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  1. Article ; Online: Foreword.

    Hasegawa, Hiroshi

    Biological & pharmaceutical bulletin

    2023  Volume 46, Issue 9, Page(s) 1161

    Language English
    Publishing date 2023-09-01
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1150271-x
    ISSN 1347-5215 ; 0918-6158
    ISSN (online) 1347-5215
    ISSN 0918-6158
    DOI 10.1248/bpb.b23-ctf4609
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1474: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  2. Book ; Online: Metals in Soil

    Ara Begum, Zinnat / Rahman, Ismail M. M / Hasegawa, Hiroshi

    Contamination and Remediation

    2019  

    Keywords Soil science, sedimentology ; mortality, bioavailability, decontamination, plant growth, monitoring
    Language English
    Size 1 electronic resource (88 pages)
    Publisher IntechOpen
    Document type Book ; Online
    Note English
    HBZ-ID HT030646673
    ISBN 9781839620911 ; 1839620919
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: [Vascular Remodeling Induced by Biological Stresses].

    Hasegawa, Hiroshi

    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

    2020  Volume 140, Issue 4, Page(s) 509–512

    Abstract: The thymus is a vital organ for functional immune systems, and is the site of T cell development, which plays a central role in cellular immune defenses. Unlike other major organs, the thymus is highly dynamic in size and structure. It shrinks ... ...

    Abstract The thymus is a vital organ for functional immune systems, and is the site of T cell development, which plays a central role in cellular immune defenses. Unlike other major organs, the thymus is highly dynamic in size and structure. It shrinks immediately upon bacterial infection, aging, pregnancy, mental stress, nutritional deficiency, and more. The reduction in size and function of the thymus during such biological events is called thymic involution or thymic atrophy; thymic involution is a particularly important issue because dysfunctional T cell immunity increases the risks of tumorigenesis and infectious diseases. However, the molecular mechanisms underlying thymic involution remain obscure. Our recent study indicated that blood vessels are remodeled during thymic involution that occurs upon aging, estradiol-treatment, or nutritional deficiency. We also found that prostanoid synthesis is induced during thymic involution. Treatment with non-steroidal anti-inflammatory drugs (NSAIDs), aspirin or etodolac, at least partially inhibited thymic involution-induced remodeling of the blood vessels, suggesting that prostanoids are involved in blood vessel remodeling. Our results revealed the potential role of blood vessel remodeling during thymic involution, which can lead to biological stress-induced immunosenescence.
    MeSH term(s) Animals ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Blood Vessels/immunology ; Blood Vessels/physiopathology ; Humans ; Mice ; Prostaglandins/metabolism ; Prostaglandins/physiology ; Stress, Physiological/immunology ; Stress, Physiological/physiology ; Stress, Psychological/immunology ; T-Lymphocytes/immunology ; Thymus Gland/immunology ; Thymus Gland/pathology ; Vascular Remodeling/drug effects
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal ; Prostaglandins
    Language Japanese
    Publishing date 2020-04-01
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 200514-1
    ISSN 1347-5231 ; 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
    ISSN (online) 1347-5231
    ISSN 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
    DOI 10.1248/yakushi.19-00221-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 643: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  4. Article ; Online: Astrocytic Responses to Binge Alcohol Intake in the Mouse Hindbrain.

    Hasegawa, Hiroshi / Kondo, Mari

    Biological & pharmaceutical bulletin

    2023  Volume 46, Issue 9, Page(s) 1194–1202

    Abstract: Ethanol is the most commonly used toxic chemical in human cultures. Ethanol predominantly damages the brain causing various neurological disorders. Astrocytes are important cellular targets of ethanol in the brain and are involved in alcoholic symptoms. ... ...

    Abstract Ethanol is the most commonly used toxic chemical in human cultures. Ethanol predominantly damages the brain causing various neurological disorders. Astrocytes are important cellular targets of ethanol in the brain and are involved in alcoholic symptoms. Recent studies have revealed the diversity of astrocyte populations in the brain. However, it is unclear how the different astrocyte populations respond to an excess of ethanol. Here we examined the effect of binge ethanol levels on astrocytes in the mouse brainstem and cerebellum. Ethanol administration for four consecutive days increased the glial fibrillary acidic protein (GFAP)-immunoreactive signals in the spinal tract of the trigeminal nerve (stTN) and reticular nucleus (RN). Another astrocyte marker, aquaporin 4 (AQP4), was also increased in the stTN with a pattern similar to that of GFAP. However, in the RN, the immunoreactive signals of AQP4 were different from that of GFAP and were not changed by ethanol administration. In the cerebellum, GFAP-positive signals were found in all four astrocytic populations, and those in the Bergmann glia were selectively eliminated by ethanol administration. We next examined the effect of estradiol on the ethanol-induced changes in astrocytic immunoreactive signals. The administration of estradiol alone increased the AQP4-immunoreactivity in the stTN with a pattern similar to that of ethanol, whereas the co-administration of estradiol and ethanol suppressed the intensity of the AQP4-positive signals. Thus, binge levels of ethanol intake selectively affect astrocyte populations in the brainstem and cerebellum. Sex hormones can affect the ethanol-induced neurotoxicity via modulation of astrocyte reactivity.
    MeSH term(s) Humans ; Animals ; Mice ; Astrocytes ; Alcohol Drinking/adverse effects ; Cerebellum ; Estradiol ; Ethanol
    Chemical Substances Estradiol (4TI98Z838E) ; Ethanol (3K9958V90M)
    Language English
    Publishing date 2023-09-03
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1150271-x
    ISSN 1347-5215 ; 0918-6158
    ISSN (online) 1347-5215
    ISSN 0918-6158
    DOI 10.1248/bpb.b23-00140
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1474: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  5. Article ; Online: Demonstration of spectrum narrowing mitigation based on recurrent neural networks for ultra-dense WDM networks.

    Shiraki, Ryuta / Mori, Yojiro / Hasegawa, Hiroshi

    Optics letters

    2024  Volume 49, Issue 4, Page(s) 947–950

    Abstract: Traversing each WSS in ultra-dense WDM networks narrows the signal spectra. Simulations and experiments demonstrate, for the first time to our knowledge, spectrum narrowing mitigation based on RNN. Numerical simulations show that the RNN-based ... ...

    Abstract Traversing each WSS in ultra-dense WDM networks narrows the signal spectra. Simulations and experiments demonstrate, for the first time to our knowledge, spectrum narrowing mitigation based on RNN. Numerical simulations show that the RNN-based demodulation with impairment-aware optical path control significantly enlarges the transmission distance. Transmission experiments in the extended C-band successfully confirm an extension of the transmissible distance of 16QAM signals by over 500 km.
    Language English
    Publishing date 2024-02-07
    Publishing country United States
    Document type Journal Article
    ISSN 1539-4794
    ISSN (online) 1539-4794
    DOI 10.1364/OL.515414
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Online: Water Stress

    Mofizur Rahman, Ismail Md / Hasegawa, Hiroshi

    2012  

    Keywords Hydrology & the hydrosphere
    Language English
    Size 1 electronic resource (314 pages)
    Publisher IntechOpen
    Document type Book ; Online
    Note English
    HBZ-ID HT030644980
    ISBN 9789535143758 ; 9535143751
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  7. Book ; Online: Water Stress in Plants

    Mofizur Rahman, Ismail Md / Ara Begum, Zinnat / Hasegawa, Hiroshi

    2016  

    Keywords Hydrology & the hydrosphere
    Size 1 electronic resource (128 pages)
    Publisher IntechOpen
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021050230
    ISBN 9789535154464 ; 953515446X
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  8. Article: Blood Vessels as a Key Mediator for Ethanol Toxicity: Implication for Neuronal Damage.

    Nakayama, Kei / Hasegawa, Hiroshi

    Life (Basel, Switzerland)

    2022  Volume 12, Issue 11

    Abstract: Excessive intake of ethanol is associated with severe brain dysfunction, and the subsequent neurological and behavioral abnormalities are well-established social risks. Many research studies have addressed how ethanol induces neurological toxicity. ... ...

    Abstract Excessive intake of ethanol is associated with severe brain dysfunction, and the subsequent neurological and behavioral abnormalities are well-established social risks. Many research studies have addressed how ethanol induces neurological toxicity. However, the underlying mechanisms with which ethanol induces neurological toxicity are still obscure, perhaps due to the variety and complexity of these mechanisms. Epithelial cells are in direct contact with blood and can thus mediate ethanol neurotoxicity. Ethanol activates the endothelial cells of blood vessels, as well as lymphatic vessels, in a concentration-dependent manner. Among various signaling mediators, nitric oxide plays important roles in response to ethanol. Endothelial and inducible nitric oxide synthases (eNOS and iNOS) are upregulated and activated by ethanol and enhance neuroinflammation. On the other hand, angiogenesis and blood vessel remodeling are both affected by ethanol intake, altering blood supply and releasing angiocrine factors to regulate neuronal functions. Thus, ethanol directly acts on endothelial cells, yet the molecular target(s) on endothelial cells remain unknown. Previous studies on neurons and glial cells have validated the potential contribution of membrane lipids and some specific proteins as ethanol targets, which may also be the case in endothelial cells. Future studies, based on current knowledge, will allow for a greater understanding of the contribution and underlying mechanisms of endothelial cells in ethanol-induced neurological toxicity, protecting neurological health against ethanol toxicity.
    Language English
    Publishing date 2022-11-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life12111882
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Editorial: Environmental exercise physiology towards global warming: challenges, applications and future trends.

    Otani, Hidenori / Okazaki, Kazunobu / Hasegawa, Hiroshi

    Frontiers in sports and active living

    2023  Volume 5, Page(s) 1243587

    Language English
    Publishing date 2023-07-05
    Publishing country Switzerland
    Document type Editorial
    ISSN 2624-9367
    ISSN (online) 2624-9367
    DOI 10.3389/fspor.2023.1243587
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Can Statins Modify the Wound Healing Process After Myocardial Infarction?

    Hasegawa, Hiroshi

    International heart journal

    2017  Volume 58, Issue 4, Page(s) 472–474

    MeSH term(s) Animals ; Cells, Cultured ; Disease Models, Animal ; Female ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/administration & dosage ; Male ; Mice ; Monocyte-Macrophage Precursor Cells/drug effects ; Monocyte-Macrophage Precursor Cells/physiology ; Myocardial Infarction/diagnosis ; Myocardial Infarction/drug therapy ; Nanotechnology ; Neovascularization, Physiologic/drug effects ; Prognosis ; Quinolines/administration & dosage ; Risk Factors ; Treatment Outcome ; Wound Healing/drug effects ; Wound Healing/physiology
    Chemical Substances Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Quinolines ; pitavastatin (M5681Q5F9P)
    Language English
    Publishing date 2017-08-03
    Publishing country Japan
    Document type Editorial
    ZDB-ID 2187806-7
    ISSN 1349-3299 ; 1349-2365
    ISSN (online) 1349-3299
    ISSN 1349-2365
    DOI 10.1536/ihj.17-303
    Database MEDical Literature Analysis and Retrieval System OnLINE

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