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  1. Book: A primer of population genetics and genomics

    Hartl, Daniel L.

    2020  

    Author's details Daniel L. Hartl
    Keywords Genetik ; Quantitative Methode ; Populationsgenetik
    Subject Bevölkerungsgenetik ; Evolutionsgenetik ; Quantifizierende Methode ; Allgemeine Genetik ; Erbbiologie ; Erbforschung ; Erblehre ; Vererbungslehre ; Vererbungswissenschaft ; Erblichkeitslehre
    Language English
    Size xv, 296 Seiten, Illustrationen, Diagramme
    Edition Fourth edition
    Publisher Oxford University Press
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT020565895
    ISBN 978-0-19-886230-7 ; 978-0-19-886229-1 ; 0-19-886230-X ; 0-19-886229-6
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2020 A 1215 available for loan (reading room) Lesesaal EG

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  2. Article ; Online: Gregor Johann Mendel: From peasant to priest, pedagogue, and prelate.

    Hartl, Daniel L

    Proceedings of the National Academy of Sciences of the United States of America

    2022  Volume 119, Issue 30, Page(s) e2121953119

    Abstract: Gregor Mendel was an Augustinian priest in the Monastery of St. Thomas in Brünn (Brno, Czech Republic) as well as a civilian employee who taught natural history and physics in the Brünn Modern School. The monastery's secular function was to provide ... ...

    Abstract Gregor Mendel was an Augustinian priest in the Monastery of St. Thomas in Brünn (Brno, Czech Republic) as well as a civilian employee who taught natural history and physics in the Brünn Modern School. The monastery's secular function was to provide teachers for the public schools across Moravia. It was a cultural, educational, and artistic center with an elite core of friar-teachers with a well-stocked library and other amenities including a gourmet kitchen. It was wealthy, with far-flung holdings yielding income from agricultural productions. Mendel had failed his tryout as a parish priest and did not complete his examination for teaching certification despite 2 y of study at the University of Vienna. In addition to his teaching and religious obligations, Mendel carried out daily meteorological and astronomical observations, cared for the monastery's fruit orchard and beehives, and tended plants in the greenhouse and small outdoor gardens. In the years 1856 to 1863, he carried out experiments on heredity of traits in garden peas regarded as revolutionary today but not widely recognized during his lifetime and until 16 y after his death. In 1868 he was elected abbot of the monastery, a significantly elevated position in the ecclesiastical and civil hierarchy. While he had hoped to be elected, and was honored to accept, he severely underestimated its administrative responsibilities and gradually had to abandon his scientific interests. The last decade of his life was marred by an ugly dispute with civil authorities over monastery taxation.
    MeSH term(s) Clergy ; Dissent and Disputes ; Genetics/history ; Heredity ; History, 19th Century ; Pisum sativum/genetics
    Language English
    Publishing date 2022-07-18
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2121953119
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
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  3. Article: Universal signatures of transposable element compartmentalization across eukaryotic genomes.

    Gozashti, Landen / Hartl, Daniel L / Corbett-Detig, Russell

    bioRxiv : the preprint server for biology

    2024  

    Abstract: The evolutionary mechanisms that drive the emergence of genome architecture remain poorly understood but can now be assessed with unprecedented power due to the massive accumulation of genome assemblies spanning phylogenetic ... ...

    Abstract The evolutionary mechanisms that drive the emergence of genome architecture remain poorly understood but can now be assessed with unprecedented power due to the massive accumulation of genome assemblies spanning phylogenetic diversity
    Language English
    Publishing date 2024-03-27
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.10.17.562820
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book: Genetics

    Hartl, Daniel L. / Jones, Elizabeth W.

    analysis of genes and genomes

    2009  

    Author's details Daniel L. Hartl and Elizabeth W. Jones
    Keywords Genetics ; Genomics
    Language English
    Size XXVIII, 763 S. : zahlr. Ill. und graph. Darst.
    Edition 7. ed.
    Publisher Jones and Bartlett
    Publishing place Sudbury, Mass. u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT015715188
    ISBN 978-0-7637-5868-4 ; 0-7637-5868-X
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2008 A 6177 order for loan Magazin

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  5. Book: A primer of population genetics

    Hartl, Daniel L.

    2000  

    Author's details Daniel L. Hartl
    Keywords Populationsgenetik
    Subject Bevölkerungsgenetik ; Evolutionsgenetik
    Language English
    Size XVII, 221 S. : graph. Darst.
    Edition 3. ed.
    Publisher Sinauer
    Publishing place Sunderland, Mass
    Publishing country United States
    Document type Book
    HBZ-ID HT011254889
    ISBN 978-0-87893-304-4 ; 0-87893-304-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2000 A 4472 order for loan Magazin

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  6. Book: A primer of ecological genetics

    Conner, Jeffrey K. / Hartl, Daniel L.

    2004  

    Author's details Jeffrey K. Conner ; Daniel L. Hartl
    Keywords Genetik ; Ökologie ; Populationsgenetik
    Subject Bevölkerungsgenetik ; Evolutionsgenetik ; Umweltbiologie ; Ecology ; Allgemeine Genetik ; Erbbiologie ; Erbforschung ; Erblehre ; Vererbungslehre ; Vererbungswissenschaft ; Erblichkeitslehre
    Language English
    Size XV, 304 S. : Ill., graph. Darst.
    Edition 1. ed.
    Publisher Sinauer Assoc
    Publishing place Sunderland, Mass
    Publishing country United States
    Document type Book
    HBZ-ID HT013606574
    ISBN 0-87893-202-X ; 978-0-87893-202-3
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    058/1937 available for loan (reading room) Freihandmagazin (U1)

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  7. Article ; Online: What can we learn from fitness landscapes?

    Hartl, Daniel L

    Current opinion in microbiology

    2014  Volume 21, Page(s) 51–57

    Abstract: A combinatorially complete data set consists of studies of all possible combinations of a set of mutant sites in a gene or mutant alleles in a genome. Among the most robust conclusions from these studies is that epistasis between beneficial mutations ... ...

    Abstract A combinatorially complete data set consists of studies of all possible combinations of a set of mutant sites in a gene or mutant alleles in a genome. Among the most robust conclusions from these studies is that epistasis between beneficial mutations often shows a pattern of diminishing returns, in which favorable mutations are less fit when combined than would be expected. Another robust inference is that the number of adaptive evolutionary paths is often limited to a relatively small fraction of the theoretical possibilities, owing largely to sign epistasis requiring evolutionary steps that would entail a decrease in fitness. Here we summarize these and other results while also examining issues that remain unresolved and future directions that seem promising.
    MeSH term(s) Adaptation, Biological ; Alleles ; Bacteria/genetics ; Epistasis, Genetic ; Evolution, Molecular ; Genotype ; Models, Genetic ; Mutation
    Language English
    Publishing date 2014-10
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1418474-6
    ISSN 1879-0364 ; 1369-5274
    ISSN (online) 1879-0364
    ISSN 1369-5274
    DOI 10.1016/j.mib.2014.08.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5514: Show issues Location:
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  8. Book: A primer of population genetics

    Hartl, Daniel L.

    1988  

    Author's details Daniel L. Hartl
    Keywords Genetics, Population
    Size XI, 305 S. : Ill., graph. Darst.
    Edition 2. ed., 1. [Dr.]
    Publisher Sinauer
    Publishing place Sunderland, Mass
    Publishing country United States
    Document type Book
    HBZ-ID HT003304092
    ISBN 0-87893-301-8 ; 978-0-87893-301-3
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1991 A 5297 order for loan Magazin

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  9. Article ; Online: James F. Crow and the art of teaching and mentoring.

    Hartl, Daniel L

    Genetics

    2011  Volume 189, Issue 4, Page(s) 1129–1133

    Abstract: To honor James F. Crow on the occasion of his 95th birthday, GENETICS has commissioned a series of Perspectives and Reviews. For GENETICS to publish the honorifics is fitting, as from their birth Crow and GENETICS have been paired. Crow was scheduled to ... ...

    Abstract To honor James F. Crow on the occasion of his 95th birthday, GENETICS has commissioned a series of Perspectives and Reviews. For GENETICS to publish the honorifics is fitting, as from their birth Crow and GENETICS have been paired. Crow was scheduled to be born in January 1916, the same month that the first issue of GENETICS was scheduled to appear, and in the many years that Crow has made major contributions to the conceptual foundations of modern genetics, GENETICS has chronicled his and other major advances in the field. The commissioned Perspectives and Reviews summarize and celebrate Professor Crow's contributions as a research scientist, administrator, colleague, community supporter, international leader, teacher, and mentor. In science, Professor Crow was the international leader of his generation in the application of genetics to populations of organisms and in uncovering the role of genetics in health and disease. In education, he was a superb undergraduate teacher whose inspiration changed the career paths of many students. His teaching skills are legendary, his lectures urbane and witty, rigorous and clear. He was also an extraordinary mentor to numerous graduate students and postdoctoral fellows, many of whom went on to establish successful careers of their own. In public service, Professor Crow served in key administrative positions at the University of Wisconsin, participated as a member of numerous national and international committees, and served as president of both the Genetics Society of America and the American Society for Human Genetics. This Perspective examines Professor Crow as teacher and mentor through the eyes and experiences of one student who was enrolled in his genetics course as an undergraduate and who later studied with him as a graduate student.
    MeSH term(s) Genetics/education ; History, 20th Century ; History, 21st Century ; Mentors ; Teaching ; United States
    Language English
    Publishing date 2011-12-14
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article
    ZDB-ID 2167-2
    ISSN 1943-2631 ; 0016-6731
    ISSN (online) 1943-2631
    ISSN 0016-6731
    DOI 10.1534/genetics.111.135160
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 767: Show issues Location:
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  10. Article ; Online: A New Take on John Maynard Smith's Concept of Protein Space for Understanding Molecular Evolution.

    Ogbunugafor, C Brandon / Hartl, Daniel L

    PLoS computational biology

    2016  Volume 12, Issue 10, Page(s) e1005046

    Abstract: Much of the public lacks a proper understanding of Darwinian evolution, a problem that can be addressed with new learning and teaching approaches to be implemented both inside the classroom and in less formal settings. Few analogies have been as ... ...

    Abstract Much of the public lacks a proper understanding of Darwinian evolution, a problem that can be addressed with new learning and teaching approaches to be implemented both inside the classroom and in less formal settings. Few analogies have been as successful in communicating the basics of molecular evolution as John Maynard Smith's protein space analogy (1970), in which he compared protein evolution to the transition between the terms WORD and GENE, changing one letter at a time to yield a different, meaningful word (in his example, the preferred path was WORD → WORE → GORE → GONE → GENE). Using freely available computer science tools (Google Books Ngram Viewer), we offer an update to Maynard Smith's analogy and explain how it might be developed into an exploratory and pedagogical device for understanding the basics of molecular evolution and, more specifically, the adaptive landscape concept. We explain how the device works through several examples and provide resources that might facilitate its use in multiple settings, ranging from public engagement activities to formal instruction in evolution, population genetics, and computational biology.
    MeSH term(s) Algorithms ; Animals ; Evolution, Molecular ; Genetics/education ; Humans ; Models, Genetic ; Proteins/genetics ; Teaching
    Chemical Substances Proteins
    Language English
    Publishing date 2016-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2193340-6
    ISSN 1553-7358 ; 1553-734X
    ISSN (online) 1553-7358
    ISSN 1553-734X
    DOI 10.1371/journal.pcbi.1005046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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