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  1. Article ; Online: Shedding lights on diagnostic challenges in Wilson's disease: The positive impact of introducing steatotic liver disease new nomenclature umbrella.

    Hassan, Marwa Khalaf / Alswat, Khalid / El-Kassas, Mohamed

    Liver international : official journal of the International Association for the Study of the Liver

    2024  Volume 44, Issue 5, Page(s) 1267–1268

    MeSH term(s) Humans ; Hepatolenticular Degeneration/diagnosis ; Liver ; Copper ; Fatty Liver
    Chemical Substances Copper (789U1901C5)
    Language English
    Publishing date 2024-02-12
    Publishing country United States
    Document type Letter
    ZDB-ID 2102783-3
    ISSN 1478-3231 ; 1478-3223
    ISSN (online) 1478-3231
    ISSN 1478-3223
    DOI 10.1111/liv.15868
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Clinical characteristics of human fascioliasis in Egypt.

    Ibrahim, Nagat / Abdel Khalek, Ekram M / Makhlouf, Nahed A / Abdel-Gawad, Muhammad / Mekky, Mohamed / Ramadan, Haidi Karam-Allah / Abu-Elfatth, Ahmed / El-Latif, Naglaa Abd / Hassan, Marwa Khalaf / Eldeeb, Rabab / Abdelmalek, Mohamed / Abd-Elsalam, Sherief / Attia, Hanaa / Mohammed, Ahmed Qasem / Aboalam, Hani / Farouk, Mahmoud / Alboraie, Mohamed

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 16254

    Abstract: There is a lack of epidemiological data on fascioliasis in Egypt regarding disease characteristics and treatment outcomes across different governorates. We aimed to identify the demographic, epidemiologic, clinical, laboratory, and radiological ... ...

    Abstract There is a lack of epidemiological data on fascioliasis in Egypt regarding disease characteristics and treatment outcomes across different governorates. We aimed to identify the demographic, epidemiologic, clinical, laboratory, and radiological characteristics and treatment outcomes of patients diagnosed with fascioliasis in Egypt. Data on human fascioliasis were collected retrospectively from patients' medical records in the period between January 2018 and January 2020. The study included 261 patients. More than 40% of enrolled patients were in the age group of 21-40 years old. Geographically, 247 (94.6%) were from Assiut Governorate with 69.3% were from rural areas. The most frequent symptoms were right upper quadrant pain (96.9%), and fever (80.1%). Eosinophilia was found in 250 cases (95.8%). Hepatic focal lesions were detected in 131 (50.2%); out of them 64/131 (48.9%) had a single lesion. All patients received a single dose of 10 mg/kg of triclabendazole, 79.7% responded well to a single dose, while in 20.3% a second ± a third dose of treatment was requested. After therapy, there was a reduction in leucocytes, Fasciola antibodies titer, eosinophilic count, bilirubin, and liver enzymes with an increase in hemoglobin level. According to our findings, a high index of suspicion should be raised in cases with fever, right upper abdominal pain, and peripheral eosinophilia, and further imaging workup is mandated to detect hepatic focal lesions. Prompt treatment by triclabendazole can serve as a standard-of-care regimen even for suspected cases.
    MeSH term(s) Animals ; Humans ; Young Adult ; Adult ; Fascioliasis/diagnostic imaging ; Fascioliasis/drug therapy ; Triclabendazole/therapeutic use ; Retrospective Studies ; Egypt/epidemiology ; Abdominal Pain ; Eosinophilia ; Fasciola hepatica
    Chemical Substances Triclabendazole (4784C8E03O)
    Language English
    Publishing date 2023-09-27
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-42957-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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