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  1. Book ; Thesis: Nutzen und Risiken CT-gestützter Biopsien und Punktionen bei der Diagnose von Infektionserkrankungen

    Raeder, Sascha / Hagel, Stefan / Reuken, Philipp Alexander / Harsch, Igor Alexander

    eine retrospektive Analyse am Universitätsklinikum Jena

    2023  

    Institution Friedrich-Schiller-Universität Jena
    Author's details von Sascha Raeder
    Language German
    Size 37 Blätter, Illustrationen, Diagramme, 29,5 cm
    Publishing place Jena
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Friedrich-Schiller-Universität Jena, 2023
    Note Tag der Verteidigung: 05.12.2023
    HBZ-ID HT030704274
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2024 E 540 Magazin

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  2. Article: Fast Clinical, but Long-Term, Biochemical Remission after Waterhouse-Friderichsen Syndrome.

    Harsch, Igor Alexander

    Case reports in endocrinology

    2021  Volume 2021, Page(s) 8885348

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2021-01-20
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2627633-1
    ISSN 2090-651X ; 2090-6501
    ISSN (online) 2090-651X
    ISSN 2090-6501
    DOI 10.1155/2021/8885348
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Abdominal erythema ab igne-An "old" finding revisited.

    Harsch, Igor Alexander

    Clinical case reports

    2020  Volume 8, Issue 7, Page(s) 1315–1316

    Abstract: Abdominal erythema ab igne may be the result of insufficient pain medication in chronic pancreatitis. Stenting therapy is to be considered, and the patient should be informed about the risk of developing cutaneous squamous or Merkel cell carcinoma. ...

    Abstract Abdominal erythema ab igne may be the result of insufficient pain medication in chronic pancreatitis. Stenting therapy is to be considered, and the patient should be informed about the risk of developing cutaneous squamous or Merkel cell carcinoma.
    Language English
    Publishing date 2020-04-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.2834
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A 16-year History of Dyspnea.

    Ghopreal, Talaat / Harsch, Igor Alexander

    Deutsches Arzteblatt international

    2022  Volume 119, Issue 5, Page(s) 69

    MeSH term(s) Diagnosis, Differential ; Dyspnea/diagnosis ; Dyspnea/etiology ; Humans
    Language English
    Publishing date 2022-03-30
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2406159-1
    ISSN 1866-0452 ; 1866-0452
    ISSN (online) 1866-0452
    ISSN 1866-0452
    DOI 10.3238/arztebl.m2021.0166
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Hypothesis: does adrenalitis caused by immune checkpoint-inhibitors put melanoma patients at an elevated risk for recurrence?

    Harsch, Igor Alexander

    Journal for immunotherapy of cancer

    2019  Volume 7, Issue 1, Page(s) 166

    Abstract: Primary adrenal failure (Addison's disease) is a rare complication of immune checkpoint inhibitor (ICI) therapy. Untreated - and also sometimes under adequate hydrocortisone replacement therapy - the levels of ACTH (Adrenocorticotropic hormone) and MSH ( ... ...

    Abstract Primary adrenal failure (Addison's disease) is a rare complication of immune checkpoint inhibitor (ICI) therapy. Untreated - and also sometimes under adequate hydrocortisone replacement therapy - the levels of ACTH (Adrenocorticotropic hormone) and MSH (Melanocyte stimulating hormone) are elevated. This may be a reason for concern in patients with malignant melanoma (MM): Melanocortin receptors bind to ACTH and the different isoforms of MSH. For example, the melanocortin 1 receptor (MC1R) is overexpressed in many human melanoma cells. Since it is also involved in the proliferation of melanoma cells, the elevated levels of ACTH and its proteolytic cleavage product α-MSH typical for primary failure may lead to an activation of the receptor and, thus, put MM patients that suffered from primary adrenal failure after ICI therapy at an elevated risk for recurrence or an unfavorable course of the disease. Novel dual-release hydrocortisone therapy results in lower ACTH (and most probably lower α-MSH) levels due to the more physiological mode of hydrocortisone release. Given that the concern raised in this hypothesis is confirmed in future investigations, patients who suffer from primary adrenal failure after ICI therapy may benefit from a dual-release hydrocortisone replacement regimen.
    MeSH term(s) Addison Disease/blood ; Addison Disease/chemically induced ; Addison Disease/drug therapy ; Adrenocorticotropic Hormone/blood ; Antineoplastic Agents, Immunological/adverse effects ; Drug Administration Schedule ; Hormone Replacement Therapy ; Humans ; Hydrocortisone/administration & dosage ; Melanoma/blood ; Melanoma/drug therapy ; alpha-MSH/blood
    Chemical Substances Antineoplastic Agents, Immunological ; alpha-MSH (581-05-5) ; Adrenocorticotropic Hormone (9002-60-2) ; Hydrocortisone (WI4X0X7BPJ)
    Language English
    Publishing date 2019-07-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2719863-7
    ISSN 2051-1426 ; 2051-1426
    ISSN (online) 2051-1426
    ISSN 2051-1426
    DOI 10.1186/s40425-019-0651-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Extent of lipohypertrophy in diabetic patients-Sometimes much more than meets the eye.

    Harsch, Igor Alexander

    Clinical case reports

    2019  Volume 7, Issue 9, Page(s) 1813–1814

    Abstract: Lipohypertrophies frequently occur during insulin therapy. They alter insulin absorption, causing higher insulin requirements (and costs), fluctuating blood glucose and episodes of unpredictable hypoglycemia. Screening is mandatory, as well as assessment ...

    Abstract Lipohypertrophies frequently occur during insulin therapy. They alter insulin absorption, causing higher insulin requirements (and costs), fluctuating blood glucose and episodes of unpredictable hypoglycemia. Screening is mandatory, as well as assessment of their actual size. Counseling recommending regular changes of the injection sites ("rotating") is important to prevent LH.
    Language English
    Publishing date 2019-07-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.2347
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Multiple Symmetric Lipomas in a 63-Year-Old Man.

    Harsch, Igor Alexander

    Deutsches Arzteblatt international

    2019  Volume 116, Issue 7, Page(s) 118

    MeSH term(s) Humans ; Lipomatosis, Multiple Symmetrical/diagnosis ; Male ; Middle Aged
    Language English
    Publishing date 2019-03-21
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2406159-1
    ISSN 1866-0452 ; 1866-0452
    ISSN (online) 1866-0452
    ISSN 1866-0452
    DOI 10.3238/arztebl.2019.0118b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: How much liver does a person need?

    Harsch, Igor Alexander

    Clinical case reports

    2019  Volume 7, Issue 12, Page(s) 2598–2599

    Abstract: In patients who had no medical care for years, it is wise to expect the unexpected. Here, a gigantic liver cyst compressed abdominal organs, vessels, and the gut. The patient is thus far doing well in a nursing home, exemplifying the low amount of ... ...

    Abstract In patients who had no medical care for years, it is wise to expect the unexpected. Here, a gigantic liver cyst compressed abdominal organs, vessels, and the gut. The patient is thus far doing well in a nursing home, exemplifying the low amount of residual liver tissue necessary for survival.
    Language English
    Publishing date 2019-11-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.2552
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book ; Thesis: Metabolische Effekte der nCPAP (nasal continuous positive airway pressure) Therapie beim obstruktiven Schlafapnoesyndrom

    Harsch, Igor Alexander

    2003  

    Author's details vorgelegt von Igor Alexander Harsch
    Language German
    Size 72 Bl. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Erlangen, Nürnberg, Univ., Habil.-Schr., 2003
    HBZ-ID HT014142691
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2004 E 1750 order to use in reading room Magazin

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  10. Article ; Online: Para-Articular Cysts in a 64-Year-Old Man.

    Harsch, Igor Alexander

    Deutsches Arzteblatt international

    2018  Volume 115, Issue 14, Page(s) 249

    MeSH term(s) Ganglion Cysts/diagnosis ; Ganglion Cysts/surgery ; Humans ; Male ; Middle Aged ; Physical Examination ; Rotator Cuff/pathology ; Rotator Cuff/surgery ; Shoulder Joint/pathology ; Shoulder Joint/surgery ; Treatment Outcome
    Language English
    Publishing date 2018-05-04
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 2406159-1
    ISSN 1866-0452 ; 1866-0452
    ISSN (online) 1866-0452
    ISSN 1866-0452
    DOI 10.3238/arztebl.2018.0249b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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