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  1. Article ; Online: Precise genome editing underlines the distinct contributions of mutations in

    Hartuis, Sophie / Ourliac-Garnier, Isabelle / Robert, Estelle / Albassier, Marjorie / Duchesne, Léa / Beaufils, Clara / Kuhn, Joséphine / Le Pape, Patrice / Morio, Florent

    Antimicrobial agents and chemotherapy

    2024  , Page(s) e0002224

    Abstract: ... Candida ... ...

    Abstract Candida parapsilosis
    Language English
    Publishing date 2024-04-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/aac.00022-24
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 809: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Einzelsignatur: Show issues

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  2. Article ; Online: Automatic patient-level recognition of four

    Guemas, Emilie / Routier, Baptiste / Ghelfenstein-Ferreira, Théo / Cordier, Camille / Hartuis, Sophie / Marion, Bénédicte / Bertout, Sébastien / Varlet-Marie, Emmanuelle / Costa, Damien / Pasquier, Grégoire

    Microbiology spectrum

    2024  Volume 12, Issue 2, Page(s) e0144023

    Abstract: Malaria remains a global health problem, with 247 million cases and 619,000 deaths in 2021. Diagnosis ... ...

    Abstract Malaria remains a global health problem, with 247 million cases and 619,000 deaths in 2021. Diagnosis of
    MeSH term(s) Humans ; Plasmodium ; Malaria ; Malaria, Falciparum ; Algorithms ; Plasmodium falciparum ; Piperazines
    Chemical Substances RHC 3281 (33353-30-9) ; Piperazines
    Language English
    Publishing date 2024-01-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.01440-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The Novodiag

    Hartuis, Sophie / Lavergne, Rose-Anne / Nourrisson, Céline / Verweij, Jaco / Desoubeaux, Guillaume / Lussac-Sorton, Florian / Lemoine, Jean-Philippe / Cateau, Estelle / Jeddi, Fakhri / Poirier, Philippe / Le Pape, Patrice / Morio, Florent

    Parasite (Paris, France)

    2022  Volume 29, Page(s) 27

    Abstract: Objectives: We provide the first evaluation of the CE-IVD marked Novodiag: Methods: A total of 254 samples (n = 205 patients) were prospectively processed by the NVD and our routine procedure (RP). Performances of the NVD were compared with RP. ... ...

    Title translation Le test Novodiag
    Abstract Objectives: We provide the first evaluation of the CE-IVD marked Novodiag
    Methods: A total of 254 samples (n = 205 patients) were prospectively processed by the NVD and our routine procedure (RP). Performances of the NVD were compared with RP. Samples only positive by the NVD assay were investigated by external PCR assays. Sensitivity and specificity (Se/Sp) and time from sample receipt to results were determined for each method. The NVD was also evaluated against 77 additional samples positive for a wide range of parasites.
    Results: Overall positivity rate was 16.9% for RP compared with 34% using the NVD assay, and 164 samples (66%) were negative by both methods. Only 30 positive samples (12%) showed full concordance between RP and NVD. Fifty-three discordant samples were sent for external investigations. Except for Giardia intestinalis and Trichuris spp., higher Se was observed for the NVD assay for Blastocystis spp. (100% vs. 63%), Dientamoeba fragilis (100% vs. 0%), Schistosoma spp. (100% vs. 17%), and Enterobius vermicularis (100% vs. 67%) but roughly similar to RP for the remaining parasites tested. False-positive results were identified for Blastocystis spp., G. intestinalis, and Trichuris spp. using the NVD assay. The NVD mostly provides a diagnosis on the day of sample receipt compared with a mean of three days with RP.
    Conclusions: Besides some limitations, the NVD is a new diagnostic strategy allowing rapid and high-plex detection of gastrointestinal parasites from unpreserved stools.
    MeSH term(s) Animals ; Blastocystis ; Feces/parasitology ; Helminths ; Humans ; Microsporidia/genetics ; Parasites ; Prospective Studies ; Retrospective Studies
    Language English
    Publishing date 2022-05-13
    Publishing country France
    Document type Journal Article
    ZDB-ID 1187629-3
    ISSN 1776-1042 ; 1252-607X
    ISSN (online) 1776-1042
    ISSN 1252-607X
    DOI 10.1051/parasite/2022026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3965: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Medicopsis romeroi nodular subcutaneous infection in a kidney transplant recipient.

    Jeddi, Fakhri / Paugam, Charlotte / Hartuis, Sophie / Denis-Musquer, Marie / Sabou, Marcela / Lavergne, Rose-Anne / Muguet, Louise / Le Pape, Patrice

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2020  Volume 95, Page(s) 262–264

    Abstract: Phaeohyphomycosis is a set of fungal infections caused by various dematiaceous fungi such as coelomycetes. These infections can occur either in immunocompetent or immunocompromised patients like solid organ transplants. Here we describe a nodular lesion ... ...

    Abstract Phaeohyphomycosis is a set of fungal infections caused by various dematiaceous fungi such as coelomycetes. These infections can occur either in immunocompetent or immunocompromised patients like solid organ transplants. Here we describe a nodular lesion of the right hallux that occurred in a kidney transplant patient. Microscopic examination of the biopsy revealed fungal hyphae and culture was positive to a grey to black mould that lacked characteristic elements to be identified. Nucleic acid sequencing targeting the internal transcribed spacer of the ribosomal DNA identified this mould as Medicopsis romeroi. The patient benefited of an antifungal therapy with voriconazole associated with surgical excision of the lesion. No relapse of the lesion was observed during a six-month follow-up. In solid organ transplants, phaeohyphomycosis caused by Medicopsis romeroi are very rare with only 12 cases reported. The clinical history should be well assessed since the lesion can appear several years after a cutaneous trauma that happened in a tropical region. Therapy generally combines antifungals with surgical excision of the lesion in order to avoid any relapse or dissemination of the infection.
    MeSH term(s) Adult ; Antifungal Agents/therapeutic use ; Ascomycota/classification ; Ascomycota/genetics ; Ascomycota/isolation & purification ; DNA, Fungal ; DNA, Ribosomal ; Humans ; Kidney Transplantation ; Male ; Microscopy ; Phaeohyphomycosis/diagnosis ; Phaeohyphomycosis/microbiology ; Phaeohyphomycosis/pathology ; Voriconazole/therapeutic use
    Chemical Substances Antifungal Agents ; DNA, Fungal ; DNA, Ribosomal ; Voriconazole (JFU09I87TR)
    Language English
    Publishing date 2020-04-24
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2020.04.028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4516: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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