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  1. Article ; Online: Autophagy May Allow a Cell to Forbear Pyroptosis When Confronted With Cytosol-Invasive Bacteria.

    Harvest, Carissa K / Miao, Edward A

    Frontiers in immunology

    2022  Volume 13, Page(s) 871190

    Abstract: Inflammatory caspases detect cytosol-invasive Gram-negative bacteria by monitoring for the presence of LPS in the cytosol. This should provide defense against the cytosol- ... ...

    Abstract Inflammatory caspases detect cytosol-invasive Gram-negative bacteria by monitoring for the presence of LPS in the cytosol. This should provide defense against the cytosol-invasive
    MeSH term(s) Autophagy ; Caspase 1/metabolism ; Caspases/metabolism ; Cytosol/metabolism ; Pyroptosis
    Chemical Substances Caspases (EC 3.4.22.-) ; Caspase 1 (EC 3.4.22.36)
    Language English
    Publishing date 2022-03-29
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.871190
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Validation of the Intermolecular Disulfide Bond in Caspase-2.

    Amason, Megan E / Li, Lupeng / Harvest, Carissa K / Lacey, Carolyn A / Miao, Edward A

    Biology

    2024  Volume 13, Issue 1

    Abstract: Caspases are a family of proteins involved in cell death. Although several caspase members have been well characterized, caspase-2 remains enigmatic. Caspase-2 has been implicated in several phenotypes, but there has been no consensus in the field about ... ...

    Abstract Caspases are a family of proteins involved in cell death. Although several caspase members have been well characterized, caspase-2 remains enigmatic. Caspase-2 has been implicated in several phenotypes, but there has been no consensus in the field about its upstream activating signals or its downstream protein targets. In addition, the unique ability of caspase-2 to form a disulfide-bonded dimer has not been studied in depth. Herein, we investigate the disulfide bond in the context of inducible dimerization, showing that disulfide bond formation is dimerization dependent. We also explore and review several stimuli published in the caspase-2 field, test ferroptosis-inducing stimuli, and study in vivo infection models. We hypothesize that the disulfide bond will ultimately prove to be essential for the evolved function of caspase-2. Proving this will require the discovery of cell death phenotypes where caspase-2 is definitively essential.
    Language English
    Publishing date 2024-01-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology13010049
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Chemokine expression profile of an innate granuloma.

    Amason, Megan E / Harvest, Carissa K / Beatty, Cole J / Saban, Daniel R / Miao, Edward A

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Granulomas are defined by the presence of organized layers of immune cells that include macrophages. Granulomas are often characterized as a way for the immune system to contain an infection and prevent its dissemination. We recently established a mouse ... ...

    Abstract Granulomas are defined by the presence of organized layers of immune cells that include macrophages. Granulomas are often characterized as a way for the immune system to contain an infection and prevent its dissemination. We recently established a mouse infection model where
    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.01.30.577927
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Overexpression of T3SS translocation signals in

    Abele, Taylor J / Billman, Zachary P / Harvest, Carissa K / Bryan, Alexia K / Larson, Heather N / Coers, Jörn / Miao, Edward A

    Infection and immunity

    2023  Volume 92, Issue 1, Page(s) e0032923

    Abstract: Engineering pathogens is a useful method for discovering new details of microbial pathogenesis and host defense. However, engineering can result in off-target effects. We previously ... ...

    Abstract Engineering pathogens is a useful method for discovering new details of microbial pathogenesis and host defense. However, engineering can result in off-target effects. We previously engineered
    MeSH term(s) Animals ; Mice ; Salmonella typhimurium ; Virulence ; Type III Secretion Systems/genetics ; Virulence Factors/metabolism ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism
    Chemical Substances Type III Secretion Systems ; Virulence Factors ; Bacterial Proteins
    Language English
    Publishing date 2023-12-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218698-6
    ISSN 1098-5522 ; 0019-9567
    ISSN (online) 1098-5522
    ISSN 0019-9567
    DOI 10.1128/iai.00329-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 684: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Cyclic Diguanylate Regulates Virulence Factor Genes via Multiple Riboswitches in

    McKee, Robert W / Harvest, Carissa K / Tamayo, Rita

    mSphere

    2018  Volume 3, Issue 5

    Abstract: The intracellular signaling molecule cyclic diguanylate (c-di-GMP) regulates many processes in bacteria, with a central role in controlling the switch between motile and nonmotile lifestyles. Recent work has shown that ... ...

    Abstract The intracellular signaling molecule cyclic diguanylate (c-di-GMP) regulates many processes in bacteria, with a central role in controlling the switch between motile and nonmotile lifestyles. Recent work has shown that in
    MeSH term(s) Bacterial Proteins/genetics ; Clostridium difficile/genetics ; Clostridium difficile/pathogenicity ; Cyclic GMP/analogs & derivatives ; Cyclic GMP/genetics ; Gene Expression Regulation, Bacterial/genetics ; Riboswitch/physiology ; Virulence/genetics ; Virulence Factors/biosynthesis ; Virulence Factors/genetics
    Chemical Substances Bacterial Proteins ; Riboswitch ; Virulence Factors ; bis(3',5')-cyclic diguanylic acid (61093-23-0) ; Cyclic GMP (H2D2X058MU)
    Language English
    Publishing date 2018-10-24
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 2379-5042
    ISSN (online) 2379-5042
    DOI 10.1128/mSphere.00423-18
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Apoptotic signaling clears engineered

    Abele, Taylor J / Billman, Zachary P / Li, Lupeng / Harvest, Carissa K / Bryan, Alexia K / Magalski, Gabrielle R / Lopez, Joseph P / Larson, Heather N / Yin, Xiao-Ming / Miao, Edward A

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Pyroptosis and apoptosis are two forms of regulated cell death that can defend against intracellular infection. Although pyroptosis and apoptosis have distinct signaling pathways, when a cell fails to complete pyroptosis, backup pathways will initiate ... ...

    Abstract Pyroptosis and apoptosis are two forms of regulated cell death that can defend against intracellular infection. Although pyroptosis and apoptosis have distinct signaling pathways, when a cell fails to complete pyroptosis, backup pathways will initiate apoptosis. Here, we investigated the utility of apoptosis compared to pyroptosis in defense against an intracellular bacterial infection. We previously engineered
    Language English
    Publishing date 2023-08-19
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.05.06.539681
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Apoptotic signaling clears engineered

    Abele, Taylor J / Billman, Zachary P / Li, Lupeng / Harvest, Carissa K / Bryan, Alexia K / Magalski, Gabrielle R / Lopez, Joseph P / Larson, Heather N / Yin, Xiao-Ming / Miao, Edward A

    eLife

    2023  Volume 12

    Abstract: Pyroptosis and apoptosis are two forms of regulated cell death that can defend against intracellular infection. When a cell fails to complete pyroptosis, backup pathways will initiate apoptosis. Here, we investigated the utility of apoptosis compared to ... ...

    Abstract Pyroptosis and apoptosis are two forms of regulated cell death that can defend against intracellular infection. When a cell fails to complete pyroptosis, backup pathways will initiate apoptosis. Here, we investigated the utility of apoptosis compared to pyroptosis in defense against an intracellular bacterial infection. We previously engineered
    MeSH term(s) Animals ; Mice ; Flagellin ; Apoptosis ; Cell Death ; Caspase 1/metabolism ; Salmonella typhimurium/genetics ; Salmonella typhimurium/metabolism ; Pyroptosis ; Inflammasomes/metabolism
    Chemical Substances Flagellin (12777-81-0) ; Caspase 1 (EC 3.4.22.36) ; Inflammasomes
    Language English
    Publishing date 2023-12-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.89210
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: An innate granuloma eradicates an environmental pathogen using Gsdmd and Nos2.

    Harvest, Carissa K / Abele, Taylor J / Yu, Chen / Beatty, Cole J / Amason, Megan E / Billman, Zachary P / DePrizio, Morgan A / Souza, Fernando W / Lacey, Carolyn A / Maltez, Vivien I / Larson, Heather N / McGlaughon, Benjamin D / Saban, Daniel R / Montgomery, Stephanie A / Miao, Edward A

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 6686

    Abstract: Granulomas often form around pathogens that cause chronic infections. Here, we discover an innate granuloma model in mice with an environmental bacterium called Chromobacterium violaceum. Granuloma formation not only successfully walls off, but also ... ...

    Abstract Granulomas often form around pathogens that cause chronic infections. Here, we discover an innate granuloma model in mice with an environmental bacterium called Chromobacterium violaceum. Granuloma formation not only successfully walls off, but also clears, the infection. The infected lesion can arise from a single bacterium that replicates despite the presence of a neutrophil swarm. Bacterial replication ceases when macrophages organize around the infection and form a granuloma. This granuloma response is accomplished independently of adaptive immunity that is typically required to organize granulomas. The C. violaceum-induced granuloma requires at least two separate defense pathways, gasdermin D and iNOS, to maintain the integrity of the granuloma architecture. This innate granuloma successfully eradicates C. violaceum infection. Therefore, this C. violaceum-induced granuloma model demonstrates that innate immune cells successfully organize a granuloma and thereby resolve infection by an environmental pathogen.
    MeSH term(s) Animals ; Mice ; Granuloma ; Macrophages/metabolism ; Neutrophils ; Nitric Oxide Synthase Type II/metabolism
    Chemical Substances Nitric Oxide Synthase Type II (EC 1.14.13.39) ; Nos2 protein, mouse (EC 1.14.13.39) ; Gsdmd protein, mouse
    Language English
    Publishing date 2023-10-21
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-42218-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: An innate granuloma eradicates an environmental pathogen using

    Harvest, Carissa K / Abele, Taylor J / Yu, Chen / Beatty, Cole J / Amason, Megan E / Billman, Zachary P / DePrizio, Morgan A / Lacey, Carolyn A / Maltez, Vivien I / Larson, Heather N / McGlaughon, Benjamin D / Saban, Daniel R / Montgomery, Stephanie A / Miao, Edward A

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Granulomas often form around pathogens that cause chronic infections. Here, we discover a novel granuloma model in mice. ...

    Abstract Granulomas often form around pathogens that cause chronic infections. Here, we discover a novel granuloma model in mice.
    Language English
    Publishing date 2023-03-09
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.03.07.531568
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Caspase-7 activates ASM to repair gasdermin and perforin pores.

    Nozaki, Kengo / Maltez, Vivien I / Rayamajhi, Manira / Tubbs, Alan L / Mitchell, Joseph E / Lacey, Carolyn A / Harvest, Carissa K / Li, Lupeng / Nash, William T / Larson, Heather N / McGlaughon, Benjamin D / Moorman, Nathaniel J / Brown, Michael G / Whitmire, Jason K / Miao, Edward A

    Nature

    2022  Volume 606, Issue 7916, Page(s) 960–967

    Abstract: Among the caspases that cause regulated cell death, a unique function for caspase-7 has remained elusive. Caspase-3 performs apoptosis, whereas caspase-7 is typically considered an inefficient back-up. Caspase-1 activates gasdermin D pores to lyse the ... ...

    Abstract Among the caspases that cause regulated cell death, a unique function for caspase-7 has remained elusive. Caspase-3 performs apoptosis, whereas caspase-7 is typically considered an inefficient back-up. Caspase-1 activates gasdermin D pores to lyse the cell; however, caspase-1 also activates caspase-7 for unknown reasons
    MeSH term(s) Animals ; Apoptosis ; Caspase 7/metabolism ; Chromobacterium/immunology ; Epithelial Cells/cytology ; Intestines/cytology ; Killer Cells, Natural/immunology ; Listeria monocytogenes/immunology ; Mice ; Organoids ; Perforin/metabolism ; Phosphate-Binding Proteins/metabolism ; Pore Forming Cytotoxic Proteins/metabolism ; Sphingomyelin Phosphodiesterase/metabolism ; T-Lymphocytes, Cytotoxic/immunology
    Chemical Substances Gsdmd protein, mouse ; Phosphate-Binding Proteins ; Pore Forming Cytotoxic Proteins ; Perforin (126465-35-8) ; acid sphingomyelinase-1 (EC 3.1.4.-) ; Sphingomyelin Phosphodiesterase (EC 3.1.4.12) ; Casp7 protein, mouse (EC 3.4.22.-) ; Caspase 7 (EC 3.4.22.-)
    Language English
    Publishing date 2022-06-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-022-04825-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 26: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 9: Show issues
    Zs.MO 244: Show issues

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