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  1. Article: Spontaneous Acalculous Gallbladder Perforation in an Adolescent Male: A Case Report and Literature Review.

    Ajmal, Hassan Bin / Hasnain, Nimra / Sagheer, Saima

    Cureus

    2021  Volume 13, Issue 12, Page(s) e20077

    Abstract: Though a rare event, gallbladder perforation (GBP) can occur in children and adolescents in the absence of pre-existing cholelithiasis. Moreover, type 1 perforation is seldom found in this cohort. Vague clinical presentation and inconclusive routine ... ...

    Abstract Though a rare event, gallbladder perforation (GBP) can occur in children and adolescents in the absence of pre-existing cholelithiasis. Moreover, type 1 perforation is seldom found in this cohort. Vague clinical presentation and inconclusive routine investigations can often result in delayed diagnosis. Computed tomography (CT) and intraoperative diagnosis should be utilized to timely diagnose and prevent fatal outcomes. Here, we present a rare case of type 1 GBP in an otherwise healthy 15-year-old boy with no known underlying etiology. Our purpose is to emphasize that although rare, a high clinical suspicion of GBP should be kept in mind even when dealing with acute abdomen in a pediatric population for preventing associated mortality.
    Language English
    Publishing date 2021-12-01
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.20077
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Efficacy of Positron Emission Tomography in distinguishing brain tumours from inflammation.

    Hasnain, Nimra / Mustafa, Rabia Maryam / Bakhshi, Saqib Kamran / Shamim, Muhammad Shahzad

    JPMA. The Journal of the Pakistan Medical Association

    2021  Volume 70, Issue 12(A), Page(s) 2291–2293

    Abstract: Positron Emission Tomography (PET) enables noninvasive evaluation of brain tumours, most commonly gliomas and metastases. However, the application of PET in distinguishing a tumour from an inflammatory lesion is still uncertain. The principle of this ... ...

    Abstract Positron Emission Tomography (PET) enables noninvasive evaluation of brain tumours, most commonly gliomas and metastases. However, the application of PET in distinguishing a tumour from an inflammatory lesion is still uncertain. The principle of this imaging test is based on fundamental differences in the central metabolic pathways in neoplastic and non-neoplastic tissues. 2-deoxy-2-fluoro-D-glucose (FDG) is the most widely used PET marker, whose uptake is closely related to the expression of the glucose transporter (GLUT) in malignant tumours. A limitation of FDG-PET studies is false-positive results, e.g., due to inflammation. This problem may be overcome by the use of different radiotracers targeted at different cellular sites; these include, fluoroethyl-l-tyrosine (FET), C- methionine (c- MET), 13-N ammonia, translocator receptor protein (TSPO) and ligand-11C-PK11195. All markers show variable diagnostic potential, however, more prospective trials are required to prove the efficacy.
    MeSH term(s) Brain Neoplasms/diagnostic imaging ; Fluorodeoxyglucose F18 ; Glioma/diagnostic imaging ; Humans ; Inflammation/diagnostic imaging ; Positron-Emission Tomography ; Prospective Studies ; Radiopharmaceuticals ; Receptors, GABA
    Chemical Substances Radiopharmaceuticals ; Receptors, GABA ; TSPO protein, human ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2021-01-21
    Publishing country Pakistan
    Document type Journal Article
    ZDB-ID 603873-6
    ISSN 0030-9982
    ISSN 0030-9982
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 845: Show issues Location:
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  3. Article ; Online: Efficacy of bariatric surgery in COVID-19 patients: An updated systematic review and meta-analysis.

    Hasnain, Nimra / Moeed, Abdul / Waqar, Eisha / Farhan, Syed Ali / Amreek, Fnu

    Surgery in practice and science

    2022  Volume 11, Page(s) 100140

    Abstract: Introduction: Obesity is linked with poor outcomes in patients with SARS-CoV-2 infection. In patients with BMI > 35 kg/m: Methods: An extensive literature search was conducted of electronic databases. Screening of the articles based on the ... ...

    Abstract Introduction: Obesity is linked with poor outcomes in patients with SARS-CoV-2 infection. In patients with BMI > 35 kg/m
    Methods: An extensive literature search was conducted of electronic databases. Screening of the articles based on the eligibility criteria was followed by relevant data extraction. In addition to articles used in a previous meta-analysis, relevant databases were searched to filter for any new articles. Initially, two independent reviewers screened Pubmed and the Cochrane database followed by a thorough search of additional databases such as Google scholar and Medrxiv. Articles were first screened using title and abstract, followed by a full text read. Duplicates, meta-analysis, letter to the editors, and commentaries were excluded. No language restrictions were applied.
    Results: A total of nine articles with a population of 1,130,341 were entered into RevMan. Patients with bariatric surgery displayed significantly decreased hospitalization (OR: 0.52, 95% CI [0.45, 0.61]), were less likely to be admitted to the ICU (OR: 0.44, 95% CI [0.29, 0.67]), and had reduced overall mortality (OR: 0.42, 95% CI [0.25, 0.70]).
    Conclusion: Surgically induced weight loss is beneficial in reducing morbidity and mortality of COVID-19.
    Language English
    Publishing date 2022-10-28
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2666-2620
    ISSN (online) 2666-2620
    DOI 10.1016/j.sipas.2022.100140
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Association between sex and Huntington's disease: an updated review on symptomatology and prognosis of neurodegenerative disorders.

    Hasnain, Nimra / Arif, Taha Bin / Shafaut, Roha / Zakaria, Faiza / Fatima, Syeda Zainab / Haque, Ibtehaj Ul

    Wiener medizinische Wochenschrift (1946)

    2022  Volume 174, Issue 5-6, Page(s) 87–94

    Abstract: Huntington's disease is a rare autosomal dominant disorder presenting with chorea, rigidity, hypo-/akinesia, cognitive decline, and psychiatric disturbances. Numerous risk factors have been defined in the onset of this disease. However, the number of CAG ...

    Title translation Zusammenhang zwischen Geschlecht und Huntington-Chorea: aktualisierte Übersicht zur Symptomatologie und Prognose neurodegenerativer Erkrankungen.
    Abstract Huntington's disease is a rare autosomal dominant disorder presenting with chorea, rigidity, hypo-/akinesia, cognitive decline, and psychiatric disturbances. Numerous risk factors have been defined in the onset of this disease. However, the number of CAG repeats in the genes are the most crucial factor rendering patients susceptible to the disease. Studies have shown significant differences in onset and disease presentation among the sexes, which prompts analysis of the impact of different sexes on disease etiology and progression. This article therefore discusses the evidence-based role of sex in aspects of symptomatology, pathogenesis, biomarkers, progression, and prognosis of Huntington's disease, with a secondary review of sex-linked differences in Alzheimer's and Parkinson's disease.
    MeSH term(s) Humans ; Huntington Disease/diagnosis ; Huntington Disease/genetics ; Huntington Disease/psychology ; Prognosis
    Language English
    Publishing date 2022-06-20
    Publishing country Austria
    Document type Journal Article ; Review
    ZDB-ID 123613-1
    ISSN 1563-258X ; 0254-7945 ; 0043-5341
    ISSN (online) 1563-258X
    ISSN 0254-7945 ; 0043-5341
    DOI 10.1007/s10354-022-00941-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 903: Show issues Location:
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  5. Article: Frequency and Association of Stress Levels with Modes of Commuting Among Medical Students of a Developing Country.

    Jahangeer, Syed Muhammad Ashraf / Hasnain, Nimra / Tariq, Muhammad Taha / Jamil, Ammara / Zia, Syeda Yamna / Amir, Washma

    The Malaysian journal of medical sciences : MJMS

    2021  Volume 28, Issue 4, Page(s) 113–122

    Abstract: Introduction: This study aimed at determining the frequency and association of stress levels with modes of transportation and was likely to reveal the contributing transportation-related factors for stress in medical students.: Methods: This was a ... ...

    Abstract Introduction: This study aimed at determining the frequency and association of stress levels with modes of transportation and was likely to reveal the contributing transportation-related factors for stress in medical students.
    Methods: This was a questionnaire-based, cross-sectional study that included undergraduate medical students of a public sector medical university in Karachi, Pakistan. A total of 573 students participated voluntarily, of which 300 were provided a manual questionnaire and 273 filled it online. The reliability of the questionnaire was assessed using Cronbach's alpha at 0.791. The collected data were analysed using IBM SPSS Statistics for Windows, version 21.0.
    Results: Out of 573 participants, 99.3%
    Conclusion: Poor transportation has adverse effects on health and academic performance. Administration in their respective jurisdictions is needed to investigate this matter to make commuting a routine rather than a hassle.
    Language English
    Publishing date 2021-08-26
    Publishing country Malaysia
    Document type Journal Article
    ZDB-ID 2197205-9
    ISSN 2180-4303 ; 1394-195X
    ISSN (online) 2180-4303
    ISSN 1394-195X
    DOI 10.21315/mjms2021.28.4.12
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Infective Endocarditis Associated with Atrial Septal Defect in an Intravenous Drug Abuser: A Case Report.

    Jahangir, Maha / Nawaz, Marrium / Jabbar, Fareha / Khan, Fahad / Hasnain, Nimra

    Cureus

    2018  Volume 10, Issue 4, Page(s) e2482

    Abstract: Atrial septal defect (ASD) is a common congenital abnormality, which accounts for 20-40% of all the adult patients with congenital heart diseases. Due to the slow velocity of shunt flow, ASD has a negligible risk for infective endocarditis (IE). However, ...

    Abstract Atrial septal defect (ASD) is a common congenital abnormality, which accounts for 20-40% of all the adult patients with congenital heart diseases. Due to the slow velocity of shunt flow, ASD has a negligible risk for infective endocarditis (IE). However, intravenous drug abuse (IVDA) is a potential cause for IE. IE remains a diagnostic and therapeutic challenge. Our case report demonstrates the atypical presentation of IE in an ASD patient. The diagnosis was made on the basis of modified Duke criteria, and blood cultures were found out to be positive for methicillin-resistant Staphylococcus aureus (MRSA). The treatment for IE was completed in six weeks with full recovery, and the patient underwent a surgery for ASD closure. This case highlights that IE should not be overlooked in ASD patients and that a high index of suspicion, in addition to proper antibiotic therapy, is lifesaving. Also, follow-up, along with rehabilitation measures, should be taken for patients with a history of drug abuse in order to prevent the risk of reinfection.
    Language English
    Publishing date 2018-04-15
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.2482
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Ticagrelor versus prasugrel for secondary prevention after percutaneous coronary intervention: A systematic review and meta-analysis.

    Ahmed, Jawad / Hasnain, Nimra / Malik, Farheen / Siddiqi, Tariq Jamal / Usman, Muhammad Shariq / Alkhouli, Mohamad

    European journal of preventive cardiology

    2019  Volume 27, Issue 19, Page(s) 2267–2271

    MeSH term(s) Cardiovascular Diseases/prevention & control ; Humans ; Percutaneous Coronary Intervention ; Platelet Aggregation Inhibitors/therapeutic use ; Prasugrel Hydrochloride/therapeutic use ; Secondary Prevention ; Ticagrelor/therapeutic use
    Chemical Substances Platelet Aggregation Inhibitors ; Prasugrel Hydrochloride (G89JQ59I13) ; Ticagrelor (GLH0314RVC)
    Language English
    Publishing date 2019-11-07
    Publishing country England
    Document type Letter ; Meta-Analysis ; Systematic Review
    ZDB-ID 2626011-6
    ISSN 2047-4881 ; 2047-4873
    ISSN (online) 2047-4881
    ISSN 2047-4873
    DOI 10.1177/2047487319885194
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4686: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Prophylactic Mesh Placement for the Prevention of Incisional Hernia in High-Risk Patients After Abdominal Surgery: A Systematic Review and Meta-Analysis.

    Ahmed, Jawad / Hasnain, Nimra / Fatima, Iayla / Malik, Farheen / Chaudhary, Muhammad A / Ahmad, Junaid / Malik, Mehreen / Malik, Laraib / Osama, Muhammad / Baig, Mirza Zain / Khosa, Faisal / Bhora, Faiz

    Cureus

    2020  Volume 12, Issue 9, Page(s) e10491

    Abstract: Background and objectives In high-risk populations, the efficacy of mesh placement in incisional hernia (IH) prevention after elective abdominal surgeries has been supported by many published studies. This meta-analysis aimed at providing comprehensive ... ...

    Abstract Background and objectives In high-risk populations, the efficacy of mesh placement in incisional hernia (IH) prevention after elective abdominal surgeries has been supported by many published studies. This meta-analysis aimed at providing comprehensive and updated clinical implications of prophylactic mesh placement (PMP) for the prevention of IH as compared to primary suture closure (PSC). Materials and methods PubMed, Science Direct, Cochrane, and Google Scholar were systematically searched until March 3, 2020, for studies comparing the efficacy of PMP to PSC in abdominal surgeries. The main outcome of interest was the incidence of IH at different follow-up durations. All statistical analyses were carried out using Review Manager version 5.3 (The Nordic Cochrane Centre, The Cochrane Collaboration, 2014) and Stata 11.0 (Stata Corporation LP, College Station, TX). The data were pooled using the random-effects model, and odds ratio (OR) and weighted mean differences (WMD) were calculated with the corresponding 95% confidence interval (CI). Results A total of 3,330 were identified initially and after duplicate removal and exclusion based on title and abstract, 26 studies comprising 3,000 patients, were included. The incidence of IH was significantly reduced for PMP at follow-up periods of one year (OR= 0.16 [0.05, 0.51]; p=0.002; I
    Language English
    Publishing date 2020-09-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.10491
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Glioblastome Multiforme: A Bibliometric Analysis.

    Akmal, Manahil / Hasnain, Nimra / Rehan, Aiman / Iqbal, Unzela / Hashmi, Shariq / Fatima, Kaneez / Farooq, Muhammad Zain / Khosa, Faisal / Siddiqi, Javed / Khan, Mohammad K

    World neurosurgery

    2020  Volume 136, Page(s) 270–282

    Abstract: Bibliometric analyses are widely used to gauge the scholarly impact of any scientific publication. We conducted a bibliometric analysis of the 100 most influential articles on glioblastoma multiforme (GBM). We searched Scopus using the keywords " ... ...

    Abstract Bibliometric analyses are widely used to gauge the scholarly impact of any scientific publication. We conducted a bibliometric analysis of the 100 most influential articles on glioblastoma multiforme (GBM). We searched Scopus using the keywords "Glioblastoma multiforme," "GBM," Glioblastoma," and "Grade IV glioma." A list of the top 100 articles was prepared. The articles were sorted according to the number of citations. A detailed analysis was carried out to identify the characteristics of the most influential studies. The 100 most cited articles in the field were published over 38 years between 1978 and 2018, with the maximum number of articles published in the 10-year period from 2001 to 2010. The total number of citations for 100 articles was 148,594 and 4.8% were self-citations. Citations ranged from 9624 to 617, with a median of 935 (interquartile range, 906). The top cited articles originated from 22 countries, with the greatest contributions from the United States. Nature made the greatest contribution to the research on GBM, with a total of 14 articles, and Cancer Cell and New England Journal of Medicine were the second biggest contributors. Fifty-seven studies focused on the pathogenesis of GBM. There were 12 authors who had ≥5 articles in the top 100 citation list. Only 31% of the articles were funded by public and private sector organizations. Our analysis highlights the characteristics of the most influential articles on GBM and provides valuable insight into the research that has been conducted in this field.
    MeSH term(s) Bibliometrics ; Glioblastoma ; Humans ; Journal Impact Factor ; Periodicals as Topic/statistics & numerical data ; Research Support as Topic/statistics & numerical data
    Language English
    Publishing date 2020-01-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2020.01.027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1159: Show issues Location:
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