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  1. Article ; Online: Ulcerative Colitis and Diverticulitis Are Possibly Connected to the Same Hub.

    Hasan, Badar / Ur Rahman, Asad

    Inflammatory bowel diseases

    2022  Volume 28, Issue 8, Page(s) e125

    MeSH term(s) Colitis/complications ; Colitis, Ulcerative/complications ; Diverticulitis/complications ; Humans ; Inflammatory Bowel Diseases/complications
    Language English
    Publishing date 2022-04-22
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1340971-2
    ISSN 1536-4844 ; 1078-0998
    ISSN (online) 1536-4844
    ISSN 1078-0998
    DOI 10.1093/ibd/izac057
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Combined Histological and Endoscopic Endpoints at Post-induction Lack Additional Prognostic Value Compared with Endoscopic Improvement Alone in Ulcerative Colitis: A Post hoc Analysis of the VARSITY study.

    Wong, Emily C L / Dulai, Parambir S / Hasan, Badar / Marshall, John K / Reinisch, Walter / Narula, Neeraj

    Journal of Crohn's & colitis

    2023  Volume 17, Issue 7, Page(s) 1114–1121

    Abstract: Background and aims: Evaluating histological outcomes in ulcerative colitis [UC] has become common in recent clinical trials. In this study, we explored the additional value of the combined endpoint of histo-endoscopic mucosal improvement [HEMI] ... ...

    Abstract Background and aims: Evaluating histological outcomes in ulcerative colitis [UC] has become common in recent clinical trials. In this study, we explored the additional value of the combined endpoint of histo-endoscopic mucosal improvement [HEMI] compared with endoscopic improvement [EI] at post-induction [Week 14] and post-maintenance [1 year].
    Methods: This post hoc analysis included 620 UC participants with available data from the VARSITY trial. Participants achieving post-induction and post-maintenance HEMI [Mayo endoscopic subscore ≤1 and Geboes score <3.2] were compared across clinical outcomes, patient-reported outcomes [PROs], and inflammatory markers. Univariate analyses were performed to identify variables associated with the outcome of interest. Multivariate analyses included covariates with a p <0.05 on univariate analyses.
    Results: Among the 468 patients with 1-year data available, a total of 166 [35.5%] attained HEMI and 209 [44.7%] attained EI at post-induction. No difference in achievement of clinical remission [CR] at 1 year was observed among those who attained post-induction HEMI vs EI (121/166 [72.9%] vs 147/209 [70.3%], p = 0.903). Similar findings were observed for the outcome of 1-year treatment failure (45/166 [27.1%] vs 55/209 [26.3%], p = 0.781). Patients who achieved HEMI at post-induction had lower total and partial Mayo scores and had the largest improvement from baseline. Faecal calprotectin and C-reactive protein [CRP] were also significantly lower among HEMI achievers at post-induction [p <0.001]. Similar findings were observed at post-maintenance.
    Conclusions: In this post hoc analysis, at post-induction, HEMI did not demonstrate additional prognostic value in predicting 1-year outcomes over EI. However, HEMI was associated with lower clinical disease activity at post-induction and at 1 year compared with endoscopic or histological outcomes in isolation.
    MeSH term(s) Humans ; Colitis, Ulcerative/diagnosis ; Colitis, Ulcerative/drug therapy ; Colitis, Ulcerative/metabolism ; Prognosis ; Remission Induction ; Endoscopy ; C-Reactive Protein/metabolism
    Chemical Substances C-Reactive Protein (9007-41-4)
    Language English
    Publishing date 2023-02-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2390120-2
    ISSN 1876-4479 ; 1873-9946
    ISSN (online) 1876-4479
    ISSN 1873-9946
    DOI 10.1093/ecco-jcc/jjad033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Abdominal Pain in a Patient With Diverted Bowel and Inflammatory Bowel Disease.

    Hasan, Badar / Khalid, Rumman / Charles, Roger / Shen, Bo

    ACG case reports journal

    2020  Volume 7, Issue 8, Page(s) e00437

    Abstract: Patients with medically refractory inflammatory bowel disease may undergo total proctocolectomy with ileal pouch-anal anastomosis. However, fecal diversion is necessary in patients with pouch failure. We present a rare case of pyogenic liver abscess (PLA) ...

    Abstract Patients with medically refractory inflammatory bowel disease may undergo total proctocolectomy with ileal pouch-anal anastomosis. However, fecal diversion is necessary in patients with pouch failure. We present a rare case of pyogenic liver abscess (PLA) in a patient with ulcerative colitis with a history of ileal pouch-anal anastomosis complicated by chronic pouchitis requiring fecal diversion via loop ileostomy. The PLA was managed with computed tomography-guided aspiration drainage and antibiotics, followed by permanent ileostomy and pouch excision to prevent recurrence of PLA. This is the first case report of PLA in a patient with ulcerative colitis with a long-standing history of diversion pouchitis.
    Language English
    Publishing date 2020-08-10
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2814825-3
    ISSN 2326-3253
    ISSN 2326-3253
    DOI 10.14309/crj.0000000000000437
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: End of induction patient reported outcomes predict clinical remission and endoscopic improvement with vedolizumab and adalimumab in ulcerative colitis.

    Wong, Emily Chu Lee / Hasan, Badar / Dulai, Parambir S / Marshall, John K / Reinisch, Walter / Narula, Neeraj

    Scandinavian journal of gastroenterology

    2022  Volume 58, Issue 1, Page(s) 7–14

    Abstract: Background: Patient-reported outcomes (PROs) are increasingly emphasized as endpoints in clinical trials of ulcerative colitis (UC). However, the prognostic value of early improvement in PROs for long-term outcomes remains unclear.: Methods: This was ...

    Abstract Background: Patient-reported outcomes (PROs) are increasingly emphasized as endpoints in clinical trials of ulcerative colitis (UC). However, the prognostic value of early improvement in PROs for long-term outcomes remains unclear.
    Methods: This was a post-hoc analysis of 611 vedolizumab-treated or adalimumab-treated patients in the VARSITY trial (Clinicaltrial.gov: NCT02497469). Stool frequency (SF) and rectal bleeding score (RBS) as reported in the Mayo score at post-induction (week 6 and 14) was assessed for their association with one-year endoscopic improvement (EI), defined as Mayo endoscopic subscore <2; histo-endoscopic mucosal improvement (HEMI), defined as EI and Geboes highest grade <3.2, clinical remission (CR), defined as total Mayo score ≤2; and PRO-2 remission, defined as RBS of 0 and SF ≤1. Multivariable logistic regression models adjusted for confounders assessed the relationships between post-induction PROs and outcomes of interest at one-year.
    Results: Patients with severe SF at week 6 were significantly less likely to achieve one-year EI compared to those with non-severe SF [aOR 0.40 (95% CI: 0.24-0.68),
    Conclusions: Post-induction PROs strongly predict the odds of CR and EI in UC and simplified evaluations can be used to assess early response to UC therapies.
    MeSH term(s) Humans ; Adalimumab/therapeutic use ; Colitis, Ulcerative/drug therapy ; Patient Reported Outcome Measures ; Remission Induction
    Chemical Substances Adalimumab (FYS6T7F842) ; vedolizumab (9RV78Q2002)
    Language English
    Publishing date 2022-07-30
    Publishing country England
    Document type Clinical Trial ; Journal Article
    ZDB-ID 82042-8
    ISSN 1502-7708 ; 0036-5521
    ISSN (online) 1502-7708
    ISSN 0036-5521
    DOI 10.1080/00365521.2022.2105169
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Correction: Lidocaine-Induced Systemic Toxicity: A Case Report and Review of Literature.

    Hasan, Badar / Asif, Talal / Hasan, Maryam

    Cureus

    2019  Volume 11, Issue 8, Page(s) c24

    Abstract: This corrects the article DOI: 10.7759/cureus.1275.]. ...

    Abstract [This corrects the article DOI: 10.7759/cureus.1275.].
    Language English
    Publishing date 2019-08-23
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.c24
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  6. Article: Potential clinical complications of Orise™ gel use, a new submucosal lifting agent: experience from a tertiary care center and review of the literature.

    Colak, Yasar / Hasan, Badar / Tandon, Kanwarpreet / Khan, Sikandar / Wadhwa, Vaibhav / Bejarano, Pablo A / Erim, Tolga

    Annals of gastroenterology

    2022  Volume 35, Issue 4, Page(s) 407–413

    Abstract: Background: Endoscopic mucosal resection (EMR) involves forming a fluid cushion in the submucosal area with a lifting agent, followed by superficial resection. Orise™ gel is one of the commonly used lifting agents for EMR. We present a case series and ... ...

    Abstract Background: Endoscopic mucosal resection (EMR) involves forming a fluid cushion in the submucosal area with a lifting agent, followed by superficial resection. Orise™ gel is one of the commonly used lifting agents for EMR. We present a case series and literature review that analyzes the characteristic histopathological findings and clinical implications observed where Orise™ gel was used before EMR.
    Methods: Colon resection specimens and prior EMR specimens where Orise™ gel was used were reviewed for patients undergoing EMR between January 2018 and December 2020. The literature review included relevant studies from the Medline and Cochrane databases from January 2018 to December 2020.
    Results: A total of 12 colon polyp EMRs using Orise gel were performed during the study period. Seven patients (58.34%) underwent surgical resection. Histological examination revealed that, after the EMR procedure, the Orise™ gel material changed its morphological characteristics over time from a basophilic (bluish) non-inflamed pattern to an eosinophilic (pink) type pattern, eliciting a foreign body reaction. The endoscopic appearance and examination of the excised specimens weeks after injection gave the impression of a mass in some cases. The material was also present transmurally and in some cases in the peri-intestinal adipose tissue.
    Conclusions: It was observed that Orise™ gel use elicits a foreign body-type granulomatous reaction. This potential side effect may lead to overdiagnosis of a mass/lesion and unnecessary surgical interventions. This case series and review of the literature aims to increase awareness of the changes caused by Orise™ gel in the gastrointestinal tract.
    Language English
    Publishing date 2022-06-02
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 2032850-3
    ISSN 1108-7471
    ISSN 1108-7471
    DOI 10.20524/aog.2022.0726
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Risk factors for local recurrence of large gastrointestinal lesions after endoscopic mucosal resection.

    Colak, Yasar / Hasan, Badar / Hassaballa, Walid / Ur Rashid, Mamoon / Strassmann, Victor / DaSilva, Giovanna / Wexner, Steven D / Erim, Tolga

    Techniques in coloproctology

    2022  Volume 26, Issue 7, Page(s) 545–550

    Abstract: Background: Endoscopic mucosal resection (EMR) is the primary treatment modality for superficial gastrointestinal mucosal lesions > 2 cm. However, the procedure carries some risk of complications including bleeding, perforation, and local recurrence. ... ...

    Abstract Background: Endoscopic mucosal resection (EMR) is the primary treatment modality for superficial gastrointestinal mucosal lesions > 2 cm. However, the procedure carries some risk of complications including bleeding, perforation, and local recurrence. This study aimed to examine factors associated with EMR outcomes, especially in terms of local recurrence.
    Methods: This study retrospectively evaluated patients who underwent EMR and full closure with prophylactic clips for upper and lower gastrointestinal lesions > 2 cm at Cleveland Clinic Florida, between January 2013 and December 2018 with follow-up endoscopic evaluation for recurrence.
    Results: A total of 2031 endoscopic polypectomy cases were examined; 307 EMR procedures among 271 patients (52% were female, mean age 65.6 ± 11.1 years) who satisfied the inclusion criteria were included in the study. There were no perforations reported. The rate of post-polypectomy delayed bleeding was 1.6%, and the local recurrence rate in this cohort was 7.1%. Recurrent cases were successfully endoscopically managed. In the multivariate regression analysis, age > 70 years (OR = 3.20, 95% CI 1.17-8.76, p = .023), body mass index (OR = 1.12, 95% CI 1.03-1.23 p = .008), and lesion size ≥ 35 mm (OR = 11.51, 95% CI 3.54-37.40, p =  < .001) were independent predictors for recurrence.
    Conclusions: Age > 70 years, increased lesion size, and obesity were found to be independent predictors of local recurrence among EMR procedures for gastrointestinal lesions > 2 cm. However, there is a need for larger-scale studies on this topic.
    MeSH term(s) Aged ; Endoscopic Mucosal Resection/adverse effects ; Endoscopic Mucosal Resection/methods ; Endoscopy ; Female ; Humans ; Male ; Middle Aged ; Neoplasm Recurrence, Local/etiology ; Neoplasm Recurrence, Local/surgery ; Retrospective Studies ; Risk Factors ; Treatment Outcome
    Language English
    Publishing date 2022-05-02
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2083309-X
    ISSN 1128-045X ; 1123-6337
    ISSN (online) 1128-045X
    ISSN 1123-6337
    DOI 10.1007/s10151-022-02623-y
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  8. Article: Colovesical Fistula: An Unusual Complication of Cytomegalovirus Colitis.

    Asif, Talal / Hasan, Badar / Likhitsup, Alisa / Bamberger, David

    Cureus

    2017  Volume 9, Issue 7, Page(s) e1426

    Abstract: Cytomegalovirus (CMV) is a double-stranded DNA virus that is associated with clinically significant disease in patients with advanced immunosuppression, particularly those with human immunodeficiency virus (HIV) infection and acquired immunodeficiency ... ...

    Abstract Cytomegalovirus (CMV) is a double-stranded DNA virus that is associated with clinically significant disease in patients with advanced immunosuppression, particularly those with human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS). End-organ disease with CMV is classically associated with a CD4 cell count less than 50 cells/microliter. CMV colitis is the second most common manifestation of end-organ disease in this patient population. CMV-associated enteric fistula is a rare complication that has been described in only a few case reports in the literature. These cases describe gastrocolic, enterocutaneous, enterocolic, rectovaginal, and colocutaneous fistulae. However, colovesical fistula has not been described previously. Here, we report the first case of CMV-associated colovesical fistula in a patient with HIV infection and AIDS.
    Language English
    Publishing date 2017-07-05
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.1426
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  9. Article: Infective Endocarditis Presenting as Subarachnoid Hemorrhage: An Appeal for Caution.

    Asif, Talal / Mohiuddin, Amena / Hasan, Badar / Masoud, Amgad

    Cureus

    2017  Volume 9, Issue 4, Page(s) e1176

    Abstract: Spontaneous subarachnoid hemorrhage (SAH) as the presenting feature of infective endocarditis (IE) is rare. It has classically been described in association with the rupture of intracranial mycotic aneurysms (ICMA). Here we describe a very rare case of ... ...

    Abstract Spontaneous subarachnoid hemorrhage (SAH) as the presenting feature of infective endocarditis (IE) is rare. It has classically been described in association with the rupture of intracranial mycotic aneurysms (ICMA). Here we describe a very rare case of non-aneurysmal spontaneous SAH in a patient with IE. The patient originally presented with a headache and low-grade fever. Neuroimaging including computed tomography (CT) and magnetic resonance imaging (MRI) of the head revealed SAH. She was eventually diagnosed with streptococcus gallolyticus (formerly streptococcus bovis) IE. Through this case, we advocate consideration of the diagnosis of IE in patients with SAH so that there is timely recognition of this reversible but serious disease.
    Language English
    Publishing date 2017-04-19
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.1176
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Lidocaine-Induced Systemic Toxicity: A Case Report and Review of Literature.

    Hasan, Badar / Asif, Talal / Hasan, Maryam

    Cureus

    2017  Volume 9, Issue 5, Page(s) e1275

    Abstract: For the past 50 years, local anesthetics such as lidocaine have been commonly used in various clinical settings. Its use is not just limited to anesthesia and surgery but is also frequently utilized in internal medicine and in primary care setting for ... ...

    Abstract For the past 50 years, local anesthetics such as lidocaine have been commonly used in various clinical settings. Its use is not just limited to anesthesia and surgery but is also frequently utilized in internal medicine and in primary care setting for bedside procedures. Despite its widespread use, most physicians are not familiar with the life-threatening manifestations of lidocaine toxicity and its treatment. Our case demonstrates a successful resuscitation after cardiac arrest in a healthy 33-year-old female with systemic lidocaine toxicity after she received lidocaine as a local anesthetic. Our goal is to educate general internists and primary care physicians of the possible hazards of lidocaine use. We also aim to create mindfulness of the symptoms of lidocaine toxicity and the use of intravenous lipid emulsion as an antidote.
    Language English
    Publishing date 2017-05-25
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.1275
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