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  1. Article: Scallop mantle extract inhibits insulin signaling in HepG2 cells

    Hasegawa, Yasushi

    Food Science & Nutrition, 7(6):2159-2166

    2019  

    Abstract: Scallops are important marine products in Hokkaido, Japan. Not only scallop adductor muscle but also mantle is often eaten at sashimi or smoking in Japan. We showed previously that feeding the scallop mantle epithelial cell layer causes an increase in ... ...

    Abstract Scallops are important marine products in Hokkaido, Japan. Not only scallop adductor muscle but also mantle is often eaten at sashimi or smoking in Japan. We showed previously that feeding the scallop mantle epithelial cell layer causes an increase in serum glucose concentration and the death of rats. To clarify the mechanism of glucose metabolism disorder by mantle epithelial cell layer, we investigated whether extracts from mantle tissue (mantle extract) induce insulin resistance using HepG2 cells. Mantle extract suppressed insulin‐stimulated phosphorylation of Akt, key protein which is involved in insulin signaling. In addition, treatment of HepG2 cells with mantle extract decreased significantly glycogen content and mRNA expression levels of glucose‐6‐phosphatase (G6Pase) and phosphoenolpyruvate carboxykinase (PEPCK) involved in gluconeogenesis, suggesting that mantle extract inhibits insulin signaling. These results show that mantle extract inhibits insulin signaling in HepG2 cells, suggesting that an increase in serum glucose concentration in vivo may be due to the inhibition of insulin signaling.
    Keywords HepG2 cell ; insulin signaling ; scallop mantle ; toxin
    Language English
    Document type Article
    Database Repository for Life Sciences

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  2. Article ; Online: Thermodynamic Correlation Inequality.

    Hasegawa, Yoshihiko

    Physical review letters

    2024  Volume 132, Issue 8, Page(s) 87102

    Abstract: Trade-off relations place fundamental limits on the operations that physical systems can perform. This Letter presents a trade-off relation that bounds the correlation function, which measures the relationship between a system's current and future states, ...

    Abstract Trade-off relations place fundamental limits on the operations that physical systems can perform. This Letter presents a trade-off relation that bounds the correlation function, which measures the relationship between a system's current and future states, in Markov processes. The obtained bound, referred to as the thermodynamic correlation inequality, states that the change in the correlation function has an upper bound comprising the dynamical activity, a thermodynamic measure of the activity of a Markov process. Moreover, by applying the obtained relation to the linear response function, it is demonstrated that the effect of perturbation can be bounded from above by the dynamical activity.
    Language English
    Publishing date 2024-03-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.132.087102
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  3. Article ; Online: Unifying speed limit, thermodynamic uncertainty relation and Heisenberg principle via bulk-boundary correspondence.

    Hasegawa, Yoshihiko

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 2828

    Abstract: The bulk-boundary correspondence provides a guiding principle for tackling strongly correlated and coupled systems. In the present work, we apply the concept of the bulk-boundary correspondence to thermodynamic bounds described by classical and quantum ... ...

    Abstract The bulk-boundary correspondence provides a guiding principle for tackling strongly correlated and coupled systems. In the present work, we apply the concept of the bulk-boundary correspondence to thermodynamic bounds described by classical and quantum Markov processes. Using the continuous matrix product state, we convert a Markov process to a quantum field, such that jump events in the Markov process are represented by the creation of particles in the quantum field. Introducing the time evolution of the continuous matrix product state, we apply the geometric bound to its time evolution. We find that the geometric bound reduces to the speed limit relation when we represent the bound in terms of the system quantity, whereas the same bound reduces to the thermodynamic uncertainty relation when expressed based on quantities of the quantum field. Our results show that the speed limits and thermodynamic uncertainty relations are two aspects of the same geometric bound.
    Language English
    Publishing date 2023-05-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-38074-8
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  4. Article ; Online: Thermodynamic uncertainty relation for quantum first-passage processes.

    Hasegawa, Yoshihiko

    Physical review. E

    2022  Volume 105, Issue 4-1, Page(s) 44127

    Abstract: We derive a thermodynamic uncertainty relation for first passage processes in quantum Markov chains. We consider first passage processes that stop after a fixed number of jump events, which contrasts with typical quantum Markov chains which end at a ... ...

    Abstract We derive a thermodynamic uncertainty relation for first passage processes in quantum Markov chains. We consider first passage processes that stop after a fixed number of jump events, which contrasts with typical quantum Markov chains which end at a fixed time. We obtain bounds for the observables of the first passage processes in quantum Markov chains by the Loschmidt echo, which quantifies the extent of irreversibility in quantum many-body systems. Considering a particular case, we show that the lower bound corresponds to the quantum Fisher information, which plays a fundamental role in uncertainty relations in quantum systems. Moreover, considering classical dynamics, our bound reduces to a thermodynamic uncertainty relation for classical first passage processes.
    Language English
    Publishing date 2022-04-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2844562-4
    ISSN 2470-0053 ; 2470-0045
    ISSN (online) 2470-0053
    ISSN 2470-0045
    DOI 10.1103/PhysRevE.105.044127
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  5. Article ; Online: New perspectives on obesity-induced adipose tissue fibrosis and related clinical manifestations.

    Hasegawa, Yutaka

    Endocrine journal

    2022  Volume 69, Issue 7, Page(s) 739–748

    Abstract: Adipose tissue is a complex heterogeneous tissue composed of adipocytes along with several non-adipocyte populations, including blood, stromal, endothelial, and progenitor cells, as well as extracellular matrix (ECM) components. As obesity progresses, ... ...

    Abstract Adipose tissue is a complex heterogeneous tissue composed of adipocytes along with several non-adipocyte populations, including blood, stromal, endothelial, and progenitor cells, as well as extracellular matrix (ECM) components. As obesity progresses, the adipose tissue expands dynamically through adipocyte hypertrophy and/or hyperplasia. This expansion requires continuous ECM remodeling to properly accommodate the size increase as well as functional changes. Upon reaching a hypertrophic threshold beyond the adipocyte buffering capacity, excess ECM components are deposited, causing fibrosis and ultimately resulting in unhealthy metabolic maladaptation. These complex ECM remodeling processes in adipose tissues are regulated by the local environment, several key mediators, and genetic factors that are closely linked to insulin sensitivity. It is crucial to understand how adipocytes interact with nonadipocyte populations and various mediators (i.e., immune cells, ECM components, and adipokines) during these processes. This mini-review provides an overview of the latest research into the biology of obesity-induced adipose tissue fibrosis and its related clinical manifestations, providing insight for further studies aimed at controlling metabolic syndrome and its comorbidities.
    MeSH term(s) Adipocytes/metabolism ; Adipose Tissue/metabolism ; Fibrosis ; Humans ; Insulin Resistance ; Obesity/metabolism
    Language English
    Publishing date 2022-06-08
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 1151918-6
    ISSN 1348-4540 ; 0918-8959
    ISSN (online) 1348-4540
    ISSN 0918-8959
    DOI 10.1507/endocrj.EJ22-0035
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  6. Book ; Online: Quantum thermodynamic uncertainty relation under feedback control

    Hasegawa, Yoshihiko

    2023  

    Abstract: The thermodynamic uncertainty relation posits that higher thermodynamic costs are essential for a system to function with greater precision. Recent discussions have expanded thermodynamic uncertainty relations beyond classical non-equilibrium systems, ... ...

    Abstract The thermodynamic uncertainty relation posits that higher thermodynamic costs are essential for a system to function with greater precision. Recent discussions have expanded thermodynamic uncertainty relations beyond classical non-equilibrium systems, investigating how quantum characteristics can be utilized to improve precision. In this Letter, we explore how quantum feedback, a control technique used to manipulate quantum systems, can enhance the precision. Specifically, we derive a quantum thermodynamic uncertainty relation for feedback control under jump measurement, which provides the lower bound to the scaled variance of the number of jumps. We find that the presence of feedback control can increase the accuracy of continuous measured systems, which is verified with numerical simulations. Moreover, we derive a quantum thermodynamic uncertainty relation for feedback control under homodyne detection.

    Comment: 6 pages, 2 figure; 4 pages of supplemental material
    Keywords Quantum Physics ; Condensed Matter - Statistical Mechanics
    Subject code 612
    Publishing date 2023-12-12
    Publishing country us
    Document type Book ; Online
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  7. Article ; Online: Thermodynamic Uncertainty Relation for General Open Quantum Systems.

    Hasegawa, Yoshihiko

    Physical review letters

    2021  Volume 126, Issue 1, Page(s) 10602

    Abstract: We derive a thermodynamic uncertainty relation for general open quantum dynamics, described by a joint unitary evolution on a composite system comprising a system and an environment. By measuring the environmental state after the system-environment ... ...

    Abstract We derive a thermodynamic uncertainty relation for general open quantum dynamics, described by a joint unitary evolution on a composite system comprising a system and an environment. By measuring the environmental state after the system-environment interaction, we bound the counting observables in the environment by the survival activity, which reduces to the dynamical activity in classical Markov processes. Remarkably, the relation derived herein holds for general open quantum systems with any counting observable and any initial state. Therefore, our relation is satisfied for classical Markov processes with arbitrary time-dependent transition rates and initial states. We apply our relation to continuous measurement and the quantum walk to find that the quantum nature of the system can enhance the precision. Moreover, we can make the lower bound arbitrarily small by employing appropriate continuous measurement.
    Language English
    Publishing date 2021-01-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.126.010602
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  8. Article ; Online: Irreversibility, Loschmidt Echo, and Thermodynamic Uncertainty Relation.

    Hasegawa, Yoshihiko

    Physical review letters

    2021  Volume 127, Issue 24, Page(s) 240602

    Abstract: Entropy production characterizes irreversibility. This viewpoint allows us to consider the thermodynamic uncertainty relation, which states that a higher precision can be achieved at the cost of higher entropy production, as a relation between precision ... ...

    Abstract Entropy production characterizes irreversibility. This viewpoint allows us to consider the thermodynamic uncertainty relation, which states that a higher precision can be achieved at the cost of higher entropy production, as a relation between precision and irreversibility. Considering the original and perturbed dynamics, we show that the precision of an arbitrary counting observable in continuous measurement of quantum Markov processes is bounded from below by the Loschmidt echo between the two dynamics, representing the irreversibility of quantum dynamics. When considering particular perturbed dynamics, our relation leads to several thermodynamic uncertainty relations, indicating that our relation provides a unified perspective on classical and quantum thermodynamic uncertainty relations.
    Language English
    Publishing date 2021-12-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.127.240602
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  9. Article ; Online: Lie Algebraic Quantum Phase Reduction.

    Setoyama, Wataru / Hasegawa, Yoshihiko

    Physical review letters

    2024  Volume 132, Issue 9, Page(s) 93602

    Abstract: We introduce a general framework of phase reduction theory for quantum nonlinear oscillators. By employing the quantum trajectory theory, we define the limit-cycle trajectory and the phase according to a stochastic Schrödinger equation. Because a ... ...

    Abstract We introduce a general framework of phase reduction theory for quantum nonlinear oscillators. By employing the quantum trajectory theory, we define the limit-cycle trajectory and the phase according to a stochastic Schrödinger equation. Because a perturbation is represented by unitary transformation in quantum dynamics, we calculate phase response curves with respect to generators of a Lie algebra. Our method shows that the continuous measurement yields phase clusters and alters the phase response curves. The observable clusters capture the phase dynamics of individual quantum oscillators, unlike indirect indicators obtained from density operators. Furthermore, our method can be applied to finite-level systems that lack classical counterparts.
    Language English
    Publishing date 2024-03-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.132.093602
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  10. Article ; Online: Quantum Thermodynamic Uncertainty Relation for Continuous Measurement.

    Hasegawa, Yoshihiko

    Physical review letters

    2020  Volume 125, Issue 5, Page(s) 50601

    Abstract: We use quantum estimation theory to derive a thermodynamic uncertainty relation in Markovian open quantum systems, which bounds the fluctuation of continuous measurements. The derived quantum thermodynamic uncertainty relation holds for arbitrary ... ...

    Abstract We use quantum estimation theory to derive a thermodynamic uncertainty relation in Markovian open quantum systems, which bounds the fluctuation of continuous measurements. The derived quantum thermodynamic uncertainty relation holds for arbitrary continuous measurements satisfying a scaling condition. We derive two relations; the first relation bounds the fluctuation by the dynamical activity and the second one does so by the entropy production. We apply our bounds to a two-level atom driven by a laser field and a three-level quantum thermal machine with jump and diffusion measurements. Our result shows that there exists a universal bound upon the fluctuations, regardless of continuous measurements.
    Language English
    Publishing date 2020-08-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.125.050601
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