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  1. Article ; Online: The Multifaceted Role of Oxytocinergic System and

    Hasan, Rakibul

    Global medical genetics

    2024  Volume 11, Issue 1, Page(s) 29–33

    Abstract: The article explores the multifaceted role of the neuropeptide oxytocin in human behavior and its connection to the oxytocin receptor ( ...

    Abstract The article explores the multifaceted role of the neuropeptide oxytocin in human behavior and its connection to the oxytocin receptor (
    Language English
    Publishing date 2024-01-18
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 3009997-3
    ISSN 2699-9404 ; 2699-9404
    ISSN (online) 2699-9404
    ISSN 2699-9404
    DOI 10.1055/s-0044-1779039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Thesis: The role of zinc and zinc signals in the immunological functions of neutrophil granulocytes

    Hasan, Rafah

    2015  

    Author's details vorgelegt von Rafah Hasan
    Language English
    Size 118 S. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Aachen, Techn. Hochsch., Diss., 2015
    HBZ-ID HT018538921
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2015 D 949 order for loan Magazin

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  3. Article: The Multifaceted Role of Oxytocinergic System and OXTR Gene

    Hasan, Rakibul

    Global Medical Genetics

    2024  Volume 11, Issue 01, Page(s) 29–33

    Abstract: The article explores the multifaceted role of the neuropeptide oxytocin in human behavior and its connection to the oxytocin receptor ( OXTR ) gene. Oxytocin, produced in specific brain nuclei, is implicated in emotional, social, and maternal behaviors, ... ...

    Abstract The article explores the multifaceted role of the neuropeptide oxytocin in human behavior and its connection to the oxytocin receptor ( OXTR ) gene. Oxytocin, produced in specific brain nuclei, is implicated in emotional, social, and maternal behaviors, stress reduction, uterine contraction during childbirth, and lactation. The OXTR gene, located on chromosome 3, encodes oxytocin receptors found in various body parts, including critical brain regions associated with social behaviors. The article delves into studies on rodents, revealing correlations between OXTR gene expression and pair bonding in the prefrontal cortex and social behavior regulation in the amygdala. The discussion extends to the impact of oxytocin on social support-seeking behavior, focusing on a specific genetic variation, rs53576. The article explores how this genetic variation influences empathy, stress reactivity, and susceptibility to disorders such as autism and social anxiety. Furthermore, the article examines structural and functional changes in the brain associated with OXTR gene variations. It discusses the role of DNA methylation in influencing oxytocin receptor availability, affecting social perception and responsiveness to negative stimuli. The article also highlights the oxytocinergic system's involvement in disorders such as autism and social anxiety, emphasizing the interplay between genetics and environmental factors. The article also touches on the potential therapeutic use of exogenous oxytocin in mitigating symptoms associated with these disorders. In summary, the article underscores the intricate relationship between oxytocin, the OXTR gene, and diverse aspects of human behavior, providing insights into social bonding, perception, and the development of behavioral disorders.
    Keywords oxytocin ; gene ; social behavior
    Language English
    Publishing date 2024-01-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 3009997-3
    ISSN 2699-9404 ; 2699-9404
    ISSN (online) 2699-9404
    ISSN 2699-9404
    DOI 10.1055/s-0044-1779039
    Database Thieme publisher's database

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  4. Article: Knowledge and attitude towards children's oral health: findings from a sample of first-time mothers in Malaysia.

    Wan Abdul Rahman, W M / Saddki, N / Mahmood, Z / Hasan, R / Samsudin, N A

    The Medical journal of Malaysia

    2024  Volume 79, Issue 1, Page(s) 1–8

    Abstract: Introduction: Women's important roles within families which include modelling appropriate oral health behaviours require them to have good knowledge and positive attitude in oral health. This study determined knowledge and attitude towards children's ... ...

    Abstract Introduction: Women's important roles within families which include modelling appropriate oral health behaviours require them to have good knowledge and positive attitude in oral health. This study determined knowledge and attitude towards children's oral health among first-time mothers and factors associated with the attributes.
    Materials and methods: A total of 154 first-time mothers in the third trimester of pregnancy who attended two health clinics in the state of Sarawak, Malaysia for antenatal care participated in this cross-sectional study. A structured selfadministered questionnaire was used to measure the variables of interest.
    Results: Most mothers could correctly identify the aetiological factors of dental caries and strategies for preventing the disease in children. However, a substantial portion could not identify certain cariogenic and noncariogenic foods or drinks. Most pregnant women have appropriate attitudes towards children's oral health although some showed unfavourable attitude about care of primary teeth. Women who were older and had attended a talk on children's oral health were more likely to have higher mean knowledge score than their respective counterparts, and higher mean knowledge score was associated with higher mean attitude score.
    Conclusion: Most first-time mothers in this study had correct knowledge and favourable attitude about children's oral health, although misunderstandings and misperceptions in several issues were also common. Significant association found between experience of attending oral health talk and oral health knowledge, and between oral health knowledge and attitude, substantiate the importance of an educational intervention program to optimise the mothers' roles in caries prevention in children.
    MeSH term(s) Child ; Female ; Humans ; Pregnancy ; Oral Health ; Malaysia ; Cross-Sectional Studies ; Dental Caries/etiology ; Dental Caries/prevention & control ; Health Knowledge, Attitudes, Practice ; Mothers
    Language English
    Publishing date 2024-01-29
    Publishing country Malaysia
    Document type Journal Article
    ZDB-ID 604286-7
    ISSN 0300-5283
    ISSN 0300-5283
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1206: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: The effects of e-cigarette use on the oral microbiome.

    Adam, Mohammed / Hasan, Ridah

    Evidence-based dentistry

    2023  Volume 24, Issue 4, Page(s) 153–154

    Abstract: Aim: To investigate the effects of electronic cigarette (EC) use on the oral microbiome and gingival inflammation.: Sample selection: Saliva and gingival crevicular fluid samples were collected from 150 adult humans between 18 and 34 years in age (50% ...

    Abstract Aim: To investigate the effects of electronic cigarette (EC) use on the oral microbiome and gingival inflammation.
    Sample selection: Saliva and gingival crevicular fluid samples were collected from 150 adult humans between 18 and 34 years in age (50% EC users). Exclusion criteria included professional dental cleaning, antibiotic, or corticosteroid therapy in the last 3 months. Convenience sampling occurred between June 2017 and October 2018.
    Materials and methods: Clinical gingival inflammation was recorded by a single operator using a novel 4-point scale. RNA sequencing was used to determine microbial composition of samples (16S rRNA amplicon sequencing). Statistical analysis included synthesizing alpha and beta diversity using various indices, taxonomic differential abundance analysis, functional differential abundance analysis and mediation analysis. Taxonomic annotation was performed using QIIME2 with functional annotations generated using PICRUSt2. Age, sex, and frequency of tooth brushed were adjusted for.
    Results: EC users exhibited significantly greater alpha diversity in microbial species and greater differences between EC users and users in beta diversity. Saliva samples were typically more diverse than subgingival samples. EC users demonstrated greater gingival inflammation when adjusted for age, sex and toothbrushing frequency.
    Conclusion: EC use may increase oral dysbiosis. Further clinical studies on the effects of EC use on the oral microbiome and oral diseases are recommended.
    MeSH term(s) Humans ; Adult ; Electronic Nicotine Delivery Systems ; RNA, Ribosomal, 16S/genetics ; Vaping ; Gingivitis ; Microbiota ; Inflammation
    Chemical Substances RNA, Ribosomal, 16S
    Language English
    Publishing date 2023-10-24
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1457588-7
    ISSN 1476-5446 ; 1462-0049
    ISSN (online) 1476-5446
    ISSN 1462-0049
    DOI 10.1038/s41432-023-00946-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4972: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: A Comparison of the Periprosthetic Fracture Rate of Cemented and Cementless Mobile Bearing Unicompartmental Knee Arthroplasties: An Analysis of Data From the National Joint Registry for England, Wales, Northern Ireland, and the Isle of Man.

    Mohammad, Hasan R / Judge, Andrew / Murray, David W

    The Journal of arthroplasty

    2024  

    Abstract: Background: Periprosthetic fractures are rare but serious complications of unicompartmental knee arthroplasty (UKA). Although cementless UKA has a lower risk of loosening than cemented, there are concerns that tibial fracture risk may be higher given ... ...

    Abstract Background: Periprosthetic fractures are rare but serious complications of unicompartmental knee arthroplasty (UKA). Although cementless UKA has a lower risk of loosening than cemented, there are concerns that tibial fracture risk may be higher given the reliance on interference fit for primary stability. The risk of fracture and the effect of surgical fixation are currently unknown. We compared the periprosthetic fracture rate following cemented and cementless UKA surgery.
    Methods: A total of 14,122 medial mobile-bearing UKAs (7,061 cemented and 7,061 cementless) from the National Joint Registry and Hospital Episodes Statistics database were propensity score-matched. Cumulative fracture rates were calculated and Cox regressions were used to compare fixation groups.
    Results: The three-month periprosthetic fracture rates were similar (P = .80), being 0.10% in the cemented group and 0.11% in the cementless group. The fracture rates were highest during the first three months postoperatively, but then decreased and remained constant between one and 10 years after surgery. The one-year cumulative fracture rates were 0.2% (confidence interval [CI]: 0.1 to 0.3) for cemented and 0.2% (CI: 0.1 to 0.3) for cementless cases. The 10-year cumulative fracture rates were 0.8% (CI: 0.2 to 1.3) and 0.8% (CI: 0.3 to 1.3), respectively. The hazard ratio during the whole study period was 1.06 (CI: 0.64 to 1.77; P = .79).
    Conclusions: The periprosthetic fracture rate following mobile bearing UKA surgery is low, being about 1% at 10 years. There were no significant differences in fracture rates between cemented and cementless implants after matching. We surmise that surgeons are aware of the higher theoretical risk of early fracture with cementless components and take care with tibial preparation.
    Levels of evidence: III.
    Language English
    Publishing date 2024-02-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632770-9
    ISSN 1532-8406 ; 0883-5403
    ISSN (online) 1532-8406
    ISSN 0883-5403
    DOI 10.1016/j.arth.2024.02.019
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2134: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Water-deficit stress induces prenylated stilbenoid production and affects biomass in peanut hairy roots: Exploring the role of stilbenoid prenyltransferase downregulation.

    Gajurel, Gaurav / Hasan, Rokib / Medina-Bolivar, Fabricio

    Plant physiology and biochemistry : PPB

    2024  Volume 210, Page(s) 108596

    Abstract: The peanut plant is one of the most economically important crops around the world. Abiotic stress, such as drought, causes over five hundred million dollars in losses in peanut production per year. Peanuts are known to produce prenylated stilbenoids to ... ...

    Abstract The peanut plant is one of the most economically important crops around the world. Abiotic stress, such as drought, causes over five hundred million dollars in losses in peanut production per year. Peanuts are known to produce prenylated stilbenoids to counteract biotic stress. However, their role in abiotic stress tolerance has not been elucidated. To address this issue, hairy roots with the capacity to produce prenylated stilbenoids were established. An RNA-interference (RNAi) molecular construct targeting the stilbenoid-specific prenyltransferase AhR4DT-1 was designed and expressed via Agrobacterium rhizogenes-mediated transformation in hairy roots of peanut cultivar Georgia Green. Two transgenic hairy roots with the RNAi molecular construct were established, and the downregulation of AhR4DT-1 was validated using reverse transcriptase quantitative PCR. To determine the efficacy of the RNAi-approach in modifying the levels of prenylated stilbenoids, the hairy roots were co-treated with methyl jasmonate, hydrogen peroxide, cyclodextrin, and magnesium chloride to induce the production of stilbenoids and then the stilbenoids were analyzed in extracts of the culture medium. Highly reduced levels of prenylated stilbenoids were observed in the RNAi hairy roots. Furthermore, the hairy roots were evaluated in a polyethylene glycol (PEG) assay to assess the role of prenylated stilbenoids on water-deficit stress. Upon PEG treatment, stilbenoids were induced and secreted into the culture medium of RNAi and wild-type hairy roots. Additionally, the biomass of the RNAi hairy roots decreased by a higher amount as compared to the wild-type hairy roots suggesting that prenylated stilbenoids might play a role against water-deficit stress.
    Language English
    Publishing date 2024-04-02
    Publishing country France
    Document type Journal Article
    ZDB-ID 742978-2
    ISSN 1873-2690 ; 0981-9428
    ISSN (online) 1873-2690
    ISSN 0981-9428
    DOI 10.1016/j.plaphy.2024.108596
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  8. Article ; Online: Design of graphene and nanotubes from aromatic compounds: a theoretical study.

    Lateef, Asaad Ali / Obayes, Hasan R

    Journal of molecular modeling

    2022  Volume 28, Issue 10, Page(s) 320

    Abstract: A group of aromatic compounds (benzene, naphthalene, anthracene, and tetracene) was selected to design four sheets of graphene based on quantum mechanics calculations using the density function theory (DFT), leaning on the cyclic polymerization mechanism. ...

    Abstract A group of aromatic compounds (benzene, naphthalene, anthracene, and tetracene) was selected to design four sheets of graphene based on quantum mechanics calculations using the density function theory (DFT), leaning on the cyclic polymerization mechanism. Theoretical results offer that graphene-I is the most stable depending on the values of EHOMO (- 4.91601 eV), gap energy (2.76549 eV), and total energy (- 3447.42377654 a.u.). The thermodynamic theoretical outcome showed that all reactions are exothermic and spontaneous. Graphene is a two-dimensional plane, so the nanotube design process is with two possibilities: the first about the x-axis (horizontal (H)) and the second about the y-axis (vertical (V)). The theoretical results gave two groups: the first gave more stability to graphene at the expense of the nanotubes prepared from it, namely, graphene-I and the second gave less stability to graphene compared to the nanotubes prepared from it, namely, graphene-II, graphene-III, and graphene-IV), depending on the energy of HOMO and gap energy. The value of gap energy ranged (from 1.10370 to 1.79922 eV) for the following compounds (graphene-II, nanotube-II-V, nanotube-III-H, and nanotube-IV-V), making those important compounds in solar cells. These theoretical results showed the possibility of preparing graphene and then nanotubes from aromatic compounds, giving the benefit of doubling the preparation of new compounds with important applications and at the same time eliminating aromatic compounds harmful to the environment.
    Language English
    Publishing date 2022-09-17
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1284729-X
    ISSN 0948-5023 ; 1610-2940
    ISSN (online) 0948-5023
    ISSN 1610-2940
    DOI 10.1007/s00894-022-05322-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Fetal Neurosurgical Interventions for Spinal Malformations, Cerebral Malformations, and Hydrocephalus: Past, Present, and Future.

    Donoho, Daniel A / Syed, Hasan R

    Seminars in pediatric neurology

    2022  Volume 42, Page(s) 100964

    Abstract: In this article we review the last 40 years of progress in fetal neurosurgery with special attention to current controversies and upcoming challenges in the field. We surveyed the published literature describing prenatal interventions for spinal ... ...

    Abstract In this article we review the last 40 years of progress in fetal neurosurgery with special attention to current controversies and upcoming challenges in the field. We surveyed the published literature describing prenatal interventions for spinal malformations, cerebral malformations, and hydrocephalus. Even the most mature treatment paradigm, intrauterine repair of myelomeningocele, stands to benefit from advances in imaging and therapeutic modalities to improve patient selection, refine surgical techniques, validate novel biologic therapies, and streamline postoperative patient care. Other conditions under evaluation include congenital cerebral malformations, such as encephalocele, cerebrovascular malformations, and hydrocephalus. We describe cross-cutting needs for advances in fetal neuroimaging, basic disease models and new therapeutic devices to support further progress across various neurosurgical conditions affecting patients during the fetal period.
    MeSH term(s) Female ; Humans ; Hydrocephalus/etiology ; Hydrocephalus/surgery ; Meningomyelocele/surgery ; Nervous System Malformations ; Neuroimaging ; Neurosurgical Procedures/methods ; Pregnancy
    Language English
    Publishing date 2022-03-29
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1290000-x
    ISSN 1558-0776 ; 1071-9091
    ISSN (online) 1558-0776
    ISSN 1071-9091
    DOI 10.1016/j.spen.2022.100964
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    Zs.A 4772: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Detection of

    Naji Hasan, R / Abdal Kareem Jasim, S

    Archives of Razi Institute

    2021  Volume 76, Issue 4, Page(s) 1054–1059

    Abstract: A gram-positive bacterium, ...

    Abstract A gram-positive bacterium,
    MeSH term(s) Bacterial Proteins/genetics ; Bacterial Toxins ; Exotoxins/genetics ; Humans ; Iraq/epidemiology ; Leukocidins/genetics ; Methicillin-Resistant Staphylococcus aureus/genetics ; Penicillin-Binding Proteins/genetics ; Staphylococcal Infections/diagnosis ; Staphylococcus aureus/genetics
    Chemical Substances Bacterial Proteins ; Bacterial Toxins ; Exotoxins ; Leukocidins ; Panton-Valentine leukocidin ; Penicillin-Binding Proteins ; mecA protein, Staphylococcus aureus
    Language English
    Publishing date 2021-10-31
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2555498-0
    ISSN 2008-9872 ; 0365-3439
    ISSN (online) 2008-9872
    ISSN 0365-3439
    DOI 10.22092/ari.2021.355962.1751
    Database MEDical Literature Analysis and Retrieval System OnLINE

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