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  1. Article ; Online: Acquired Juvenile-Type Polyposis Syndrome Presenting After Age 70 Years: Cap Polyposis Syndrome.

    Ertem, Furkan U / Hartman, Doug / Dubner, Howard M

    The American journal of gastroenterology

    2021  Volume 117, Issue 2, Page(s) 214

    MeSH term(s) Aged ; Colon/pathology ; Colonoscopy ; Diagnosis, Differential ; Humans ; Intestinal Polyposis/congenital ; Intestinal Polyposis/diagnosis ; Male ; Neoplastic Syndromes, Hereditary/diagnosis
    Language English
    Publishing date 2021-10-19
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 390122-1
    ISSN 1572-0241 ; 0002-9270
    ISSN (online) 1572-0241
    ISSN 0002-9270
    DOI 10.14309/ajg.0000000000001536
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui V Zs.36: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Unexpected Cause of Obscure Gastrointestinal Bleeding: Primary Small-Intestinal Angiosarcoma.

    Ertem, Furkan U / Hartman, Doug / Dubner, Howard M

    The American journal of gastroenterology

    2021  Volume 116, Issue 8, Page(s) 1579

    MeSH term(s) Aged ; Bone Neoplasms/secondary ; Capsule Endoscopy ; Diagnosis, Differential ; Endoscopy, Gastrointestinal ; Erythrocyte Transfusion ; Gastrointestinal Hemorrhage/etiology ; Hemangiosarcoma/complications ; Hemangiosarcoma/diagnosis ; Humans ; Intestinal Neoplasms/complications ; Intestinal Neoplasms/diagnosis ; Intestine, Small ; Male
    Language English
    Publishing date 2021-09-29
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 390122-1
    ISSN 1572-0241 ; 0002-9270
    ISSN (online) 1572-0241
    ISSN 0002-9270
    DOI 10.14309/ajg.0000000000001106
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui V Zs.36: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Unusual Infection of the Small Intestine: Mycobacterium avium Complex.

    Ertem, Furkan U / Hartman, Doug / Brand, Randall E

    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

    2020  Volume 19, Issue 3, Page(s) e26

    MeSH term(s) Communicable Diseases ; Humans ; Intestine, Small ; Mycobacterium avium
    Language English
    Publishing date 2020-02-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2119789-1
    ISSN 1542-7714 ; 1542-3565
    ISSN (online) 1542-7714
    ISSN 1542-3565
    DOI 10.1016/j.cgh.2020.01.043
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5836: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Granuloma Presence at Initial Surgery Predicts Need for Repeat Surgery Independent of Rutgeerts Score in Crohn's Disease.

    Ertem, Furkan U / Rivers, Claudia Ramos / Watson, Andrew R / Tang, Gong / Schwartz, Marc / Johnston, Elyse / Barrie, Arthur / Harrison, Janet / Dueker, Jeffrey M / Hartman, Doug / Binion, David G

    Inflammatory bowel diseases

    2023  Volume 29, Issue 12, Page(s) 1895–1900

    Abstract: Background: Approximately half of Crohn's disease (CD) patients experience recurrence and need for repeat resections, highlighting need for prognostic biomarkers. Presence of epithelioid granuloma on surgical tissue and high Rutgeerts endoscopic score ... ...

    Abstract Background: Approximately half of Crohn's disease (CD) patients experience recurrence and need for repeat resections, highlighting need for prognostic biomarkers. Presence of epithelioid granuloma on surgical tissue and high Rutgeerts endoscopic score are associated with postoperative CD clinical recurrence. We sought to evaluate presence of epithelioid granuloma at first surgery and Rutgeerts score as a combined risk assessment for CD surgical recurrence.
    Methods: Our study included consented CD patients who underwent initial ileocecal resection and were prospectively followed postoperatively. From 2009 to 2019, 418 CD patients underwent initial ileocecal resection with >4 years of follow-up, including postoperative endoscopic assessment (Rutgeerts score).
    Results: Postoperative CD patients were grouped based on granuloma presence (30.6%; n = 128) or absence (69.4%; n = 290). Endoscopic recurrence (defined as Rutgeerts score ≥i2) was similar between the granuloma (26%) and no granuloma (25%) groups, respectively (P = .82). Patients with granuloma and CD endoscopic recurrence at first postoperative endoscopy had higher number of bowel surgeries compared with all other groups (no granuloma or CD endoscopic recurrence, P = .007; no granuloma but CD endoscopic recurrence present, P = .04; granuloma present and no CD endoscopic recurrence, P = .04). Epithelioid granuloma presence was associated with 1.65 times higher risk of subsequent surgery independently from first postoperative endoscopic recurrence Rutgeerts score.
    Conclusions: Granuloma presence on initial surgical histology is immediately available and identifies high-risk CD patients who may benefit from early postoperative treatment, and these precision intervention trials are warranted.
    MeSH term(s) Humans ; Crohn Disease/drug therapy ; Colon/surgery ; Colon/pathology ; Colonoscopy ; Reoperation ; Ileum/surgery ; Ileum/pathology ; Granuloma/etiology ; Granuloma/surgery ; Granuloma/pathology ; Recurrence ; Retrospective Studies
    Language English
    Publishing date 2023-01-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 1340971-2
    ISSN 1536-4844 ; 1078-0998
    ISSN (online) 1536-4844
    ISSN 1078-0998
    DOI 10.1093/ibd/izad008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4530: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Implementation of Digital Image Analysis in Assessment of Ki67 Index in Breast Cancer.

    Vanderschelden, Rachel K / Jerome, Jacob A / Gonzalez, Daniel / Seigh, Lindsey / Carter, Gloria J / Clark, Beth Z / Elishaev, Esther / Louis Fine, Jeffrey / Harinath, Lakshmi / Jones, Mirka W / Villatoro, Tatiana M / Soong, Thing Rinda / Yu, Jing / Zhao, Chengquan / Hartman, Doug / Bhargava, Rohit

    Applied immunohistochemistry & molecular morphology : AIMM

    2023  Volume 32, Issue 1, Page(s) 17–23

    Abstract: The clinical utility of the proliferation marker Ki67 in breast cancer treatment and prognosis is an active area of research. Studies have suggested that differences in pre-analytic and analytic factors contribute to low analytical validity of the assay, ...

    Abstract The clinical utility of the proliferation marker Ki67 in breast cancer treatment and prognosis is an active area of research. Studies have suggested that differences in pre-analytic and analytic factors contribute to low analytical validity of the assay, with scoring methods accounting for a large proportion of this variability. Use of standard scoring methods is limited, in part due to the time intensive nature of such reporting protocols. Therefore, use of digital image analysis tools may help to both standardize reporting and improve workflow. In this study, digital image analysis was utilized to quantify Ki67 indices in 280 breast biopsy and resection specimens during routine clinical practice. The supervised Ki67 indices were then assessed for agreement with a manual count of 500 tumor cells. Agreement was excellent, with an intraclass correlation coefficient of 0.96 for the pathologist-supervised analysis. This study illustrates an example of a rapid, accurate workflow for implementation of digital image analysis in Ki67 scoring in breast cancer.
    MeSH term(s) Humans ; Female ; Breast Neoplasms/diagnosis ; Breast Neoplasms/pathology ; Ki-67 Antigen ; Image Processing, Computer-Assisted/methods ; Diagnostic Imaging ; Research Design ; Biomarkers, Tumor/analysis
    Chemical Substances Ki-67 Antigen ; Biomarkers, Tumor
    Language English
    Publishing date 2023-11-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1473273-7
    ISSN 1533-4058 ; 1062-3345 ; 1541-2016
    ISSN (online) 1533-4058
    ISSN 1062-3345 ; 1541-2016
    DOI 10.1097/PAI.0000000000001171
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3783: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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