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Article ; Online: The latest advances in the pharmacological management of endometriosis.

Hartner, Gabriel / Husslein, Heinrich / Kuessel, Lorenz / Gstoettner, Manuela / Tiringer, Denise / Wenzl, René / Perricos, Alexandra

Expert opinion on pharmacotherapy

2022 , Page(s) 1–13

Abstract: Introduction: Endometriosis is a benign disease, characterized by a wide range of symptoms and different degrees of severity, which is why therapy should be individually adapted to the patient's needs. Over the years, a lot of research has gone into ... ...

Abstract	Introduction: Endometriosis is a benign disease, characterized by a wide range of symptoms and different degrees of severity, which is why therapy should be individually adapted to the patient's needs. Over the years, a lot of research has gone into finding new therapeutic approaches for this enigmatic disease. Areas covered: This review presents the latest advances in pharmacological management of endometriosis and is solely focused on studies published from 2010 to 2021. Expert opinion: Clinicians and researchers are constantly searching for new therapeutic strategies for endometriosis patients. As there are well-established treatments, however, any new medication should fulfill at least one of the three criteria: increased efficacy, comparable efficacy but a better safety profile, or treatments that have a lack of accompanying contraceptive effects that are seen in most endometriosis treatments. While some new substances show promising results, further studies are needed to demonstrate the fulfillment of one of the above-mentioned criteria.
Language	English
Publishing date	2022-03-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2001535-5
ISSN	1744-7666 ; 1465-6566
ISSN (online)	1744-7666
ISSN	1465-6566
DOI	10.1080/14656566.2022.2045274
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Article: Kardologiepflege: Die Herzinsuffizienz-Nurse tut dem Patienten gut

Hartner, Gabriele / Reinhard, Nicole / Störk, Stefan

Procare

2019 Volume 24, Issue 9, Page(s) 10

Language	German
Document type	Article
ZDB-ID	2011381-X
ISSN	0949-7323
Database	Current Contents Medicine

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Article ; Online: TRPV1 antagonist BCTC inhibits pH 6.0-induced pain in human skin.

Heber, Stefan / Ciotu, Cosmin I / Hartner, Gabriel / Gold-Binder, Markus / Ninidze, Nino / Gleiss, Andreas / Kress, Hans-Georg / Fischer, Michael J M

Pain

2020 Volume 161, Issue 7, Page(s) 1532–1541

Abstract: Tissue acidosis due to ischemia occurs under several pathological conditions and is believed to contribute to pain in these circumstances. TRPV1, TRPA1, and ASICs are known to be sensitive to acidic pH. Addressing their possible role in acidosis ... ...

Abstract	Tissue acidosis due to ischemia occurs under several pathological conditions and is believed to contribute to pain in these circumstances. TRPV1, TRPA1, and ASICs are known to be sensitive to acidic pH. Addressing their possible role in acidosis perception, the respective antagonists BCTC, A-967079, and amiloride were injected in the volar forearm skin of 32 healthy volunteers. To investigate possible redundancies between channels, a full-factorial study design was used. Injections were performed in a prerandomized, double-blind, and balanced design. Each injection included a three-step pH protocol from pH 7.0 over pH 6.5 to pH 6.0 with a step duration of 90 seconds. Pain was reported by volunteers on a numerical scale every 10 seconds during injections. Confirming the primary hypothesis, the combination of all 3 antagonists reduced acid-induced pain at pH 6.0. Because of the full-factorial design, it could be concluded that BCTC alone, but not A-967079 or amiloride, or any combination thereof, was responsible for the observed effects, suggesting TRPV1 as primary sensor for pH 6.0-induced pain. Surprisingly, A-967079 even enhanced pain induced by pH 6.0. In cultured mouse dorsal root ganglion neurons, TPRV1 dependence of pH 6-induced calcium responses could be confirmed. Responses of hTRPV1 to acidic stimulation showed a maximum around pH6, providing an explanation for the pH-dependent inhibition by BCTC. A-967079 sensitizes pH responses is a TRPA1-responsive dorsal root ganglion neuron population, and a direct effect of A-967079 on hTRPA1 and hTRPV1 was excluded. In conclusion, inhibiting TRPV1-mediated acidosis-induced pain could be a symptomatic and potentially also a disease-modifying approach.
MeSH term(s)	Amiloride/therapeutic use ; Animals ; Ganglia, Spinal ; Humans ; Hydrogen-Ion Concentration ; Mice ; Pain/chemically induced ; Pain/drug therapy ; TRPV Cation Channels
Chemical Substances	TRPV Cation Channels ; TRPV1 protein, human ; TRPV1 protein, mouse ; Amiloride (7DZO8EB0Z3)
Language	English
Publishing date	2020-02-24
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	193153-2
ISSN	1872-6623 ; 0304-3959
ISSN (online)	1872-6623
ISSN	0304-3959
DOI	10.1097/j.pain.0000000000001848
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Article ; Online: Large area x-ray collimator-the zone plate approach.

Menz, Benedikt / Braig, Christoph / Bräuninger, Heinrich / Burwitz, Vadim / Hartner, Gisela / Predehl, Peter

Applied optics

2015 Volume 54, Issue 26, Page(s) 7851–7858

Abstract: One question of particular interest in the measurement of x-ray imaging optics for space telescopes concerns the characteristics of the point spread function (PSF) in orbit and the focal length for an infinite source distance. In order to measure such a ... ...

Abstract	One question of particular interest in the measurement of x-ray imaging optics for space telescopes concerns the characteristics of the point spread function (PSF) in orbit and the focal length for an infinite source distance. In order to measure such a PSF, a parallel x-ray beam with a diameter of several centimeters to meters is required. For this purpose a large area transmission x-ray zone plate (ZP) for collimating x-ray beams has been designed, built, and tested. Furthermore we present a setup to determine large-scale aberrations of the collimated beam. From x-ray measurements we obtain an upper limit for the angular resolution of ±0.2 arc sec and a first-order diffraction efficiency of ≈13%. These results show that it is possible to use a ZP as a collimator for the PANTER x-ray test facility.
Language	English
Publishing date	2015-09-10
Publishing country	United States
Document type	Journal Article
ISSN	1539-4522
ISSN (online)	1539-4522
DOI	10.1364/AO.54.007851
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Book ; Online: Performance Testing of a Large-Format Reflection Grating Prototype for a Suborbital Rocket Payload

Donovan, Benjamin D. / McEntaffer, Randall L. / DeRoo, Casey T. / Tutt, James H. / Grisé, Fabien / Eichfel, Chad M. / Gall, Oren Z. / Burwitz, Vadim / Hartner, Gisela / Pelliciari, Carlo / La Caria, Marlis-Madeleine

2020

Abstract: The soft X-ray grating spectrometer on board the Off-plane Grating Rocket Experiment (OGRE) hopes to achieve the highest resolution soft X-ray spectrum of an astrophysical object when it is launched via suborbital rocket. Paramount to the success of the ... ...

Abstract	The soft X-ray grating spectrometer on board the Off-plane Grating Rocket Experiment (OGRE) hopes to achieve the highest resolution soft X-ray spectrum of an astrophysical object when it is launched via suborbital rocket. Paramount to the success of the spectrometer are the performance of the $>250$ reflection gratings populating its reflection grating assembly. To test current grating fabrication capabilities, a grating prototype for the payload was fabricated via electron-beam lithography at The Pennsylvania State University's Materials Research Institute and was subsequently tested for performance at Max Planck Institute for Extraterrestrial Physics' PANTER X-ray Test Facility. Bayesian modeling of the resulting data via Markov chain Monte Carlo (MCMC) sampling indicated that the grating achieved the OGRE single-grating resolution requirement of $R_{g}(\lambda/\Delta\lambda)>4500$ at the 94% confidence level. The resulting $R_g$ posterior probability distribution suggests that this confidence level is likely a conservative estimate though, since only a finite $R_g$ parameter space was sampled and the model could not constrain the upper bound of $R_g$ to less than infinity. Raytrace simulations of the system found that the observed data can be reproduced with a grating performing at $R_g=\infty$. It is therefore postulated that the behavior of the obtained $R_g$ posterior probability distribution can be explained by a finite measurement limit of the system and not a finite limit on $R_g$. Implications of these results and improvements to the test setup are discussed. Comment: 25 pages, 16 figures, preprint of an article accepted for publication in the Journal of Astronomical Instrumentation \copyright 2020 [copyright World Scientific Publishing Company] [https://www.worldscientific.com/worldscinet/jai]
Keywords	Astrophysics - Instrumentation and Methods for Astrophysics
Subject code	621
Publishing date	2020-11-02
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Thesis: Währung und Notenbankwesen Persiens unter besonderer Berücksichtigung der neuesten Zeit

Hartner, Gottfried

(Wirtschaftsstudien, mit besonderer Berücksichtigung Bayerns ; 127)

1932

Author's details	von Gottfried Hartner
Series title	Wirtschaftsstudien, mit besonderer Berücksichtigung Bayerns ; 127
Language	German
Size	108 S, 8°
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Zugl.: Würzburg, Univ., Diss., 1931
Note	Mit Bibliographie
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Article: First Light Measurements of Capella with the Low-Energy Transmission Grating Spectrometer aboard the Chandra X-Ray Observatory.

Brinkman / Gunsing / Kaastra / van Der Meer RL / Mewe / Paerels / Raassen / van Rooijen JJ / Bräuninger / Burkert / Burwitz / Hartner / Predehl / Ness / Schmitt / Drake / Johnson / Juda / Kashyap /

Murray / Pease / Ratzlaff / Wargelin

The Astrophysical journal

2000 Volume 530, Issue 2, Page(s) L111–L114

Abstract: We present the first X-ray spectrum obtained by the Low-Energy Transmission Grating Spectrometer (LETGS) aboard the Chandra X-Ray Observatory. The spectrum is of Capella and covers a wavelength range of 5-175 Å (2.5-0.07 keV). The measured wavelength ... ...

Abstract	We present the first X-ray spectrum obtained by the Low-Energy Transmission Grating Spectrometer (LETGS) aboard the Chandra X-Ray Observatory. The spectrum is of Capella and covers a wavelength range of 5-175 Å (2.5-0.07 keV). The measured wavelength resolution, which is in good agreement with ground calibration, is Deltalambda approximately 0.06 Å (FWHM). Although in-flight calibration of the LETGS is in progress, the high spectral resolution and unique wavelength coverage of the LETGS are well demonstrated by the results from Capella, a coronal source rich in spectral emission lines. While the primary purpose of this Letter is to demonstrate the spectroscopic potential of the LETGS, we also briefly present some preliminary astrophysical results. We discuss plasma parameters derived from line ratios in narrow spectral bands, such as the electron density diagnostics of the He-like triplets of carbon, nitrogen, and oxygen, as well as resonance scattering of the strong Fe xvii line at 15.014 Å.
Language	English
Publishing date	2000-02-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2960-9
ISSN	0004-637X
ISSN	0004-637X
DOI	10.1086/312504
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Article: Inclusive K(S);(0)K(S);(0) resonance production in ep collisions at HERA.

Chekanov, S / Derrick, M / Magill, S / Musgrave, B / Nicholass, D / Repond, J / Yoshida, R / Mattingly, M C K / Antonioli, P / Bari, G / Bellagamba, L / Boscherini, D / Bruni, A / Bruni, G / Cindolo, F / Corradi, M / Iacobucci, G / Margotti, A / Nania, R /

Polini, A / Antonelli, S / Basile, M / Bindi, M / Cifarelli, L / Contin, A / De Pasquale, S / Sartorelli, G / Zichichi, A / Bartsch, D / Brock, I / Hartmann, H / Hilger, E / Jakob, H-P / Jüngst, M / Nuncio-Quiroz, A E / Paul, E / Samson, U / Schönberg, V / Shehzadi, R / Wlasenko, M / Brook, N H / Heath, G P / Morris, J D / Capua, M / Fazio, S / Mastroberardino, A / Schioppa, M / Susinno, G / Tassi, E / Kim, J Y / Ibrahim, Z A / Kamaluddin, B / Wan Abdullah, W A T / Ning, Y / Ren, Z / Sciulli, F / Chwastowski, J / Eskreys, A / Figiel, J / Galas, A / Gil, M / Olkiewicz, K / Stopa, P / Zawiejski, L / Adamczyk, L / Bołd, T / Grabowska-Bołd, I / Kisielewska, D / Lukasik, J / Przybycień, M / Suszycki, L / Kotański, A / Słomiński, W / Behrens, U / Blohm, C / Bonato, A / Borras, K / Ciesielski, R / Coppola, N / Fang, S / Fourletova, J / Geiser, A / Göttlicher, P / Grebenyuk, J / Gregor, I / Haas, T / Hain, W / Hüttmann, A / Januschek, F / Kahle, B / Katkov, I I / Klein, U / Kötz, U / Kowalski, H / Lobodzinska, E / Löhr, B / Mankel, R / Melzer-Pellmann, I-A / Miglioranzi, S / Montanari, A / Namsoo, T / Notz, D / Parenti, A / Rinaldi, L / Roloff, P / Rubinsky, I / Santamarta, R / Schneekloth, U / Spiridonov, A / Szuba, D / Szuba, J / Theedt, T / Wolf, G / Wrona, K / Yagües Molina, A G / Youngman, C / Zeuner, W / Drugakov, V / Lohmann, W / Schlenstedt, S / Barbagli, G / Gallo, E / Pelfer, P G / Bamberger, A / Dobur, D / Karstens, F / Vlasov, N N / Bussey, P J / Doyle, A T / Dunne, W / Forrest, M / Rosin, M / Saxon, D H / Skillicorn, I O / Gialas, I / Papageorgiu, K / Holm, U / Klanner, R / Lohrmann, E / Schleper, P / Schörner-Sadenius, T / Sztuk, J / Stadie, H / Turcato, M / Foudas, C / Fry, C / Long, K R / Tapper, A D / Matsumoto, T / Nagano, K / Tokushuku, K / Yamada, S / Yamazaki, Y / Barakbaev, A N / Boos, E G / Pokrovskiy, N S / Zhautykov, B O / Aushev, V / Borodin, M / Kadenko, I / Kozulia, A / Libov, V / Lisovyi, M / Lontkovskyi, D / Makarenko, I / Sorokin, Iu / Verbytskyi, A / Volynets, O / Son, D / de Favereau, J / Piotrzkowski, K / Barreiro, F / Glasman, C / Jimenez, M / Labarga, L / Del Peso, J / Ron, E / Soares, M / Terrón, J / Zambrana, M / Corriveau, F / Liu, C / Schwartz, J / Walsh, R / Zhou, C / Tsurugai, T / Antonov, A / Dolgoshein, B A / Gladkov, D / Sosnovtsev, V / Stifutkin, A / Suchkov, S / Dementiev, R K / Ermolov, P F / Gladilin, L K / Golubkov, Yu A / Khein, L A / Korzhavina, I A / Kuzmin, V A / Levchenko, B B / Lukina, O Yu / Proskuryakov, A S / Shcheglova, L M / Zotkin, D S / Abt, I / Caldwell, A / Kollar, D / Reisert, B / Schmidke, W B / Grigorescu, G / Keramidas, A / Koffeman, E / Kooijman, P / Pellegrino, A / Tiecke, H / Vázquez, M / Wiggers, L / Brümmer, N / Bylsma, B / Durkin, L S / Lee, A / Ling, T Y / Allfrey, P D / Bell, M A / Cooper-Sarkar, A M / Devenish, R C E / Ferrando, J / Foster, B / Korcsak-Gorzo, K / Oliver, K / Robertson, A / Uribe-Estrada, C / Walczak, R / Bertolin, A / Dal Corso, F / Dusini, S / Longhin, A / Stanco, L / Bellan, P / Brugnera, R / Carlin, R / Garfagnini, A / Limentani, S / Oh, B Y / Raval, A / Ukleja, J / Whitmore, J J / Iga, Y / D'Agostini, G / Marini, G / Nigro, A / Cole, J E / Hart, J C / Abramowicz, H / Ingbir, R / Kananov, S / Levy, A / Stern, A / Kuze, M / Maeda, J / Hori, R / Kagawa, S / Okazaki, N / Shimizu, S / Tawara, T / Hamatsu, R / Kaji, H / Kitamura, S / Ota, O / Ri, Y D / Costa, M / Ferrero, M I / Monaco, V / Sacchi, R / Solano, A / Arneodo, M / Ruspa, M / Fourletov, S / Martin, J F / Stewart, T P / Boutle, S K / Butterworth, J M / Gwenlan, C / Jones, T W / Loizides, J H / Wing, M / Brzozowska, B / Ciborowski, J / Grzelak, G / Kulinski, P / Luzniak, P / Malka, J / Nowak, R J / Pawlak, J M / Tymieniecka, T / Ukleja, A / Zarnecki, A F / Adamus, M / Plucinski, P / Eisenberg, Y / Hochman, D / Karshon, U / Brownson, E / Danielson, T / Everett, A / Kçira, D / Reeder, D D / Ryan, P / Savin, A A / Smith, W H / Wolfe, H / Bhadra, S / Catterall, C D / Cui, Y / Hartner, G / Menary, S / Noor, U / Standage, J / Whyte, J

Physical review letters

2008 Volume 101, Issue 11, Page(s) 112003

Abstract: Inclusive K_{S};{0}K_{S};{0} production in ep collisions at the DESY ep collider HERA was studied with the ZEUS detector using an integrated luminosity of 0.5 fb;{-1}. Enhancements in the mass spectrum were observed and are attributed to the production ... ...

Abstract	Inclusive K_{S};{0}K_{S};{0} production in ep collisions at the DESY ep collider HERA was studied with the ZEUS detector using an integrated luminosity of 0.5 fb;{-1}. Enhancements in the mass spectrum were observed and are attributed to the production of f_{2}(1270)/a_{2};{0}(1320), f_{2};{'}(1525) and f_{0}(1710). Masses and widths were obtained using a fit which takes into account theoretical predictions based on SU(3) symmetry arguments, and are consistent with the Particle Data Group values. The f_{0}(1710) state, which has a mass consistent with a glueball candidate, was observed with a statistical significance of 5 standard deviations. However, if this state is the same as that seen in gammagamma-->K_{S};{0}K_{S};{0}, it is unlikely to be a pure glueball state.
Language	English
Publishing date	2008-09-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.101.112003
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