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  1. Article ; Online: Severe Dengue Epidemic, Sri Lanka, 2017

    Hasitha A. Tissera / Bernard D.W. Jayamanne / Rajendra Raut / Sakunthala M.D. Janaki / Yesim Tozan / Preshila C. Samaraweera / Prasad Liyanage / Azhar Ghouse / Chaturaka Rodrigo / Aravinda M. de Silva / Sumadhya D. Fernando

    Emerging Infectious Diseases, Vol 26, Iss 4, Pp 682-

    2020  Volume 691

    Abstract: In 2017, a dengue epidemic of unexpected magnitude occurred in Sri Lanka. A total of 186,101 suspected cases and 440 dengue-related deaths occurred. We conducted a comprehensive analysis of this epidemic by comparing national surveillance data for 2017 ... ...

    Abstract In 2017, a dengue epidemic of unexpected magnitude occurred in Sri Lanka. A total of 186,101 suspected cases and 440 dengue-related deaths occurred. We conducted a comprehensive analysis of this epidemic by comparing national surveillance data for 2017 with data from the preceding 5 years. In all Sri Lanka districts, dengue incidence in 2017 increased significantly over incidence during the previous 5 years. Older schoolchildren and young adults were more clinically symptomatic than those at extremes of age. Limited virologic surveillance showed the dominant circulating variant was dengue virus type 2 cosmopolitan genotype in the most affected district. One quarter of total annual cases were reported 5 weeks after the southwest monsoon started. Changes in vector abundance were not predictive of the increased incidence. Direct government expenditures on dengue control activities in 2017 were US $12.7 million. The lessons learned from this outbreak are useful for other tropical nations facing increasing dengue incidence.
    Keywords Dengue ; epidemic ; Sri Lanka ; surveillance ; serotype ; age group ; Medicine ; R ; Infectious and parasitic diseases ; RC109-216
    Language English
    Publishing date 2020-04-01T00:00:00Z
    Publisher Centers for Disease Control and Prevention
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Emergence and diversification of dengue 2 cosmopolitan genotype in Pakistan, 2011.

    Mohammad A Khan / Esther M Ellis / Hasitha A Tissera / Mohammad Y Alvi / Fatima F Rahman / Faisal Masud / Angelia Chow / Shiqin Howe / Vijaykrishna Dhanasekaran / Brett R Ellis / Duane J Gubler

    PLoS ONE, Vol 8, Iss 3, p e

    2013  Volume 56391

    Abstract: Major dengue epidemics have been observed in the Indian subcontinent since the 1980s and have occurred with increased hospitalizations and mortality. In 2011, the first major epidemic of dengue occurred in Lahore, the second largest city in Pakistan, and ...

    Abstract Major dengue epidemics have been observed in the Indian subcontinent since the 1980s and have occurred with increased hospitalizations and mortality. In 2011, the first major epidemic of dengue occurred in Lahore, the second largest city in Pakistan, and resulted in 21,685 confirmed cases and 350 deaths. To investigate the possible viral causes for the increased epidemic activity, we determined the predominant serotype and characterized the viruses genetically. Of 50 patients carefully selected as probable dengue fever or dengue hemorrhagic fever, 34 were positive by virologic testing (i.e. PCR and/or virus isolation). DENV-2 was detected in 32 patients and DENV-1 in two. A total of 24 partial and three full DENV genomes were sequenced. Phylogenetic analyses of the capsid (C), pre-membrane (prM), and envelope genes comprising 2500 nucleotides in length indicated that all DENV-2 isolates in Pakistan since 2007 form a monophyletic lineage that is endemic in the country. These viruses were all of the cosmopolitan genotype (IV) and most closely related to viruses isolated in India and Sri Lanka in the past two decades. Phylogenetic analyses of data currently available in GenBank suggest that the Cosmopolitan genotype has diverged into two geographically distinct sub-lineages: sub-lineage IV-a has only been observed in Southeast Asia, China and Oceania, while IV-b is prevalent in the Indian subcontinent. These results highlight the increased diversity of dengue viruses as they spread geographically within the region.
    Keywords Medicine ; R ; Science ; Q
    Subject code 572
    Language English
    Publishing date 2013-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Severe Dengue Epidemics in Sri Lanka, 2003–2006

    Nalaka Kanakaratne / Wahala M.P.B. Wahala / William B. Messer / Hasitha A. Tissera / Aruna Shahani / Nihal Abeysinghe / Aravinda M. de Silva / Maya Gunasekera

    Emerging Infectious Diseases, Vol 15, Iss 2, Pp 192-

    2009  Volume 199

    Abstract: Recent emergence of dengue hemorrhagic fever in the Indian subcontinent has been well documented in Sri Lanka. We compare recent (2003–2006) and past (1980–1997) dengue surveillance data for Sri Lanka. The 4 dengue virus (DENV) serotypes have been ... ...

    Abstract Recent emergence of dengue hemorrhagic fever in the Indian subcontinent has been well documented in Sri Lanka. We compare recent (2003–2006) and past (1980–1997) dengue surveillance data for Sri Lanka. The 4 dengue virus (DENV) serotypes have been cocirculating in Sri Lanka for >30 years. Over this period, a new genotype of DENV-1 has replaced an old genotype. Moreover, new clades of DENV-3 genotype III viruses have replaced older clades. Emergence of new clades of DENV-3 in 1989 and 2000 coincided with abrupt increases in the number of reported dengue cases, implicating this serotype in severe epidemics. In 1980–1997, most reported dengue cases were in children. Recent epidemics have been characterized by many cases in children and adults. Changes in local transmission dynamics and genetic changes in DENV-3 are likely increasing emergence of severe dengue epidemics in Sri Lanka.
    Keywords Dengue ; dengue hemorrhagic fever ; dengue serotype 3 ; flavivirus ; molecular epidemiology ; phylogeny ; Medicine ; R ; Infectious and parasitic diseases ; RC109-216
    Subject code 028
    Language English
    Publishing date 2009-02-01T00:00:00Z
    Publisher Centers for Disease Control and Prevention
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: New Dengue Virus Type 1 Genotype in Colombo, Sri Lanka

    Hasitha A. Tissera / Eng Eong Ooi / Duane J. Gubler / Ying Tan / Barathy Logendra / Wahala M.P.B. Wahala / Aravinda M. de Silva / M.R. Nihal Abeysinghe / Paba Palihawadana / Sunethra Gunasena / Clarence C. Tam / Ananda Amarasinghe / G. William Letson / Harold S. Margolis / Aruna Dharshan De Silva

    Emerging Infectious Diseases, Vol 17, Iss 11, Pp 2053-

    2011  Volume 2055

    Abstract: The number of cases and severity of disease associated with dengue infection in Sri Lanka has been increasing since 1989, when the first epidemic of dengue hemorrhagic fever was recorded. We identified a new dengue virus 1 strain circulating in Sri Lanka ...

    Abstract The number of cases and severity of disease associated with dengue infection in Sri Lanka has been increasing since 1989, when the first epidemic of dengue hemorrhagic fever was recorded. We identified a new dengue virus 1 strain circulating in Sri Lanka that coincided with the 2009 dengue epidemic.
    Keywords dengue ; dengue hemorrhagic fever ; dengue virus ; viruses ; genotype ; flavivirus ; Medicine ; R ; Infectious and parasitic diseases ; RC109-216
    Language English
    Publishing date 2011-11-01T00:00:00Z
    Publisher Centers for Disease Control and Prevention
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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