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  1. Article ; Online: Patient Selection Criteria in Ambulatory Spine Surgery: Single Canadian Provincial Experience.

    Ajisebutu, Andrew / Hasen, Mohammed / Berrington, Neil / Dhaliwal, Perry

    World neurosurgery

    2023  Volume 178, Page(s) e213–e220

    Abstract: Background: Ambulatory spinal surgery is a care delivery model meant to improve patient outcomes and reduce in-hospital length of stay (LOS). We reviewed the experience of implementing an outpatient spine surgery program in Manitoba, Canada and ... ...

    Abstract Background: Ambulatory spinal surgery is a care delivery model meant to improve patient outcomes and reduce in-hospital length of stay (LOS). We reviewed the experience of implementing an outpatient spine surgery program in Manitoba, Canada and highlight elements that can be used to reduce LOS and re-presentation to hospital.
    Methods: This is a retrospective cohort study using data from the Canadian Spine Outcomes and Research Network and independent chart review of adult patients undergoing outpatient spinal surgery between 2015 and 2018. Patient demographics, comorbidities, perioperative course, LOS, and readmissions were analyzed.
    Results: We included 217 patients in this analysis. The mean LOS was 36.2 hours; 71.98% of patients had a LOS <24 hours. A Kruskal-Wallis test by ranks analysis was conducted and identified 7 elements that correlated with prolonged length of stay (>1 day): age older than 55 (P = 0.027), body mass index >25 (P = 0.045), uncontrolled diabetes (P = 0.015), preoperative use of opioid medication (P = 0.024), American Society of Anesthesiologists classification of 3 (P = 0.023), non-minimally invasive surgical approach, and multilevel procedures. Most (94.1%) of the patients with none of these elements (i.e., age <55, low body mass index, normal/controlled diabetes, minimal preoperative opioid use, American Society of Anesthesiologist classification <3, minimally invasive surgical procedure) had a favorable LOS, <24 hours, compared with 84.8% with 1 risk factor, 80.4% of those with two, 69.8% with three, 53.1% with four, and 31.2% with 5 or more. A small number of patients (14.98%) presented to an emergency department within 90 days of their operation, and there was a 6.28% readmission rate.
    Conclusions: We identified several patient and surgical criteria that correlate with prolonged length of stays following planned ambulatory spine surgery. Our work provides some empiric evidence to help guide surgeons on which patients and approaches are ideal for ambulatory surgery.
    MeSH term(s) Adult ; Humans ; Ambulatory Surgical Procedures ; Analgesics, Opioid/therapeutic use ; Canada ; Diabetes Mellitus/drug therapy ; Length of Stay ; Patient Readmission ; Patient Selection ; Postoperative Complications/drug therapy ; Retrospective Studies
    Chemical Substances Analgesics, Opioid
    Language English
    Publishing date 2023-07-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2023.07.034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Autonomic Dysfunction and Associations with Functional and Neurophysiological Outcome in Moderate/Severe Traumatic Brain Injury: A Scoping Review.

    Hasen, Mohammed / Almojuela, Alysa / Zeiler, Frederick A

    Journal of neurotrauma

    2019  Volume 36, Issue 10, Page(s) 1491–1504

    Abstract: The quantification and objective documentation of autonomic dysfunction in traumatic brain injury (TBI) is neither well studied nor extensively validated. Most of the descriptions of autonomic dysfunction in the literature are in the form of vague non- ... ...

    Abstract The quantification and objective documentation of autonomic dysfunction in traumatic brain injury (TBI) is neither well studied nor extensively validated. Most of the descriptions of autonomic dysfunction in the literature are in the form of vague non-specific clinical manifestations. Few studies propose the use of objective measures of assessing the extent of autonomic dysfunction to link them to the outcome of TBI. Our goal was to perform a scoping systematic review of the literature on the objective documentation of autonomic dysfunction in terms of functional and physiological variables to be linked to outcome of TBI. PubMed/MEDLINE
    MeSH term(s) Autonomic Nervous System Diseases/etiology ; Autonomic Nervous System Diseases/physiopathology ; Brain Injuries, Traumatic/complications ; Brain Injuries, Traumatic/physiopathology ; Humans ; Recovery of Function/physiology
    Language English
    Publishing date 2019-01-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Systematic Review
    ZDB-ID 645092-1
    ISSN 1557-9042 ; 0897-7151
    ISSN (online) 1557-9042
    ISSN 0897-7151
    DOI 10.1089/neu.2018.6073
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The Full Outline of UnResponsiveness (FOUR) Score and Its Use in Outcome Prediction: A Scoping Review of the Pediatric Literature.

    Almojuela, Alysa / Hasen, Mohammed / Zeiler, Frederick A

    Journal of child neurology

    2019  Volume 34, Issue 4, Page(s) 189–198

    Abstract: The Full Outline of UnResponsiveness (FOUR) score is a neurologic assessment score. Its benefit over pre-existing scores is its evaluation of brainstem reflexes and respiratory pattern. Our goal was to perform a scoping systematic review of the ... ...

    Abstract The Full Outline of UnResponsiveness (FOUR) score is a neurologic assessment score. Its benefit over pre-existing scores is its evaluation of brainstem reflexes and respiratory pattern. Our goal was to perform a scoping systematic review of the literature on the application of the FOUR score within pediatric patients. Six databases were searched and 2 reviewers independently screened the results. The initial search yielded 1709 citations; ultimately, 6 studies composed of 571 pediatric patients were used. Four studies examined interobserver reliability of the FOUR score and found it to be good to excellent. All 6 studies demonstrated equivalency of the FOUR score and Glasgow Coma Scale (GCS) in predicting outcome. The existing literature suggests the FOUR score is equivalent to GCS in outcome prediction in pediatric patients; its true superiority over the GCS has not yet been established. It displays good to excellent inter-rater reliability among physicians and nurses.
    MeSH term(s) Child ; Consciousness Disorders/diagnosis ; Glasgow Coma Scale ; Humans ; Neurologic Examination ; Prognosis ; Reproducibility of Results
    Language English
    Publishing date 2019-01-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 639288-x
    ISSN 1708-8283 ; 0883-0738
    ISSN (online) 1708-8283
    ISSN 0883-0738
    DOI 10.1177/0883073818822359
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Hypertonic Saline for Moderate Traumatic Brain Injury: A Scoping Review of Impact on Neurological Deterioration.

    Rossong, Heather / Hasen, Mohammed / Ahmed, Bilal / Zeiler, Frederick A / Dhaliwal, Perry

    Neurotrauma reports

    2020  Volume 1, Issue 1, Page(s) 253–260

    Abstract: Hypertonic saline (HTS) is a commonly administered agent for intracranial pressure (ICP) control in traumatic brain injury (TBI). The literature on its use is mainly in moderate/severe TBI where invasive ICP monitoring is present. The role of HTS in ... ...

    Abstract Hypertonic saline (HTS) is a commonly administered agent for intracranial pressure (ICP) control in traumatic brain injury (TBI). The literature on its use is mainly in moderate/severe TBI where invasive ICP monitoring is present. The role of HTS in patients with moderate TBI (mTBI) outside of the intensive care unit (ICU) setting remains unclear. The goal of this scoping review was to provide an overview of the available literature on HTS administration in patients with mTBI without ICP monitoring, assessing its impact on outcome and transitions in care. We performed a scoping systematic review of the literature of MEDLINE, Embase, Scopus, BIOSIS, and the Cochrane Databases from inception to July 31, 2020. We searched for those published articles documenting the administration of HTS in patients with mTBI with recorded functional outcome or transitions in hospital care. A two-step review process was conducted in accordance with methodology outlined in the
    Language English
    Publishing date 2020-12-15
    Document type Journal Article ; Review
    ISSN 2689-288X
    ISSN (online) 2689-288X
    DOI 10.1089/neur.2020.0056
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Using Fluorescein in the Resection of a Pediatric Posterior Fossa Tumor.

    Almojuela, Alysa / Honey, C Michael / Gomez, Alwyn / Hasen, Mohammed / MacDonald, Carling / Kazina, Colin / Serletis, Demitre

    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques

    2020  Volume 47, Issue 4, Page(s) 578–580

    MeSH term(s) Child, Preschool ; Female ; Fluorescein/administration & dosage ; Fluorescein/metabolism ; Fluorescent Dyes/administration & dosage ; Fluorescent Dyes/metabolism ; Humans ; Infratentorial Neoplasms/diagnostic imaging ; Infratentorial Neoplasms/metabolism ; Infratentorial Neoplasms/surgery ; Injections, Intravenous
    Chemical Substances Fluorescent Dyes ; Fluorescein (TPY09G7XIR)
    Language English
    Publishing date 2020-03-31
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 197622-9
    ISSN 0317-1671
    ISSN 0317-1671
    DOI 10.1017/cjn.2020.52
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Alternative continuous intracranial pressure-derived cerebrovascular reactivity metrics in traumatic brain injury: a scoping overview.

    Hasen, Mohammed / Gomez, Alwyn / Froese, Logan / Dian, Joshua / Raj, Rahul / Thelin, Eric P / Zeiler, Frederick A

    Acta neurochirurgica

    2020  Volume 162, Issue 7, Page(s) 1647–1662

    Abstract: Background: Pressure reactivity index (PRx) has emerged as a means to continuously monitor cerebrovascular reactivity in traumatic brain injury (TBI). However, other intracranial pressure (ICP)-based continuous metrics exist, and may have advantages ... ...

    Abstract Background: Pressure reactivity index (PRx) has emerged as a means to continuously monitor cerebrovascular reactivity in traumatic brain injury (TBI). However, other intracranial pressure (ICP)-based continuous metrics exist, and may have advantages over PRx. The goal of this study was to perform a scoping overview of the literature on non-PRx ICP-based continuous cerebrovascular reactivity metrics in adult TBI.
    Methods: We searched MEDLINE, BIOSIS, EMBASE, Global Health, SCOPUS, and Cochrane Library from inception to December 2019. Using a two-stage filtering of title/abstract, and then full manuscript, we identified pertinent articles. Data was abstracted to tables and each technique summarized, including pulse amplitude index (PAx), correlation between pulse amplitude of ICP and cerebral perfusion pressure (RAC), PRx
    Results: A total of 23 articles met the inclusion criteria, with the vast majority being retrospective in nature and based out of European centers. Sixteen articles focused on high-resolution metrics PAx, RAC, and PRx
    Conclusions: Non-PRx continuous ICP-based cerebrovascular reactivity metrics can be split into high-resolution and low-resolution measures. High-resolution indices include PAx, RAC, and PRx
    MeSH term(s) Benchmarking ; Brain Injuries, Traumatic/pathology ; Brain Injuries, Traumatic/physiopathology ; Cerebrovascular Circulation ; Heart Rate ; Homeostasis ; Humans ; Intracranial Pressure ; Monitoring, Physiologic/methods ; Monitoring, Physiologic/standards
    Language English
    Publishing date 2020-05-08
    Publishing country Austria
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80010-7
    ISSN 0942-0940 ; 0001-6268
    ISSN (online) 0942-0940
    ISSN 0001-6268
    DOI 10.1007/s00701-020-04378-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Conference proceedings: Morphometry of Vertebrae in Saudi Population with a Comparison to Other Population

    Hasen, Mohammed / Al-Habeeb, Husam / Molani, Fadhel

    Global Spine Journal

    2016  

    Abstract: Introduction: Precise anatomical knowledge of human vertebra is necessary for the safe placement of screws, pre-surgical planning and designing surgical instruments. There are no existed reports about the morphometry of vertebrae in Saudi population. ... ...

    Event/congress Global Spine Congress & World Forum for Spine Research, Grand Hyatt Dubai Convention Centre, Dubai, United Arab Emirates, 2016
    Abstract Introduction: Precise anatomical knowledge of human vertebra is necessary for the safe placement of screws, pre-surgical planning and designing surgical instruments. There are no existed reports about the morphometry of vertebrae in Saudi population. Methods: This is a descriptive study. A total of 50 spine CT was collected from the PACS system and reviewed for any abnormal pathology. Any CT with major pathology like tumor, fracture and deformity was excluded. Each vertebra was measured for the following parameters: 1- Pedicle Width. 2- Distance from Pedicle to Ant. Vertebrae. 3- Ant. Vertebrae width. 4- Canal Diameter. 5- Height of Pedicle. 6- Angle of Pedicle. All data was entered in statistical analysis program (SPSS) and compared with the existed date of other population. Result and Conclusion: The values of the parameters with the standard deviation have been concluded and compared with the Korean, Mexican, Israeli and Indian populations which shows remarkable difference and characteristic pattern important to be addressed in safe placement of screws, pre-surgical planning and designing surgical instruments.
    Language English
    Publishing date 2016-04-04
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ISSN 2192-5690 ; 2192-5682
    ISSN (online) 2192-5690
    ISSN 2192-5682
    DOI 10.1055/s-0036-1583037
    Database Thieme publisher's database

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  8. Article: Demographic and histopathological patterns of neuro-epithelial brain tumors in Eastern Province of Saudi Arabia.

    Taha, Mahmoud S / Almsned, Fahad M / Hasen, Mohammed / Atean, Ibrahim M / Alwbari, Ahmed M / Alharbi, Qasim K / Abdulkader, Marwah M / Almuhaish, Husam S

    Neurosciences (Riyadh, Saudi Arabia)

    2018  Volume 23, Issue 1, Page(s) 18–22

    Abstract: Objective: To review the demographic and pathological pattern of neuro-epithelial brain tumors in a tertiary referral center in the Eastern Province of Saudi Arabia and to compare the results of our study with other national and international studies.!## ...

    Abstract Objective: To review the demographic and pathological pattern of neuro-epithelial brain tumors in a tertiary referral center in the Eastern Province of Saudi Arabia and to compare the results of our study with other national and international studies.
    Methods: This is a retrospective chart-review study of all patients with neuro-epithelial brain tumors referred and treated in our center between January 2010 and January 2015. The age, gender, tumor location, and histopathology were recorded.
    Results: The total number of cases was 149 including 96 adult cases and 53 pediatric cases. 58% of cases were male, and 42% were female. The age group distribution showed 2 peaks; one in the first 5 years of life and the second was in the age range from 26-45 years old. Glioblastoma multiforme was the most common pathological type (32%), followed by medulloblastoma (13.3%). This study showed similar results to a previous study conducted in the Eastern Province in terms of age and gender distribution, but pathologically, the tumors diagnosed in our study were generally of a higher grading. When comparing our results to other international studies in nearby countries (Jordan and Egypt), we found similarities in pathological patterns and age distribution. However, when comparing our results to a western country (USA), we found considerable differences in the age group distribution.
    Conclusion: Neuro-epithelial brain tumors in Saudi Arabia affect younger population according to our study compared to Western countries. These findings are similar to other studies from Middle Eastern countries. In addition, our study showed a significant increase in high grade gliomas in the Eastern Province compared to an old historical study. This increase should be interpreted cautiously due to possible selection errors, changes in pathological grading, and expertise.
    MeSH term(s) Adolescent ; Adult ; Age Factors ; Brain Neoplasms/epidemiology ; Brain Neoplasms/pathology ; Child ; Child, Preschool ; Female ; Glioblastoma/epidemiology ; Glioblastoma/pathology ; Humans ; Infant ; Male ; Middle Aged ; Neoplasm Grading ; Saudi Arabia ; Sex Factors
    Language English
    Publishing date 2018-01-10
    Publishing country Saudi Arabia
    Document type Journal Article
    ZDB-ID 2214806-1
    ISSN 1319-6138
    ISSN 1319-6138
    DOI 10.17712/nsj.2018.1.20160543
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: A Canadian National Survey of the Neurosurgical Management of Intracranial Abscesses.

    Kameda-Smith, Michelle M / Ragulojan, Malavan / Hart, Shannon / Duda, Taylor R / MacLean, Mark A / Chainey, Jonathan / Aminnejad, Minoo / Rizzuto, Michael / Bergeron, David / Eagles, Mathew / Chalil, Alan / Langlois, Anne-Mare / Gariepy, Charles / Persad, Amit / Hasen, Mohammed / Wang, Alick / Elkaim, Lior / Christie, Sean / Farrokhyar, Forough /
    Reddy, Kesava

    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques

    2022  Volume 50, Issue 5, Page(s) 679–686

    Abstract: Objective: Intracerebral abscess is a life-threatening condition for which there are no current, widely accepted neurosurgical management guidelines. The purpose of this study was to investigate Canadian practice patterns for the medical and surgical ... ...

    Abstract Objective: Intracerebral abscess is a life-threatening condition for which there are no current, widely accepted neurosurgical management guidelines. The purpose of this study was to investigate Canadian practice patterns for the medical and surgical management of primary, recurrent, and multiple intracerebral abscesses.
    Methods: A self-administered, cross-sectional, electronic survey was distributed to active staff and resident members of the Canadian Neurosurgical Society and Canadian Neurosurgery Research Collaborative. Responses between subgroups were analyzed using the Chi-square test.
    Results: In total, 101 respondents (57.7%) completed the survey. The majority (60.0%) were staff neurosurgeons working in an academic, adult care setting (80%). We identified a consensus that abscesses >2.5 cm in diameter should be considered for surgical intervention. The majority of respondents were in favor of excising an intracerebral abscess over performing aspiration if located superficially in non-eloquent cortex (60.4%), located in the posterior fossa (65.4%), or causing mass effect leading to herniation (75.3%). The majority of respondents were in favor of reoperation for recurrent abscesses if measuring greater than 2.5 cm, associated with progressive neurological deterioration, the index operation was an aspiration and did not include resection of the abscess capsule, and if the recurrence occurred despite prior surgery combined with maximal antibiotic therapy. There was no consensus on the use of topical intraoperative antibiotics.
    Conclusion: This survey demonstrated heterogeneity in the medical and surgical management of primary, recurrent, and multiple brain abscesses among Canadian neurosurgery attending staff and residents.
    MeSH term(s) Adult ; Humans ; Cross-Sectional Studies ; Canada ; Brain Abscess/surgery ; Neurosurgical Procedures ; Neurosurgery ; Anti-Bacterial Agents/therapeutic use
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2022-10-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 197622-9
    ISSN 0317-1671
    ISSN 0317-1671
    DOI 10.1017/cjn.2022.299
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: A Method for Reconstruction of Severely Damaged Spinal Cord using Autologous Hematopoietic Stem Cells and Platelet-rich Protein as a Biological Scaffold.

    Ammar, Ahmed Sabry / Osman, Yasser / Hendam, Ahmed Taher / Hasen, Mohammed Ahmed / Al Rubaish, Fatma Abdullah / Al Nujaidi, Danya Yaagoub / Al Abbas, Faisal Mishal

    Asian journal of neurosurgery

    2017  Volume 12, Issue 4, Page(s) 681–690

    Abstract: Introduction: There have been attempts to alter the prognosis of severe spinal cord injury in different centers, but none of which have reliably altered the outcome. Some trials use stem cells (SCs) that produced widely differing results. We hereby add ... ...

    Abstract Introduction: There have been attempts to alter the prognosis of severe spinal cord injury in different centers, but none of which have reliably altered the outcome. Some trials use stem cells (SCs) that produced widely differing results. We hereby add our experience in our center of a surgical reconstruction of the damaged spinal cord using a mixture of SCs and Platelet-Rich Protein (PRP) with fibrin coated as a biological scaffold.
    Materials and methods: Four cases of severely damaged spinal cord have been operated for neurolysis and reconstruction of the spinal cord using SCs and platelet-rich protein (PRP) with fibrin coated harvested from the peripheral circulation of the patient. PRP serves to maintain the position of the SCs. One milliliter suspension contains an average of 2.8 × 10
    Results: One patient demonstrated motor and objective sensory improvement (
    Conclusion: SCs may play a role in restoring spinal cord functions. However, the unsolved problems of the use of SCs and related ethical issues should be addressed.
    Language English
    Publishing date 2017-08-29
    Publishing country India
    Document type Journal Article
    ZDB-ID 2621446-5
    ISSN 2248-9614 ; 1793-5482
    ISSN (online) 2248-9614
    ISSN 1793-5482
    DOI 10.4103/ajns.AJNS_351_16
    Database MEDical Literature Analysis and Retrieval System OnLINE

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