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  1. Article ; Online: Early Tocilizumab Dosing Is Associated With Improved Survival in Critically Ill Patients Infected With Severe Acute Respiratory Syndrome Coronavirus-2.

    Petrak, Russell M / Van Hise, Nicholas W / Skorodin, Nathan C / Fliegelman, Robert M / Chundi, Vishnu / Didwania, Vishal / Han, Alice / Harting, Brian P / Hines, David W

    Critical care explorations

    2021  Volume 3, Issue 4, Page(s) e0395

    Abstract: To identify the most efficacious timing for tocilizumab administration in critically ill patients infected with severe acute respiratory syndrome coronavirus-2.: Design: Observational multicenter cohort study.: Setting: A total of 23 acute care ... ...

    Abstract To identify the most efficacious timing for tocilizumab administration in critically ill patients infected with severe acute respiratory syndrome coronavirus-2.
    Design: Observational multicenter cohort study.
    Setting: A total of 23 acute care hospitals in four states.
    Patients: One-hundred eighteen patients admitted between March 13, 2020, and April 16, 2020. Eighty-one patients received tocilizumab, and 37 were untreated and served as a control group.
    Measurements and main results: The main outcome was mortality and was analyzed by timing of tocilizumab dosing. Early dosing was defined as a tocilizumab dose administered prior to or within 1 day of intubation. Late dosing was defined as a dose administered greater than 1 day after intubation. A control group that was treated only with standard of care, and without tocilizumab, was used for comparison. Early tocilizumab therapy was associated with a statistically significant decrease in mortality as compared to patients who were untreated (
    Conclusions: Early tocilizumab administration was associated with decreased mortality in critically ill severe acute respiratory syndrome coronavirus-2 patients, but a potential detriment was suggested by dosing later in a patient's course.
    Language English
    Publishing date 2021-03-29
    Publishing country United States
    Document type Journal Article
    ISSN 2639-8028
    ISSN (online) 2639-8028
    DOI 10.1097/CCE.0000000000000395
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Value and Clinical Impact of an Infectious Disease-Supervised Outpatient Parenteral Antibiotic Therapy Program.

    Petrak, Russell M / Skorodin, Nathan C / Fliegelman, Robert M / Hines, David W / Chundi, Vishnu V / Harting, Brian P

    Open forum infectious diseases

    2016  Volume 3, Issue 4, Page(s) ofw193

    Abstract: Background. ...

    Abstract Background.
    Language English
    Publishing date 2016-10-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofw193
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Tocilizumab as a Therapeutic Agent for Critically Ill Patients Infected with SARS-CoV-2.

    Petrak, Russell M / Skorodin, Nathan C / Van Hise, Nicholas W / Fliegelman, Robert M / Pinsky, Jonathan / Didwania, Vishal / Anderson, Michael / Diaz, Melina / Shah, Kairav / Chundi, Vishnu V / Hines, David W / Harting, Brian P / Sidwha, Kamo / Yu, Brian / Brune, Paul / Owaisi, Anjum / Beezhold, David / Kent, Joseph / Vais, Dana /
    Han, Alice / Gowda, Neethi / Sahgal, Nishi / Silverman, Jan / Stake, Jonathan / Nepomuceno, Jenie / Heddurshetti, Renuka

    Clinical and translational science

    2021  Volume 14, Issue 6, Page(s) 2146–2151

    Abstract: Tocilizumab is an IL-6 receptor antagonist with the ability to suppress the cytokine storm in critically ill patients infected with severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2). We evaluated patients treated with tocilizumab for a SARS- ... ...

    Abstract Tocilizumab is an IL-6 receptor antagonist with the ability to suppress the cytokine storm in critically ill patients infected with severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2). We evaluated patients treated with tocilizumab for a SARS-CoV-2 infection who were admitted between March 13, 2020, and April 16, 2020. This was a multicenter study with data collected by chart review both retrospectively and concurrently. Parameters evaluated included age, sex, race, use of mechanical ventilation (MV), usage of steroids and vasopressors, inflammatory markers, and comorbidities. Early dosing was defined as a tocilizumab dose administered prior to or within 1 day of intubation. Late dosing was defined as a dose administered > 1 day after intubation. In the absence of MV, the timing of the dose was related to the patient's date of admission only. We evaluated 145 patients. The average age was 58.1 years, 64% were men, 68.3% had comorbidities, and 60% received steroid therapy. Disposition of patients was 48.3% discharged and 29.3% died, of which 43.9% were African American. MV was required in 55.9%, of which 34.5% died. Avoidance of MV (P = 0.002) and increased survival (P < 0.001) was statistically associated with early dosing. Tocilizumab therapy was effective at decreasing mortality and should be instituted early in the management of critically ill patients with coronavirus disease 2019) COVID-19).
    MeSH term(s) Antibodies, Monoclonal, Humanized/therapeutic use ; COVID-19/drug therapy ; COVID-19/immunology ; COVID-19/mortality ; COVID-19/therapy ; COVID-19/virology ; Critical Illness/mortality ; Critical Illness/therapy ; Cytokine Release Syndrome/immunology ; Cytokine Release Syndrome/mortality ; Cytokine Release Syndrome/therapy ; Cytokine Release Syndrome/virology ; Female ; Hospital Mortality ; Humans ; Male ; Middle Aged ; Respiration, Artificial/statistics & numerical data ; Retrospective Studies ; SARS-CoV-2/immunology ; Severity of Illness Index ; Time Factors ; Time-to-Treatment ; Treatment Outcome
    Chemical Substances Antibodies, Monoclonal, Humanized ; tocilizumab (I031V2H011)
    Keywords covid19
    Language English
    Publishing date 2021-10-27
    Publishing country United States
    Document type Journal Article ; Multicenter Study
    ZDB-ID 2433157-0
    ISSN 1752-8062 ; 1752-8054
    ISSN (online) 1752-8062
    ISSN 1752-8054
    DOI 10.1111/cts.12894
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Tocilizumab as a Therapeutic Agent for Critically Ill Patients Infected with SARS‐CoV‐2

    Petrak, Russell M. / Skorodin, Nathan C. / Van Hise, Nicholas W. / Fliegelman, Robert M. / Pinsky, Jonathan / Didwania, Vishal / Anderson, Michael / Diaz, Melina / Shah, Kairav / Chundi, Vishnu V. / Hines, David W. / Harting, Brian P. / Sidwha, Kamo / Yu, Brian / Brune, Paul / Owaisi, Anjum / Beezhold, David / Kent, Joseph / Vais, Dana /
    Han, Alice / Gowda, Neethi / Sahgal, Nishi / Silverman, Jan / Stake, Jonathan / Nepomuceno, Jenie / Heddurshetti, Renuka

    Clinical and Translational Science ; ISSN 1752-8054 1752-8062

    2020  

    Keywords General Pharmacology, Toxicology and Pharmaceutics ; General Biochemistry, Genetics and Molecular Biology ; General Neuroscience ; General Medicine ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    DOI 10.1111/cts.12894
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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  5. Article: University HealthSystem Consortium quality performance benchmarking study of the insertion and care of central venous catheters.

    Harting, Brian P / Talbot, Thomas R / Dellit, Timothy H / Hebden, Joan / Cuny, Joanne / Greene, William H / Segreti, John

    Infection control and hospital epidemiology

    2008  Volume 29, Issue 5, Page(s) 440–442

    Abstract: We report data from an observational benchmarking study of adherence to recommended practices for insertion and maintenance of central venous catheters at a heterogeneous group of academic medical centers. These centers demonstrated a need for ... ...

    Abstract We report data from an observational benchmarking study of adherence to recommended practices for insertion and maintenance of central venous catheters at a heterogeneous group of academic medical centers. These centers demonstrated a need for significant improvement in implementation and documentation of quality performance measures for the prevention of catheter-related bloodstream infections.
    MeSH term(s) Benchmarking/methods ; Catheterization, Central Venous/adverse effects ; Catheterization, Central Venous/methods ; Catheterization, Central Venous/standards ; Catheters, Indwelling/adverse effects ; Catheters, Indwelling/standards ; Guideline Adherence/statistics & numerical data ; Hospitals, University/standards ; Humans ; Quality Indicators, Health Care ; Sepsis/prevention & control ; United States
    Language English
    Publishing date 2008-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639378-0
    ISSN 1559-6834 ; 0899-823X ; 0195-9417
    ISSN (online) 1559-6834
    ISSN 0899-823X ; 0195-9417
    DOI 10.1086/587716
    Database MEDical Literature Analysis and Retrieval System OnLINE

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