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Article ; Online: Food-derived compounds for CYP-phenotyping.

Haschke, Manuel

British journal of clinical pharmacology

2024 Volume 90, Issue 3, Page(s) 713–714

MeSH term(s)	Humans ; Cytochrome P-450 Enzyme System/genetics ; Phenotype ; Food
Chemical Substances	Cytochrome P-450 Enzyme System (9035-51-2)
Language	English
Publishing date	2024-01-11
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	188974-6
ISSN	1365-2125 ; 0306-5251 ; 0264-3774
ISSN (online)	1365-2125
ISSN	0306-5251 ; 0264-3774
DOI	10.1111/bcp.15989
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Article: Arzneistoffe und Diarrhoe.

Haschke, Manuel

Therapeutische Umschau. Revue therapeutique

2014 Volume 71, Issue 9, Page(s) 565–569

Abstract: Drug induced diarrhea is a frequent adverse event. The pathophysiological mechanisms include intraluminal accumulation of osmotically active substances, increased secretion or impaired resorption of gastrointestinal fluids, stimulation of ... ...

Title translation	Drugs and diarrhea.
Abstract	Drug induced diarrhea is a frequent adverse event. The pathophysiological mechanisms include intraluminal accumulation of osmotically active substances, increased secretion or impaired resorption of gastrointestinal fluids, stimulation of gastrointestinal motility, or inflammation of gastrointestinal mucosa. For many drugs, however, the causative mechanism is unknown. A careful drug history, including non-prescription drugs and additives that frequently cause diarrhea, is essential for the identification of potential causative substances. The clinical course of drug-induced diarrhea in many cases is mild and self-limited. In severe cases fluid-and electrolyte substitution, symptomatic and in certain cases specific therapy can be necessary. Symptomatic treatment primarily includes opioids and intraluminal adsorbents. In special cases octreotide or scopolamine can be used.
MeSH term(s)	Administration, Oral ; Administration, Rectal ; Analgesics, Opioid/adverse effects ; Analgesics, Opioid/therapeutic use ; Antidiarrheals/adverse effects ; Antidiarrheals/therapeutic use ; Charcoal/adverse effects ; Charcoal/therapeutic use ; Cholestyramine Resin/adverse effects ; Cholestyramine Resin/therapeutic use ; Diagnosis, Differential ; Diarrhea/chemically induced ; Diarrhea/diagnosis ; Diarrhea/drug therapy ; Humans ; Octreotide/adverse effects ; Octreotide/therapeutic use ; Prescription Drugs/adverse effects
Chemical Substances	Analgesics, Opioid ; Antidiarrheals ; Prescription Drugs ; Cholestyramine Resin (11041-12-6) ; Charcoal (16291-96-6) ; Octreotide (RWM8CCW8GP)
Language	German
Publishing date	2014-09
Publishing country	Switzerland
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	82044-1
ISSN	1664-2864 ; 0040-5930
ISSN (online)	1664-2864
ISSN	0040-5930
DOI	10.1024/0040-5930/a000553
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Book ; Thesis: Die Rolle respiratorischer Viren bei der Ätiologie der Epiglottitis im Kindesalter

Haschke, Manuel Martin

1997

Author's details	vorgelegt von Manuel Martin Haschke
Language	German
Size	43 Bl. : graph. Darst.
Publishing country	Switzerland
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Zürich, Univ., Diss., 1997
HBZ-ID	HT009717729
Database	Catalogue ZB MED Medicine, Health

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99 E 393	order for loan	Magazin

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Article ; Online: Developing indicators for medication-related readmissions based on a Delphi consensus study.

Schönenberger, Nicole / Blanc, Anne-Laure / Hug, Balthasar L / Haschke, Manuel / Goetschi, Aljoscha N / Wernli, Ursina / Meyer-Massetti, Carla

Research in social & administrative pharmacy : RSAP

2024

Abstract: Background: Medication-related readmissions challenge healthcare systems by burdening patients, increasing costs and straining resources. However, to date, there has been no consensus study on indicators for medication-related readmissions.: ... ...

Abstract	Background: Medication-related readmissions challenge healthcare systems by burdening patients, increasing costs and straining resources. However, to date, there has been no consensus study on indicators for medication-related readmissions. Objectives: This Delphi study aimed to develop a consensus-based set of indicators for detecting patients at risk of medication-related readmission. Methods: An expert panel of clinical pharmacists, physicians and nursing experts participated in a two-round Delphi study. In round 1, 31 indicators taken from the literature were rated for relevance on a scale from 1 to 9, with a median rating of 7 or higher suggesting relevance. The RAND/UCLA method was used to determine consensus. In round 2, indicators lacking consensus were re-rated together with a series of new indicators generated by the experts. Additional details were sought for some indicators. The main outcomes were the relevance of, consensus on, and completeness of the proposed indicators for identifying risks of 30-day medication-related readmission. Results: Thirty-eight experts participated in round 1. Consensus was found for all the indicators, with 25 included and 6 excluded. Thirty-four experts participated in round 2. Consensus was found for all 5 newly suggested indicators, and 4 were included. The expert panel prioritized the following indicators: (1) insufficient communication between different healthcare providers, (2) polypharmacy (≥7 medications), (3) low rates of medication adherence (twice-weekly mistakes or missing administration), (4) complex medication regimens (≥3 doses, ≥2 dosage forms and ≥2 administration routes per day), and (5) multimorbidity (≥3 chronic conditions). The final set comprised 29 indicators. Conclusions: The indicator set developed for flagging potential medication-related readmissions could guide priorities for clinical pharmacy services at hospital discharge, improving patient outcomes and resource use. A validation study of these indicators is planned.
Language	English
Publishing date	2024-02-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2192059-X
ISSN	1934-8150 ; 1551-7411
ISSN (online)	1934-8150
ISSN	1551-7411
DOI	10.1016/j.sapharm.2024.02.012
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Article ; Online: Use of metamizole and other non-opioid analgesics in Switzerland between 2014 and 2019: an observational study using a large health insurance claims database.

Gut, Stephan / Rauch, Marlene / Haschke, Manuel / Huber, Carola A / Gaertner, Jan / Schur, Nadine / Meier, Christoph R / Spoendlin, Julia

Swiss medical weekly

2024 Volume 154, Page(s) 3535

Abstract: Objective: To investigate claims patterns for metamizole and other non-opioid analgesics in Switzerland. To characterise users of these non-opioid analgesics regarding sex, age, comedications and canton of residence.: Methods: We conducted a ... ...

Abstract	Objective: To investigate claims patterns for metamizole and other non-opioid analgesics in Switzerland. To characterise users of these non-opioid analgesics regarding sex, age, comedications and canton of residence. Methods: We conducted a retrospective descriptive study using administrative claims data of outpatient prescribed non-opioid analgesics of the Swiss health insurance company Helsana between January 2014 and December 2019. First, we evaluated the number of claims and defined daily doses per year of metamizole, ibuprofen, diclofenac and paracetamol in adults aged 18 years or over. Second, we characterised new users of these non-opioid analgesics in terms of sex, age, claimed comedications and canton of residence. Results: From 2014 to 2019, among the investigated non-opioid analgesics, metamizole showed the highest increase in claims (+9545 claims, +50%) and defined daily doses (+86,869 defined daily doses, +84%) per 100,000 adults. Metamizole users had the highest median age (62 years [IQR: 44-77]) compared to ibuprofen (47 years [IQR: 33-62]), diclofenac (57 years [IQR: 43-71]) and paracetamol (58 years [IQR: 39-75]) users. Metamizole users also more frequently claimed proton pump inhibitors, anticoagulants, platelet aggregation inhibitors and antihypertensive drugs than users of other non-opioid analgesics. While metamizole was most frequently claimed in German-speaking regions of Switzerland, ibuprofen and paracetamol were most frequently claimed in the French-speaking regions and diclofenac in German- and Italian-speaking regions. Conclusion: In Switzerland, metamizole was increasingly claimed between 2014 and 2019. Metamizole was most frequently claimed by older adults and patients with comedications suggestive of underlying conditions, which can be worsened or caused by use of nonsteroidal anti-inflammatory drugs. The lack of studies regarding the effectiveness and safety of metamizole in this population warrants further investigation.
MeSH term(s)	Humans ; Aged ; Adult ; Middle Aged ; Analgesics, Non-Narcotic ; Dipyrone/therapeutic use ; Acetaminophen/therapeutic use ; Switzerland ; Ibuprofen/therapeutic use ; Diclofenac/therapeutic use ; Retrospective Studies ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Analgesics, Opioid ; Insurance, Health
Chemical Substances	Analgesics, Non-Narcotic ; Dipyrone (6429L0L52Y) ; Acetaminophen (362O9ITL9D) ; Ibuprofen (WK2XYI10QM) ; Diclofenac (144O8QL0L1) ; Anti-Inflammatory Agents, Non-Steroidal ; Analgesics, Opioid
Language	English
Publishing date	2024-02-05
Publishing country	Switzerland
Document type	Observational Study ; Journal Article
ZDB-ID	2036179-8
ISSN	1424-3997 ; 1424-7860
ISSN (online)	1424-3997
ISSN	1424-7860
DOI	10.57187/s.3535
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Article: Arzneistoffe und Diarrhoe

Haschke, Manuel

Therapeutische Umschau

2014 Volume 71, Issue 9, Page(s) 565–569

Abstract: Diarrhoe ist eine häufige unerwünschte Arzneimittelwirkung. Die zugrundeliegenden Mechanismen umfassen die Akkumulation von osmotisch aktiven Stoffen im Darmlumen, vermehrte Sekretion oder verminderte Resorption von gastrointestinalen Sekreten, die ... ...

Abstract	Diarrhoe ist eine häufige unerwünschte Arzneimittelwirkung. Die zugrundeliegenden Mechanismen umfassen die Akkumulation von osmotisch aktiven Stoffen im Darmlumen, vermehrte Sekretion oder verminderte Resorption von gastrointestinalen Sekreten, die Aktivierung der Peristaltik oder das Auslösen einer Schleimhautentzündung. Für viele Arzneistoffe ist jedoch der genaue Mechanismus nicht bekannt, der zu Durchfall führt. Eine genaue Anamnese, welche auch nicht rezeptpflichtige Medikamente und typische Durchfall-auslösende Hilfsstoffe einschließt, ist wesentlich für die Identifikation von möglichen Auslösern. Die Symptomatik ist in vielen Fällen leicht und selbstlimitiert. In schwereren Fällen kann eine Flüssigkeits- und Elektrolytsubstitution, eine symptomatische Therapie oder in gewissen Fällen eine spezifische Therapie nötig werden. Zur symptomatischen Therapie der Diarrhoe werden primär Opioide und intraluminale Wirkstoffe (Adsorbentien) eingesetzt. In speziellen Fällen können Octreotid oder Scopolamin eingesetzt werden.
Keywords	Durchfall ; Medikamenteneinnahme ; Diarrhöe
Language	German
Document type	Article
ZDB-ID	82044-1
ISSN	1664-2864 ; 0040-5930
ISSN (online)	1664-2864
ISSN	0040-5930
DOI	10.1024/0040-5930/a000553
Database	bibnet.org

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Article ; Online: Pharmacokinetics and pharmacodynamics of inhaled nicotine salt and free-base using an e-cigarette: A randomized crossover study.

Christen, Samuel E / Hermann, Laura / Bekka, Elias / Vonwyl, Celina / Hammann, Felix / van der Velpen, Vera / Eap, Chin B / Benowitz, Neal L / Haschke, Manuel / Liakoni, Evangelia

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco

2024

Abstract: Background: Popular "pod-style" e-cigarettes commonly use nicotine salt-based e-liquids that cause less irritation when inhaled and can deliver higher nicotine concentrations than free-base nicotine. We aimed to investigate the pharmacokinetic and ... ...

Abstract	Background: Popular "pod-style" e-cigarettes commonly use nicotine salt-based e-liquids that cause less irritation when inhaled and can deliver higher nicotine concentrations than free-base nicotine. We aimed to investigate the pharmacokinetic and pharmacodynamic effects of different nicotine formulations (salt vs. free-base) and concentrations that might influence systemic nicotine absorption and appeal of e-cigarettes. Methods: In this randomized, double-blind, within-subject crossover study, 20 non nicotine-naïve participants were switched among three e-liquids (free-base nicotine 20mg/mL, nicotine salt 20mg/mL, nicotine salt 40mg/mL) using a refillable pod system and a standardized vaping protocol (one puff every 30 seconds, 10 puffs total). Serum nicotine concentrations and vital signs were assessed over 180 minutes; direct effects, craving, satisfaction, withdrawal, and respiratory symptoms were measured using questionnaires. CYP2A6 genotypes and the nicotine metabolite ratio were also assessed. Results: Eleven (55%) participants were male and the median age was 23.5 years (range 18-67). All three formulations differed significantly in peak serum nicotine concentration (baseline adjusted Cmax, median (range): 12.0ng/mL (1.6-27.3), 5.4ng/mL (1.9-18.7) and 3.0ng/mL (1.3-8.8) for nicotine salt 40mg/mL, nicotine salt 20mg/mL and free-base 20mg/mL, respectively). All groups reached Cmax 2.0-2.5min (median) after their last puff. Differences in subjective effects were not statistically significant. No serious adverse events were observed. Conclusion: Free-base 20mg/mL formulations achieved lower blood nicotine concentrations than nicotine salt 20mg/mL, while 40mg/mL nicotine salt yielded concentrations similar to cigarette smoking. The findings can inform regulatory policy regarding e-liquids and their potential use in smoking cessation. Implications: Nicotine salt formulations inhaled by an e-cigarette led to higher nicotine delivery compared to nicotine free-base formulations with the same nicotine concentration. These findings should be considered in future regulatory discussions. The 40mg/mL nicotine salt formulation showed similar nicotine delivery as combustible cigarettes, albeit at concentrations over the maximum limit for e-liquids allowed in the European Union. Nicotine delivery resembling combustible cigarettes might be beneficial for smokers willing to quit to adequately alleviate withdrawal symptoms. However, increased nicotine delivery can also pose a public health risk, raising concerns about abuse liability, especially among youth and non-smokers.
Language	English
Publishing date	2024-04-10
Publishing country	England
Document type	Journal Article
ZDB-ID	1452315-2
ISSN	1469-994X ; 1462-2203
ISSN (online)	1469-994X
ISSN	1462-2203
DOI	10.1093/ntr/ntae074
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Zs.A 5789: Show issues

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Article ; Online: Development and validation of an LC-MS/MS method for the bioanalysis of the major metamizole metabolites in human plasma.

Bachmann, Fabio / Blaser, Lea / Haschke, Manuel / Krähenbühl, Stephan / Duthaler, Urs

Bioanalysis

2020 Volume 12, Issue 3, Page(s) 175–189

Abstract: Aim: ...

Abstract	Aim:
MeSH term(s)	Anti-Inflammatory Agents, Non-Steroidal/blood ; Anti-Inflammatory Agents, Non-Steroidal/pharmacokinetics ; Chromatography, Liquid/methods ; Dipyrone/blood ; Dipyrone/pharmacology ; Humans ; Plasma/chemistry ; Tandem Mass Spectrometry/methods
Chemical Substances	Anti-Inflammatory Agents, Non-Steroidal ; Dipyrone (6429L0L52Y)
Language	English
Publishing date	2020-02-13
Publishing country	England
Document type	Journal Article
ISSN	1757-6199
ISSN (online)	1757-6199
DOI	10.4155/bio-2019-0251
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Article ; Online: Retrospective analysis of adverse drug reactions leading to short-term emergency hospital readmission.

Banholzer, Sarah / Dunkelmann, Lea / Haschke, Manuel / Derungs, Adrian / Exadaktylos, Aristomenis / Krähenbühl, Stephan / Liakoni, Evangelia

Swiss medical weekly

2021 Volume 151, Page(s) w20400

Abstract: Aims of the study: Adverse drug reactions (ADRs) are an important cause of hospital admissions. Insufficient data are available about the frequency and characteristics of ADR-related emergency readmissions in Switzerland. The aim of this retrospective ... ...

Abstract	Aims of the study: Adverse drug reactions (ADRs) are an important cause of hospital admissions. Insufficient data are available about the frequency and characteristics of ADR-related emergency readmissions in Switzerland. The aim of this retrospective study was to characterise ADRs related to short-term emergency readmissions in a large Swiss University Hospital and to assess their reporting frequency. Methods: Electronic records of all patients discharged from the University Hospital Bern within a 12-month period (1 January to 31 December 2012) and emergency readmission within 30 calendar days were reviewed. Case inclusion required a known ADR. Cases with intentional overdosing, lack of compliance or insufficient documentation were excluded. Identified ADR-related readmission cases were searched in the Swiss ADR reporting system to assess reporting rate. Results: There were 1294 emergency readmissions among the 4792 readmissions (14% of all admissions) within 30 days after discharge. We identified 270 cases of ADR-related readmissions, corresponding to 21% of emergency readmissions and 6% of all readmissions within 30 days. The most frequent ADRs were gastrointestinal disorders (26%), infections and infestations (19%), and nervous system disorders (10%). The most frequent drug classes leading to ADRs were antineoplastic/immunomodulating (35%) and antithrombotic agents (25%). Only 8 (3%) of the 270 cases were reported to the Swiss ADR reporting system. Conclusion: ADR-related readmissions constituted a considerable part of short-term emergency readmissions. Despite being a relevant cause for rehospitalisation, only a minority of the ADRs were reported to the regulatory authorities. Strategies to prevent ADR-related readmissions and to improve reporting rates are needed.
MeSH term(s)	Adverse Drug Reaction Reporting Systems ; Drug-Related Side Effects and Adverse Reactions/epidemiology ; Emergency Service, Hospital ; Hospitalization ; Humans ; Patient Readmission ; Retrospective Studies
Language	English
Publishing date	2021-01-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2036179-8
ISSN	1424-3997 ; 1424-7860
ISSN (online)	1424-3997
ISSN	1424-7860
DOI	10.4414/smw.2021.20400
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Article: Neue orale Antikoagulantien aus klinisch pharmakologischer Sicht

Haschke, Manuel

Therapeutische Umschau

2012 Volume 69, Issue 11 Neue Antikoagulantien, Page(s) 657

Language	German
Document type	Article
ZDB-ID	82044-1
ISSN	0040-5930
Database	Current Contents Medicine

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