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Article ; Online: Protective effect of rivastigmine against lung injury in acute pancreatitis model in rats via Hsp 70/IL6/ NF-κB signaling cascade.

Yehia Kamel, Maha / Zekry Attia, Josef / Mahmoud Ahmed, Sabreen / Hassan Saeed, Zainab / Welson, Nermeen N / Yehia Abdelzaher, Walaa

International journal of immunopathology and pharmacology

2023 Volume 37, Page(s) 3946320231222804

Abstract: Acute lung injury (ALI) that develops as a result of AP can progress to acute respiratory distress syndrome. Some hypotheses are proposed to explain the pathophysiology of AP and its related pulmonary hazards. This experiment aimed to evaluate the ... ...

Abstract	Acute lung injury (ALI) that develops as a result of AP can progress to acute respiratory distress syndrome. Some hypotheses are proposed to explain the pathophysiology of AP and its related pulmonary hazards. This experiment aimed to evaluate the mitigating action of rivastigmine (Riva) in lung injury that occurs on the top of acute pancreatitis (AP) induced in rats. Thirty-two male Wister rats were randomized to one of four groups: control, Riva-treated, acute pancreatitis (AP), and acute pancreatitis treated by Riva. Serum amylase and lipase levels were assessed. Pulmonary oxidative stress and inflammatory indicators were estimated. A pancreatic and pulmonary histopathological examination, as well as an immunohistochemical study of HSP70, was carried out. Riva significantly attenuated the L-arginine-related lung injury that was characterized by increased pulmonary inflammatory biomarkers (interleukin-6 [IL-6]), nuclear factor kappa B (NF-κB), tumor necrosis factor-α (TNF-α), increased pulmonary oxidative markers (total nitrite/nitrate [NOx]), MDA, decreased total antioxidant capacity (TAC), and reduced glutathione level (GSH)) with increased caspase-3 expression. Therefore, Riva retains potent ameliorative effects against lung injury that occur on the top of AP by relieving oxidative stress, inflammation, and apoptosis via HSP70/IL6/NF-κB signaling.
MeSH term(s)	Animals ; Male ; Rats ; Acute Disease ; Acute Lung Injury/drug therapy ; Acute Lung Injury/etiology ; Interleukin-6 ; NF-kappa B/metabolism ; Pancreatitis/chemically induced ; Pancreatitis/metabolism ; Rats, Wistar ; Rivastigmine/therapeutic use ; Tumor Necrosis Factor-alpha/metabolism
Chemical Substances	Interleukin-6 ; NF-kappa B ; Rivastigmine (PKI06M3IW0) ; Tumor Necrosis Factor-alpha
Language	English
Publishing date	2023-12-19
Publishing country	England
Document type	Randomized Controlled Trial, Veterinary ; Journal Article
ZDB-ID	645171-8
ISSN	2058-7384 ; 0394-6320
ISSN (online)	2058-7384
ISSN	0394-6320
DOI	10.1177/03946320231222804
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Article ; Online: Short-term influence of antimicrobial photodynamic therapy as an adjuvant to mechanical debridement in reducing soft-tissue inflammation and subgingival yeasts colonization in patients with peri-implant mucositis.

Aldosari, Lujain Ibrahim N / Hassan, Saeed Awod Bin / Alshadidi, Abdulkhaliq Ali F / Rangaiah, Gururaju Chimmanahally / Divakar, Darshan Devang

Photodiagnosis and photodynamic therapy

2023 Volume 42, Page(s) 103320

Abstract: Objective: The objective of this short-term follow-up study was to evaluate the influence of antimicrobial photodynamic therapy (aPDT) as an adjuvant to mechanical debridement (MD) in reducing soft-tissue inflammation and subgingival yeasts colonization ...

Abstract	Objective: The objective of this short-term follow-up study was to evaluate the influence of antimicrobial photodynamic therapy (aPDT) as an adjuvant to mechanical debridement (MD) in reducing soft-tissue inflammation and subgingival yeasts colonization (SYC) in patients with peri‑implant mucositis (PiM). Methods: Individuals diagnosed with PiM were included. Demographic data was collected using a questionnaire. Peri-implant plaque index (PI), bleeding index (BI), probing depth (PD), crestal bone levels and SYC were measured at baseline. Therapeutically, these individuals were divided into test and control groups. In the control-group patients underwent MD and in the test-group patients underwent MD with adjunct single session of aPDT. Clinical peri‑implant parameters and SYC were reassessed after 12-weeks. Correlation between age, gender and duration of implants with SYC and clinical peri‑implant status was assessed using logistic regression models. P < 0.05 was selected as an indicator of statistical significance. Results: The test and control-groups comprised of 24 and 23 individuals, respectively. In the test and control groups, toothbrushing twice daily was reported by 7 (29.2%) and 5 (21.7%) individuals, respectively. None of the individuals had ever used a dental floss. At baseline, there was no difference in peri‑implant PI, BI, PD and CBL in the test and control groups. At follow-up, peri‑implant PI (P < 0.01), BI (P < 0.01) and PD (P < 0.01) were significantly higher in the control compared with the test-group. At baseline, SYC in the test and control groups were 1865.3 ± 403.4 CFU/ml and 1963.7 ± 512.4 CFU/ml, respectively. At 90 days' follow-up, SYC in the test and control groups were 1472 ± 202.7 and 1538.4 ± 331.7 CFU/ml, respectively. There was no significant difference in SYC in both groups when baseline values were compared with 90 days' follow-up. Conclusion: One session of aPDT after MC with adjunct aPDT is effective in reducing soft tissue inflammation but not SYC in patients with PiM.
MeSH term(s)	Humans ; Photochemotherapy/methods ; Follow-Up Studies ; Mucositis/drug therapy ; Debridement ; Photosensitizing Agents/therapeutic use ; Peri-Implantitis/drug therapy ; Inflammation/drug therapy ; Anti-Infective Agents/therapeutic use ; Dental Implants/adverse effects
Chemical Substances	Photosensitizing Agents ; Anti-Infective Agents ; Dental Implants
Language	English
Publishing date	2023-02-01
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2149918-4
ISSN	1873-1597 ; 1572-1000
ISSN (online)	1873-1597
ISSN	1572-1000
DOI	10.1016/j.pdpdt.2023.103320
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Properties of a novel composite elastomeric polymer vinyl polyether siloxane in comparison to its parent materials: a systemic review and meta-analysis.

Saini, Ravinder S / Alshadidi, Abdulkhaliq Ali F / Hassan, Saeed Awod Bin / Aldosari, Lujain Ibrahim N / Mosaddad, Seyed Ali / Heboyan, Artak

BMC oral health

2024 Volume 24, Issue 1, Page(s) 54

Abstract: Background: The effectiveness of newly developed elastomeric polymer hybrid siloxane (PVES), which combines the properties of polyethylene (PE) and polyvinyl siloxane (PVS) elastomers, has been a subject of interest in recent studies. This study aimed ... ...

Abstract	Background: The effectiveness of newly developed elastomeric polymer hybrid siloxane (PVES), which combines the properties of polyethylene (PE) and polyvinyl siloxane (PVS) elastomers, has been a subject of interest in recent studies. This study aimed to assess the physical properties of hybrid PVES materials by analyzing existing data from recent studies on this topic. Methods: A systematic literature search was conducted to retrieve peer-reviewed articles published up to February 5, 2023. The population, intervention, comparison, and pertinent outcomes were specified under the PICO framework. The primary data analysis was performed in Microsoft Excel, while statistical analysis used Meta-Essentials. Results: Of the 1152 articles assessed, 14 met the inclusion criteria. The meta-analysis of the selected studies indicated that polyether (PE) and polyvinyl siloxane (PVS) were highly correlated (two-tailed p-values of 0.000 and 0.001, respectively) with the improved tensile strength of vinyl polyether siloxane (PVES) with a significantly positive effect size. Similarly, the hydrophilic characteristics of PVES were significantly improved compared to those of PE and PVS. PE was a significant contributor to the hydrophilic characteristics of PVES, with a two-tailed p-value of 0.000. The effect size was highly positive for hydrophilicity but showed high heterogeneity. It was also observed that the dimensional accuracy of PVES was comparable to those of PE and PVS, with no statistically significant differences among the three materials. Conclusions: PVES showed promising features, with improved tensile strength and hydrophilic characteristics compared to those of PE and PVS.
MeSH term(s)	Humans ; Siloxanes ; Polyethylene ; Elastomers ; Parents
Chemical Substances	vinyl polysiloxane ; Siloxanes ; elastomeric polymer ; Polyethylene (9002-88-4) ; Elastomers
Language	English
Publishing date	2024-01-09
Publishing country	England
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2091511-1
ISSN	1472-6831 ; 1472-6831
ISSN (online)	1472-6831
ISSN	1472-6831
DOI	10.1186/s12903-023-03830-1
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Article ; Online: Impact of Green Roof and Orientation on the Energy Performance of Buildings

Hassan Saeed Khan / Muhammad Asif

Sustainability, Vol 9, Iss 4, p

A Case Study from Saudi Arabia

2017 Volume 640

Abstract: Saudi Arabia is one of the largest countries in the Middle East region in terms of population, geographic area and scale of economy. It has a fast growing energy sector with over 76% of the total electricity being consumed in the building sector. ... ...

Abstract	Saudi Arabia is one of the largest countries in the Middle East region in terms of population, geographic area and scale of economy. It has a fast growing energy sector with over 76% of the total electricity being consumed in the building sector. Domestic buildings account for 51% of total electricity consumption. Predominantly due to hot climatic conditions, most of the energy consumption in buildings is attributed to the heating, ventilation and air conditioning (HVAC) loads. In terms of supply mix, the country entirely relies on oil and gas to meet its energy requirements. The high growth in energy demand is imposing stringent energy, environmental and economic challenges for Saudi Arabia. The present work aims to explore prospects of energy saving in buildings through the application of green roof technology. With the help of ECOTECT modelling, the work examines the effectiveness of green roof on considering modern faculty homes built in the King Fahd University of Petroleum and Minerals situated in the hot-humid climatic conditions of the Easter Province of the country. The same building has also been investigated for the hot-dry climate of Riyadh, the capital city. The work also examines the impact of orientations on the energy performance of buildings.
Keywords	buildings ; sustainability ; green roof ; energy modeling ; energy efficiency ; monthly load discomfort analysis ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	690
Language	English
Publishing date	2017-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Cyperus iria aqueous-ethanol extract ameliorated hyperglycemia, oxidative stress, and regulated inflammatory cytokines in streptozotocin-induced diabetic rats

Saeed, Myeda / Sharīf, ʻAlī / Hassan, Saeed Ul / Akhtar, Bushra / Muhammad, Faqir / Malik, Maryam

Environ Sci Pollut Res. 2022 Jan., v. 29, no. 3 p.4769-4784

2022

Abstract: Type 2 diabetes mellitus is a complicated metabolic disorder with no definite treatment. Cyperus iria (Cyperaceae) possess several traditional therapeutic uses. According to the folklore tales, the whole plant of Cyperus iria possesses antihyperglycemic ... ...

Abstract	Type 2 diabetes mellitus is a complicated metabolic disorder with no definite treatment. Cyperus iria (Cyperaceae) possess several traditional therapeutic uses. According to the folklore tales, the whole plant of Cyperus iria possesses antihyperglycemic activity. The present study was undertaken to investigate whether aqueous-ethanol extract of Cyperus iria can ameliorate the altered activities of carbohydrate metabolism in streptozotocin (STZ)-induced diabetic rats along with appraisal of inflammatory and stress markers involved in endocrine dysfunction. Presence of biophenolics and flavonoids might be responsible for the antidiabetic potential. STZ-induced diabetic rats were treated orally with Cyperus iria extract (125, 250, and 500 mg/kg) for 15 days. Blood samples were collected. Metformin was used as positive control. Significantly higher quantities of phenolic (82.79±0.003 mg/g GAE) and flavonoid (13.61±0.002 mg/g QE) contents were present. Inhibitory concentration (IC50) exhibited an excellent potential for both antioxidant (IC50= 3.22 μg/mL) and alpha amylase (IC50=36.29 μg/mL) inhibitory assays. High-performance liquid chromatography (HPLC) confirmed the existence of myercetin, quercetin, kaempferol, and ferulic acid. Cyperus iria aqueous-ethanol extract exhibits good tolerance against glucose at 90 min in normal rats. Streptozotocin-induced hyperglycemia declined significantly at day 9 (265 mg/dL) along with improvement in inflammatory (TNF-α=15.6± 0.2 g/l, COX-2=357±0.396 U/l, IL-6= 572±0.99 pg/l) and oxidative stress markers (SOD= 163±0.616 and GSH-ST= 95.8±0.44 U/mL) along with biochemical parameters in a dose-dependent manner. Present study suggests that Cyperus iria aqueous-ethanol extract possesses hypoglycemic potential which might be attributed to the decrease in oxidative stress and inflammatory markers.
Keywords	Cyperus iria ; alpha-amylase ; antioxidants ; blood ; carbohydrate metabolism ; cytokines ; dose response ; ferulic acid ; glucose ; glycemic effect ; high performance liquid chromatography ; hyperglycemia ; inhibitory concentration 50 ; kaempferol ; metformin ; noninsulin-dependent diabetes mellitus ; oxidative stress ; quercetin ; streptozotocin ; traditional medicine
Language	English
Dates of publication	2022-01
Size	p. 4769-4784.
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-021-15917-9
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The influence of daily weather types on the development and intensity of the urban heat island in two Mediterranean coastal metropolises

Kassomenos, Pavlos / Kissas, Giannis / Petrou, Ilias / Begou, Paraskevi / Khan, Hassan Saeed / Santamouris, Mattheos

Science of the Total Environment. 2022 May, v. 819 p.153071-

2022

Abstract: In this study we investigated the association between daily weather types (WTs) and the Urban Heat Island (UHI) in two Mediterranean coastal metropolises. For this purpose, we employed an existing weather type classification scheme and examined which WTs ...

Abstract	In this study we investigated the association between daily weather types (WTs) and the Urban Heat Island (UHI) in two Mediterranean coastal metropolises. For this purpose, we employed an existing weather type classification scheme and examined which WTs influence or drive the intensity of the UHI. We used the gridded weather typing classification (GWTC), in which meteorological conditions at a single location are categorized in daily WTs. We compared these WTs with the maximum temperature differences between urban centers and rural areas in the two major metropolises of Greece (Athens and Thessaloniki). These metropolises have dissimilar geography and spatial planning as well as their urban climate characteristics have differences. We used two groups of temperature time series on a daily basis. One with high and the other with low temperature differences (upper 5% and lower 5% of the maximum temperature differences (ΔΤₘₐₓ)) which reported the WTs that contribute to increase of UHI Intensity. We found that urban overheating was amplified during daytime under Humid, Humid Warm and Warm conditions in both Athens and Thessaloniki. As for nighttime, urban overheating is associated with Warm, Dry and Dry Warm conditions in Thessaloniki while in Athens increased under Humid, Humid Warm and Warm conditions.
Keywords	climate ; environment ; geography ; heat island ; temperature ; time series analysis ; weather ; Greece ; Urban overheating ; Urban Heat Island ; Synoptic classification ; Weather types
Language	English
Dates of publication	2022-05
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2022.153071
Database	NAL-Catalogue (AGRICOLA)

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Article: Medicinal Plants Used To Treat Overactive Bladder.

Anjum, Irfan / Mushtaq, Muhammad Naveed / Ul Hassan, Saeed

Alternative therapies in health and medicine

2020

Abstract: Background and objective: Overactive bladder (OAB) is a medical condition characterized by an increase frequency and urgency, with or without urge incontinence. 80% of the world's population presently uses herbal medicine for some aspect of primary ... ...

Abstract	Background and objective: Overactive bladder (OAB) is a medical condition characterized by an increase frequency and urgency, with or without urge incontinence. 80% of the world's population presently uses herbal medicine for some aspect of primary health care according to a survey conducted by World Health Organization. The objective of present review was to present an updated, comprehensive and categorized information about medicinal plants used or with potential for the treatment of overactive bladder. Methods: All relevant literature databases were searched up. The sources of data included Google Scholar, Science Direct, Web of Science and PubMed. The search terms were plant, herb, herbal therapy, phytotherapy, overactive bladder, cystitis and urinary incontinence. Results: Studies on a number of medicinal plants revealed that phytochemials extracted from different plant's part showed protective effect against increased contractile activity of urinary bladder and increased urination frequency, the characteristic manifestations of OAB. Medicinal plant extracts also reduced urinary oxidative stress markers,inflammation and agonist induced bladder contractile response. Conclusion: A variety of medicinal plants promise their use in overactive bladder diseases. In addition to the standardization of these medicinal plants, screening plants as anti-overactive bladder agents may help to find new sources of therapy for overactive bladder.
Language	English
Publishing date	2020-07-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	1225073-9
ISSN	1078-6791
ISSN	1078-6791
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Article: Social mining for sustainable cities: thematic study of gender-based violence coverage in news articles and domestic violence in relation to COVID-19.

Manzoor, Muhammad Asad / Hassan, Saeed-Ul / Muazzam, Amina / Tuarob, Suppawong / Nawaz, Raheel

Journal of ambient intelligence and humanized computing

2022 , Page(s) 1–12

Abstract: We argue that social computing and its diverse applications can contribute to the attainment of sustainable development goals (SDGs)-specifically to the SDGs concerning gender equality and empowerment of all women and girls, and to make cities and human ... ...

Abstract	We argue that social computing and its diverse applications can contribute to the attainment of sustainable development goals (SDGs)-specifically to the SDGs concerning gender equality and empowerment of all women and girls, and to make cities and human settlements inclusive. To achieve the above goals for the sustainable growth of societies, it is crucial to study gender-based violence (GBV) in a smart city context, which is a common component of violence across socio-economic groups globally. This paper analyzes the nature of news articles reported in English newspapers of Pakistan, India, and the UK-accumulating 12,693 gender-based violence-related news articles. For the qualitative textual analysis, we employ Latent Dirichlet allocation for topic modeling and propose a Doc2Vec based word-embeddings model to classify gender-based violence-related content, called GBV2Vec. Further, by leveraging GBV2Vec, we also build an online tool that analyzes the sensitivity of Gender-based violence-related content from the textual data. We run a case study on GBV concerning COVID-19 by feeding the data collected through Google News API. Finally, we show different news reporting trends and the nature of the gender-based violence committed during the testing times of COVID-19. The approach and the toolkit that this paper proposes will be of great value to decision-makers and human rights activists, given the prompt and coordinated performance against gender-based violence in smart city context-and can contribute to the achievement of SDGs for sustainable growth of human societies.
Language	English
Publishing date	2022-04-08
Publishing country	Germany
Document type	News
ZDB-ID	2543187-0
ISSN	1868-5145 ; 1868-5137
ISSN (online)	1868-5145
ISSN	1868-5137
DOI	10.1007/s12652-021-03401-8
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Article ; Online: The influence of daily weather types on the development and intensity of the urban heat island in two Mediterranean coastal metropolises.

Kassomenos, Pavlos / Kissas, Giannis / Petrou, Ilias / Begou, Paraskevi / Khan, Hassan Saeed / Santamouris, Mattheos

The Science of the total environment

2022 Volume 819, Page(s) 153071

Abstract	In this study we investigated the association between daily weather types (WTs) and the Urban Heat Island (UHI) in two Mediterranean coastal metropolises. For this purpose, we employed an existing weather type classification scheme and examined which WTs influence or drive the intensity of the UHI. We used the gridded weather typing classification (GWTC), in which meteorological conditions at a single location are categorized in daily WTs. We compared these WTs with the maximum temperature differences between urban centers and rural areas in the two major metropolises of Greece (Athens and Thessaloniki). These metropolises have dissimilar geography and spatial planning as well as their urban climate characteristics have differences. We used two groups of temperature time series on a daily basis. One with high and the other with low temperature differences (upper 5% and lower 5% of the maximum temperature differences (ΔΤ
MeSH term(s)	Cities ; Environmental Monitoring ; Greece ; Hot Temperature ; Seasons ; Weather
Language	English
Publishing date	2022-01-14
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2022.153071
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Article ; Online: Spatiotemporal variation in urban overheating magnitude and its association with synoptic air-masses in a coastal city

Hassan Saeed Khan / Mat Santamouris / Pavlos Kassomenos / Riccardo Paolini / Peter Caccetta / Ilias Petrou

Scientific Reports, Vol 11, Iss 1, Pp 1-

2021 Volume 15

Abstract: Abstract Urban overheating (UO) may interact with synoptic-scale weather conditions. The association between meteorological parameters and UO has already been a subject of considerable research, however, the impact of synoptic-scale weather conditions on ...

Abstract	Abstract Urban overheating (UO) may interact with synoptic-scale weather conditions. The association between meteorological parameters and UO has already been a subject of considerable research, however, the impact of synoptic-scale weather conditions on UO magnitude, particularly in a coastal city that is also near the desert landmass (Sydney) has never been investigated before. The present research examines the influence of synoptic-scale weather conditions on UO magnitude in Sydney by utilizing the newly developed gridded weather typing classification (GWTC). The diurnal, and seasonal variations in suburban-urban temperature contrast (ΔT) in association with synoptic-scale weather conditions, and ΔT response to synoptic air-masses during extreme heat events are investigated in three zones of Sydney. Generally, an exacerbation in UO magnitude was reported at daytime over the years, whereas the nocturnal UO magnitude was alleviated over time. The humid warm (HW), and warm (W) air-masses were found primarily responsible for exacerbated daytime UO during extreme heat events and in all other seasons, raising the mean daily maximum ΔT to 8–10.5 °C in Western Sydney, and 5–6.5 °C in inner Sydney. The dry warm (DW), and W conditions were mainly responsible for urban cooling (UC) at nighttime, bringing down the mean daily minimum ΔT to − 7.5 to − 10 °C in Western Sydney, and − 6 to − 7.5 °C in inner Sydney. The appropriate mitigation technologies can be planned based on this study to alleviate the higher daytime temperatures in the Sydney suburbs.
Keywords	Medicine ; R ; Science ; Q
Subject code	910 ; 333
Language	English
Publishing date	2021-03-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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