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Article ; Online: Display of Professionalism of the Highest Standard.

Sim, Joong Hiong / Hassan, Hamimah

Academic medicine : journal of the Association of American Medical Colleges

2017 Volume 93, Issue 1, Page(s) 11–12

MeSH term(s)	Learning ; Professionalism
Language	English
Publishing date	2017-12-24
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	96192-9
ISSN	1938-808X ; 1040-2446
ISSN (online)	1938-808X
ISSN	1040-2446
DOI	10.1097/ACM.0000000000002007
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Article ; Online: In vitro properties of designed antimicrobial peptides that exhibit potent antipneumococcal activity and produces synergism in combination with penicillin.

Le, Cheng-Foh / Yusof, Mohd Yasim Mohd / Hassan, Hamimah / Sekaran, Shamala Devi

Scientific reports

2015 Volume 5, Page(s) 9761

Abstract: Antimicrobial peptides (AMPs) represent a promising class of novel antimicrobial agents owing to their potent antimicrobial activity. In this study, two lead peptides from unrelated classes of AMPs were systematically hybridized into a series of five ... ...

Abstract	Antimicrobial peptides (AMPs) represent a promising class of novel antimicrobial agents owing to their potent antimicrobial activity. In this study, two lead peptides from unrelated classes of AMPs were systematically hybridized into a series of five hybrid peptides (DM1-DM5) with conserved N- and C-termini. This approach allows sequence bridging of two highly dissimilar AMPs and enables sequence-activity relationship be detailed down to single amino acid level. Presence of specific amino acids and physicochemical properties were used to describe the antipneumococcal activity of these hybrids. Results obtained suggested that cell wall and/or membrane targeting could be the principal mechanism exerted by the hybrids leading to microbial cell killing. Moreover, the pneumocidal rate was greater than penicillin (PEN). Combination treatment with both DMs and PEN produced synergism. The hybrids were also broad spectrum against multiple common clinical bacteria. Sequence analysis showed that presence of specific residues has a major role in affecting the antimicrobial and cell toxicity of the hybrids than physicochemical properties. Future studies should continue to investigate the mechanisms of actions, in vivo therapeutic potential, and improve rational peptide design based on the current strategy.
Language	English
Publishing date	2015-05-18
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/srep09761
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Article ; Online: Using students' formative feedback to advocate reflective teaching.

Foong, Chan Choong / Hassan, Hamimah / Lee, Shuh Shing / Vadivelu, Jamuna

Medical education

2015 Volume 49, Issue 5, Page(s) 535

MeSH term(s)	Education, Medical/standards ; Faculty, Medical/standards ; Formative Feedback ; Humans ; Students, Medical ; Teaching
Language	English
Publishing date	2015-05
Publishing country	England
Document type	Journal Article
ZDB-ID	195274-2
ISSN	1365-2923 ; 0308-0110
ISSN (online)	1365-2923
ISSN	0308-0110
DOI	10.1111/medu.12697
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Article ; Online: Development of an instrument to measure medical students' perceptions of the assessment environment: initial validation.

Hiong Sim, Joong / Ting Tong, Wen / Hong, Wei-Han / Vadivelu, Jamuna / Hassan, Hamimah

Medical education online

2015 Volume 20, Issue 1, Page(s) 28612

Abstract: Introduction Assessment environment, synonymous with climate or atmosphere, is multifaceted. Although there are valid and reliable instruments for measuring the educational environment, there is no validated instrument for measuring the assessment ... ...

Abstract	Introduction Assessment environment, synonymous with climate or atmosphere, is multifaceted. Although there are valid and reliable instruments for measuring the educational environment, there is no validated instrument for measuring the assessment environment in medical programs. This study aimed to develop an instrument for measuring students' perceptions of the assessment environment in an undergraduate medical program and to examine the psychometric properties of the new instrument. Method The Assessment Environment Questionnaire (AEQ), a 40-item, four-point (1=Strongly Disagree to 4=Strongly Agree) Likert scale instrument designed by the authors, was administered to medical undergraduates from the authors' institution. The response rate was 626/794 (78.84%). To establish construct validity, exploratory factor analysis (EFA) with principal component analysis and varimax rotation was conducted. To examine the internal consistency reliability of the instrument, Cronbach's α was computed. Mean scores for the entire AEQ and for each factor/subscale were calculated. Mean AEQ scores of students from different academic years and sex were examined. Results Six hundred and eleven completed questionnaires were analysed. EFA extracted four factors: feedback mechanism (seven items), learning and performance (five items), information on assessment (five items), and assessment system/procedure (three items), which together explained 56.72% of the variance. Based on the four extracted factors/subscales, the AEQ was reduced to 20 items. Cronbach's α for the 20-item AEQ was 0.89, whereas Cronbach's α for the four factors/subscales ranged from 0.71 to 0.87. Mean score for the AEQ was 2.68/4.00. The factor/subscale of 'feedback mechanism' recorded the lowest mean (2.39/4.00), whereas the factor/subscale of 'assessment system/procedure' scored the highest mean (2.92/4.00). Significant differences were found among the AEQ scores of students from different academic years. Conclusions The AEQ is a valid and reliable instrument. Initial validation supports its use to measure students' perceptions of the assessment environment in an undergraduate medical program.
Language	English
Publishing date	2015-01
Publishing country	United States
Document type	Journal Article
ISSN	1087-2981
ISSN (online)	1087-2981
DOI	10.3402/meo.v20.28612
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Article ; Online: Development of an instrument to measure medical students' perceptions of the assessment environment: initial validation.

Sim, Joong Hiong / Tong, Wen Ting / Hong, Wei-Han / Vadivelu, Jamuna / Hassan, Hamimah

Medical education online

2015 Volume 20, Page(s) 28612

Abstract: Introduction: Assessment environment, synonymous with climate or atmosphere, is multifaceted. Although there are valid and reliable instruments for measuring the educational environment, there is no validated instrument for measuring the assessment ... ...

Abstract	Introduction: Assessment environment, synonymous with climate or atmosphere, is multifaceted. Although there are valid and reliable instruments for measuring the educational environment, there is no validated instrument for measuring the assessment environment in medical programs. This study aimed to develop an instrument for measuring students' perceptions of the assessment environment in an undergraduate medical program and to examine the psychometric properties of the new instrument. Method: The Assessment Environment Questionnaire (AEQ), a 40-item, four-point (1=Strongly Disagree to 4=Strongly Agree) Likert scale instrument designed by the authors, was administered to medical undergraduates from the authors' institution. The response rate was 626/794 (78.84%). To establish construct validity, exploratory factor analysis (EFA) with principal component analysis and varimax rotation was conducted. To examine the internal consistency reliability of the instrument, Cronbach's α was computed. Mean scores for the entire AEQ and for each factor/subscale were calculated. Mean AEQ scores of students from different academic years and sex were examined. Results: Six hundred and eleven completed questionnaires were analysed. EFA extracted four factors: feedback mechanism (seven items), learning and performance (five items), information on assessment (five items), and assessment system/procedure (three items), which together explained 56.72% of the variance. Based on the four extracted factors/subscales, the AEQ was reduced to 20 items. Cronbach's α for the 20-item AEQ was 0.89, whereas Cronbach's α for the four factors/subscales ranged from 0.71 to 0.87. Mean score for the AEQ was 2.68/4.00. The factor/subscale of 'feedback mechanism' recorded the lowest mean (2.39/4.00), whereas the factor/subscale of 'assessment system/procedure' scored the highest mean (2.92/4.00). Significant differences were found among the AEQ scores of students from different academic years. Conclusions: The AEQ is a valid and reliable instrument. Initial validation supports its use to measure students' perceptions of the assessment environment in an undergraduate medical program.
MeSH term(s)	Cross-Sectional Studies ; Educational Measurement/methods ; Factor Analysis, Statistical ; Female ; Formative Feedback ; Humans ; Learning ; Male ; Perception ; Principal Component Analysis ; Psychometrics ; Reproducibility of Results ; Students, Medical/psychology ; Surveys and Questionnaires/standards
Language	English
Publishing date	2015
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1087-2981
ISSN (online)	1087-2981
DOI	10.3402/meo.v20.28612
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: In vitro activity of tigecycline against Acinetobacter baumannii isolates from a teaching hospital in Malaysia.

Dhabaan, Ghulam N / AbuBakar, Sazaly / Shorman, M A / Hassan, Hamimah

Journal of chemotherapy (Florence, Italy)

2012 Volume 24, Issue 2, Page(s) 87–92

Abstract: The In vitro susceptibility of clinical and environmental isolates of Acinetobacter baumannii to tigecycline and other antibiotics was determined by disk diffusion method. The E-test was used to determine the minimum inhibitory concentration (MIC). The ... ...

Abstract	The In vitro susceptibility of clinical and environmental isolates of Acinetobacter baumannii to tigecycline and other antibiotics was determined by disk diffusion method. The E-test was used to determine the minimum inhibitory concentration (MIC). The growth curves of tigecycline treated environmental and clinical strains were established. Fifty-seven percent and 75% of the clinical and environmental isolates were MDR strains, respectively. Ninety-five percent of the clinical isolates were susceptible to tigecycline and 5% showed intermediate resistance with MIC ranging between 0.032 and 3 mg/l. Tigecycline susceptible and intermediate resistance among the environmental isolates were 40% and 60%, respectively, with a significantly lower MIC range of 0.5-4 mg/l. The bacterial growth curves demonstrated the higher ability of the environmental strains to tolerate the antibiotic effects than the clinical strains. The relatively high resistance profile among the environmental isolate suggests an insidious emergence of tigecycline resistance amongst A. baumannii. Strict infection control procedures are imperative to prevent the dissemination of tigecycline-resistant A. baumannii strains in the hospital environment.
MeSH term(s)	Acinetobacter Infections/drug therapy ; Acinetobacter Infections/microbiology ; Acinetobacter baumannii/drug effects ; Acinetobacter baumannii/growth & development ; Acinetobacter baumannii/isolation & purification ; Anti-Bacterial Agents/pharmacology ; Drug Resistance, Bacterial ; Hospitals, Teaching ; Humans ; In Vitro Techniques ; Malaysia ; Microbial Sensitivity Tests ; Minocycline/analogs & derivatives ; Minocycline/pharmacology
Chemical Substances	Anti-Bacterial Agents ; tigecycline (70JE2N95KR) ; Minocycline (FYY3R43WGO)
Language	English
Publishing date	2012-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1036294-0
ISSN	1973-9478 ; 1120-009X
ISSN (online)	1973-9478
ISSN	1120-009X
DOI	10.1179/1120009X12Z.00000000017
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Article ; Online: Proteinase, phospholipase, biofilm forming abilities and antifungal susceptibilities of Malaysian Candida isolates from blood cultures.

Tay, Sun Tee / Abidin, Ira Azzura Zainal / Hassan, Hamimah / Ng, Kee Peng

Medical mycology

2011 Volume 49, Issue 5, Page(s) 556–560

Abstract: This study was conducted to determine the proteinase, phospholipase, and biofilm forming abilities of Candida isolates in blood cultures of specimens from patients at the University Malaya Medical Center, Kuala Lumpur, Malaysia. Proteinase and ... ...

Abstract	This study was conducted to determine the proteinase, phospholipase, and biofilm forming abilities of Candida isolates in blood cultures of specimens from patients at the University Malaya Medical Center, Kuala Lumpur, Malaysia. Proteinase and phospholipase activities were detected in 93.7% and 73.3%, respectively, of 15 Candida albicans isolates. Amongst the 26 non-C. albicans Candida isolates, proteinase and phospholipase activities were detected in 88.5% and 7.7% of the isolates, respectively. There was no significant difference in the expression levels of proteinase amongst the Candida isolates studied (P = 0.272), but the phospholipase activity of C. albicans was significantly higher than that of the non-C. albicans Candida isolates (P = 0.003). There was no significant difference in the biofilm forming abilities of C. albicans and non-C. albicans Candida isolates on the polystyrene microtiter wells (P = 0.379). In addition, the findings of this study demonstrate increased resistance of Candida isolates in biofilms to amphotericin and fluconazole, as compared to their planktonic counterparts.
MeSH term(s)	Academic Medical Centers ; Antifungal Agents/pharmacology ; Biofilms/growth & development ; Candida albicans/drug effects ; Candida albicans/enzymology ; Candida albicans/isolation & purification ; Candida albicans/physiology ; Candidemia/microbiology ; Humans ; Malaysia ; Microbial Sensitivity Tests ; Peptide Hydrolases/biosynthesis ; Phospholipases/biosynthesis
Chemical Substances	Antifungal Agents ; Phospholipases (EC 3.1.-) ; Peptide Hydrolases (EC 3.4.-)
Language	English
Publishing date	2011-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1421796-x
ISSN	1460-2709 ; 1369-3786
ISSN (online)	1460-2709
ISSN	1369-3786
DOI	10.3109/13693786.2010.551424
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Article ; Online: High Prevalence of Toxigenic and Nontoxigenic Clostridium difficile Strains in Malaysia.

Riley, Thomas V / Collins, Deirdre A / Karunakaran, Rina / Kahar, Maria Abdul / Adnan, Ariza / Hassan, Siti Asma / Zainul, Nadiah Hanim / Rustam, F R Mohammed / Wahab, Z Abd / Ramli, Ramliza / Lee, Yeong Yeh / Hassan, Hamimah

Journal of clinical microbiology

2018 Volume 56, Issue 6

Abstract: Accumulating evidence shows a high prevalence ... ...

Abstract	Accumulating evidence shows a high prevalence of
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Bacterial Proteins/genetics ; Bacterial Toxins/genetics ; Clostridioides difficile/genetics ; Clostridioides difficile/isolation & purification ; Clostridium Infections/epidemiology ; DNA, Bacterial/genetics ; Diarrhea/epidemiology ; Diarrhea/microbiology ; Enterotoxins/genetics ; Feces/chemistry ; Feces/microbiology ; Female ; Glutamate Dehydrogenase/analysis ; Humans ; Immunoenzyme Techniques ; Indonesia/epidemiology ; Malaysia/epidemiology ; Male ; Middle Aged ; Polymerase Chain Reaction ; Prevalence ; Ribotyping ; Thailand/epidemiology ; Young Adult
Chemical Substances	Bacterial Proteins ; Bacterial Toxins ; DNA, Bacterial ; Enterotoxins ; tcdA protein, Clostridium difficile ; toxB protein, Clostridium difficile ; Glutamate Dehydrogenase (EC 1.4.1.2)
Language	English
Publishing date	2018-05-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	390499-4
ISSN	1098-660X ; 0095-1137
ISSN (online)	1098-660X
ISSN	0095-1137
DOI	10.1128/JCM.00170-18
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Article ; Online: Fatal case of amoebic liver abscess in a child.

Ng, Khuen Foong / Tan, Kah Kee / Ngui, Romano / Lim, Yvonne Al / Amir, Amirah / Rajoo, Yamuna / Hassan, Hamimah / Mahmud, Rohela

Asian Pacific journal of tropical medicine

2015 Volume 8, Issue 10, Page(s) 878–880

Abstract: We reported a case of amoebic liver abscess (ALA) in a 6-year-old Malaysian boy who presented with fever, lethargy, diarrhoea and right hypochondriac pain. On admission he was diagnosed with perforated acute appendicitis and a laparotomy was done. After ... ...

Abstract	We reported a case of amoebic liver abscess (ALA) in a 6-year-old Malaysian boy who presented with fever, lethargy, diarrhoea and right hypochondriac pain. On admission he was diagnosed with perforated acute appendicitis and a laparotomy was done. After surgery he developed acute respiratory distress. Ultrasonography, chest X-Ray and CT scan revealed two ALAs in the posterior segment of right lobe of liver, pleural effusion and collapsed consolidation of lungs bilaterally. Percutaneous liver abscesses drainage was done and intravenous Metronidazole was started. PCR carried out on the pus from the abscess was positive for Entamoeba histolytica. Patient however succumbed to the infection one week after admission.
Language	English
Publishing date	2015-10
Publishing country	China
Document type	Journal Article
ISSN	2352-4146
ISSN (online)	2352-4146
DOI	10.1016/j.apjtm.2015.09.018
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Article ; Online: Activity of Novel Synthetic Peptides against Candida albicans.

Lum, Kah Yean / Tay, Sun Tee / Le, Cheng Foh / Lee, Vannajan Sanghiran / Sabri, Nadia Hanim / Velayuthan, Rukumani Devi / Hassan, Hamimah / Sekaran, Shamala Devi

Scientific reports

2015 Volume 5, Page(s) 9657

Abstract: Candida spp. are the most common causes of fungal infections worldwide. Among the Candida species, Candida albicans remains the predominant species that causes invasive candidiasis in most countries. In this study, we used two peptides, KABT-AMP and ... ...

Abstract	Candida spp. are the most common causes of fungal infections worldwide. Among the Candida species, Candida albicans remains the predominant species that causes invasive candidiasis in most countries. In this study, we used two peptides, KABT-AMP and uperin 3.6 as templates to develop novel antifungal peptides. Their anticandidal activity was assessed using a combination of MIC, time-killing assay and biofilm reduction assay. Hybrid peptides, KU2 and KU3 containing a mixed backbone of KABT-AMP and Uperin 3.6 demonstrated the most potent anticandidal activity with MIC values ranging from 8-16 mg/L. The number of Trp residues and the amphipathic structure of peptides probably enhanced the anticandidal activity of peptides. Increasing the cationicity of the uperin 3.6 analogues resulted in reduced MIC from the range of 64-128 mg/L to 16-64 mg/L and this was also correlated with the antibiofilm activity and killing kinetics of the peptides. Peptides showed synergistic effects when used in combination with conventional antifungals. Peptides demonstrated low haemolytic activity but significant toxicity on two normal human epithelial cell lines. This study provides us with a better understanding on the structure-activity relationship and the balance between cationicity and hydrophobicity of the peptides although the therapeutic application of the peptides is limited.
MeSH term(s)	Antifungal Agents/chemical synthesis ; Antifungal Agents/chemistry ; Antifungal Agents/pharmacology ; Candida albicans/growth & development ; Candidiasis/drug therapy ; Humans ; Peptides/chemical synthesis ; Peptides/chemistry ; Peptides/pharmacology
Chemical Substances	Antifungal Agents ; Peptides
Language	English
Publishing date	2015-05-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/srep09657
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