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  1. Article ; Online: Phase structure of harmonically mode-locked optical frequency combs.

    Hasegawa, Taro

    Optics express

    2024  Volume 32, Issue 5, Page(s) 8092–8100

    Abstract: Carrier phase of a harmonically mode-locked optical frequency comb (OFC) is investigated in detail. While harmonically mode-locked OFCs show promise for high-repetition-rate applications, their mode spacing is not the same as the pulse repetition rate, ... ...

    Abstract Carrier phase of a harmonically mode-locked optical frequency comb (OFC) is investigated in detail. While harmonically mode-locked OFCs show promise for high-repetition-rate applications, their mode spacing is not the same as the pulse repetition rate, unlike fundamentally mode-locked OFCs. Consequently, harmonically mode-locked OFCs are unsuitable for applications requiring OFCs with wide mode spacing. This study examines the pulse-to-pulse carrier phase evolution of 4th- and 5th-order harmonically mode-locked OFCs, revealing uneven carrier phase evolution responsible for the narrow mode spacing. The possibility of achieving harmonically mode-locked OFCs with wide mode spacing is suggested by implementing pulse-to-pulse phase modulation to ensure even phase evolution.
    Language English
    Publishing date 2024-03-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1491859-6
    ISSN 1094-4087 ; 1094-4087
    ISSN (online) 1094-4087
    ISSN 1094-4087
    DOI 10.1364/OE.516634
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Nuclear Quantum Dynamics of Three-Dimensional Condensed-Phase Systems by Constant Uncertainty Molecular Dynamics.

    Hasegawa, Taisuke

    The journal of physical chemistry letters

    2023  Volume 14, Issue 36, Page(s) 8043–8049

    Abstract: Constant uncertainty molecular dynamics (CUMD), which was developed to include nuclear quantum effects (NQEs) in molecular dynamics (MD) simulations, is extended to three-dimensional condensed-phase systems. Its applicability was verified via CUMD ... ...

    Abstract Constant uncertainty molecular dynamics (CUMD), which was developed to include nuclear quantum effects (NQEs) in molecular dynamics (MD) simulations, is extended to three-dimensional condensed-phase systems. Its applicability was verified via CUMD simulations of bulk water and ice Ih with the q-TIP4P/F potential model. The simulated radial distribution functions, proton momentum distributions, and infrared spectra were compared with those of previous studies in which the simulations were carried out on the basis of the imaginary-time path-integral formalism. We found that CUMD can function as an alternative trajectory-based simulation method for including static and dynamic NQEs in MD simulations of three-dimensional condensed-phase systems.
    Language English
    Publishing date 2023-08-31
    Publishing country United States
    Document type Journal Article
    ISSN 1948-7185
    ISSN (online) 1948-7185
    DOI 10.1021/acs.jpclett.3c01254
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Investigation of the body-centred tetragonal structure of Fe-Co-V-N Bulk foils using the rolling and ammonia-gas-nitriding method.

    Hasegawa, Takashi

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 5666

    Abstract: Improving the properties of permanent magnets is essential for the advancement of electric motors in reducing energy consumption and carbon emissions. This study investigated the effect of V and N addition to FeCo foils on the stability of tetragonally ... ...

    Abstract Improving the properties of permanent magnets is essential for the advancement of electric motors in reducing energy consumption and carbon emissions. This study investigated the effect of V and N addition to FeCo foils on the stability of tetragonally distorted FeCo-based bulk magnets. The incorporation of these two elements stabilised the body-centred tetragonal structure in thin-film and bulk systems. Fe-Co-V ingots were rolled and nitrided by ammonia gas at 650 °C for 5 h. A body-centred tetragonal lattice with an axial ratio of c/a ≈ 1.1 was observed by transmission electron microscopy, and the collected data suggested the induction of a large uniaxial magnetic anisotropy. This study is expected to improve our understanding of rare-earth-free magnets.
    Language English
    Publishing date 2023-04-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-32290-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: [Novel Treatment of Multiple System Atrophy in the Era of the New MDS Criteria].

    Hasegawa, Takafumi

    Brain and nerve = Shinkei kenkyu no shinpo

    2023  Volume 75, Issue 2, Page(s) 149–156

    Abstract: As our understanding of the pathogenesis of multiple system atrophy (MSA) continues to advance, significant research has focused on the development of disease-modifying therapies. In addition to inhibiting the aggregation of α-synuclein (αS) protein, a ... ...

    Abstract As our understanding of the pathogenesis of multiple system atrophy (MSA) continues to advance, significant research has focused on the development of disease-modifying therapies. In addition to inhibiting the aggregation of α-synuclein (αS) protein, a major culprit of MSA pathogenesis, disease-modifying drugs have been developed to mitigate cell-to-cell transmission of aggregated αS, thereby suppressing subsequent neuroinflammation, and release of trophic factors. However, most of these therapies have been unsuccessful. The diagnostic criteria for MSA have recently been revised to allow for earlier and more reliable diagnosis. In addition, clear criteria for prodromal MSA have been established, which is expected to narrow the translational gap.
    MeSH term(s) Humans ; Multiple System Atrophy ; alpha-Synuclein/metabolism
    Chemical Substances alpha-Synuclein
    Language Japanese
    Publishing date 2023-02-08
    Publishing country Japan
    Document type English Abstract ; Journal Article
    ZDB-ID 390389-8
    ISSN 1344-8129 ; 1881-6096 ; 0006-8969
    ISSN (online) 1344-8129
    ISSN 1881-6096 ; 0006-8969
    DOI 10.11477/mf.1416202295
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 398: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Author response to OSIN-D-23-00510, "Comment on: A multicenter retrospective study of the risk factors associated with medication-related osteonecrosis of the jaw after tooth extraction in patients receiving oral bisphosphonate therapy: can primary wound closure and a drug holiday really prevent MRONJ?"

    Hasegawa, Takumi

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

    2023  Volume 34, Issue 10, Page(s) 1809

    MeSH term(s) Humans ; Retrospective Studies ; Diphosphonates/adverse effects ; Bone Density Conservation Agents/adverse effects ; Osteonecrosis/chemically induced ; Tooth Extraction/adverse effects ; Risk Factors
    Chemical Substances Diphosphonates ; Bone Density Conservation Agents
    Language English
    Publishing date 2023-07-07
    Publishing country England
    Document type Multicenter Study ; Letter
    ZDB-ID 1064892-6
    ISSN 1433-2965 ; 0937-941X
    ISSN (online) 1433-2965
    ISSN 0937-941X
    DOI 10.1007/s00198-023-06835-2
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3163: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  6. Article: [Interpretation and Application of Restricted Mean Survival Time].

    Hasegawa, Takahiro

    Gan to kagaku ryoho. Cancer & chemotherapy

    2022  Volume 49, Issue 4, Page(s) 389–396

    Abstract: Many clinical research and studies evaluate a time-to-event data, illustrate survival curves, and conventionally report an estimated hazard ratio to express the magnitude of the treatment effect when comparing between groups. However, it may not be ... ...

    Abstract Many clinical research and studies evaluate a time-to-event data, illustrate survival curves, and conventionally report an estimated hazard ratio to express the magnitude of the treatment effect when comparing between groups. However, it may not be straightforward to interpret the hazard ratio clinically and statistically when the proportional hazards assumption is invalid. In some recent papers published in clinical journals, the use of restricted mean survival time(RMST)or t-year mean survival time is discussed as one of the alternative summary measures for the time-to-event data. The RMST is defined as the expected value of time-to-event limited to a specific time point corresponding to the area under the survival curve up to the specific time point. This article summarizes the necessary information to conduct statistical analysis using the RMST, including the definition and statistical properties of the RMST, and clinical and statistical meaning and interpretation as compared with other summary measures of time-to-event data by application examples.
    MeSH term(s) Humans ; Proportional Hazards Models ; Research Design ; Survival Rate
    Language Japanese
    Publishing date 2022-04-20
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 604842-0
    ISSN 0385-0684
    ISSN 0385-0684
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2573: Show issues Location:
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  7. Article ; Online: Celebrate the renewal of Analytical Sciences.

    Hasegawa, Takeshi

    Analytical sciences : the international journal of the Japan Society for Analytical Chemistry

    2022  Volume 38, Issue 1, Page(s) 9

    Language English
    Publishing date 2022-03-23
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 1483376-1
    ISSN 1348-2246 ; 1348-2246
    ISSN (online) 1348-2246
    ISSN 1348-2246
    DOI 10.1007/s44211-022-00054-1
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  8. Article ; Online: Updating the pathophysiology of arthritic bone destruction: identifying and visualizing pathological osteoclasts in pannus.

    Hasegawa, Tetsuo

    Immunological medicine

    2021  Volume 44, Issue 4, Page(s) 246–251

    Abstract: Osteoclasts have a unique capacity to destroy bone, playing key roles in physiological bone remodeling and arthritic bone erosion. It is not known whether the osteoclast populations in different tissue settings arise from similar monocytoid precursors. ... ...

    Abstract Osteoclasts have a unique capacity to destroy bone, playing key roles in physiological bone remodeling and arthritic bone erosion. It is not known whether the osteoclast populations in different tissue settings arise from similar monocytoid precursors. The rapid progress in the next-generation sequencing technologies has provided many valuable insights into the field of osteoimmunology, and single-cell RNA sequencing (scRNA-Seq) can elucidate cellular heterogeneity within the synovial microenvironment. The application of scRNA-Seq to the defined osteoclast precursor (OP)-containing population enabled the identification of individual cells differentiating into mature osteoclasts in the inflamed synovium, which were distinct from conventional OPs in the bone marrow. In addition, an intravital imaging system using multi-photon microscopy has been applied to the synovial tissues of arthritic mice to observe the real-time dynamics of osteoclasts and immune cells in the pannus. These technologies have contributed to elucidate the transcriptomics and dynamics of specific cells involved in pathological osteoclastogenesis, improving our understand of the pathophysiology of inflammatory osteolytic diseases. Here, we review how novel technologies such as scRNA-Seq and intravital imaging help to better understand the pathogenesis of bone erosion and we introduce recent studies that have identified and directly visualized pathological OPs in inflamed synovium.
    MeSH term(s) Animals ; Arthritis, Rheumatoid/diagnostic imaging ; Bone Resorption ; Mice ; Osteoclasts ; Pannus ; Synovial Membrane
    Language English
    Publishing date 2021-05-19
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2578-5826
    ISSN (online) 2578-5826
    DOI 10.1080/25785826.2021.1913883
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  9. Article ; Online: The Essence of Clinical Practice Guidelines for Ossification of Spinal Ligaments, 2019: 1. Epidemiology of OPLL.

    Hasegawa, Tomohiko

    Spine surgery and related research

    2021  Volume 5, Issue 5, Page(s) 318–321

    Language English
    Publishing date 2021-09-27
    Publishing country Japan
    Document type Journal Article
    ISSN 2432-261X
    ISSN (online) 2432-261X
    DOI 10.22603/ssrr.2021-0096
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Pancreatic Head Cancer Leading to Pancreatic Pseudocyst Resolved by Colonic Fistula Formation.

    Kazumori, Hideaki / Hasegawa, Tomoya

    The American journal of gastroenterology

    2024  

    Language English
    Publishing date 2024-03-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 390122-1
    ISSN 1572-0241 ; 0002-9270
    ISSN (online) 1572-0241
    ISSN 0002-9270
    DOI 10.14309/ajg.0000000000002724
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    Ui V Zs.36: Show issues Location:
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