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Article ; Online: From Rhetoric to Reality: Commentary on Flynn & Brown (2016).

Hartnett, Tim

2016 Volume 64, Page(s) 3–4

MeSH term(s)	Humans ; Language
Language	English
Publishing date	2016-05
Publishing country	United States
Document type	Comment ; Journal Article
ZDB-ID	605923-5
ISSN	1873-6483 ; 0740-5472
ISSN (online)	1873-6483
ISSN	0740-5472
DOI	10.1016/j.jsat.2015.12.009
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Book ; Online: Consensus-oriented decision-making

Hartnett, Tim

the CODM model for facilitating groups to widespread agreement

2011

Abstract: A step-by-step guide to the most efficient and effective method for participatory group decision- ... ...

Institution	ebrary, Inc
Author's details	Tim Hartnett
Abstract	A step-by-step guide to the most efficient and effective method for participatory group decision-making
Keywords	Consensus (Social sciences) ; Group decision making ; Group facilitation
Language	English
Size	Online-Ressource (xxiv, 169 p)
Publisher	New Society
Publishing place	Gabriola, B.C
Document type	Book ; Online
Note	Includes bibliographical references and index
ISBN	9780865716896 ; 0865716897
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article ; Online: Individual Placement and Support (IPS) for Methadone Maintenance Therapy Patients: A Pilot Randomized Controlled Trial.

Lones, Carrie E / Bond, Gary R / McGovern, Mark P / Carr, Kathryn / Leckron-Myers, Teresa / Hartnett, Tim / Becker, Deborah R

Administration and policy in mental health

2017 Volume 44, Issue 3, Page(s) 359–364

Abstract: Individual Placement and Support (IPS) is an evidence-based employment model for people with severe mental illness, but it has not been evaluated for clients enrolled in substance abuse treatment programs. This study evaluated the effectiveness of IPS ... ...

Abstract	Individual Placement and Support (IPS) is an evidence-based employment model for people with severe mental illness, but it has not been evaluated for clients enrolled in substance abuse treatment programs. This study evaluated the effectiveness of IPS for people with opioid use disorders enrolled in an opioid treatment program. Within a randomized controlled experiment, 45 patients receiving methadone maintenance therapy were assigned to either IPS or a 6-month waitlist. The waitlist group received IPS after 6 months. The primary outcome assessed over 1 year compared the attainment of a job for the IPS condition to the waitlist comparison group. During the first 6 months after enrollment, 11 (50%) active IPS participants gained competitive employment compared to 1 (5%) waitlist participant (Χ
MeSH term(s)	Adult ; Employment, Supported/organization & administration ; Female ; Humans ; Male ; Methadone/administration & dosage ; Middle Aged ; Opiate Substitution Treatment/methods ; Opioid-Related Disorders/rehabilitation ; Pilot Projects ; Socioeconomic Factors
Chemical Substances	Methadone (UC6VBE7V1Z)
Language	English
Publishing date	2017-05
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	1025319-1
ISSN	1573-3289 ; 0894-587X
ISSN (online)	1573-3289
ISSN	0894-587X
DOI	10.1007/s10488-017-0793-2
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Article: A heat shock-activated cDNA rescues the recessive lethality of mutations in the heterochromatin-associated protein HP1 of Drosophila melanogaster.

Eissenberg, J C / Hartnett, T

Molecular & general genetics : MGG

1993 Volume 240, Issue 3, Page(s) 333–338

Abstract: HP1 is a small nonhistone chromosomal protein of Drosophila melanogaster predominantly localized to the pericentric heterochromatin. We have shown previously that mutations in the HP1 coding sequences are associated with dominant suppression of ... ...

Abstract	HP1 is a small nonhistone chromosomal protein of Drosophila melanogaster predominantly localized to the pericentric heterochromatin. We have shown previously that mutations in the HP1 coding sequences are associated with dominant suppression of heterochromatic position-effect variegation, and with recessive lethality. When fused to an Hsp70 heat shock gene promoter, the cDNA encoding HP1 supports the heat shock-inducible accumulation of HP1 protein in transgenic flies; this cDNA construct complements the dominant suppression of position-effect variegation associated with mutations in the HP1 gene. Here, we report experiments demonstrating that the heat shock-driven HP1 cDNA is capable of fully rescuing the recessive lethality associated with HP1 mutations in a heat shock-dependent fashion. If heat shock-induced HP1 expression is delayed for as long as 5 days, more than half of the mutant flies still survive until adulthood, consistent with a substantial maternal contribution to embryonic and larval viability. Elevating HP1 levels as late as 7-8 days of development is sufficient to enhance variegation three-fold, suggesting that the extent of heterochromatic position effect can be modified subsequent to the initial appearance of HP1 in the nuclei of syncytial blastoderm embryos.
MeSH term(s)	Animals ; Base Sequence ; Chromosomal Proteins, Non-Histone/genetics ; DNA, Complementary/physiology ; Drosophila melanogaster/embryology ; Drosophila melanogaster/genetics ; Drosophila melanogaster/metabolism ; Female ; Genes, Lethal ; Genes, Recessive ; Genotype ; Heterochromatin ; Hot Temperature ; Male ; Molecular Sequence Data ; Mutation ; Oligodeoxyribonucleotides
Chemical Substances	Chromosomal Proteins, Non-Histone ; DNA, Complementary ; Heterochromatin ; Oligodeoxyribonucleotides ; heterochromatin-specific nonhistone chromosomal protein HP-1 (107283-02-3)
Language	English
Publishing date	1993-09
Publishing country	Germany
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	2169-6
ISSN	1432-1874 ; 1617-4623 ; 0026-8925
ISSN (online)	1432-1874 ; 1617-4623
ISSN	0026-8925
DOI	10.1007/bf00280383
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Zs.A 1198: Show issues

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Article: A comparison of long-term and short-term residential treatment programs for dual diagnosis patients.

Brunette, M F / Drake, R E / Woods, M / Hartnett, T

Psychiatric services (Washington, D.C.)

2001 Volume 52, Issue 4, Page(s) 526–528

Abstract: The authors compared measures of process and six-month outcomes for 45 individuals who were treated in a long-term residential treatment program for patients with dual diagnoses with measures for 39 individuals who were treated in a short-term program. ... ...

Abstract	The authors compared measures of process and six-month outcomes for 45 individuals who were treated in a long-term residential treatment program for patients with dual diagnoses with measures for 39 individuals who were treated in a short-term program. They also compared outcomes for individuals within each group. Those who received long-term treatment experienced improvements between entry into the program and six-month follow-up, and they were more likely to have engaged in treatment than individuals in the short-term group. At follow-up, individuals in the long-term residential treatment group were more likely to have maintained abstinence and less likely to have experienced homelessness than those in the short-term group.
MeSH term(s)	Adult ; Diagnosis, Dual (Psychiatry) ; Female ; Follow-Up Studies ; Humans ; Length of Stay/statistics & numerical data ; Long-Term Care/statistics & numerical data ; Male ; Mental Disorders/complications ; Mental Disorders/rehabilitation ; Program Evaluation ; Residential Treatment/statistics & numerical data ; Substance-Related Disorders/complications ; Treatment Outcome
Language	English
Publishing date	2001-04
Publishing country	United States
Document type	Comparative Study ; Evaluation Studies ; Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	1220173-x
ISSN	1557-9700 ; 1075-2730
ISSN (online)	1557-9700
ISSN	1075-2730
DOI	10.1176/appi.ps.52.4.526
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Zs.A 416: Show issues

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Article: Charting a path between research and practice in alcoholism treatment.

McCarty, Dennis / Edmundson, Eldon / Hartnett, Tim

Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism

2006 Volume 29, Issue 1, Page(s) 5–10

Abstract: The journey between research and practice in alcoholism treatment is worthwhile but can be difficult because of the inherent differences between the treatment and research disciplines. This article describes how the path between research and practice can ...

Abstract	The journey between research and practice in alcoholism treatment is worthwhile but can be difficult because of the inherent differences between the treatment and research disciplines. This article describes how the path between research and practice can be navigated successfully, discusses the factors that influence the journey, and offers specific pharmaceutical and behavioral interventions as examples of research-based treatment approaches that can be implemented more widely.
MeSH term(s)	Alcoholism/therapy ; Evidence-Based Medicine/methods ; Humans
Language	English
Publishing date	2006-06-11
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	1498691-7
ISSN	1930-0573 ; 1535-7414 ; 0090-838X
ISSN (online)	1930-0573
ISSN	1535-7414 ; 0090-838X
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Book ; Online: Computing and Memory Technologies based on Magnetic Skyrmions

Vakili, Hamed / Zhou, Wei / Ma, Chung T / Morshed, Md Golam / Sakib, Mohammad Nazmus / Hartnett, Tim / Xu, Jun-Wen / Ganguly, Samiran / Litzius, Kai / Quessab, Yassine / Balachandran, Prasanna / Stan, Mircea / Poon, S J / Kent, Andrew D. / Beach, Geoffrey / Ghosh, Avik W.

2021

Abstract: Solitonic magnetic excitations such as domain walls and, specifically, skyrmionics enable the possibility of compact, high density, ultrafast,all-electronic, low-energy devices, which is the basis for the emerging area of skyrmionics. The topological ... ...

Abstract	Solitonic magnetic excitations such as domain walls and, specifically, skyrmionics enable the possibility of compact, high density, ultrafast,all-electronic, low-energy devices, which is the basis for the emerging area of skyrmionics. The topological winding of skyrmion spins affects their overall lifetime, energetics and dynamical behavior. In this review, we discuss skyrmionics in the context of the present day solid state memory landscape, and show how their size, stability and mobility can be controlled by material engineering, as well as how they can be nucleated and detected. Ferrimagnetsnear their compensation points are important candidates for this application, leading to detailed exploration of amorphous CoGd as well as the study of emergent materials such as Mn$_4$N and Inverse Heusler alloys. Along with material properties, geometrical parameters such as film thickness, defect density and notches can be used to tune skyrmion properties, such as their size and stability. Topology, however, can be a double-edged sword, especially for isolated metastable skyrmions, as it brings stability at the cost of additional damping and deflective Magnus forces compared to domain walls. Skyrmion deformation in response to forces also makes them intrinsically slower than domain walls. We explore potential analog applications of skyrmions, including temporal memory at low density, and decorrelator for stochastic computing at a higher density that capitalizes on their interactions. We summarize the main challenges to achieve a skyrmionics technology, including maintaining positional stability with very high accuracy, electrical readout, especially for small ferrimagnetic skyrmions, deterministic nucleation and annihilation, and overall integration with digital circuits with the associated circuit overhead. Comment: 41 pages, 34 figure, review
Keywords	Condensed Matter - Materials Science ; Condensed Matter - Mesoscale and Nanoscale Physics
Subject code	620
Publishing date	2021-01-25
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Planning and Designing the Improving Addiction Care Team (IMPACT) for Hospitalized Adults with Substance Use Disorder.

Englander, Honora / Weimer, Melissa / Solotaroff, Rachel / Nicolaidis, Christina / Chan, Benjamin / Velez, Christine / Noice, Alison / Hartnett, Tim / Blackburn, Ed / Barnes, Pen / Korthuis, P. Todd

Journal of hospital medicine

2017 Volume 12, Issue 5, Page(s) 339–342

Abstract: People with substance use disorders (SUD) have high rates of hospitalization and readmission, long lengths of stay, and skyrocketing healthcare costs. Yet, models for improving care are extremely limited. We performed a needs assessment and then convened ...

Abstract	People with substance use disorders (SUD) have high rates of hospitalization and readmission, long lengths of stay, and skyrocketing healthcare costs. Yet, models for improving care are extremely limited. We performed a needs assessment and then convened academic and community partners, including a hospital, community SUD organizations, and Medicaid accountable care organizations, to design a care model for medically complex hospitalized patients with SUD. Needs assessment showed that 58% to 67% of participants who reported active substance use said they were interested in cutting back or quitting. Many reported interest in medication for addiction treatment (MAT). Participants had high rates of costly readmissions and longer than expected length of stay. Community stakeholders identified long wait times and lack of resources for medically complex patients as key barriers. We developed the Improving Addiction Care Team (IMPACT), which includes an inpatient addiction medicine consultation service, rapid-access pathways to posthospital SUD treatment, and a medically enhanced residential care model that integrates antibiotic infusion and residential addiction care. We developed a business case and secured funding from Medicaid and hospital payers. IMPACT provides one pathway for hospitals, payers, and communities to collaboratively address the SUD epidemic. Journal of Hospital Medicine 2017;12:339-342.
Language	English
Publishing date	2017
Publishing country	United States
Document type	Journal Article
ZDB-ID	2233783-0
ISSN	1553-5606 ; 1553-5592
ISSN (online)	1553-5606
ISSN	1553-5592
DOI	10.12788/jhm.2736
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Zs.A 6276: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 542: Show issues

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Article: Functional analysis of the chromo domain of HP1.

Platero, J S / Hartnett, T / Eissenberg, J C

The EMBO journal

1995 Volume 14, Issue 16, Page(s) 3977–3986

Abstract: Heterochromatin protein 1 (HP1) is a non-histone chromosomal protein in Drosophila with dosage-dependent effects on heterochromatin-mediated gene silencing. An evolutionarily conserved amino acid sequence in the N-terminal half of HP1 (the 'chromo domain' ...

Abstract	Heterochromatin protein 1 (HP1) is a non-histone chromosomal protein in Drosophila with dosage-dependent effects on heterochromatin-mediated gene silencing. An evolutionarily conserved amino acid sequence in the N-terminal half of HP1 (the 'chromo domain') shares > 60% sequence identity with a motif found in the Polycomb protein, a silencer of homeotic genes. We report here that point mutations in the HP1 chromo domain abolish the ability of HP1 to promote gene silencing. We show that the HP1 chromo domain, like the Polycomb chromo domain, has chromosome binding activity, but to distinct chromosomal sites. We constructed a chimeric HP1-Polycomb protein, consisting of the chromo domain of Polycomb in the context of HP1, and show that it binds to both heterochromatin and Polycomb binding sites in polytene chromosomes. In flies expressing chimeric HP1-Polycomb protein, endogenous HP1 is mislocalized to Polycomb binding sites, and endogenous polycomb is misdirected to the heterochromatic chromocenter, suggesting that both proteins are recruited to their distinct chromosomal binding sites through protein-protein contacts. Chimeric HP1-Polycomb protein expression in transgenic flies promotes heterochromatin-mediated gene silencing, supporting the view that the chromo domain homology reflects a common mechanistic basis for homeotic and heterochromatic silencing.
MeSH term(s)	Amino Acid Sequence ; Animals ; Animals, Genetically Modified ; Base Sequence ; Binding Sites ; Cell Nucleus/chemistry ; Chromobox Protein Homolog 5 ; Chromosomal Proteins, Non-Histone/analysis ; Chromosomal Proteins, Non-Histone/chemistry ; Chromosomal Proteins, Non-Histone/genetics ; Chromosomal Proteins, Non-Histone/metabolism ; Chromosomes/metabolism ; Conserved Sequence ; Drosophila Proteins ; Drosophila melanogaster/genetics ; Gene Expression Regulation/physiology ; Genes, Insect/genetics ; Heterochromatin/metabolism ; Models, Genetic ; Molecular Sequence Data ; Point Mutation ; Polycomb Repressive Complex 1 ; Proteins/genetics ; Proteins/metabolism ; Recombinant Fusion Proteins/analysis ; Recombinant Fusion Proteins/biosynthesis ; Sequence Homology, Amino Acid
Chemical Substances	Chromosomal Proteins, Non-Histone ; Drosophila Proteins ; Heterochromatin ; Pc protein, Drosophila ; Proteins ; Recombinant Fusion Proteins ; Chromobox Protein Homolog 5 (107283-02-3) ; Polycomb Repressive Complex 1 (EC 2.3.2.27)
Language	English
Publishing date	1995-08-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	586044-1
ISSN	1460-2075 ; 0261-4189
ISSN (online)	1460-2075
ISSN	0261-4189
DOI	10.1002/j.1460-2075.1995.tb00069.x
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Zs.A 1808: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Increased phosphorylation of HP1, a heterochromatin-associated protein of Drosophila, is correlated with heterochromatin assembly.

Eissenberg, J C / Ge, Y W / Hartnett, T

The Journal of biological chemistry

1994 Volume 269, Issue 33, Page(s) 21315–21321

Abstract: The heterochromatin-associated nonhistone chromosomal protein HP1 exerts dosage-dependent effects on the silencing of genes juxtaposed to pericentric heterochromatin in Drosophila melanogaster. Here, we report that HP1 is multiply phosphorylated in ... ...

Abstract	The heterochromatin-associated nonhistone chromosomal protein HP1 exerts dosage-dependent effects on the silencing of genes juxtaposed to pericentric heterochromatin in Drosophila melanogaster. Here, we report that HP1 is multiply phosphorylated in Drosophila tissue, predominantly at serine and threonine residues. Pulse-labeling studies of explanted Drosophila tissues suggest that phosphorylation is relatively rapid and that phosphate is incorporated into existing protein. Maternally synthesized HP1 is underphosphorylated. The appearance of more highly phosphorylated HP1 isoforms at 1.5-2 h of development coincides with the embryonic stage at which cytologically visible heterochromatin appears and HP1 concentrates in heterochromatin. The extent of HP1 phosphorylation is lower in polytene tissue, where heterochromatin is underrepresented. These results are consistent with a role for phosphorylation of HP1 in the assembly and maintenance of heterochromatin in Drosophila.
MeSH term(s)	Amino Acid Sequence ; Animals ; Blotting, Western ; Chromosomal Proteins, Non-Histone/metabolism ; Drosophila melanogaster/metabolism ; Electrophoresis, Gel, Two-Dimensional ; Female ; Heterochromatin/metabolism ; Larva ; Male ; Molecular Sequence Data ; Phosphoproteins/metabolism ; Phosphorylation ; Protein Processing, Post-Translational ; Serine/metabolism ; Threonine/metabolism
Chemical Substances	Chromosomal Proteins, Non-Histone ; Heterochromatin ; Phosphoproteins ; heterochromatin-specific nonhistone chromosomal protein HP-1 (107283-02-3) ; Threonine (2ZD004190S) ; Serine (452VLY9402)
Language	English
Publishing date	1994-08-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
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