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Article: Endovascular management of aortoiliac artery occlusive disease with pseudo-stenosis of the external iliac artery.

Matsushima, Hirokazu / Shintani, Tsunehiro / Kita, Hidenori / Hasegawa, Yuto

2024 Volume 2024, Issue 2, Page(s) rjae078

Abstract: In recent years, endovascular treatment has become the first-line revascularisation method for aortoiliac artery occlusive disease. Rarely, aortoiliac artery occlusive disease may be associated with stenosis of the external iliac artery (EIA) that ... ...

Abstract	In recent years, endovascular treatment has become the first-line revascularisation method for aortoiliac artery occlusive disease. Rarely, aortoiliac artery occlusive disease may be associated with stenosis of the external iliac artery (EIA) that suggested pseudo-stenosis. We describe a case of aortoiliac artery occlusive disease with EIA stenosis without calcification or atheroma. Stent grafts were inserted from the abdominal aorta to the bilateral common iliac arteries. Pre-operative computed tomography and intravascular ultrasound findings confirmed the absence of calcification or atheroma in both EIA, suggesting that the EIA had developed pseudo-stenosis. Following endovascular treatment, the EIA diameter recovered only with balloon dilation after inflow improvement. Consideration is necessary when placing an easy stent graft in the narrow EIA during endovascular treatment for aortoiliac artery occlusive disease with EIA stenosis to avoid a potential stent graft diameter mismatch.
Language	English
Publishing date	2024-02-13
Publishing country	England
Document type	Case Reports
ZDB-ID	2580919-2
ISSN	2042-8812
ISSN	2042-8812
DOI	10.1093/jscr/rjae078
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Article: Endovascular repair of a ruptured axillary artery during open reduction of the shoulder dislocation with humerus fracture.

Matsushima, Hirokazu / Shintani, Tsunehiro / Kita, Hidenori / Hasegawa, Yuto

Journal of surgical case reports

2023 Volume 2023, Issue 12, Page(s) rjad660

Abstract: Axillary artery injury secondary to shoulder dislocation with humerus fracture is rare. Rupture of the axillary artery during open reduction is extremely rare. Here, we report about a rare case of a ruptured axillary artery during an open reduction for ... ...

Abstract	Axillary artery injury secondary to shoulder dislocation with humerus fracture is rare. Rupture of the axillary artery during open reduction is extremely rare. Here, we report about a rare case of a ruptured axillary artery during an open reduction for shoulder dislocation with humerus fracture. A 58-year-old man with left shoulder pain because of a fall after alcohol consumption was diagnosed as having left shoulder dislocation with a humerus fracture. He underwent open reduction surgery. During the procedure, bleeding was observed, and further examination through angiography revealed an ruptured axillary artery. To address this urgent situation, stent grafts were promptly deployed retrogradely from the brachial artery. The postoperative course was uneventful, except for brachial plexus palsy. In the emergent setting, endovascular repair is an efficient alternative to conventional open surgery for controlling bleeding when a ruptured axillary artery occur during open reduction for shoulder dislocation.
Language	English
Publishing date	2023-12-05
Publishing country	England
Document type	Case Reports
ZDB-ID	2580919-2
ISSN	2042-8812
ISSN	2042-8812
DOI	10.1093/jscr/rjad660
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Article: Comparison of Genetic Structure between Endangered and Common Butterflies,

Hasegawa, Yuto / Takeuchi, Tsuyoshi / Ueda, Shouhei / Hirai, Norio

Zoological science

2020 Volume 37, Issue 2, Page(s) 109–116

Abstract: Genetic structures of two closely related butterflies, ...

Abstract	Genetic structures of two closely related butterflies,
MeSH term(s)	Animals ; Butterflies/classification ; Butterflies/enzymology ; Butterflies/genetics ; DNA, Mitochondrial/genetics ; Electron Transport Complex IV/genetics ; Gene Flow ; Genetic Variation ; Japan ; Life Cycle Stages ; Mitochondrial Proteins/genetics ; Species Specificity
Chemical Substances	DNA, Mitochondrial ; Mitochondrial Proteins ; Electron Transport Complex IV (EC 1.9.3.1)
Language	English
Publishing date	2020-04-13
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2038883-4
ISSN	2212-3830 ; 0289-0003
ISSN (online)	2212-3830
ISSN	0289-0003
DOI	10.2108/zs190002
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Article ; Online: Olfactory impairment in psychiatric disorders: Does nasal inflammation impact disease psychophysiology?

Hasegawa, Yuto / Ma, Minghong / Sawa, Akira / Lane, Andrew P / Kamiya, Atsushi

Translational psychiatry

2022 Volume 12, Issue 1, Page(s) 314

Abstract: Olfactory impairments contribute to the psychopathology of mental illnesses such as schizophrenia and depression. Recent neuroscience research has shed light on the previously underappreciated olfactory neural circuits involved in regulation of higher ... ...

Abstract	Olfactory impairments contribute to the psychopathology of mental illnesses such as schizophrenia and depression. Recent neuroscience research has shed light on the previously underappreciated olfactory neural circuits involved in regulation of higher brain functions. Although environmental factors such as air pollutants and respiratory viral infections are known to contribute to the risk for psychiatric disorders, the role of nasal inflammation in neurobehavioral outcomes and disease pathophysiology remains poorly understood. Here, we will first provide an overview of published findings on the impact of nasal inflammation in the olfactory system. We will then summarize clinical studies on olfactory impairments in schizophrenia and depression, followed by preclinical evidence on the neurobehavioral outcomes produced by olfactory dysfunction. Lastly, we will discuss the potential impact of nasal inflammation on brain development and function, as well as how we can address the role of nasal inflammation in the pathophysiological mechanisms underlying psychiatric disorders. Considering the current outbreak of Coronavirus Disease 2019 (COVID-19), which often causes nasal inflammation and serious adverse effects for olfactory function that might result in long-lasting neuropsychiatric sequelae, this line of research is particularly critical to understanding of the potential significance of nasal inflammation in the pathophysiology of psychiatric disorders.
MeSH term(s)	COVID-19 ; Humans ; Inflammation/complications ; Mental Disorders/psychology ; Olfaction Disorders/etiology ; Psychophysiology
Language	English
Publishing date	2022-08-05
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2609311-X
ISSN	2158-3188 ; 2158-3188
ISSN (online)	2158-3188
ISSN	2158-3188
DOI	10.1038/s41398-022-02081-y
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Article ; Online: Characterization of diterpene synthase genes in Brachypodium distachyon, a monocotyledonous model plant, provides evolutionary insight into their multiple homologs in cereals.

Shimada, Takeru / Minato, Shiho / Hasegawa, Yuto / Miyamoto, Koji / Minato, Yasumasa / Shenton, Matthew R / Okada, Kazunori / Kawaide, Hiroshi / Toyomasu, Tomonobu

Bioscience, biotechnology, and biochemistry

2023 Volume 88, Issue 1, Page(s) 8–15

Abstract: Gibberellins are diterpenoid phytohormones that regulate plant growth, and are biosynthesized from a diterpene intermediate, ent-kaurene, which is produced from geranylgeranyl diphosphate via ent-copalyl diphosphate (ent-CDP). The successive 2 ... ...

Abstract	Gibberellins are diterpenoid phytohormones that regulate plant growth, and are biosynthesized from a diterpene intermediate, ent-kaurene, which is produced from geranylgeranyl diphosphate via ent-copalyl diphosphate (ent-CDP). The successive 2 cyclization reactions are catalyzed by 2 distinct diterpene synthases, ent-CDP synthase (ent-CPS) and ent-kaurene synthase (KS). Various diterpene synthase genes involved in specialized metabolism were likely created through duplication and neofunctionalization of gibberellin-biosynthetic ent-CPS and KS genes in crops. Brachypodium distachyon is a monocotyledonous species that is a model plant in grasses. We herein found 1 ent-CPS gene homolog BdCPS and 4 tandemly arrayed KS-like genes BdKS1, KSL2, KSL3, and KSL4 in the B. distachyon genome, a simpler collection of paralogs than in crops. Phylogenetic and biochemical analyses showed that BdCPS and BdKS1 are responsible for gibberellin biosynthesis. BdKSL2 and BdKSL3 are suggested to be involved in specialized diterpenoid metabolism. Moreover, we restored KS activity of BdKSL2 through amino acid substitution.
MeSH term(s)	Gibberellins ; Edible Grain/metabolism ; Brachypodium/genetics ; Brachypodium/metabolism ; Phylogeny ; Alkyl and Aryl Transferases/genetics ; Diterpenes/metabolism ; Plant Proteins/genetics ; Plant Proteins/metabolism
Chemical Substances	Gibberellins ; Alkyl and Aryl Transferases (EC 2.5.-) ; Diterpenes ; Plant Proteins
Language	English
Publishing date	2023-10-13
Publishing country	England
Document type	Journal Article
ZDB-ID	1106450-x
ISSN	1347-6947 ; 0916-8451
ISSN (online)	1347-6947
ISSN	0916-8451
DOI	10.1093/bbb/zbad146
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Article ; Online: NV-5138 as a fast-acting antidepressant via direct activation of mTORC1 signaling.

Hasegawa, Yuto / Zhu, Xiaolei / Kamiya, Atsushi

The Journal of clinical investigation

2019 Volume 129, Issue 6, Page(s) 2207–2209

Abstract: Growing evidence implicates altered mTORC1 signaling cascades in the pathophysiology of depression, suggesting that direct modulation of mTORC1 signaling may offer novel therapeutic potential. In this issue of the JCI, Kato and colleagues reported that ... ...

Abstract	Growing evidence implicates altered mTORC1 signaling cascades in the pathophysiology of depression, suggesting that direct modulation of mTORC1 signaling may offer novel therapeutic potential. In this issue of the JCI, Kato and colleagues reported that administration of NV-5138, a recently developed synthetic leucine analog, has a rapid and sustained antidepressant action in rat models via activation of mTORC1 signaling. The investigators also found that the antidepressant effect of NV-5138 is mediated by upregulation of brain-derived neurotrophic factor (BDNF) signaling and that NV-5138 treatment produces rapid synaptic responses in the medial prefrontal cortex. These findings highlight the direct activation of mTORC1 signaling as a potential pharmacological intervention for the treatment of depression.
MeSH term(s)	Animals ; Antidepressive Agents ; Brain-Derived Neurotrophic Factor ; Depression ; Mechanistic Target of Rapamycin Complex 1 ; Rats ; Signal Transduction/drug effects
Chemical Substances	Antidepressive Agents ; Brain-Derived Neurotrophic Factor ; Mechanistic Target of Rapamycin Complex 1 (EC 2.7.11.1)
Language	English
Publishing date	2019-05-20
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Comment
ZDB-ID	3067-3
ISSN	1558-8238 ; 0021-9738
ISSN (online)	1558-8238
ISSN	0021-9738
DOI	10.1172/JCI129702
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Article: Variability of photosensitive period and voltinism among populations of a butterfly, Ypthima multistriata, inhabiting similar latitudes and altitudes

Hasegawa, Yuto / Takeuchi, Tsuyoshi / Hirai, Norio

Entomologia experimentalis et applicata. 2019 May, v. 167, no. 5

2019

Abstract: In Ypthima multistriata Butler (Lepidoptera: Nymphalidae), there are univoltine and bivoltine populations in adjacent areas with similar climatic conditions. A previous study revealed that larvae of both univoltine and bivoltine populations diapause ... ...

Abstract	In Ypthima multistriata Butler (Lepidoptera: Nymphalidae), there are univoltine and bivoltine populations in adjacent areas with similar climatic conditions. A previous study revealed that larvae of both univoltine and bivoltine populations diapause under a constant short day (i.e., a constant short light period; L13:D11), but not under a constant long‐day condition (L16:D8). However, in both types of populations, adults of an overwintering generation appear and oviposit in June and soon thereafter larvae hatch. Therefore, the younger larvae (at least the first instars) of both types of populations experience a long day; nevertheless, the larvae of univoltine populations diapause in nature. To resolve this inconsistency, we set up two hypotheses: (1) the photosensitive stage of larvae is the second instar or later, and (2) the photosensitive stage of univoltine populations is later than that of bivoltine populations. To test these hypotheses, we performed rearing experiments with two univoltine populations and two bivoltine ones. The results indicated that the photosensitive stage was the second or third instar and that the photosensitive stage was later in one univoltine population than in the two bivoltine populations. Larvae of the other univoltine population diapaused under all conditions. The former result supports our hypothesis, and the latter result indicates that the response to photoperiod is different among univoltine populations. In addition, larval development was slower in one univoltine population than in the bivoltine populations, which also delays the timing of the diapause decision in this univoltine population. Larvae that experienced a long day during the first and middle instars but experienced a short day at the end of their larval stage developed faster than larvae that experienced a constant long day. This may be an adaptation to enable emergence before the start of a cold season that is unsuitable for reproduction.
Keywords	Nymphalidae ; adults ; altitude ; butterflies ; climatic factors ; cold season ; diapause ; instars ; larvae ; larval development ; latitude ; overwintering ; oviposition ; photophase ; photosensitivity ; rearing ; univoltine habit
Language	English
Dates of publication	2019-05
Size	p. 467-475.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	216272-6
ISSN	0013-8703
ISSN	0013-8703
DOI	10.1111/eea.12799
Database	NAL-Catalogue (AGRICOLA)

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Article: Type B Acute Aortic Dissection as a Perioperative Complication after an Endovascular Abdominal Aortic Repair.

Natsume, Kayoko / Shintani, Tsunehiro / Hayahi, Masanori / Ohkura, Kazuhiro / Hasegawa, Yuto / Ariya, Takumi

Annals of vascular diseases

2021 Volume 14, Issue 1, Page(s) 83–87

Abstract: Type B aortic dissection (TBAD) is a rare but catastrophic complication of endovascular aneurysm repair (EVAR). We report two cases of TBAD occurring in the perioperative period of EVAR. The intraoperative and postoperative courses were unremarkable. ... ...

Abstract	Type B aortic dissection (TBAD) is a rare but catastrophic complication of endovascular aneurysm repair (EVAR). We report two cases of TBAD occurring in the perioperative period of EVAR. The intraoperative and postoperative courses were unremarkable. Routine postoperative computed tomography angiography (CTA) revealed TBAD. Conservative treatment was successful, and no adverse aortic events occurred. TBAD that occurs in the perioperative period is likely to be iatrogenic in origin, uncomplicated, and managed with medical therapy: its prognosis is better than when the condition develops in the midterm postoperative period.
Language	English
Publishing date	2021-03-03
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2394256-3
ISSN	1881-6428 ; 1881-641X
ISSN (online)	1881-6428
ISSN	1881-641X
DOI	10.3400/avd.cr.20-00107
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Article ; Online: Inflamed brain: Targeting immune changes and inflammation for treatment of depression.

Sakamoto, Shinji / Zhu, Xiaolei / Hasegawa, Yuto / Karma, Sadik / Obayashi, Mizuho / Alway, Emily / Kamiya, Atsushi

Psychiatry and clinical neurosciences

2021 Volume 75, Issue 10, Page(s) 304–311

Abstract: Although there are a number of clinically effective treatments for depression, many patients exhibit treatment resistance. Recent clinical and preclinical studies reveal that peripheral and brain immune changes and inflammation are involved in the ... ...

Abstract	Although there are a number of clinically effective treatments for depression, many patients exhibit treatment resistance. Recent clinical and preclinical studies reveal that peripheral and brain immune changes and inflammation are involved in the pathophysiology of depression. This 'Inflamed Brain' research provides critical clues for understanding of disease pathophysiology and many candidate molecules that are potentially useful for identifying novel drug targets for the treatment of depression. In this review, we will present clinical evidence on the role of inflammation in the pathophysiology of depression. We will also summarize current clinical trials which test drugs targeting inflammation for the treatment of patients with depression. Furthermore, we will briefly provide preclinical evidence demonstrating altered immune system function and inflammation in stress-induced animal models and will discuss the future potential of inflammation-related drug targets. Collectively, inflammatory signatures identified in clinical and preclinical studies may allow us to stratify depressive patients based on biotypes, contributing to the development of novel mechanism-based interventions that target specific patient populations.
MeSH term(s)	Animals ; Brain/drug effects ; Brain/immunology ; Brain/pathology ; Depression/complications ; Depression/drug therapy ; Depression/immunology ; Depression/pathology ; Humans ; Inflammation/complications ; Inflammation/drug therapy ; Inflammation/immunology ; Inflammation/pathology ; Stress, Psychological/complications ; Stress, Psychological/immunology ; Stress, Psychological/pathology
Language	English
Publishing date	2021-07-28
Publishing country	Australia
Document type	Journal Article ; Review
ZDB-ID	1292906-2
ISSN	1440-1819 ; 1323-1316
ISSN (online)	1440-1819
ISSN	1323-1316
DOI	10.1111/pcn.13286
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Article ; Online: Identification of Novel Oxindole Compounds That Suppress ER Stress-Induced Cell Death as Chemical Chaperones.

Hasegawa, Yuto / Motoyama, Masanari / Hamamoto, Akie / Kimura, Shintaro / Kamatari, Yuji O / Kamishina, Hiroaki / Oh-Hashi, Kentaro / Furuta, Kyoji / Hirata, Yoko

ACS chemical neuroscience

2022 Volume 13, Issue 7, Page(s) 1055–1064

Abstract: Endoplasmic reticulum (ER) stress and oxidative stress lead to protein misfolding, and the resulting accumulation of protein aggregates is often associated with the pathogenesis of neurodegenerative diseases, including Alzheimer's disease, Parkinson's ... ...

Abstract	Endoplasmic reticulum (ER) stress and oxidative stress lead to protein misfolding, and the resulting accumulation of protein aggregates is often associated with the pathogenesis of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and prion disease. Small molecules preventing these pathogenic processes may be effective interventions for such neurodegenerative disorders. In this paper, we identify several novel oxindole compounds that can prevent ER stress- and oxidative stress-induced cell death. Among them, derivatives of the lead compound GIF-0726-r in which a hydrogen atom at the oxindole ring 5 position is substituted with a methyl (GIF-0852-r), bromine (GIF-0854-r), or nitro (GIF-0856-r) group potently suppressed global ER stress. Furthermore, GIF-0854-r and -0856-r prevented protein aggregate accumulation
MeSH term(s)	Cell Death ; Endoplasmic Reticulum Stress ; Hippocampus/metabolism ; Oxindoles/pharmacology
Chemical Substances	Oxindoles ; 2-oxindole (0S9338U62H)
Language	English
Publishing date	2022-03-16
Publishing country	United States
Document type	Journal Article
ISSN	1948-7193
ISSN (online)	1948-7193
DOI	10.1021/acschemneuro.2c00064
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