development of disease prevention strategies. Additionally, we review important advances in our understanding of the pathophysiology of pancreatitis and potential areas for therapeutic manipulation based thereof. The outcome of pathophysiologic mechanisms and the development of clinical disease is dependent on the balance between stressors and protective mechanisms, which can be evaluated using the critical threshold theory.
    Schlagwörter colocalization ; critical threshold theory ; ER stress ; impaired autophagy ; mitochondrial dysfunction ; oxidative stress ; Veterinary medicine ; SF600-1100
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2022-05-01T00:00:00Z
    Verlag Wiley
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Cardiovascular abnormalities in dogs with acute pancreatitis

    Harry Cridge / Daniel K. Langlois / Jörg M. Steiner / Robert A. Sanders

    Journal of Veterinary Internal Medicine, Vol 37, Iss 1, Pp 28-

    2023  Band 36

    Abstract: Abstract Background The prevalence and clinical importance of cardiac abnormalities in dogs with acute pancreatitis (AP) is unknown. Animals Twelve dogs with AP and 60 archived serum samples from dogs with suspected AP. Methods Two‐phase study. Phase I: ... ...

    Abstract Abstract Background The prevalence and clinical importance of cardiac abnormalities in dogs with acute pancreatitis (AP) is unknown. Animals Twelve dogs with AP and 60 archived serum samples from dogs with suspected AP. Methods Two‐phase study. Phase I: Analysis of archived serum samples from dogs with clinical signs of AP and high Spec cPL concentrations. High sensitivity troponin I (TnIH) and N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP) concentrations were measured in achieved serum samples. Phase II: Prospective observational study. Dogs with AP underwent echocardiography and Holter monitoring. Serum cardiac troponin I (cTnI) and plasma NT‐proBNP concentrations were measured. Previously described disease severity indices were calculated for each dog. Results Phase I: 41 of 60 dogs suspected of having AP had abnormally high TnIH concentrations and 13 of 60 had abnormally high serum NT‐proBNP concentrations. Higher TnIH concentrations were observed in dogs with Spec cPL concentration >2000 μg/L as compared to those with concentrations of 1000‐2000 μg/L. Phase II: 11 of 12 dogs diagnosed with pancreatitis had abnormal cTnI concentrations (median: 0.384 ng/mL, range: 0.041‐2.966 ng/mL, RI: ≤0.06 ng/mL) and 7 of 12 dogs had plasma NT‐proBNP concentrations above the reference interval (median: 971 pmol/L, range: 250‐2215 pmol/L, RI: ≤900 pmol/L). Supraventricular and ventricular ectopic beats occurred in 3 dogs. Echocardiographic abnormalities were detected in 5 dogs. Cardiovascular variables were not associated with indices of disease severity. Conclusions and Clinical Importance Myocardial injury is common in dogs with AP, but clinical consequences appeared to be uncommon in our small cohort. Cardiac biomarkers should be interpreted with caution in dogs with AP.
    Schlagwörter arrythmia ; echocardiogram ; NT‐proBNP ; Spec cPL ; troponin ; Veterinary medicine ; SF600-1100
    Thema/Rubrik (Code) 630 ; 610
    Sprache Englisch
    Erscheinungsdatum 2023-01-01T00:00:00Z
    Verlag Wiley
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Response to letter regarding “Association between abdominal ultrasound findings, the specific canine pancreatic lipase assay, clinical severity indices, and clinical diagnosis in dogs with pancreatitis”

    Harry Cridge / Alyssa Sullivant / Alison M. Lee

    Journal of Veterinary Internal Medicine, Vol 34, Iss 5, Pp 1689-

    2020  Band 1689

    Schlagwörter Veterinary medicine ; SF600-1100
    Sprache Englisch
    Erscheinungsdatum 2020-09-01T00:00:00Z
    Verlag Wiley
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  6. Artikel ; Online: Advances in the diagnosis of acute pancreatitis in dogs

    Harry Cridge / David C. Twedt / Angela J. Marolf / Leslie C. Sharkey / Jörg M. Steiner

    Journal of Veterinary Internal Medicine, Vol 35, Iss 6, Pp 2572-

    2021  Band 2587

    Abstract: Abstract In the last 20 years, the diagnosis of pancreatitis has become more frequent as a result of improved diagnostic modalities such as abdominal ultrasound examination, advanced imaging, and immunoassays for the measurement of pancreatic lipase. Our ...

    Abstract Abstract In the last 20 years, the diagnosis of pancreatitis has become more frequent as a result of improved diagnostic modalities such as abdominal ultrasound examination, advanced imaging, and immunoassays for the measurement of pancreatic lipase. Our aim is to provide a state‐of‐the‐art overview of the clinical diagnosis of acute pancreatitis (AP) in dogs with a particular focus on pancreatic lipase assay validation and clinical performance, in addition to advanced imaging modalities. We also discuss the potential indications for cytology and histopathology in dogs with suspected AP.
    Schlagwörter acute pancreatitis ; catalytic ; CTA ; cytology ; DGGR ; immunologic ; Veterinary medicine ; SF600-1100
    Sprache Englisch
    Erscheinungsdatum 2021-11-01T00:00:00Z
    Verlag Wiley
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Efficacy of a low‐dose praziquantel and fenbendazole protocol in the treatment of asymptomatic schistosomiasis in dogs

    Harry Cridge / Henrique Lupiano / Julia D. Nipper / Andrew J. Mackin / Jörg M. Steiner

    Journal of Veterinary Internal Medicine, Vol 35, Iss 3, Pp 1368-

    2021  Band 1375

    Abstract: Abstract Background Established treatment protocols for schistosomiasis (Heterobilharzia americana) in dogs are expensive. Anecdotal reports suggest that lower doses of praziquantel, combined with fenbendazole, may eliminate asymptomatic infections. ... ...

    Abstract Abstract Background Established treatment protocols for schistosomiasis (Heterobilharzia americana) in dogs are expensive. Anecdotal reports suggest that lower doses of praziquantel, combined with fenbendazole, may eliminate asymptomatic infections. Objectives Evaluate the efficacy of a low‐dose praziquantel and fenbendazole protocol to manage asymptomatic schistosomiasis in dogs and compare fecal saline sedimentation (FSS) and fecal PCR (FPCR) for therapeutic monitoring. Animals Twelve asymptomatic dogs with positive FPCR and FSS results for schistosomiasis. Methods Prospective observational study. On day 0, dogs received praziquantel at a median dose of 5 mg/kg PO q8h for 2 days, with fenbendazole at 24 mg/kg PO q24h for 7 days. Fecal PCR and FSS were repeated in all dogs on days 30, 60, and 90. Results By day 30, 10 of 12 dogs were negative by FSS, but only 3 of 12 were negative by FPCR. By day 60, all 12 dogs were negative by FSS, and 8 of 12 had become negative by FPCR. By day 90, all 12 dogs remained negative by FSS, but 5 of 12 were positive by FPCR (including 2 that were negative by FPCR on day 60). Three dogs that were positive by FPCR on day 60 were re‐treated and subsequently became both FPCR and FSS negative. One FPCR‐positive dog developed a mild increase in serum ALP activity, another developed mild hypercalcemia, and a third developed diarrhea. Conclusions and Clinical Importance A low‐dose praziquantel/fenbendazole protocol may be effective for asymptomatic schistosomiasis in some dogs, but monitoring to ensure treatment success is recommended. Fecal saline sedimentation and FPCR may demonstrate discrepant results, with FPCR being positive more frequently.
    Schlagwörter fecal ; monitoring ; PCR ; saline sedimentation ; schistosomiasis ; trematode ; Veterinary medicine ; SF600-1100
    Thema/Rubrik (Code) 630
    Sprache Englisch
    Erscheinungsdatum 2021-05-01T00:00:00Z
    Verlag Wiley
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: Multiorgan neutrophilic inflammation in a Border Collie with “trapped” neutrophil syndrome

    Alyssa Zoto / Chelsea Stecklein / Michael A. Scott / Thomas R. Bauer Jr. / Cynthia Lucidi / Harry Cridge

    Journal of Veterinary Internal Medicine, Vol 36, Iss 6, Pp 2170-

    2022  Band 2176

    Abstract: Abstract Trapped neutrophil syndrome is a rare congenital disease recognized in Border Collies and is characterized by persistent neutropenia with myeloid hyperplasia. The mechanism of neutropenia has not been described. We document the case of a young ... ...

    Abstract Abstract Trapped neutrophil syndrome is a rare congenital disease recognized in Border Collies and is characterized by persistent neutropenia with myeloid hyperplasia. The mechanism of neutropenia has not been described. We document the case of a young Border Collie diagnosed with trapped neutrophil syndrome based on clinical features, blood and bone marrow evaluation, and presence of the associated homozygous mutation. Results from flow cytometric and storage studies suggested lower neutrophil survival time. The dog had substantial neutrophilic inflammation in multiple organs, indicating that neutrophils could leave the marrow and enter tissues, making the term “trapped” neutrophil syndrome a misnomer.
    Schlagwörter bone marrow ; Cohen syndrome ; ineffective myelopoiesis ; neutropenia ; VPS13B ; Veterinary medicine ; SF600-1100
    Sprache Englisch
    Erscheinungsdatum 2022-11-01T00:00:00Z
    Verlag Wiley
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: Peripheral biomarkers of oxidative stress in dogs with acute pancreatitis

    Nicole V. Tusa / Angel Abuelo / Nyssa A. Levy / Jeffery C. Gandy / Daniel K. Langlois / Harry Cridge

    Journal of Veterinary Internal Medicine, Vol 36, Iss 6, Pp 1958-

    2022  Band 1965

    Abstract: Abstract Background Oxidative stress is considered a pathomechanism of acute pancreatitis (AP), but no studies have extensively characterized oxidant status in dogs with naturally‐occurring AP. Hypothesis or Objectives Evaluate measures of oxidant status ...

    Abstract Abstract Background Oxidative stress is considered a pathomechanism of acute pancreatitis (AP), but no studies have extensively characterized oxidant status in dogs with naturally‐occurring AP. Hypothesis or Objectives Evaluate measures of oxidant status in dogs with AP and explore whether these measures correlate with AP severity. Animals Fifteen dogs with AP and 9 control dogs. Methods Prospective, controlled observational study. Plasma reactive metabolite (RM) concentrations, antioxidant potential (AOP), and urinary F2 isoprostane concentrations were measured in AP dogs and healthy controls. Severity of AP was assessed by length of hospitalization and 3 disease severity indices: canine acute pancreatitis severity (CAPS), modified canine activity index (M‐CAI), and the acute patient physiologic and laboratory evaluation score (APPLEfull). Results Reactive metabolite (RM) concentrations (median, 65 relative fluorescent units [RFU]/μL; range, 20‐331 RFU/μL) and RM:AOP (median, 7; range, 4‐109) were higher in AP dogs than healthy controls (median RM, 25 RFU/μL; range, 16‐41 RFU/μL; median RM:AOP, 4; range, 2‐7; P < .001 for both comparisons). Reactive metabolite (rS = 0.603, P = .08) and RM:AOP (rS = 0.491, P = .06) were not correlated with the duration of hospitalization or disease severity indices evaluated. However, disease severity indices did not predict mortality in our study. Normalized urine 2,3‐dinor‐8‐iso‐prostaglandin F2α concentrations were correlated with C‐reactive protein (CRP; rS = 0.491, P = .03), canine specific pancreatic lipase (Spec cPL; rS = 0.746, P = .002), and CAPS (rS = 0.603, P = .02). Conclusions and Clinical Importance Oxidant status is altered in dogs with naturally occurring AP, but the clinical relevance of this finding is unknown.
    Schlagwörter antioxidant potential ; C‐reactive protein ; isoprostanes ; oxidant status ; reactive metabolites ; Spec cPL ; Veterinary medicine ; SF600-1100
    Thema/Rubrik (Code) 610 ; 630
    Sprache Englisch
    Erscheinungsdatum 2022-11-01T00:00:00Z
    Verlag Wiley
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Artikel ; Online: Comparative repeatability of pancreatic lipase assays in the commercial and in‐house laboratory environments

    Harry Cridge / Andrew J. Mackin / Jonathan A. Lidbury / Jan S. Suchodolski / Jörg M. Steiner

    Journal of Veterinary Internal Medicine, Vol 34, Iss 3, Pp 1150-

    2020  Band 1156

    Abstract: Abstract Background Sensitivity and specificity for commercial and in‐house pancreatic lipase immunoreactivity (cPLI) assays have been reported, but repeatability under routine clinical conditions is unknown. Objectives To determine: Coefficient of ... ...

    Abstract Abstract Background Sensitivity and specificity for commercial and in‐house pancreatic lipase immunoreactivity (cPLI) assays have been reported, but repeatability under routine clinical conditions is unknown. Objectives To determine: Coefficient of variation (CV) between replicates of a commercial assay (Spec cPL) and 2 in‐house assays (VetScan cPL, Vcheck cPL) under routine conditions. Effects of sample condition or personnel on results. Potential directional bias between assays. Animals Serum from 12 canine clinical patients. Methods Prospective study. Serum Spec cPL, VetScan cPL, and Vcheck cPL (6 aliquots each) were measured, and CVs were calculated, effects of sample condition and personnel were assessed using a linear mixed model, and direction of bias was assessed using least square mean cPLI concentration. Results Mean %CVs for Spec cPL, VetScan cPL, and Vcheck cPL were 5.5, 17.0, and 23.7%. Three of 6 VetScan cPL samples and 5/9 Vcheck cPL samples had an unacceptably high %CV (>20%). Transportation (Spec cPL) and sample condition or personnel (VetScan cPL, Vcheck cPL) did not affect repeatability. Least square mean cPL was higher for Spec cPL (807.9 μg/L) than for VetScan cPL (558.5 μg/L) or Vcheck cPL (399.8 μg/L). Conclusions and Clinical Importance For clinical use, the commercial Spec cPL has the highest repeatability, and Vcheck cPL has significantly lower repeatability. Both in‐house assays evaluated may provide discrepant categorical results (“pancreatitis” versus “equivocal” versus “not pancreatitis”) for the same sample. In‐house pancreatic lipase concentrations may be lower than those determined by the Spec cPL assay.
    Schlagwörter quality control ; Spec cPL ; transportation ; Vcheck cPL ; VetScan cPL ; Veterinary medicine ; SF600-1100
    Thema/Rubrik (Code) 310
    Sprache Englisch
    Erscheinungsdatum 2020-05-01T00:00:00Z
    Verlag Wiley
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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