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Article ; Online: FERARI and cargo adaptors coordinate cargo flow through sorting endosomes

Jachen A. Solinger / Harun-Or Rashid / Anne Spang

Nature Communications, Vol 13, Iss 1, Pp 1-

2022 Volume 17

Abstract: It is estimated that about 80% of endocytosed material is recycled back to the plasma membrane. Here, the authors show that kiss-and-run of Rab5 early endocytic and Rab11 recycling vesicles on sorting endosomes allow cargo flow, providing more robustness ...

Abstract	It is estimated that about 80% of endocytosed material is recycled back to the plasma membrane. Here, the authors show that kiss-and-run of Rab5 early endocytic and Rab11 recycling vesicles on sorting endosomes allow cargo flow, providing more robustness and fidelity to the sorting process.
Keywords	Science ; Q
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
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Article ; Online: Serum oxidative biomarkers associated with genital HPV infection and cervical lesions in women.

Lin, Hui-Yi / Zhu, Xiaodan / Mazumder, Harun Or Rashid / Ronis, Martin / Pedersen, Kim Brint / Hagensee, Michael

Journal of medical virology

2024 Volume 96, Issue 1, Page(s) e29362

Abstract: Human papillomavirus (HPV) infection is a major cause of cervical cancer. Studies showed HPV carcinogenesis may be induced by oxidative stress affecting the host immune system. The objective of this study is to evaluate levels of four circulating ... ...

Abstract	Human papillomavirus (HPV) infection is a major cause of cervical cancer. Studies showed HPV carcinogenesis may be induced by oxidative stress affecting the host immune system. The objective of this study is to evaluate levels of four circulating oxidative stress biomarkers associated with the HPV infection, persistence, and cervical lesion status in women. The three serum biomarkers measuring oxidative damage to biomolecules (8-oxodG, 8-oxo-7,8-dihydro-2'-deoxyguanosine [8-oxodG] for DNA, 4-hydroxy-2-nonenal [4-HNE] for lipid, and protein carbonyl [PC] for protein) and one antioxidant (glutathione, GSH) collected from 38 women were evaluated. The PC levels were significantly higher for women with oncogenic HPV infection (p = 0.047) and persistence (p = 0.053) based on the unadjusted linear model. In particular, women with ≥3 oncogenic HPV types had a higher PC level than those without HPV infection (p = 0.041). Women with low-grade squamous intraepithelial lesions showed an elevated PC (p = 0.058). These trends remained similar after adjusting for age. The GSH levels were lower for women infected with ≥3 oncogenic HPV types based on age-adjusted results (p = 0.061). This study supported that serum PC was associated with HPV infection, persistence, and cervical lesions, so it can potentially be used to monitor HPV carcinogenesis. Further large-scale studies will be needed to confirm these findings.
MeSH term(s)	Female ; Humans ; Papillomavirus Infections/complications ; 8-Hydroxy-2'-Deoxyguanosine ; Sexually Transmitted Diseases ; Biomarkers ; Carcinogenesis ; Glutathione ; Oxidative Stress ; Genitalia
Chemical Substances	8-Hydroxy-2'-Deoxyguanosine (88847-89-6) ; Biomarkers ; Glutathione (GAN16C9B8O)
Language	English
Publishing date	2024-01-05
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.29362
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Article ; Online: Reduced Flavin in Aqueous Solution Is Nonfluorescent.

McBride, Rylee A / Barnard, David T / Jacoby-Morris, Kimberly / Harun-Or-Rashid, Md / Stanley, Robert J

Biochemistry

2023 Volume 62, Issue 3, Page(s) 759–769

Abstract: Flavins are blue-light-absorbing chromophores with rich redox activity. Biologically, the most important are riboflavin (vitamin ... ...

Abstract	Flavins are blue-light-absorbing chromophores with rich redox activity. Biologically, the most important are riboflavin (vitamin B
MeSH term(s)	Flavins/metabolism ; Riboflavin ; Oxidation-Reduction ; Electron Transport ; Flavin-Adenine Dinucleotide/chemistry ; Flavin Mononucleotide/chemistry ; Organic Chemicals
Chemical Substances	4,6-dinitro-o-cresol (1604ZJR09T) ; Flavins ; Riboflavin (TLM2976OFR) ; Flavin-Adenine Dinucleotide (146-14-5) ; Flavin Mononucleotide (7N464URE7E) ; Organic Chemicals
Language	English
Publishing date	2023-01-23
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1108-3
ISSN	1520-4995 ; 0006-2960
ISSN (online)	1520-4995
ISSN	0006-2960
DOI	10.1021/acs.biochem.2c00538
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Article: In vitro morphophysiological screening of drought-tolerant potato genotypes

Harun-Or-Rashid, M / Miah, M.A. Bari / Islam, S.M. Shahinul

In vitro cellular & developmental biology. 2021 June, v. 57, no. 3

2021

Abstract: Sixteen potato genotypes were assessed for drought tolerance through morphophysiological characteristics using stress tolerance trait index (STTI), principal component analysis (PCA), and cluster analysis (CA). Two to three wk old nodal segments explants ...

Abstract	Sixteen potato genotypes were assessed for drought tolerance through morphophysiological characteristics using stress tolerance trait index (STTI), principal component analysis (PCA), and cluster analysis (CA). Two to three wk old nodal segments explants (1.0 to 2.0 cm long) derived from in vitro grown sprouts were cultured on MS medium that contained with different concentrations of sorbitol. After 6 wk of culture initiation, the length of shoots, roots, and internodes; thickness of shoot and roots; number of leaves and roots; fresh and dry weight of whole plant; and water content of plants were recorded. For PCA, the cultivars Arun, Granola, Surjomukhi, Sheelbilati, Jamalu, Chollisha, Patnai, and Dohazari showed relatively higher values regarding drought tolerance and Diamant, Asterix, Courage, Cardinal, Lalpakri, Sindurkouta, Ausha, and Sadaguti were drought-sensitive cultivars. For cluster analysis, the cultivars Arun, Granola, and Surjomukhi showed high tolerances to drought and Diamant was sensitive. Analysis of variance (ANOVA), Duncan’s multiple range test (DMRT), and correlation coefficient for different morphological and physiological traits showed significantly higher values at p < 0.01 level among the tested genotypes. The protocols standardized under this study may be helpful for plant breeders and biotechnologist to develop mass production of potato seeds/tubers in drought-prone areas.
Keywords	analysis of variance ; cluster analysis ; cultivars ; drought ; drought tolerance ; potatoes ; principal component analysis ; sorbitol ; stress tolerance ; water content
Language	English
Dates of publication	2021-06
Size	p. 519-528.
Publishing place	Springer US
Document type	Article
Note	NAL-AP-2-clean
ISSN	1054-5476
DOI	10.1007/s11627-020-10155-z
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Socio-economic inequalities in and factors associated with minimum dietary diversity among children aged 6–23 months in South Asia

Md Akhtarul Islam / Md Ashfikur Rahman / Satyajit Kundu / Harun Or Rashid / Mortuja Mahamud Tohan

BMJ Open, Vol 13, Iss

a decomposition analysis

2023 Volume 12

Abstract: Objective This study aimed to determine the factors associated with minimum dietary diversity (MDD) and estimate the socioeconomic inequalities in MDD among children from five South Asian countries.Design Cross-sectional.Setting The study used the most ... ...

Abstract	Objective This study aimed to determine the factors associated with minimum dietary diversity (MDD) and estimate the socioeconomic inequalities in MDD among children from five South Asian countries.Design Cross-sectional.Setting The study used the most recent round of secondary databases of Demographic Health Survey data of Bangladesh (2017–2018), India (2019–2021), Maldives (2016–2017), Nepal (2018) and Pakistan (2017–2018).Participants This study used information on MDD and other explanatory variables from a total of 136 980 (weighted) children aged 6–23 months.Methods Multivariable logistic regression was employed to identify the factors associated with MDD and concentration index (CIX) and Lorenz curve were used to measure the socioeconomic inequalities in MDD.Results The overall weighted prevalence of MDD in South Asia was 23.37%. The highest prevalence of MDD was found among children from Maldives (70.7%), while the lowest was in Pakistan (14.2%). Living in affluent versus poor households, having a mother who is employed versus a mother who is unemployed, exposure to various forms of media (newspapers and magazines), seeking antenatal care (ANC) more than four times compared with those who sought ANC less than four times and having children older than 4 years old are the most common significant factors associated with MDD deficiency. This study found the value of the CIX for MDD (MDD: CI=0.0352; p<0.001) among children with a higher socioeconomic status, suggesting inequality in MDD in favour of the more among well-off households.Conclusion Inequality in the prevalence of MDD favours the affluent. Health policy and intervention design should prioritise minimising socioeconomic inequalities concerning the MDD. In addition, policy-makers should prioritise the associated factors of MDD such as education, wealth status, employment, media exposure while designing intervention or policies.
Keywords	Medicine ; R
Subject code	950
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	BMJ Publishing Group
Document type	Article ; Online
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Article ; Online: Association of low serum 25-Hydroxy vitamin D [25(OH) d] with hepatic encephalopathy in patients with decompensated liver cirrhosis.

Mumit Sarkar, Abdul / Al Mukit, Abdullah / Bari, Tanzilul / Islam, Rofiqul / Islam, Shafiqul / Sarker, Khalequzzaman / Chowdhury, Manzurul / Harun Or Rashid, Mohd / Alim, Abdul

Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology

2024

Abstract: Background and study aims: The mechanism of hepatic encephalopathy is complex and has not been conclusively established. Recent studies support lower serum 25-Hydroxy Vitamin D [25(OH) D] levels in patients with hepatic encephalopathy. This study aimed ... ...

Abstract	Background and study aims: The mechanism of hepatic encephalopathy is complex and has not been conclusively established. Recent studies support lower serum 25-Hydroxy Vitamin D [25(OH) D] levels in patients with hepatic encephalopathy. This study aimed to evaluate the association between serum 25(OH) D and hepatic encephalopathy in patients with decompensated cirrhosis of liver. Patients and methods: A total of 70 cirrhosis patients (35 cases of hepatic encephalopathy and 35 patients without encephalopathy as control, mean age 53.07 ± 12.99 years, 67 % male) were recruited for this study. Assessment of the severity of cirrhosis was done by using a model for end-stage liver disease(MELD) and Child Turcotte Pugh (CTP) scores, and assessment of the severity of hepatic encephalopathy was done according to West Haven criteria. Serum 25 (OH) D level was measured by Chemiluminescent Microparticle Immuno Assay(CMIA). Results: The mean serum 25(OH) D level among hepatic encephalopathy patients was significantly lower in comparison to the control group without encephalopathy (18.76 ± 8.84 nmol/L vs 31.19 ± 13.9 nmol/L, P<0.0001). 91.4 % of hepatic encephalopathy patients had moderate to severe 25(OH)D deficiency as compared to 51.4 % in the control group. There was a significant correlation observed between the severity of the 25 (OH) D deficiency and the severity of liver disease (r = - 0.35, P = 0.002). No statistically significant difference in serum 25(OH) D levels was found among patients with different hepatic encephalopathy grades (P = 0.416). Conclusion: A significant association was found between a low serum 25(OH) D leveland hepatic encephalopathy. It requires further large-scale multicenter studies to establish it as a risk factor and predictor of hepatic encephalopathy.
Language	English
Publishing date	2024-03-08
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2502114-X
ISSN	2090-2387 ; 1687-1979
ISSN (online)	2090-2387
ISSN	1687-1979
DOI	10.1016/j.ajg.2024.01.014
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Article ; Online: Reduced AMPK activation and increased HCAR activation drive anti-inflammatory response and neuroprotection in glaucoma.

Harun-Or-Rashid, Mohammad / Inman, Denise M

Journal of neuroinflammation

2018 Volume 15, Issue 1, Page(s) 313

Abstract: Background: Glaucoma is a chronic degenerative disease for which inflammation is considered to play a pivotal role in the pathogenesis and progression. In this study, we examined the impact of a ketogenic diet on the inflammation evident in glaucoma as ... ...

Abstract	Background: Glaucoma is a chronic degenerative disease for which inflammation is considered to play a pivotal role in the pathogenesis and progression. In this study, we examined the impact of a ketogenic diet on the inflammation evident in glaucoma as a follow-up to a recent set of experiments in which we determined that a ketogenic diet protected retinal ganglion cell structure and function. Methods: Both sexes of DBA/2J (D2) mice were placed on a ketogenic diet (keto) or standard rodent chow (untreated) for 8 weeks beginning at 9 months of age. DBA/2J-Gpnmb Results: Microglia activation was observed in D2 retina and ON as documented by intense microglial-specific Iba1 immunolabeling of rounded-up and enlarged microglia. Ketogenic diet treatment reduced Iba1 expression and the activated microglial phenotype. We detected low energy-induced AMP-activated protein kinase (AMPK) phosphorylation in D2 retina and ON that triggered NF-κB p65 signaling through its nuclear translocation. NF-κB induced pro-inflammatory TNF-α, IL-6, and NOS2 expression in D2 retina and ON. However, treatment with the ketogenic diet reduced AMPK phosphorylation, NF-κB p65 nuclear translocation, and expression of pro-inflammatory molecules. The ketogenic diet also induced expression of anti-inflammatory agents Il-4 and Arginase-1 in D2 retina and ON. Increased expression of hydroxycarboxylic acid receptor 1 (HCAR1) after ketogenic diet treatment was observed. HCAR1 stimulation by lactate or ketones from the ketogenic diet reduced inflammasome formation, as shown by reduced mRNA and protein expression of NLRP3 and IL-1β. We also detected increased levels of Arrestin β-2 protein, an adapter protein required for HCAR1 signaling. Conclusion: Our data demonstrate that the AMPK activation apparent in the glaucomatous retina and ON triggers NF-κB signaling and consequently induces a pro-inflammatory response. The ketogenic diet resolves energy demand and ameliorates the inflammation by inhibition of AMPK activation and stimulation of HCAR1-ARRB2 signaling that inhibits NLRP3 inflammasome-mediated inflammation. Thus, these findings depict a neuroprotective mechanism of the ketogenic diet in controlling inflammation and suggest potential therapeutic targets for inflammatory neurodegenerative diseases, including glaucoma.
MeSH term(s)	AMP-Activated Protein Kinases/metabolism ; Animals ; Calcium-Binding Proteins/metabolism ; Diet, Ketogenic/methods ; Disease Models, Animal ; Eye Proteins/genetics ; Female ; Glaucoma/complications ; Glaucoma/pathology ; Inflammation/etiology ; Inflammation/prevention & control ; Male ; Membrane Glycoproteins/genetics ; Mice ; Mice, Inbred DBA ; Mice, Transgenic ; Microfilament Proteins/metabolism ; Microglia/drug effects ; Microglia/pathology ; Mutation/genetics ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Neuroprotection/drug effects ; Neuroprotection/physiology ; Optic Nerve/pathology ; Receptors, G-Protein-Coupled/metabolism ; Retinal Ganglion Cells/drug effects ; Retinal Ganglion Cells/pathology
Chemical Substances	Aif1 protein, mouse ; Calcium-Binding Proteins ; Eye Proteins ; Gpnmb protein, mouse ; HCAR1 protein, human ; Membrane Glycoproteins ; Microfilament Proteins ; NLR Family, Pyrin Domain-Containing 3 Protein ; Receptors, G-Protein-Coupled ; AMP-Activated Protein Kinases (EC 2.7.11.31)
Language	English
Publishing date	2018-11-13
Publishing country	England
Document type	Journal Article
ISSN	1742-2094
ISSN (online)	1742-2094
DOI	10.1186/s12974-018-1346-7
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Article ; Online: Alpha 2-Adrenergic Receptor Agonist Brimonidine Stimulates ERK1/2 and AKT Signaling via Transactivation of EGF Receptors in the Human MIO-M1 Müller Cell Line.

Harun-Or-Rashid, Mohammad / Hallböök, Finn

Current eye research

2018 Volume 44, Issue 1, Page(s) 34–45

Abstract: Purpose: Alpha 2-adrenergic receptor (α2-ADR) agonists are used clinically for a range of indications including reducing elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension. Animal experiments show that α2-ADR ... ...

Abstract	Purpose: Alpha 2-adrenergic receptor (α2-ADR) agonists are used clinically for a range of indications including reducing elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension. Animal experiments show that α2-ADR agonists attenuate the injury-induced Müller cell dedifferentiation by a mechanism that involves activation and regulation of extracellular signal-regulated kinase (ERK) 1/2 leading to transactivation of epidermal growth factor receptors (EGFRs). The purpose of this study was to study and corroborate the activation of this system in human cells. Material and methods: The human Müller cell line MIO-M1 was treated with the α2A-ADR agonist brimonidine in combination with inhibitors for Src-kinase, EGFR-kinase, matrix metalloproteinase (MMP) as well as small interfering RNAs (siRNAs) for the EGFR. The cells were analyzed using immunocytochemistry, quantitative PCR and western blot techniques. Results: Our results show that human MIO-M1 cells express α2A-ADRs and that stimulation of these receptors caused a robust increase of ERK1/2 and protein kinase B (PKB/AKT) (Thr-308) phosphorylation in MIO-M1 cells. P-ERK1/2 and P-AKT (Thr-308) signaling was mediated by Src-kinase and associated with phosphorylation of tyrosine residue of epidermal growth factor receptor (P-EGFR Y1173). In addition, the agonist caused activation of MMPs. These effects could be blocked by Src-kinase inhibitors (PP1, PP2), EGFR-kinase inhibitor (AG1478), EGFR-siRNA and a MMP inhibitor (GM6001). Conclusion: The results confirm that this human Müller cell line responds to ADR stimulation with phosphorylation of ERK and AKT, which suggests that it is possible to pharmacologically target ADR to modulate the early events in human Müller cell dedifferentiation in a similar fashion as been shown for chicken Müller cells. Abbreviations: CRALBP: cellular retinaldehyde binding protein; EGFR: epidermal growth factor receptor; ERK1/2: extracellular signal-regulated kinase 1/2; GS: glutamine synthetase; GPCR: G protein-coupled receptor; IR: immunoreactivity; MAPK: mitogen-activated protein kinase; MMP: matrix metalloproteinase; P-ERK1/2: phospho-ERK1/2; qRT-PCR: quantitative reverse transcriptase PCR.
MeSH term(s)	Adrenergic alpha-2 Receptor Agonists/pharmacology ; Brimonidine Tartrate/pharmacology ; Cell Line ; ErbB Receptors/metabolism ; Humans ; MAP Kinase Signaling System/drug effects ; Mitogen-Activated Protein Kinase 1/metabolism ; Mitogen-Activated Protein Kinase 3/metabolism ; Phosphorylation ; Proto-Oncogene Proteins c-akt/metabolism ; Receptors, Adrenergic, alpha-2/metabolism
Chemical Substances	Adrenergic alpha-2 Receptor Agonists ; Receptors, Adrenergic, alpha-2 ; Brimonidine Tartrate (4S9CL2DY2H) ; EGFR protein, human (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1) ; AKT1 protein, human (EC 2.7.11.1) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; MAPK1 protein, human (EC 2.7.11.24) ; MAPK3 protein, human (EC 2.7.11.24) ; Mitogen-Activated Protein Kinase 1 (EC 2.7.11.24) ; Mitogen-Activated Protein Kinase 3 (EC 2.7.11.24)
Language	English
Publishing date	2018-09-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	82079-9
ISSN	1460-2202 ; 0271-3683
ISSN (online)	1460-2202
ISSN	0271-3683
DOI	10.1080/02713683.2018.1516783
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Article ; Online: Proposal of Resilient Housing Features for the Disaster Affected Community of Bangladesh

G. M. Harun-Or-Rashid / Juan Jose Castro / Mithun Chakrabartty / Md. Kamruzzaman

Sustainability, Vol 14, Iss 14061, p

2022 Volume 14061

Abstract: Thinking resiliency in terms of housing features for post disaster housing reconstruction (PDHR) is a paramount initiative after a disaster. Therefore, the aim of this research is to ascertain the demands of the disaster victims and propose a wind- ... ...

Abstract	Thinking resiliency in terms of housing features for post disaster housing reconstruction (PDHR) is a paramount initiative after a disaster. Therefore, the aim of this research is to ascertain the demands of the disaster victims and propose a wind-resistant, resilient housing prototype that would be affordable. Based on a three-month survey of the region severely damaged by Cyclone SIDR in Bangladesh, this research argues that PDHR’s planning features are significantly short of the victims’ choice, need, and demand, forcing them to quickly modify or transform the reconstructed houses. Based on the survey, a prototype covering an area of 37.21 sq. m (400 sq. ft) with a hybrid construction technique and a cost model are proposed that will be a resilient solution against cyclones and other natural hazards. Additionally, the proposed house was modeled using finite elements, and its findings are within the International Building Code’s allowable limits. In conclusion, this paper proposes some guidelines to strengthen Bangladesh National Building Code (BNBC) that would enable to build a resilient housing society in the disaster-prone areas.
Keywords	cyclone SIDR ; resilient housing ; prototype ; wind-resistant ; finite element analysis ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	690
Language	English
Publishing date	2022-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article: Metabolic Vulnerability in the Neurodegenerative Disease Glaucoma.

Inman, Denise M / Harun-Or-Rashid, Mohammad

Frontiers in neuroscience

2017 Volume 11, Page(s) 146

Abstract: Axons can be several orders of magnitude longer than neural somas, presenting logistical difficulties in cargo trafficking and structural maintenance. Keeping the axon compartment well supplied with energy also presents a considerable challenge; even ... ...

Abstract	Axons can be several orders of magnitude longer than neural somas, presenting logistical difficulties in cargo trafficking and structural maintenance. Keeping the axon compartment well supplied with energy also presents a considerable challenge; even seemingly subtle modifications of metabolism can result in functional deficits and degeneration. Axons require a great deal of energy, up to 70% of all energy used by a neuron, just to maintain the resting membrane potential. Axonal energy, in the form of ATP, is generated primarily through oxidative phosphorylation in the mitochondria. In addition, glial cells contribute metabolic intermediates to axons at moments of high activity or according to need. Recent evidence suggests energy disruption is an early contributor to pathology in a wide variety of neurodegenerative disorders characterized by axonopathy. However, the degree to which the energy disruption is intrinsic to the axon vs. associated glia is not clear. This paper will review the role of energy availability and utilization in axon degeneration in glaucoma, a chronic axonopathy of the retinal projection.
Language	English
Publishing date	2017-03-30
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2411902-7
ISSN	1662-453X ; 1662-4548
ISSN (online)	1662-453X
ISSN	1662-4548
DOI	10.3389/fnins.2017.00146
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