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Article ; Online: Transformational leadership and work engagement as mediators on nurses' job performance in healthcare clinics: work environment as a moderator.

Hasan, Amal Abdullah / Ahmad, Syed Zamberi / Osman, Abdullah

Leadership in health services (Bradford, England)

2023 Volume ahead-of-print, Issue ahead-of-print

Abstract: Purpose: This study aims to investigate the mediating effect of transformational leadership (TL) and work engagement (WE) on health-care clinic nurses' performance and the crucial role of these variables in the work environment (WEV).: Design/ ... ...

Abstract	Purpose: This study aims to investigate the mediating effect of transformational leadership (TL) and work engagement (WE) on health-care clinic nurses' performance and the crucial role of these variables in the work environment (WEV). Design/methodology/approach: Data were collected from 353 nurses working across various health-care clinics in the United Arab Emirates. This study used descriptive correlational statistics from the Statistical Package for the Social Sciences, the Pearson correlation coefficient, confirmatory factor analysis for model validity, Cronbach's alpha for reliability and path analysis to determine the results. Findings: The relationship between TL and job performance among nurses in health-care clinics was strongly influenced by WE. In addition, a moderate WEV increased the positive influence of TL on job accomplishment. Furthermore, there were no statistically significant differences between the participants' demographics characteristics and the main variables of the study. Practical implications: Health-care management can support and enhance nurses' job performance through TL, create a more structured WEV and support WE. Originality/value: This study involves a specific investigation into WE as a mediator, WEV as a moderator and the effect of TL on nurses' job performance.
MeSH term(s)	Humans ; Work Performance ; Working Conditions ; Leadership ; Work Engagement ; Reproducibility of Results ; Job Satisfaction ; Cross-Sectional Studies ; Surveys and Questionnaires ; Nurse's Role ; Ambulatory Care Facilities ; Nurses
Language	English
Publishing date	2023-04-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2279996-5
ISSN	1751-1887 ; 1751-1879 ; 1366-0756
ISSN (online)	1751-1887
ISSN	1751-1879 ; 1366-0756
DOI	10.1108/LHS-10-2022-0097
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Article: Soluble Suppression of Tumorigenicity 2 is Directly Correlated with Glycated Hemoglobin in Individuals with an Average glycemia in the Normal/Prediabetes Range.

Hasan, Amal / Aldhahi, Waleed

Diabetes, metabolic syndrome and obesity : targets and therapy

2020 Volume 13, Page(s) 2711–2718

Abstract: Purpose: Cardiovascular disease can be detected in individuals with prediabetes. The purpose of this study was to determine whether soluble suppression of tumorigenicity 2 (sST2), which is elevated in cardiovascular disease and/or type 2 diabetes, is ... ...

Abstract	Purpose: Cardiovascular disease can be detected in individuals with prediabetes. The purpose of this study was to determine whether soluble suppression of tumorigenicity 2 (sST2), which is elevated in cardiovascular disease and/or type 2 diabetes, is correlated with glycated haemoglobin in individuals with glycemia in the normal/prediabetes range. Patients and methods: The anthropometric, biochemical and metabolic parameters were measured in 30 adults, and the plasma levels of sST2 were quantified. Results: sST2 was directly correlated with glycated hemoglobin in individuals with glycemia in the normal/prediabetes range. Participants who were at the higher end of glycated hemoglobin (5.8-6.4%) had significantly higher sST2 compared to those at the lower end (≤5.5%). Moreover, sST2 was directly correlated with homeostatic model assessment of insulin resistance (HOMA-IR), alkaline phosphatase, and waist circumference. However, the correlation between sST2 and HOMA-IR or waist circumference was lost after adjusting for age, gender or body mass index. Conclusion: Circulating sST2 may be used to establish a cut-off value for cardiometabolic risk/disease in individuals with glycemia in the normal/prediabetes range.
Language	English
Publishing date	2020-08-03
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494854-8
ISSN	1178-7007
ISSN	1178-7007
DOI	10.2147/DMSO.S251135
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Article ; Online: Sodium-glucose co-transporter 2 inhibitors & glucagon-like peptide-1 receptor agonists, efficacy & safety in diabetic kidney transplant recipients.

Mahmoud, Tarek / Yagan, Jude / Hasan, Amal / Gheith, Osama A / Mostafa, Mohamed / Rida, Suzann / El-Serwi, Nabil / Shaker, Mohamad / Khalid, Mahmoud

Clinical transplantation

2023 Volume 37, Issue 12, Page(s) e15144

Abstract: Introduction: Cardiovascular and renal complications define the outcomes of diabetic kidney transplant recipients (KTRs). The new diabetes medications have changed the management of diabetes. However, transplant physicians are still reluctant to use ... ...

Abstract	Introduction: Cardiovascular and renal complications define the outcomes of diabetic kidney transplant recipients (KTRs). The new diabetes medications have changed the management of diabetes. However, transplant physicians are still reluctant to use sodium-glucose cotransporter 2 inhibitors (SGLT2i) and Glucagon-like peptide-1 receptor agonists (GLP-1RA) post kidney transplantation due to fear of drug related complications and lack of established guidelines. Patients and methods: We collected 1-year follow-up data from records of 98 diabetic KTRs on SGLT2I, 41 on GLP- 1RA and 70 on standard-of-care medicines. Patients were more than 3 months post-transplant with a minimum estimated glomerular filtration rate (eGFR) of 25 ml/min/1.73 m Results: HbA1c dropped significantly by .4% in both SGLT2i and GLP-1RA compared to .05% in the control group. A significant decrease in BMI by .32 in SGLT2i and .34 in GLP-1RA was observed compared to an increase by .015 in control group. A tendency for better eGFR in study groups was observed but was non-significant except for the SGLT2i group with an eGFR above 90 (p = .0135). The usual dip in eGFR was observed in the SGLT2i group at 1-3 months. Albuminuria was significantly reduced in both study groups. Adverse events were minimal with comparable safety in all groups. Conclusion: The use of SGLT2i and GLP-1RA appears to be effective and safe in diabetic KTRs with good outcomes. Randomized control trials are required to confirm these findings and establish guidelines.
MeSH term(s)	Humans ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use ; Sodium-Glucose Transporter 2 Inhibitors/pharmacology ; Hypoglycemic Agents/therapeutic use ; Glucagon-Like Peptide-1 Receptor Agonists ; Diabetes Mellitus, Type 2/drug therapy ; Glycated Hemoglobin ; Kidney Transplantation/adverse effects ; Albuminuria ; Symporters/therapeutic use ; Glucose ; Sodium/therapeutic use
Chemical Substances	Sodium-Glucose Transporter 2 Inhibitors ; Hypoglycemic Agents ; Glucagon-Like Peptide-1 Receptor Agonists ; Glycated Hemoglobin ; Symporters ; Glucose (IY9XDZ35W2) ; Sodium (9NEZ333N27)
Language	English
Publishing date	2023-09-27
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	639001-8
ISSN	1399-0012 ; 0902-0063
ISSN (online)	1399-0012
ISSN	0902-0063
DOI	10.1111/ctr.15144
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Article: Differential effects of fish-oil and cocoa-butter based high-fat/high-sucrose diets on endocrine pancreas morphology and function in mice.

Albeloushi, Shaima / Hasan, Amal / Arefanian, Hossein / Sindhu, Sardar / Al-Rashed, Fatema / Kochumon, Shihab / Abukhalaf, Nermeen / Jacob, Texy / Shenouda, Steve / Al Madhoun, Ashraf / Al-Mulla, Fahd / Ahmad, Rasheed

Frontiers in endocrinology

2024 Volume 15, Page(s) 1265799

Abstract: Introduction: A high-fat/high-sucrose diet leads to adverse metabolic changes that affect insulin sensitivity, function, and secretion. The source of fat in the diet might inhibit or increase this adverse effect. Fish oil and cocoa butter are a ... ...

Abstract	Introduction: A high-fat/high-sucrose diet leads to adverse metabolic changes that affect insulin sensitivity, function, and secretion. The source of fat in the diet might inhibit or increase this adverse effect. Fish oil and cocoa butter are a significant part of our diets. Yet comparisons of these commonly used fat sources with high sucrose on pancreas morphology and function are not made. This study investigated the comparative effects of a fish oil-based high-fat/high-sucrose diet (Fish-HFDS) versus a cocoa butter-based high-fat/high-sucrose diet (Cocoa-HFDS) on endocrine pancreas morphology and function in mice. Methods: C57BL/6 male mice (n=12) were randomly assigned to dietary intervention either Fish-HFDS (n=6) or Cocoa-HFDS (n=6) for 22 weeks. Intraperitoneal glucose and insulin tolerance tests (IP-GTT and IP-ITT) were performed after 20-21 weeks of dietary intervention. Plasma concentrations of c-peptide, insulin, glucagon, GLP-1, and leptin were measured by Milliplex kit. Pancreatic tissues were collected for immunohistochemistry to measure islet number and composition. Tissues were multi-labelled with antibodies against insulin and glucagon, also including expression on Pdx1-positive cells. Results and discussion: Fish-HFDS-fed mice showed significantly reduced food intake and body weight gain compared to Cocoa-HFDS-fed mice. Fish-HFDS group had lower fasting blood glucose concentration and area under the curve (AUC) for both GTT and ITT. Plasma c-peptide, insulin, glucagon, and GLP-1 concentrations were increased in the Fish-HFDS group. Interestingly, mice fed the Fish-HFDS diet displayed higher plasma leptin concentration. Histochemical analysis revealed a significant increase in endocrine pancreas β-cells and islet numbers in mice fed Fish-HFDS compared to the Cocoa-HFDS group. Taken together, these findings suggest that in a high-fat/high-sucrose dietary setting, the source of the fat, especially fish oil, can ameliorate the effect of sucrose on glucose homeostasis and endocrine pancreas morphology and function.
MeSH term(s)	Male ; Mice ; Animals ; Leptin ; Glucagon ; Sucrose/adverse effects ; Fish Oils/pharmacology ; C-Peptide ; Mice, Inbred C57BL ; Islets of Langerhans/metabolism ; Insulin ; Glucose ; Glucagon-Like Peptide 1/metabolism ; Dietary Fats
Chemical Substances	cocoa butter (512OYT1CRR) ; Leptin ; Glucagon (9007-92-5) ; Sucrose (57-50-1) ; Fish Oils ; C-Peptide ; Insulin ; Glucose (IY9XDZ35W2) ; Glucagon-Like Peptide 1 (89750-14-1) ; Dietary Fats
Language	English
Publishing date	2024-02-13
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2024.1265799
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Article ; Online: Kuwaitiella rubra gen. et sp. nov. (Bangiales, Rhodophyta), a new filamentous genus and species from the north‐western Indian Ocean

Hasan, Amal Hajiya / Van der Aa, Pierrot / Küpper, Frithjof C. / Al‐Bader, Dhia / Peters, Akira F.

Phycological Research. 2022 Oct., v. 70, no. 4 p.192-202

2022

Abstract: A new filamentous marine red alga, Kuwaitiella rubra gen. et sp. nov. (Bangiales, Rhodophyta), is described from Kuwait in the north‐western Arabian Gulf (also referred to as the Persian Gulf). It was found on a submerged fishing line. The intensively ... ...

Abstract	A new filamentous marine red alga, Kuwaitiella rubra gen. et sp. nov. (Bangiales, Rhodophyta), is described from Kuwait in the north‐western Arabian Gulf (also referred to as the Persian Gulf). It was found on a submerged fishing line. The intensively red upright thallus of up to 1 cm in length consists of cells containing a single stellate plastid. The thallus is initially uniseriate but becomes biseriate in its distal part upon transformation into globular reproductive cells, possibly archaeospores. The biseriate fertile part is the only morphological difference from other filamentous species of the Bangiales, in which this region is parenchymatous. In culture, bipolar asymmetric germination of the spores of Kuwaitiella led to a new generation of identical erect thalli, fixed to the substratum by colourless rhizoids. According to phylogenetic analyses of partial small subunit nuclear ribosomal DNA (18S) and of the plastid‐encoded ribulose‐1,5‐bisphosphate carboxylase/oxygenase large subunit (rbcL), the new species forms an additional lineage of the Bangiales, genetic similarity with other taxa being limited (maximum 91% in SSU and 90% in rbcL). It was no clear member of any known lineage of the Bangiales but was weakly associated with the filamentous species Minerva and Dione from New Zealand. In a SSU phylogeny, it formed a basal branch in the Bangiales and clustered with M. aenigmata and D. arcuata as sister clade to all other species of the order. In a rbcL phylogeny, it was part of a large polytomy of lineages, its closest relative being D. arcuata. Kuwaitiella forms the 8ᵗʰ lineage of filamentous Bangiales detected so far.
Keywords	Bangiales ; genetic similarity ; germination ; new species ; phylogeny ; research ; ribosomal DNA ; thallus ; Indian Ocean ; Kuwait ; New Zealand ; Persian Gulf
Language	English
Dates of publication	2022-10
Size	p. 192-202.
Publishing place	John Wiley & Sons Australia, Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	2020835-2
ISSN	1440-1835 ; 1322-0829
ISSN (online)	1440-1835
ISSN	1322-0829
DOI	10.1111/pre.12498
Database	NAL-Catalogue (AGRICOLA)

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Article: Cellular and Humoral Immune Responses in Covid-19 and Immunotherapeutic Approaches.

Hasan, Amal / Al-Ozairi, Ebaa / Al-Baqsumi, Zahraa / Ahmad, Rasheed / Al-Mulla, Fahd

ImmunoTargets and therapy

2021 Volume 10, Page(s) 63–85

Abstract: Coronavirus disease 2019 (Covid-19), caused by the novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), can range in severity from asymptomatic to severe/critical disease. SARS-CoV-2 uses angiotensin-converting enzyme 2 to ... ...

Abstract	Coronavirus disease 2019 (Covid-19), caused by the novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), can range in severity from asymptomatic to severe/critical disease. SARS-CoV-2 uses angiotensin-converting enzyme 2 to infect cells leading to a strong inflammatory response, which is most profound in patients who progress to severe Covid-19. Recent studies have begun to unravel some of the differences in the innate and adaptive immune response to SARS-CoV-2 in patients with different degrees of disease severity. These studies have attributed the severe form of Covid-19 to a dysfunctional innate immune response, such as a delayed and/or deficient type I interferon response, coupled with an exaggerated and/or a dysfunctional adaptive immunity. Differences in T-cell (including CD4
Language	English
Publishing date	2021-03-09
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	2706272-7
ISSN	2253-1556
ISSN	2253-1556
DOI	10.2147/ITT.S280706
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Article ; Online: Early insight into antibody-dependent enhancement after SARS-CoV-2 mRNA vaccination.

Hasan, Amal / Al-Mulla, Mohammad R / Abubaker, Jehad / Al-Mulla, Fahd

Human vaccines & immunotherapeutics

2021 Volume 17, Issue 11, Page(s) 4121–4125

Abstract: Current vaccines, which induce a B-cell-mediated antibody response against the spike protein of SARS-CoV-2, have markedly reduced infection rates. However, the emergence of new variants as a result of SARS-CoV-2 evolution requires the development of ... ...

Abstract	Current vaccines, which induce a B-cell-mediated antibody response against the spike protein of SARS-CoV-2, have markedly reduced infection rates. However, the emergence of new variants as a result of SARS-CoV-2 evolution requires the development of novel vaccines that are T-cell-based and that target mutant-specific spike proteins along with ORF1ab or nucleocapsid protein. This approach is more accommodative in inducing highly neutralizing antibodies, without the risk of antibody-dependent enhancement, as well as memory CD8
MeSH term(s)	Antibodies, Neutralizing ; Antibodies, Viral ; Antibody-Dependent Enhancement ; COVID-19 ; Humans ; RNA, Messenger ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus ; Vaccination
Chemical Substances	Antibodies, Neutralizing ; Antibodies, Viral ; RNA, Messenger ; Spike Glycoprotein, Coronavirus
Language	English
Publishing date	2021-09-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2664176-8
ISSN	2164-554X ; 2164-5515
ISSN (online)	2164-554X
ISSN	2164-5515
DOI	10.1080/21645515.2021.1969855
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Article: Fatal COVID-19 is Associated with Reduced HLA-DR, CD123 or CD11c Expression on Circulating Dendritic Cells.

Hasan, Amal / Al-Ozairi, Ebaa / Hassan, Nosiba Y M / Ali, Shamsha / Ahmad, Rasheed / Al-Shatti, Nada / Alshemmari, Salem / Al-Mulla, Fahd

Journal of inflammation research

2022 Volume 15, Page(s) 5665–5675

Abstract: Purpose: Severe coronavirus disease 2019 (COVID-19) is linked to insufficient control of viral replication and excessive inflammation driven by an unbalanced immune response. Plasmacytoid dendritic cells (pDCs) are specialized in the rapid production of ...

Abstract	Purpose: Severe coronavirus disease 2019 (COVID-19) is linked to insufficient control of viral replication and excessive inflammation driven by an unbalanced immune response. Plasmacytoid dendritic cells (pDCs) are specialized in the rapid production of interferons in response to viral infections, and can also prime and activate T-cells. Conventional DCs (cDCs) are critical for the elimination of viral infections owing to their specialized ability to prime and activate T cells. We assessed the frequency and phenotype of pDCs and cDCs in survivors and non-survivors of COVID-19. Patients and methods: Patients with COVID-19 were enrolled, and 22 were included in this study. Peripheral whole blood was obtained during the 2 Results: The ratio of pDCs to pre-cDCs was significantly lower ( Conclusion: A lower frequency of pDCs compared to other circulating DCs, and lower expression levels of HLA-DR, CD123 or CD11c on DCs is associated with fatal COVID-19.
Language	English
Publishing date	2022-10-10
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494878-0
ISSN	1178-7031
ISSN	1178-7031
DOI	10.2147/JIR.S360207
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Article: Correlation Profile of Suppression of Tumorigenicity 2 and/or Interleukin-33 with Biomarkers in the Adipose Tissue of Individuals with Different Metabolic States.

Hasan, Amal / Kochumon, Shihab / Al-Ozairi, Ebaa / Tuomilehto, Jaakko / Al-Mulla, Fahd / Ahmad, Rasheed

Diabetes, metabolic syndrome and obesity : targets and therapy

2020 Volume 13, Page(s) 3839–3859

Abstract: Purpose: The suppression of tumorigenicity 2 (ST2) has two main splice variants including a membrane bound (ST2) form, which activates the myeloid differentiation primary response 88 (MyD88)/nuclear factor-kappa B (NF-κB) signaling pathway, and a ... ...

Abstract	Purpose: The suppression of tumorigenicity 2 (ST2) has two main splice variants including a membrane bound (ST2) form, which activates the myeloid differentiation primary response 88 (MyD88)/nuclear factor-kappa B (NF-κB) signaling pathway, and a secreted soluble form (sST2), which acts as a decoy receptor for ST2 ligand, interleukin (IL)-33. The IL-33/ST2 axis is protective against obesity, insulin resistance, and type 2 diabetes (T2D). In humans, adipose tissue IL-33 displays distinct correlation profiles with glycated hemoglobin, ST2, and other immunometabolic mediators, depending on the glycemic health of the individuals. We determined whether adipose tissue ST2 displays distinct correlation profiles with immunometabolic mediators and whether ST2 and/or IL-33 are correlated with intracellular signaling molecules. Patients and methods: A total of 91 adults with normal glycemia, prediabetes, and T2D were included. After measuring their anthropometric and biochemical parameters, subcutaneous adipose tissues were isolated and mRNA expression of biomarkers was measured. Results: In individuals with normal glycemia, adipose tissue ST2 was directly correlated with chemokine (C-C motif) ligand (CCL)-2, CCL5, IL-12, fibrinogen-like protein 2 (FGL2) and interferon regulatory factor (IRF)-4, but inversely correlated with cytochrome C oxidase subunit 7A1. IL-33 and ST2 were directly correlated with tumor necrosis factor receptor-associated factor 6 (TRAF6), NF-κB, and nuclear factor of activated T-cells 5 (NFAT5). In individuals with prediabetes, ST2 was inversely correlated with IL-5, whereas IL-33 but not ST2 was directly correlated with MyD88 and NF-κB. In individuals with T2D, ST2 was directly correlated with CCL2, IL-1β, and IRF5. IL-33 and ST2 were directly correlated with MyD88, TRAF6, and NF-κB. Conclusion: Adipose tissue ST2 and IL-33 show different correlation profiles with various immunometabolic biomarkers depending on the metabolic state of the individuals. Therefore, targeting the IL-33/ST2 axis might form the basis for novel therapies to combat metabolic disorders.
Language	English
Publishing date	2020-10-20
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494854-8
ISSN	1178-7007
ISSN	1178-7007
DOI	10.2147/DMSO.S251978
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Article ; Online: Early autoantibody screening for type 1 diabetes: a Kuwaiti perspective on the advantages of multiplexing chemiluminescent assays.

Al-Mulla, Fahd / Alhomaidah, Doha / Abu-Farha, Mohamed / Hasan, Amal / Al-Khairi, Irina / Nizam, Rasheeba / Alqabandi, Rawan / Alkandari, Hessa / Abubaker, Jehad

Frontiers in immunology

2023 Volume 14, Page(s) 1273476

Abstract: Type 1 diabetes (T1D) incidence has increased globally over the last decades, alongside other autoimmune diseases. Early screening of individuals at risk of developing T1D is vital to facilitate appropriate interventions and improve patient outcomes. ... ...

Abstract	Type 1 diabetes (T1D) incidence has increased globally over the last decades, alongside other autoimmune diseases. Early screening of individuals at risk of developing T1D is vital to facilitate appropriate interventions and improve patient outcomes. This is particularly important to avoid life-threatening diabetic ketoacidosis and hospitalization associated with T1D diagnosis. Additionally, considering that new therapies have been developed for T1D, screening the population and individuals at high risk would be of great benefit. However, adopting such screening approaches may not be feasible due to limitations, such as cost, adaptation of such programs, and sample processing. In this perspective, we explore and highlight the use of multiplexing chemiluminescent assays for T1D screening and emphasize on their advantages in detecting multiple autoantibodies simultaneously, maximizing efficiency, and minimizing sample volume requirements. These assays could be extremely valuable for pediatric populations and large-scale screening initiatives, providing a cost-efficient solution with increased diagnostic accuracy and deeper insights into T1D pathogenesis. Eventually, the adoption of such screening methods can help transform T1D diagnosis, especially in countries with high T1D prevalence, such as Kuwait, which will contribute to the development of novel therapeutic interventions, positively impacting the lives of those affected by T1D and other autoimmune diseases.
MeSH term(s)	Child ; Humans ; Diabetes Mellitus, Type 1/diagnosis ; Diabetes Mellitus, Type 1/epidemiology ; Diabetes Mellitus, Type 1/complications ; Autoantibodies ; Kuwait ; Autoimmune Diseases/diagnosis ; Autoimmune Diseases/complications
Chemical Substances	Autoantibodies
Language	English
Publishing date	2023-11-29
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1273476
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