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Article ; Online: Effect of epidural analgesia on cervical ripening using dinoprostone vaginal inserts.

Hasegawa, Junichi / Homma, Chika / Saji, Shota / Furuya, Natsumi / Sakamoto, Miki

2024 Volume 38, Issue 2, Page(s) 215–221

Abstract: Objective: To clarify whether the duration from cervical ripening induction to labor onset is prolonged when epidural analgesia is administered following application of dinoprostone vaginal inserts vs. cervical ripening balloon.: Methods: This ... ...

Abstract	Objective: To clarify whether the duration from cervical ripening induction to labor onset is prolonged when epidural analgesia is administered following application of dinoprostone vaginal inserts vs. cervical ripening balloon. Methods: This retrospective study included mothers with singleton deliveries at a single center between 2020-2021. Nulliparous women who underwent labor induction and requested epidural analgesia during labor after 37 weeks of gestation were included. The duration from cervical ripening induction to labor onset was compared between women using a dinoprostone vaginal insert and those using a cervical ripening balloon and between women who received epidural analgesia before and after labor onset. Results: In the dinoprostone vaginal insert group, the duration was significantly shorter in the subgroup that received epidural analgesia after labor onset (estimated median, 545 [95% confidence interval: 229-861 min]) than the subgroup that received it before labor onset (estimated median, 1,570 [95% confidence interval: 1,226-1,914] min, p = 0.004). However, in the cervical ripening balloon group, the difference between subgroups was not significant. The length of labor among the groups was also not significantly different. Conclusion: Epidural analgesia as labor relaxant adversely affected the progression of uterine cervical ripening when dinoprostone vaginal inserts were used, whereas it did not affect cervical ripening when a mechanical cervical dilatation balloon was used. The present results are significant for choosing the appropriate ripening method.
MeSH term(s)	Pregnancy ; Female ; Humans ; Dinoprostone/pharmacology ; Oxytocics ; Retrospective Studies ; Analgesia, Epidural ; Cervical Ripening ; Labor, Induced/methods
Chemical Substances	Dinoprostone (K7Q1JQR04M) ; Oxytocics
Language	English
Publishing date	2024-02-01
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1107821-2
ISSN	1438-8359 ; 0913-8668
ISSN (online)	1438-8359
ISSN	0913-8668
DOI	10.1007/s00540-023-03307-z
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Article ; Online: Ultrasound screening of umbilical cord abnormalities and delivery management.

Hasegawa, Junichi

Placenta

2017 Volume 62, Page(s) 66–78

Abstract: With the improvement of prenatal diagnoses of foetuses, the prevalence of stillbirth due to foetal anomaly after mid-gestation decreased, whereas that of stillbirth associated with umbilical cord factors tended to increase. Prenatal detection of ... ...

Abstract	With the improvement of prenatal diagnoses of foetuses, the prevalence of stillbirth due to foetal anomaly after mid-gestation decreased, whereas that of stillbirth associated with umbilical cord factors tended to increase. Prenatal detection of umbilical cord abnormalities and appropriate management during the antenatal period and delivery based on the ultrasound diagnosis will improve the perinatal morbidity and mortality rates. In the present review, the strategy to reduce the incidence of foetal compromise due to umbilical cord problems is discussed considering the current knowledge regarding the physiological and pathological aspects of umbilical cord abnormalities.
MeSH term(s)	Delivery, Obstetric ; Female ; Humans ; Pregnancy ; Ultrasonography, Prenatal ; Umbilical Cord/abnormalities ; Umbilical Cord/diagnostic imaging
Language	English
Publishing date	2017-12-07
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	603951-0
ISSN	1532-3102 ; 0143-4004
ISSN (online)	1532-3102
ISSN	0143-4004
DOI	10.1016/j.placenta.2017.12.003
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Article ; Online: Ectopic uterine cervical ripening dilator.

Hasegawa, Junichi / Nishimura, Yoko / Saji, Shota

Journal of medical ultrasonics (2001)

2023 Volume 51, Issue 1, Page(s) 145–146

MeSH term(s)	Pregnancy ; Female ; Humans ; Cervical Ripening ; Cervix Uteri/diagnostic imaging
Language	English
Publishing date	2023-09-16
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1396630-3
ISSN	1613-2254 ; 0287-0592 ; 1346-4523
ISSN (online)	1613-2254
ISSN	0287-0592 ; 1346-4523
DOI	10.1007/s10396-023-01361-4
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Article: [A Case of the Metastatic Colonic Carcinoma from an Endometrial Carcinoma].

Okano, Miho / Hara, Takeo / Hata, Tomoki / Takayama, Osamu / Kim, Yongkook / Imamoto, Haruhiko / Hasegawa, Junichi

Gan to kagaku ryoho. Cancer & chemotherapy

2024 Volume 50, Issue 13, Page(s) 1918–1920

Abstract: A woman in her 80s, had undergone radical surgery for an endometrial carcinoma 9 years earlier, and her 5-year postoperative follow-up had been completed without recurrence. She consulted an orthopedic surgeon with a chief complaint of a mass in the left ...

Abstract	A woman in her 80s, had undergone radical surgery for an endometrial carcinoma 9 years earlier, and her 5-year postoperative follow-up had been completed without recurrence. She consulted an orthopedic surgeon with a chief complaint of a mass in the left inguinal region, and was referred to surgery after MRI scan revealed lymph node metastases in the left inguinal and external iliac region and a sigmoid colon tumor. Due to postoperative adhesion of the uterine cancer, the colonoscope could not be inserted to the tumor, and no tissue diagnosis was made. CT and PET scans revealed a sigmoid colon tumor plus periungual lymph node metastasis, and it was determined that radical surgery was possible, and the patient underwent resection. Surgery was performed by laparoscopic resection of the sigmoid colon and lymphadenectomy, with R0 resection. The sigmoid colon tumor and lymph nodes were of the same histology as the 9-year-old endometrial carcinoma, leading to the diagnosis of colon and lymph node recurrence 9 years after endometrial carcinoma surgery.
MeSH term(s)	Female ; Humans ; Carcinoma/surgery ; Endometrial Neoplasms/surgery ; Lymph Node Excision ; Lymph Nodes/pathology ; Lymphatic Metastasis/pathology ; Sigmoid Neoplasms/surgery ; Sigmoid Neoplasms/pathology ; Aged, 80 and over
Language	Japanese
Publishing date	2024-02-01
Publishing country	Japan
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	604842-0
ISSN	0385-0684
ISSN	0385-0684
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Article: [A Case of Long-Term Survival with Metachronous Hepatic and Pulmonary Metastases from Transverse Colon Cancer by Multidisciplinary Treatment].

Hara, Takeo / Okano, Miho / Hata, Tomoki / Takayama, Osamu / Kim, Yongkook / Imamoto, Haruhiko / Hasegawa, Junichi

Gan to kagaku ryoho. Cancer & chemotherapy

2024 Volume 50, Issue 13, Page(s) 1857–1859

Abstract: A 64-year-old woman underwent right hemicolectomy for transverse colon cancer. Histopathological findings revealed T, type 2, 24×22 mm, tub2, pT2N1a(1/23)M0, and pStage Ⅲa. Postoperative adjuvant chemotherapy was not administered at the patient's request. ...

Abstract	A 64-year-old woman underwent right hemicolectomy for transverse colon cancer. Histopathological findings revealed T, type 2, 24×22 mm, tub2, pT2N1a(1/23)M0, and pStage Ⅲa. Postoperative adjuvant chemotherapy was not administered at the patient's request. One year after surgery, carcinoembryonic antigen(CEA)level was elevated, and Gd-EOB-DTPA- enhanced MRI revealed a nodule in segment 2 and 4/8 of the liver. Based on the diagnosis of hepatic metastasis, laparoscopic partial hepatectomy was performed. Three years after hepatectomy, CEA level was found to be elevated again, and chest CT showed a solitary pulmonary nodule in segment 7 of the right lung. With a diagnosis as pulmonary metastasis, FOLFIRI plus bevacizumab was performed. After 41 courses of FOLFIRI plus bevacizumab, the pulmonary nodule decreased in size, and no new lesions appeared. The chemotherapy was terminated at the patient's request. Six months later, the pulmonary nodule increased in size, and thoracoscopic partial pulmonary resection was performed. Hepatic and pulmonary resection specimens were histopathologically consistent as metastasis of colorectal cancer. The patient has been alive without recurrence for about 4 years after final surgery(pulmonary resection)without postoperative adjuvant chemotherapy. We report a case of long-term survival with metachronous hepatic and pulmonary metastases from transverse colon cancer by multidisciplinary treatment.
MeSH term(s)	Female ; Humans ; Middle Aged ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Bevacizumab/therapeutic use ; Carcinoembryonic Antigen/metabolism ; Colon, Transverse/surgery ; Colon, Transverse/pathology ; Colonic Neoplasms/drug therapy ; Colonic Neoplasms/surgery ; Colonic Neoplasms/pathology ; Hepatectomy ; Liver/pathology ; Liver Neoplasms/drug therapy ; Liver Neoplasms/surgery ; Liver Neoplasms/secondary ; Lung Neoplasms/drug therapy ; Lung Neoplasms/surgery ; Lung Neoplasms/secondary
Chemical Substances	Bevacizumab (2S9ZZM9Q9V) ; Carcinoembryonic Antigen
Language	Japanese
Publishing date	2024-02-01
Publishing country	Japan
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	604842-0
ISSN	0385-0684
ISSN	0385-0684
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Article: [A Case of Acute Circulatory Failure Due to Carbon Dioxide Embolization during Laparoscopic Hepatectomy].

Hata, Tomoki / Hara, Takeo / Okano, Miho / Takayama, Osamu / Kim, Yongkook / Hasegawa, Junichi / Imamoto, Haruhiko

Gan to kagaku ryoho. Cancer & chemotherapy

2024 Volume 50, Issue 13, Page(s) 1956–1958

Abstract: A 78-year-old man who was diagnosed as having hepatocellular carcinoma(segment 4/8)underwent laparoscopic hepatectomy. About 5 hours after the start of the operation, SpO2 and systolic blood pressure suddenly dropped to 87% and 40 mmHg. EtCO2 level ... ...

Abstract	A 78-year-old man who was diagnosed as having hepatocellular carcinoma(segment 4/8)underwent laparoscopic hepatectomy. About 5 hours after the start of the operation, SpO2 and systolic blood pressure suddenly dropped to 87% and 40 mmHg. EtCO2 level decreased to 8 mmHg and PaCO2 was 48.5 mmHg. Based on the discrepancy between the PaCO2 and EtCO2, the patient was diagnosed as having pneumoperitoneum-induced carbon dioxide embolism. The surgical procedure was immediately interrupted and the patient was hyperventilated with pure oxygen. After surgical interruption, general status was recovered to the normal condition. We carefully restarted the operation and completed it laparoscopically. The patient was discharged from the hospital on the 15th day without any postoperative complications. Carbon dioxide embolization is a serious life-threatening complication that requires careful monitoring.
MeSH term(s)	Male ; Humans ; Aged ; Carbon Dioxide ; Hepatectomy ; Laparoscopy/methods ; Liver Neoplasms/surgery ; Shock
Chemical Substances	Carbon Dioxide (142M471B3J)
Language	Japanese
Publishing date	2024-02-01
Publishing country	Japan
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	604842-0
ISSN	0385-0684
ISSN	0385-0684
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Article ; Online: Sonoembryological evaluations of the development of placenta previa and velamentous cord insertion.

Hasegawa, Junichi

The journal of obstetrics and gynaecology research

2015 Volume 41, Issue 1, Page(s) 1–5

Abstract: Longitudinal and cross-sectional investigations using ultrasound examinations during pregnancy can be used to clarify the mechanisms and pathophysiology of abnormal fetal and placental development. Such sonoembryological assessments are useful as a ... ...

Abstract	Longitudinal and cross-sectional investigations using ultrasound examinations during pregnancy can be used to clarify the mechanisms and pathophysiology of abnormal fetal and placental development. Such sonoembryological assessments are useful as a method for clarifying the etiology of disease. In the present review, we describe current knowledge based on our experience with applying sonoembryological methods to determine the developmental mechanisms of placenta previa and velamentous cord insertion.
MeSH term(s)	Female ; Humans ; Placenta/abnormalities ; Placenta Previa/diagnostic imaging ; Placenta Previa/etiology ; Pregnancy ; Pregnancy Trimester, First ; Ultrasonography, Prenatal ; Umbilical Cord/abnormalities ; Umbilical Cord/diagnostic imaging
Language	English
Publishing date	2015-01
Publishing country	Australia
Document type	Journal Article ; Review
ZDB-ID	1327307-3
ISSN	1447-0756 ; 1341-8076
ISSN (online)	1447-0756
ISSN	1341-8076
DOI	10.1111/jog.12531
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Article ; Online: Laparoscopic Right Hemicolectomy With Complete Mesocolic Excision and Central Vascular Ligation Using a Right Colon Rotation Technique (Flip-Flap Method).

Tei, Mitsuyoshi / Sueda, Toshinori / Yoshikawa, Yukihiro / Hasegawa, Junichi

The American surgeon

2022 Volume 89, Issue 5, Page(s) 1793–1797

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Humans ; Colonic Neoplasms/surgery ; Colic/surgery ; Laparoscopy/methods ; Colon, Ascending/surgery ; Mesocolon/surgery ; Colectomy/methods ; Ligation/methods ; Lymph Node Excision/methods
Language	English
Publishing date	2022-03-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	202465-2
ISSN	1555-9823 ; 0003-1348
ISSN (online)	1555-9823
ISSN	0003-1348
DOI	10.1177/00031348211033531
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Article: Ultrasound Doppler Findings in Fetal Vascular Malperfusion Due to Umbilical Cord Abnormalities: A Pilot Case Predictive for Cerebral Palsy.

Saji, Shota / Hasegawa, Junichi / Koike, Junki / Takatsuki, Misato / Furuya, Natsumi / Suzuki, Nao

Diagnostics (Basel, Switzerland)

2023 Volume 13, Issue 18

Abstract: Fetal Vascular Malperfusion (FVM), a pathologic condition in the feto-placental circulation, is a chronic vaso-occlusive disorder in the umbilical venous blood flow. Microthrombi are caused by the umbilical cord's blood flow deficiency in a congested ... ...

Abstract	Fetal Vascular Malperfusion (FVM), a pathologic condition in the feto-placental circulation, is a chronic vaso-occlusive disorder in the umbilical venous blood flow. Microthrombi are caused by the umbilical cord's blood flow deficiency in a congested umbilical vein, which also causes microvascular damage to fetal organs, especially the brain, resulting in cerebral palsy. Thrombo-occlusive events also adversely affect the upstream chorionic or stem vessels in the placenta, resulting in fetal growth restriction and fetal hypoxia. An umbilical cord structural anomaly or multiple entanglements may involve FVM. In the present report, we demonstrate a case of FVM caused by multiple umbilical cord abnormalities obtained from antenatal ultrasound Doppler findings, and we also discuss FVM, which is chronically associated with CP, comparing the ultrasonographic findings to the pathologic findings.
Language	English
Publishing date	2023-09-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics13182977
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Article ; Online: Optimal cervical-ripening method for labor induction in Japan after the era of controlled-release dinoprostone vaginal insert.

Furuya, Natsumi / Hasegawa, Junichi / Saji, Shota / Homma, Chika / Nishimura, Yoko / Suzuki, Nao

The journal of obstetrics and gynaecology research

2023 Volume 50, Issue 1, Page(s) 40–46

Abstract: Objective: To investigate the predictive value of obstetric findings when using dinoprostone (prostaglandin E2 [PGE2]) vaginal inserts for cervical ripening, and to assess the optimal cervical-ripening method between PGE2 vaginal insert and/or cervical ... ...

Abstract	Objective: To investigate the predictive value of obstetric findings when using dinoprostone (prostaglandin E2 [PGE2]) vaginal inserts for cervical ripening, and to assess the optimal cervical-ripening method between PGE2 vaginal insert and/or cervical dilators. Methods: This prospective observational study enrolled pregnant women who underwent cervical ripening for labor induction in 37-41 week' gestation in 2020. In evaluation 1, optimal obstetric findings predictive of rapid cervical ripening using PGE2 were assessed. In evaluation 2, the duration from PGE2 administration to labor onset and perinatal outcomes were compared between cases in which only PGE2 was used and cases that were treated with PGE2 after mechanical cervical dilators (Dilapan®) for extremely immature cervical ripening (uterine cervical os <2 cm). Results: In evaluation 1, uterine dilatation before the use of a PGE2 vaginal insert was mostly correlated with the time from PGE2 administration to labor onset (r = -0.428, p < 0.001). When the uterine cervical os dilatation was ≥2 cm, a shorter time-to-labor onset was found. In addition, os dilatation, effacement, and station at the time of PGE2 vaginal insert removal also significantly progressed. In evaluation 2, the median duration from PGE2 administration to labor onset was 1740 min in cases where only PGE2 was used, and 610 min in those where PGE2 was used after mechanical cervical dilators (p = 0.011). Conclusion: PGE2 vaginal inserts are relatively effective when the uterine cervical os is ≥2 cm in diameter. However, in cases of extremely immature cervical-ripening, it was feasible to use PGE2 vaginal inserts before mechanical cervical dilatation.
MeSH term(s)	Female ; Pregnancy ; Humans ; Dinoprostone/pharmacology ; Oxytocics/pharmacology ; Cervical Ripening ; Delayed-Action Preparations ; Japan ; Labor, Induced/methods ; Administration, Intravaginal
Chemical Substances	Dinoprostone (K7Q1JQR04M) ; Oxytocics ; Delayed-Action Preparations
Language	English
Publishing date	2023-10-11
Publishing country	Australia
Document type	Observational Study ; Journal Article
ZDB-ID	1327307-3
ISSN	1447-0756 ; 1341-8076
ISSN (online)	1447-0756
ISSN	1341-8076
DOI	10.1111/jog.15812
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