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  1. Article ; Online: Effects of Prebiotic Yeast Mannan on Gut Health and Sleep Quality in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Study.

    Tanihiro, Reiko / Yuki, Masahiro / Sasai, Masaki / Haseda, Akane / Kagami-Katsuyama, Hiroyo / Hirota, Tatsuhiko / Honma, Naoyuki / Nishihira, Jun

    Nutrients

    2023  Volume 16, Issue 1

    Abstract: Human gut health is closely related to sleep. We aimed to evaluate the efficacy of yeast mannan (YM) in improving bowel habits and sleep quality, along with metabolomics in fecal samples. A total of 40 healthy adults (age range, 22-64 years) with ... ...

    Abstract Human gut health is closely related to sleep. We aimed to evaluate the efficacy of yeast mannan (YM) in improving bowel habits and sleep quality, along with metabolomics in fecal samples. A total of 40 healthy adults (age range, 22-64 years) with discomfort in defecation were enrolled and randomly allocated to receive either YM (
    MeSH term(s) Adult ; Humans ; Young Adult ; Middle Aged ; Sleep Quality ; Mannans/pharmacology ; Saccharomyces cerevisiae ; Sleep ; Double-Blind Method ; Prebiotics
    Chemical Substances Mannans ; Prebiotics
    Language English
    Publishing date 2023-12-31
    Publishing country Switzerland
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu16010141
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: QTL analysis of femaleness in monoecious spinach and fine mapping of a major QTL using an updated version of chromosome-scale pseudomolecules.

    Yamano, Kaoru / Haseda, Akane / Iwabuchi, Keisuke / Osabe, Takayuki / Sudo, Yuki / Pachakkil, Babil / Tanaka, Keisuke / Suzuki, Yutaka / Toyoda, Atsushi / Hirakawa, Hideki / Onodera, Yasuyuki

    PloS one

    2024  Volume 19, Issue 2, Page(s) e0296675

    Abstract: Although spinach is predominantly dioecious, monoecious plants with varying proportions of female and male flowers are also present. Recently, monoecious inbred lines with highly female and male conditions have been preferentially used as parents for F1- ... ...

    Abstract Although spinach is predominantly dioecious, monoecious plants with varying proportions of female and male flowers are also present. Recently, monoecious inbred lines with highly female and male conditions have been preferentially used as parents for F1-hybrids, rather than dioecious lines. Accordingly, identifying the loci for monoecism is an important issue for spinach breeding. We here used long-read sequencing and Hi-C technology to construct SOL_r2.0_pseudomolecule, a set of six pseudomolecules of spinach chromosomes (total length: 879.2 Mb; BUSCO complete 97.0%) that are longer and more genetically complete than our previous version of pseudomolecules (688.0 Mb; 81.5%). Three QTLs, qFem2.1, qFem3.1, and qFem6.1, responsible for monoecism were mapped to SOL_r2.0_pseudomolecule. qFem3.1 had the highest LOD score and corresponded to the M locus, which was previously identified as a determinant of monoecious expression, by genetic analysis of progeny from female and monoecious plants. The other QTLs were shown to modulate the ratio of female to male flowers in monoecious plants harboring a dominant allele of the M gene. Our findings will enable breeders to efficiently produce highly female- and male-monoecious parental lines for F1-hybrids by pyramiding the three QTLs. Through fine-mapping, we narrowed the candidate region for the M locus to a 19.5 kb interval containing three protein-coding genes and one long non-coding RNA gene. Among them, only RADIALIS-like-2a showed a higher expression in the reproductive organs, suggesting that it might play a role in reproductive organogenesis. However, there is no evidence that it is involved in the regulation of stamen and pistil initiation, which are directly related to the floral sex differentiation system in spinach. Given that auxin is involved in reproductive organ formation in many plant species, genes related to auxin transport/response, in addition to floral organ formation, were identified as candidates for regulators of floral sex-differentiation from qFem2.1 and qFem6.1.
    MeSH term(s) Spinacia oleracea/genetics ; Plant Breeding ; Quantitative Trait Loci/genetics ; Chromosomes, Plant/genetics ; Indoleacetic Acids
    Chemical Substances Indoleacetic Acids
    Language English
    Publishing date 2024-02-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0296675
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The Impact of Purple-Flesh Potato (

    Maeda-Yamamoto, Mari / Honmou, Osamu / Sasaki, Masanori / Haseda, Akane / Kagami-Katsuyama, Hiroyo / Shoji, Toshihiko / Namioka, Ai / Namioka, Takahiro / Magota, Hirotoshi / Oka, Shinichi / Kataoka-Sasaki, Yuko / Ukai, Ryou / Takemura, Mitsuhiro / Nishihira, Jun

    Nutrients

    2022  Volume 14, Issue 12

    Abstract: The purple-flesh potato ( ...

    Abstract The purple-flesh potato (
    MeSH term(s) Adult ; Aged ; Anthocyanins/pharmacology ; Antioxidants ; Double-Blind Method ; Humans ; Middle Aged ; Solanum tuberosum
    Chemical Substances Anthocyanins ; Antioxidants
    Language English
    Publishing date 2022-06-13
    Publishing country Switzerland
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu14122446
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: The Impact of Purple-Flesh Potato (Solanum tuberosum L.) cv. “Shadow Queen” on Minor Health Complaints in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Study

    Maeda-Yamamoto, Mari / Honmou, Osamu / Sasaki, Masanori / Haseda, Akane / Kagami-Katsuyama, Hiroyo / Shoji, Toshihiko / Namioka, Ai / Namioka, Takahiro / Magota, Hirotoshi / Oka, Shinichi / Kataoka-Sasaki, Yuko / Ukai, Ryou / Takemura, Mitsuhiro / Nishihira, Jun

    Nutrients. 2022 June 13, v. 14, no. 12

    2022  

    Abstract: The purple-flesh potato (Solanum tuberosum L.) cultivar “Shadow Queen” (SQ) naturally contains anthocyanins. This randomized, double-blind, placebo-controlled study determines whether ingesting purple potatoes increases the number of mesenchymal stem ... ...

    Abstract The purple-flesh potato (Solanum tuberosum L.) cultivar “Shadow Queen” (SQ) naturally contains anthocyanins. This randomized, double-blind, placebo-controlled study determines whether ingesting purple potatoes increases the number of mesenchymal stem cells (MSC) and improves stress response, a minor health complaint in healthy adults (registration number: UMIN000038876). A total of 15 healthy subjects (ages: 50–70 years) with minor health complaints were randomly assigned to one of two groups. For 8 weeks, the placebo group received placebo potatoes cv. “Haruka” and the test group received test potato cv. SQ containing 45 mg anthocyanin. The MSC count and several stress responses were analyzed at weeks 0 and 8 of the intake periods. The ingestion of a SQ potato did not affect the MSC count but markedly improved psychological stress response, irritability, and depression as minor health complaints compared with “Haruka”. No adverse effects were noted. Hence, an 8-week intake of SQ could improve stress responses.
    Keywords Solanum tuberosum ; anthocyanins ; cultivars ; ingestion ; placebos ; potatoes ; psychological stress ; stress response
    Language English
    Dates of publication 2022-0613
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2518386-2
    ISSN 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu14122446
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: The combined effect of green tea and α-glucosyl hesperidin in preventing obesity: a randomized placebo-controlled clinical trial.

    Yoshitomi, Ren / Yamamoto, Mao / Kumazoe, Motofumi / Fujimura, Yoshinori / Yonekura, Madoka / Shimamoto, Yasuyo / Nakasone, Akari / Kondo, Satoshi / Hattori, Hiroki / Haseda, Akane / Nishihira, Jun / Tachibana, Hirofumi

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 19067

    Abstract: Green tea, a widely consumed beverage in Asia, contains green tea catechins effective against obesity, especially epigallocatechin-3-O-gallate (EGCG), but must be consumed in an impractically huge amount daily to elicit its biological effect. Meanwhile, ... ...

    Abstract Green tea, a widely consumed beverage in Asia, contains green tea catechins effective against obesity, especially epigallocatechin-3-O-gallate (EGCG), but must be consumed in an impractically huge amount daily to elicit its biological effect. Meanwhile, citrus polyphenols have various physiological effects that could enhance EGCG functionality. Here we investigated the antiobesity effect of a combination of EGCG and α-glucosyl hesperidin, a citrus polyphenol, at doses that have not been previously reported to exert antiobesity effects by themselves in any clinical trial. In a randomized, placebo-controlled, double-blinded, and parallel-group-designed clinical trial, 60 healthy Japanese males and females aged 30-75 years consumed green tea combined with α-glucosyl hesperidin (GT-gH), which contained 178 mg α-glucosyl hesperidin and 146 mg EGCG, for 12 weeks. Physical, hematological, blood biochemical, and urine examinations showed that GT-gH is safe to use. At week 12, GT-gH prevented weight gain and reduced body mass index (BMI) compared with the placebo. Especially in those aged < 50 years, triglyceride and body fat percentage decreased at week 6, visceral fat level and body fat percentage decreased at week 12; body weight, BMI, and blood LDL/HDL ratio also decreased. In conclusion, taking GT-gH prevents weight gain, and the antiobesity effect of GT-gH was more pronounced in people aged < 50 years.
    MeSH term(s) Adult ; Body Mass Index ; Catechin/administration & dosage ; Catechin/analogs & derivatives ; Catechin/therapeutic use ; Female ; Glucosides/administration & dosage ; Glucosides/therapeutic use ; Hesperidin/administration & dosage ; Hesperidin/analogs & derivatives ; Hesperidin/therapeutic use ; Humans ; Male ; Middle Aged ; Obesity/prevention & control ; Placebos ; Tea/chemistry
    Chemical Substances Glucosides ; Placebos ; Tea ; glucosyl hesperidin (432C95B6YE) ; Catechin (8R1V1STN48) ; epigallocatechin gallate (BQM438CTEL) ; Hesperidin (E750O06Y6O)
    Language English
    Publishing date 2021-09-24
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-98612-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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