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Article ; Online: Bioengineering vascularized liver tissue for biomedical research and application.

Davoodi, Parsa / Rezaei, Niloofar / Hassan, Moustapha / Hay, David C / Vosough, Massoud

Scandinavian journal of gastroenterology

2024 Volume 59, Issue 5, Page(s) 623–629

Abstract: The liver performs a wide range of biological functions that are essential to body homeostasis. Damage to liver tissue can result in reduced organ function, and if chronic in nature can lead to organ scarring and progressive disease. Currently, donor ... ...

Abstract	The liver performs a wide range of biological functions that are essential to body homeostasis. Damage to liver tissue can result in reduced organ function, and if chronic in nature can lead to organ scarring and progressive disease. Currently, donor liver transplantation is the only longterm treatment for end-stage liver disease. However, orthotopic organ transplantation suffers from several drawbacks that include organ scarcity and lifelong immunosuppression. Therefore, new therapeutic strategies are required. One promising strategy is the engineering of implantable and vascularized liver tissue. This resource could also be used to build the next generation of liver tissue models to better understand human health, disease and aging
MeSH term(s)	Humans ; Tissue Engineering/methods ; Liver/blood supply ; Organoids ; Liver Transplantation ; Bioprinting/methods ; Biomedical Research ; Neovascularization, Physiologic ; Bioengineering ; Animals
Language	English
Publishing date	2024-02-06
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	82042-8
ISSN	1502-7708 ; 0036-5521
ISSN (online)	1502-7708
ISSN	0036-5521
DOI	10.1080/00365521.2024.2310172
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Article ; Online: Chitosan-coated nanoparticles in innovative cancer bio-medicine.

Rezaei, Niloufar / Zarkesh, Ibrahim / Fotouhi, Alireza / Alikhani, Hani Keshavarz / Hassan, Moustapha / Vosough, Massoud

Drug development research

2024 Volume 85, Issue 3, Page(s) e22189

Abstract: In the recent decade, nanoparticles (NPs) have had enormous implications in cancer biomedicine, including research, diagnosis, and therapy. However, their broad application still faces obstacles due to some practical limitations and requires further ... ...

Abstract	In the recent decade, nanoparticles (NPs) have had enormous implications in cancer biomedicine, including research, diagnosis, and therapy. However, their broad application still faces obstacles due to some practical limitations and requires further development. Recently, there has been more interest in the coated class of nanoparticles to address those challenges. Chitosan-coated NPs are simple to produce, biodegradable, biocompatible, exhibit antibacterial activity, and have less cytotoxicity. This study provides an updated and comprehensive overview of the application of chitosan-coated NPs as a promising class of NPs in cancer biomedicine. Additionally, we discussed chitosan-coated lipid, metal, and polymer-based nanoparticles in biomedical applications. Furthermore, different coating methods and production/characterization procedures were reviewed. Moreover, the biological and physicochemical advantages of chitosan-coated NPs, including facilitated controlled release, greater physicochemical stability, improved cell/tissue interaction, and enhanced bioavailability of medications, were highlighted. Finally, the prospects of chitosan-coated NPs in cancer biomedicine were discussed.
MeSH term(s)	Chitosan/chemistry ; Humans ; Nanoparticles ; Neoplasms/drug therapy ; Animals ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/pharmacology
Chemical Substances	Chitosan (9012-76-4) ; Antineoplastic Agents
Language	English
Publishing date	2024-04-28
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	604587-x
ISSN	1098-2299 ; 0272-4391
ISSN (online)	1098-2299
ISSN	0272-4391
DOI	10.1002/ddr.22189
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Article: Immunomodulatory performance of GMP-compliant, clinical-grade mesenchymal stromal cells from four different sources.

Arki, Mandana Kazem / Moeinabadi-Bidgoli, Kasra / Niknam, Bahareh / Mohammadi, Parvaneh / Hassan, Moustapha / Hossein-Khannazer, Nikoo / Vosough, Massoud

Heliyon

2024 Volume 10, Issue 2, Page(s) e24948

Abstract: Inflammatory and autoimmune diseases are among the most challenging disorders for health care professionals that require systemic immune suppression which associates with various side effects. Mesenchymal stromal cells (MSCs) are capable of regulating ... ...

Abstract	Inflammatory and autoimmune diseases are among the most challenging disorders for health care professionals that require systemic immune suppression which associates with various side effects. Mesenchymal stromal cells (MSCs) are capable of regulating immune responses, mainly through paracrine effects and cell-cell contact. Since MSCs are advanced therapy medicinal products (ATMPs), they must follow Good Manufacturing Practice (GMP) regulations to ensure their safety and efficacy. In this study, we evaluated the immunomodulatory effects of GMP-compliant clinical grade MSCs obtained from four different sources (bone marrow, adipose tissue, Wharton's Jelly, and decidua tissue) on allogeneic peripheral blood mononuclear cells (PBMCs). Our results revealed that WJ-MSCs were the most successful group in inhibiting PBMC proliferation as confirmed by BrdU analysis. Moreover, WJ-MSCs were the strongest group in enhancing the regulatory T cell population of PBMCs. WJ-MSCs also had the highest secretory profile of prostaglandin E2 (PGE-2), anti-inflammatory cytokine, while interleukin-10 (IL-10) secretion was highest in the DS-MSC group. DS-MSCs also had the lowest secretion of IL-12 and IL-17 inflammatory cytokines. Transcriptome analysis revealed that WJ-MSCs had the lowest expression of IL-6, while DS-MSCs were the most potent group in the expression of immunomodulatory factors such as hepatocyte growth factor (HGF) and transforming growth factor-β (TGF- β). Taken together, our results indicated that GMP-compliant Wharton's Jelly and decidua-derived MSCs showed the best immunomodulatory performance considering paracrine factors.
Language	English
Publishing date	2024-01-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e24948
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Article: A Shadow of Knowledge in Stem Cell Science.

Omid-Shafiee, Sarina / Hassan, Moustapha / Nussler, Andreas K / Mustapha, Najimi / Vosough, Massoud

Cell journal

2023 Volume 25, Issue 10, Page(s) 738–740

Abstract: Theory of Forms" implies that a genuine version of creatures exists beyond the shapes in this world. Stem cell ... technology has adopted developmental cues to mimic real life. However, the functionality of the lab-made cells is far ... from primary ... ...

Abstract	"Theory of Forms" implies that a genuine version of creatures exists beyond the shapes in this world. Stem cell technology has adopted developmental cues to mimic real life. However, the functionality of the lab-made cells is far from primary ones. Perhaps it is time to switch from analytical to systematic perspective in stem cell science. This may be the way to define new horizons based on the systematic perspective and convergence of science in stem cell biology, bridging the current gap between the shadows of real knowledge in current research and reality in future.
Language	English
Publishing date	2023-10-01
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2647430-X
ISSN	2228-5814 ; 2228-5806
ISSN (online)	2228-5814
ISSN	2228-5806
DOI	10.22074/cellj.2023.2005680.1346
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Article ; Online: Autophagy orchestrates resistance in hepatocellular carcinoma cells.

Seydi, Homeyra / Nouri, Kosar / Rezaei, Niloufar / Tamimi, Atena / Hassan, Moustapha / Mirzaei, Hamed / Vosough, Massoud

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2023 Volume 161, Page(s) 114487

Abstract: Treatment resistance is one of the major barriers for therapeutic strategies in hepatocellular carcinoma (HCC). Many studies have indicated that chemotherapy and radiotherapy induce autophagy machinery (cell protective autophagy) in HCC cells. In ... ...

Abstract	Treatment resistance is one of the major barriers for therapeutic strategies in hepatocellular carcinoma (HCC). Many studies have indicated that chemotherapy and radiotherapy induce autophagy machinery (cell protective autophagy) in HCC cells. In addition, many experiments report a remarkable crosstalk between treatment resistance and autophagy pathways. Thus, autophagy could be one of the key factors enabling tumor cells to hinder induced cell death after medical interventions. Therefore, extensive research on the molecular pathways involved in resistance induction and autophagy have been conducted to achieve the desired therapeutic response. The key molecular pathways related to the therapy resistance are TGF-β, MAPK, NRF2, NF-κB, and non-coding RNAs. In addition, EMT, drug transports, apoptosis evasion, DNA repair, cancer stem cells, and hypoxia could have considerable impact on the hepatoma cell's response to therapies. These mechanisms protect tumor cells against various treatments and many studies have shown that each of them is connected to the molecular pathways of autophagy induction in HCC. Hence, autophagy inhibition may be an effective strategy to improve therapeutic outcome in HCC patients. In this review, we further highlight how autophagy leads to poor response during treatment through a complex molecular network and how it enhances resistance in primary liver cancer. We propose that combinational regimens of approved HCC therapeutic protocols plus autophagy inhibitors may overcome drug resistance in HCC therapy.
MeSH term(s)	Humans ; Carcinoma, Hepatocellular/drug therapy ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/metabolism ; Liver Neoplasms/drug therapy ; Liver Neoplasms/genetics ; Liver Neoplasms/metabolism ; Drug Resistance, Neoplasm ; Autophagy ; Cell Line, Tumor ; Apoptosis
Language	English
Publishing date	2023-03-22
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2023.114487
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Article ; Online: COVID-19 and hygiene hypothesis: increment of the inflammatory bowel diseases in next generation?

Shahrbaf, Mohammad Amin / Hassan, Moustapha / Vosough, Massoud

Expert review of gastroenterology & hepatology

2021 Volume 16, Issue 1, Page(s) 1–3

MeSH term(s)	COVID-19/prevention & control ; Gastrointestinal Microbiome/immunology ; Global Health/trends ; Humans ; Hygiene ; Hygiene Hypothesis ; Inflammatory Bowel Diseases/epidemiology ; Inflammatory Bowel Diseases/etiology ; Inflammatory Bowel Diseases/immunology ; Inflammatory Bowel Diseases/microbiology ; Risk Factors
Language	English
Publishing date	2021-12-27
Publishing country	England
Document type	Editorial
ZDB-ID	2481021-6
ISSN	1747-4132 ; 1747-4124
ISSN (online)	1747-4132
ISSN	1747-4124
DOI	10.1080/17474124.2022.2020647
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Article ; Online: Mini review ATF4 and GRP78 as novel molecular targets in ER-Stress modulation for critical COVID-19 patients.

Shahriari-Felordi, Mahtab / Alikhani, Hani Keshavarz / Hashemian, Seyed-Mohammad Reza / Hassan, Moustapha / Vosough, Massoud

Molecular biology reports

2022 Volume 49, Issue 2, Page(s) 1545–1549

Abstract: Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has resulted in more than 4.4 million deaths worldwide as of August 24, 2021. Viral infections such as SARS-CoV2 are associated with ... ...

Abstract	Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has resulted in more than 4.4 million deaths worldwide as of August 24, 2021. Viral infections such as SARS-CoV2 are associated with endoplasmic reticulum (ER) stress and also increased the level of reactive oxygen species. Activating transcription factor 4 (ATF4) is preferentially translated under integrated stress conditions and controls the genes involved in protein homeostasis, amino acid transport and metabolism, and also protection from oxidative stress. The GRP78, regulated either directly or indirectly by ATF4, is an essential chaperone in the ER and overexpressed and appears on the surface of almost all cells during stress and function as a SARS-CoV2 receptor. In this mini-review article, we briefly discuss the effects of SARS-CoV2 infection on the ER stress, and then the stress modulator functions of ATF4 and GRP78 as novel therapeutic targets were highlighted. Finally, the effects of GRP78 inhibitory components as potential factors for targeted therapies for COVID-19 critical cases were discussed.
MeSH term(s)	Activating Transcription Factor 4/metabolism ; COVID-19/metabolism ; Endoplasmic Reticulum Chaperone BiP/metabolism ; Endoplasmic Reticulum Stress/physiology ; Humans ; SARS-CoV-2/pathogenicity
Chemical Substances	ATF4 protein, human ; Endoplasmic Reticulum Chaperone BiP ; HSPA5 protein, human ; Activating Transcription Factor 4 (145891-90-3)
Language	English
Publishing date	2022-01-14
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	186544-4
ISSN	1573-4978 ; 0301-4851
ISSN (online)	1573-4978
ISSN	0301-4851
DOI	10.1007/s11033-021-07071-9
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Article: Umbilical Cord Blood-Derived Monocytes as A Reliable Source of Functional Macrophages for Biomedical Research.

Torabi, Shukoofeh / Zarrabi, Morteza / Hossein-Khannazer, Nikoo / Lotfinia, Majid / Nouri, Masoumeh / Gramignoli, Roberto / Hassan, Moustapha / Vosough, Massoud

Cell journal

2023 Volume 25, Issue 8, Page(s) 524–535

Abstract: Objective: Macrophages are multifunctional immune cells widely used in immunological research. While autologous macrophages have been widely used in several biomedical applications, allogeneic macrophages have also demonstrated similar or even superior ... ...

Abstract	Objective: Macrophages are multifunctional immune cells widely used in immunological research. While autologous macrophages have been widely used in several biomedical applications, allogeneic macrophages have also demonstrated similar or even superior therapeutic potential. The umbilical cord blood (UCB) is a well-described source of abundant allogenic monocytes and macrophages that is easy to collect and can be processed without invasive methods. Current monocyte isolation procedures frequently result in heterogenous cell products, with limited yields, activated cells, and high cost. This study outlines a simple isolation method that results in high yields and pure monocytes with the potential to differentiate into functional macrophages. Materials and methods: In the experimental study, we describe a simple and efficient protocol to isolate highpurity monocytes. After collection of human UCB samples, we used a gradient-based procedure composed of three consecutive gradient steps: i. Hydroxyethyl starch-based erythrocytes sedimentation, followed by ii. Mononuclear cells (MNCs) isolation by Ficoll-Hypaque gradient, and iii. Separation of monocytes from lymphocytes by a slight hyperosmolar Percoll gradient (0.573 g/ml). Then the differentiation potential of isolated monocytes to pro- and antiinflammatory macrophages were evaluated in the presence of granulocyte colony-stimulating factor (GM-CSF) and macrophage CSF (M-CSF), respectively. The macrophages were functionally characterized as well. Results: A high yield of monocytes after isolation (25 to 50 million) with a high purity (>95%) could be obtained from every 100-150 ml UCB. Isolated monocytes were defined based on their phenotype and surface markers expression pattern. Moreover, they possess the ability to differentiate into pro- or anti-inflammatory macrophages with specific phenotypes, gene/surface protein markers, cytokine secretion patterns, T-cell interactions, and phagocytosis activity. Conclusion: Here we describe a simple and reproducible procedure for isolation of pure monocytes from UCB, which could be utilized to provide functional macrophages as a reliable and feasible source of allogenic macrophages for biomedical research.
Language	English
Publishing date	2023-08-01
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2647430-X
ISSN	2228-5814 ; 2228-5806
ISSN (online)	2228-5814
ISSN	2228-5806
DOI	10.22074/cellj.2023.1990203.1238
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Article: Platelet-Rich Plasma in Regenerative Medicine: Possible Applications in Management of Burns and Post-Burn Scars: A Review.

Hosseini, Maryam Sadat / Nouri, Masoumeh / Zarrabi, Morteza / Fatemi, Mohammad Javad / Shpichka, Anastasia / Timashev, Peter / Hassan, Moustapha / Vosough, Massoud

Cell journal

2023 Volume 25, Issue 5, Page(s) 281–290

Abstract: Contribution of platelets in tissue regeneration and their possible application in regenerative medicine, which is primarily mediated via secretion of granular components following platelet activation, has been well established in the recent decades. ... ...

Abstract	Contribution of platelets in tissue regeneration and their possible application in regenerative medicine, which is primarily mediated via secretion of granular components following platelet activation, has been well established in the recent decades. Therefore, platelet rich plasma (PRP), as a portion of plasma with higher concentrations of platelets than the baseline level, is now an attractive therapeutic option in various medical fields mainly for tissue repair and regeneration following injuries. Burn injuries are devastating trauma with high rate of morbidities affecting several aspects of the patient's life. They require a long-time medical care and high costs. However, even following the best treatment procedures, post-burn scars are inevitable consequence of burn healing process. Therefore, development of new treatment modalities for both burn healing and prevention of post-burn scar establishment seems to be necessary. Regarding the well-known role of PRP in wound healing, here we aimed to provide a comprehensive insight in the possible application of PRP as an adjuvant therapy for the management of burn injuries and subsequent scars. In terms of the following keywords (individually or in combination), original/review articles were searched in PubMed, Scopus, and Google Scholar databases from 2009 to 2021: platelet rich plasma, PRP therapy, platelet biology, platelet function, burn healing, burn scar, scar formation, burn management, wound healing, regenerative medicine. All type of articles or book chapters in English language and relevant data were included in this review. This review initially focused on PRP, its mechanisms of action, preparation methods, and available sources. Then, pathophysiology of burns and subsequent scars were discussed. Finally, their current conventional therapeutic modalities and implication of PRP in their healing process were highlighted.
Language	English
Publishing date	2023-05-28
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2647430-X
ISSN	2228-5814 ; 2228-5806
ISSN (online)	2228-5814
ISSN	2228-5806
DOI	10.22074/cellj.2023.558213.1093
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Article ; Online: Circulating Tumor Cells as a Promising Tool for Early Detection of Hepatocellular Carcinoma.

Salehi, Mahsa / Lavasani, Zohre Miri / Keshavarz Alikhani, Hani / Shokouhian, Bahare / Hassan, Moustapha / Najimi, Mustapha / Vosough, Massoud

Cells

2023 Volume 12, Issue 18

Abstract: Liver cancer is a significant contributor to the cancer burden, and its incidence rates have recently increased in almost all countries. Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and is the second leading cause of ... ...

Abstract	Liver cancer is a significant contributor to the cancer burden, and its incidence rates have recently increased in almost all countries. Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and is the second leading cause of cancer-related deaths worldwide. Because of the late diagnosis and lack of efficient therapeutic modality for advanced stages of HCC, the death rate continues to increase by ~2-3% per year. Circulating tumor cells (CTCs) are promising tools for early diagnosis, precise prognosis, and follow-up of therapeutic responses. They can be considered to be an innovative biomarker for the early detection of tumors and targeted molecular therapy. In this review, we briefly discuss the novel materials and technologies applied for the practical isolation and detection of CTCs in HCC. Also, the clinical value of CTC detection in HCC is highlighted.
MeSH term(s)	Humans ; Carcinoma, Hepatocellular/diagnosis ; Liver Neoplasms/diagnosis ; Neoplastic Cells, Circulating ; Early Detection of Cancer ; Molecular Targeted Therapy
Language	English
Publishing date	2023-09-12
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells12182260
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