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  1. Book: Gesichter des Schweigens

    Hartmann, Boris

    die systemische Mutismus-Therapie/SYMUT als Therapiealternative

    (Das Gesundheitsforum)

    2006  

    Author's details Boris Hartmann (Hrsg.)
    Series title Das Gesundheitsforum
    Keywords Mutismus
    Subject Stummheit
    Language German
    Size 312 S. : Ill., graph. Darst., 21 cm
    Edition 1. Aufl.
    Publisher Schulz-Kirchner
    Publishing place Idstein
    Publishing country Germany
    Document type Book
    HBZ-ID HT014722833
    ISBN 978-3-8248-0336-1 ; 3-8248-0336-4
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2007 A 3651 order for loan Magazin

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  2. Book ; Thesis: Früherkennung des Schielens mit dem Infrarot-StraboScreener bei 1184 dreijährigen Kindergartenkindern

    Hartmann, Boris

    2007  

    Author's details vorgelegt von Ulrich Hugo Maria Hoffmann
    Language German
    Size 86 S. : Ill.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Tübingen, Univ., Diss., 2007
    HBZ-ID HT015310200
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2007 D 1127 order for loan Magazin

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  3. Book: Mutismus

    Hartmann, Boris

    zur Theorie und Kasuistik des totalen und elektiven Mutismus ; mit 3 Tabellen

    (Schriften zur Sprachheilpädagogik ; 1)

    1997  

    Author's details Boris Hartmann
    Series title Schriften zur Sprachheilpädagogik ; 1
    Collection
    Keywords Mutism ; Mutismus
    Subject Stummheit
    Language German
    Size 197 S. : Ill., graph. Darst.
    Edition 4., überarb. und erw. Aufl.
    Publisher Ed. Marhold im Wiss.-Verl. Spiess
    Publishing place Berlin
    Publishing country Germany
    Document type Book
    HBZ-ID HT007752925
    ISBN 3-89166-196-7 ; 978-3-89166-196-3
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1998 A 3122 order for loan Magazin

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  4. Book: Menschenbilder in der Sprachheilpädagogik

    Hartmann, Boris

    ein kasuistischer Beitrag zur systematischen Aphasietherapie

    (Schriften zur Sprachheilpädagogik ; 7)

    1996  

    Author's details Boris Hartmann
    Series title Schriften zur Sprachheilpädagogik ; 7
    Collection
    Keywords Speech Therapy / methods ; Speech Therapy ; Aphasia / therapy ; Professional-Patient Relations ; Aphasie ; Logopädie ; Sprachbehindertenpädagogik ; Menschenbild ; Psychosoziale Belastung ; Bewältigung
    Subject Bewältigungsstrategie ; Coping ; Problembewältigung ; Psychische Bewältigung ; Bewältigungsverhalten ; Sprachgeschädigtenpädagogik ; Sprachheilpädagogik ; Stimmheilpädagogik ; Sprachheilkunde ; Sprachstörung ; Sprachtherapie ; Sprachverlust
    Language German
    Size 294 S. : graph. Darst.
    Publisher Ed. Marhold im Wiss.-Verl. Spiess
    Publishing place Berlin
    Document type Book
    HBZ-ID HT007239057
    ISBN 3-89166-188-6 ; 978-3-89166-188-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1997 B 554 order for loan Magazin

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  5. Book: Mutismus im Kindes-, Jugend- und Erwachsenenalter

    Hartmann, Boris / Lange, Michael

    für Angehörige, Betroffene sowie therapeutische und pädagogische Berufe

    (Ratgeber für Angehörige, Betroffene und Fachleute)

    2003  

    Author's details von Boris Hartmann und Michael Lange
    Series title Ratgeber für Angehörige, Betroffene und Fachleute
    Keywords Mutismus
    Subject Stummheit
    Language German
    Size 64 S. : Ill.
    Edition 1. Aufl.
    Publisher Schulz-Kirchner
    Publishing place Idstein
    Publishing country Germany
    Document type Book
    HBZ-ID HT013660889
    ISBN 3-8248-0506-5 ; 978-3-8248-0506-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2003 A 2025 order for loan Magazin

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  6. Book: Mutismus

    Hartmann, Boris

    zur Theorie und Kasuistik des totalen und elektiven Mutismus

    (Schriften zur Sprachheilpädagogik ; 1)

    1991  

    Author's details Boris Hartmann
    Series title Schriften zur Sprachheilpädagogik ; 1
    Collection
    Keywords Mutism ; Mutismus
    Subject Stummheit
    Size VIII, 127 S. : Ill., graph. Darst.
    Publisher Ed. Marhold im Wiss.-Verl. Spiess
    Publishing place Berlin
    Document type Book
    HBZ-ID HT003818966
    ISBN 3-89166-122-3 ; 978-3-89166-122-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1991 B 1736 order for loan Magazin

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  7. Book: Mutismus im Kindes-, Jugend- und Erwachsenenalter. Für Angehörige, Betroffene sowie therapeutische und pädagogische Berufe

    Hartmann, Boris / Lange, Michael

    2021  

    Abstract: In einem Ratgeber für Angehörige, Betroffene sowie therapeutische und pädagogische Berufe wird über Mutimus bei Kindern, Jugendlichen und Erwachsenen informiert. Das Charakteristikum dieser Kommunikationsstörung ist das Schweigen der Betroffenen trotz ... ...

    Title translation Mutism in childhood, adolescence and adulthood. For relatives, affected persons as well as therapeutic and educational professions (DeepL)
    Abstract In einem Ratgeber für Angehörige, Betroffene sowie therapeutische und pädagogische Berufe wird über Mutimus bei Kindern, Jugendlichen und Erwachsenen informiert. Das Charakteristikum dieser Kommunikationsstörung ist das Schweigen der Betroffenen trotz Vorhandensein von Sprechvermögen und angemessener Sprachentwicklung. Immer noch wird dieses Schweigen als trotziges Willkürverhalten missverstanden und in seiner Bedeutung für die gesamtpersonale Entwicklung unterschätzt, obwohl die psychosozialen Begleitumstände einer mutistischen Symptomatik gravierend sein können: soziale Isolation, erschwerte Kindergartenzeit, Schulprobleme, Depressionen und reduzierte Berufsperspektiven. Die genannten Problemfelder haben in der Regel Rückwirkungen sowohl auf die seelische Entwicklung der schweigenden Person als auch auf das Zusammenleben der Familie. Nicht selten sind die Angehörigen nach einer anfänglichen Phase des mitfühlenden Engagements ähnlich überfordert und resignativ wie die Mutisten selbst, erst recht, wenn sich die Suche nach einer geeigneten Behandlungsmöglichkeit als Odyssee des Leidens herausstellt. Vor diesem Hintergrund werden folgende Themen behandelt: Erscheinungsbild und weitere Verhaltenskomponenten bei Schweigenden, Mutismus vs. Autismus-Spektrum-Störung (ASS), Erklärungsmodelle, Leserbriefe von Ratsuchenden, Beratungshilfen für den Kindergarten und die Schule, Mutismus bei Erwachsenen, therapeutische Möglichkeiten, (Internet-)Adressen und weiterführende Hinweise. - Inhalt: (1) Ein Problem äußert sich. (2) Wann tritt das Schweigen erstmals auf? (3) Was ist Mutismus? Eine Begriffsbestimmung. (4) Erscheinungsformen des Schweigens und weitere Verhaltenskomponenten. (5) Wo liegen die Ursachen für das Schweigen? (6) Mutismus im Kinder. (7) Mutismus in der Schule. (8) Mutismus im Erwachsenenalter. (9) Therapeutische Möglichkeiten. (10) Der Mund, der Indikator der Seele. - Das Buch wurde für die vorliegende achte Auflage überarbeitet.
    Keywords Bildung und Erziehung ; Diagnosis ; Diagnostik ; Education ; Etiology ; Mutism ; Mutismus ; Symptome ; Symptoms ; Therapie ; Treatment ; Ätiologie
    Language German
    Size 68 S.
    Publisher Schulz-Kirchner (8., überarb. Aufl.)
    Publishing place Idstein
    Document type Book
    ISBN 978-3-8248-0735-2 ; 3-8248-0735-1
    Database PSYNDEX

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  8. Article ; Online: Deciphering the combinatorial landscape of immunity.

    Cappuccio, Antonio / Jensen, Shane T / Hartmann, Boris M / Sealfon, Stuart C / Soumelis, Vassili / Zaslavsky, Elena

    eLife

    2020  Volume 9

    Abstract: From cellular activation to drug combinations, immunological responses are shaped by the action of multiple stimuli. Synergistic and antagonistic interactions between stimuli play major roles in shaping immune processes. To understand combinatorial ... ...

    Abstract From cellular activation to drug combinations, immunological responses are shaped by the action of multiple stimuli. Synergistic and antagonistic interactions between stimuli play major roles in shaping immune processes. To understand combinatorial regulation, we present the immune Synergistic/Antagonistic Interaction Learner (iSAIL). iSAIL includes a machine learning classifier to map and interpret interactions, a curated compendium of immunological combination treatment datasets, and their global integration into a landscape of ~30,000 interactions. The landscape is mined to reveal combinatorial control of interleukins, checkpoints, and other immune modulators. The resource helps elucidate the modulation of a stimulus by interactions with other cofactors, showing that TNF has strikingly different effects depending on co-stimulators. We discover new functional synergies between TNF and IFNβ controlling dendritic cell-T cell crosstalk. Analysis of laboratory or public combination treatment studies with this user-friendly web-based resource will help resolve the complex role of interaction effects on immune processes.
    MeSH term(s) Animals ; Databases as Topic ; Dendritic Cells/drug effects ; Humans ; Immune Checkpoint Inhibitors/pharmacology ; Immunity/drug effects ; Immunity/immunology ; Immunity/physiology ; Immunologic Factors/pharmacology ; Interferon-beta/metabolism ; Interleukins/metabolism ; Machine Learning ; Mice ; Software ; T-Lymphocytes/drug effects ; T-Lymphocytes/metabolism ; Tumor Necrosis Factor-alpha/metabolism
    Chemical Substances Immune Checkpoint Inhibitors ; Immunologic Factors ; Interleukins ; Tumor Necrosis Factor-alpha ; Interferon-beta (77238-31-4)
    Language English
    Publishing date 2020-11-23
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.62148
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Neutrophil extracellular traps induce persistent lung tissue damage via thromboinflammation without altering virus resolution in a mouse coronavirus model.

    Salzmann, Manuel / Gibler, Patrizia / Haider, Patrick / Brekalo, Mira / Plasenzotti, Roberto / Filip, Thomas / Nistelberger, Rebecca / Hartmann, Boris / Wojta, Johann / Hengstenberg, Christian / Podesser, Bruno K / Kral-Pointner, Julia B / Hohensinner, Philipp J

    Journal of thrombosis and haemostasis : JTH

    2023  Volume 22, Issue 1, Page(s) 188–198

    Abstract: Background: During infection, neutrophil extracellular traps (NETs) are associated with severity of pulmonary diseases such as acute respiratory disease syndrome. NETs induce subsequent immune responses, are directly cytotoxic to pulmonary cells, and ... ...

    Abstract Background: During infection, neutrophil extracellular traps (NETs) are associated with severity of pulmonary diseases such as acute respiratory disease syndrome. NETs induce subsequent immune responses, are directly cytotoxic to pulmonary cells, and are highly procoagulant. Anticoagulation treatment was shown to reduce in-hospital mortality, indicating thromboinflammatory complications. However, data are sparsely available on the involvement of NETs in secondary events after virus clearance, which can lead to persistent lung damage and postacute sequelae with chronic fatigue and dyspnea.
    Objectives: This study focuses on late-phase events using a murine model of viral lung infection with postacute sequelae after virus resolution.
    Methods: C57BL/6JRj mice were infected intranasally with the betacoronavirus murine coronavirus (MCoV, strain MHV-A95), and tissue samples were collected after 2, 4, and 10 days. For NET modulation, mice were pretreated with OM-85 or GSK484 and DNase I were administered intraperitoneally between days 2 to 5 and days 4 to 7, respectively.
    Results: Rapid, platelet-attributed thrombus formation was followed by a second, late phase of thromboinflammation. This phase was characterized by negligible virus titers but pronounced tissue damage, apoptosis, oxidative DNA damage, and presence of NETs. Inhibition of NETs during the acute phase did not impact virus burden but decreased lung cell apoptosis by 67% and oxidative stress by 94%. Prevention of neutrophil activation by immune training before virus infection reduced damage by 75%, NETs by 31%, and pulmonary thrombi by 93%.
    Conclusion: NETs are detrimental inducers of tissue damage during respiratory virus infection but do not contribute to virus clearance.
    MeSH term(s) Animals ; Mice ; Extracellular Traps ; Neutrophils ; Coronavirus ; Thromboinflammation ; Disease Models, Animal ; Inflammation/complications ; Thrombosis/complications ; Mice, Inbred C57BL ; Lung ; Coronavirus Infections/complications
    Language English
    Publishing date 2023-09-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2112661-6
    ISSN 1538-7836 ; 1538-7933
    ISSN (online) 1538-7836
    ISSN 1538-7933
    DOI 10.1016/j.jtha.2023.09.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5805: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 295: Show issues

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  10. Article ; Online: Comparing Host Module Activation Patterns and Temporal Dynamics in Infection by Influenza H1N1 Viruses.

    Nudelman, Irina / Kudrin, Daniil / Nudelman, German / Deshpande, Raamesh / Hartmann, Boris M / Kleinstein, Steven H / Myers, Chad L / Sealfon, Stuart C / Zaslavsky, Elena

    Frontiers in immunology

    2021  Volume 12, Page(s) 691758

    Abstract: Influenza is a serious global health threat that shows varying pathogenicity among different virus strains. Understanding similarities and differences among activated functional pathways in the host responses can help elucidate therapeutic targets ... ...

    Abstract Influenza is a serious global health threat that shows varying pathogenicity among different virus strains. Understanding similarities and differences among activated functional pathways in the host responses can help elucidate therapeutic targets responsible for pathogenesis. To compare the types and timing of functional modules activated in host cells by four influenza viruses of varying pathogenicity, we developed a new DYNAmic MOdule (DYNAMO) method that addresses the need to compare functional module utilization over time. This integrative approach overlays whole genome time series expression data onto an immune-specific functional network, and extracts conserved modules exhibiting either different temporal patterns or overall transcriptional activity. We identified a common core response to influenza virus infection that is temporally shifted for different viruses. We also identified differentially regulated functional modules that reveal unique elements of responses to different virus strains. Our work highlights the usefulness of combining time series gene expression data with a functional interaction map to capture temporal dynamics of the same cellular pathways under different conditions. Our results help elucidate conservation of the immune response both globally and at a granular level, and provide mechanistic insight into the differences in the host response to infection by influenza strains of varying pathogenicity.
    MeSH term(s) Algorithms ; Antigen Presentation ; Dendritic Cells/immunology ; Host-Pathogen Interactions/genetics ; Host-Pathogen Interactions/immunology ; Humans ; Influenza A Virus, H1N1 Subtype ; Influenza, Human/epidemiology ; Influenza, Human/genetics ; Influenza, Human/immunology ; Pandemics ; Transcriptome
    Language English
    Publishing date 2021-07-14
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.691758
    Database MEDical Literature Analysis and Retrieval System OnLINE

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