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  1. Book ; Online: Natural Products for Chronic Diseases: A Ray of Hope

    Hassan, Syed Shams ul / Abdel-Daim, Mohamed M / Behl, Tapan / Bungau, Simona Gabriela

    2023  

    Keywords Research & information: general ; Chemistry ; guaiane dimer ; melanoma ; molecular docking ; ADMET ; MM-GBSA ; marine drugs ; diabetes mellitus ; cancer ; cardiovascular disorders ; neurodegeneration ; shrimp (Penaeus Chinensis) ; peptides ; immunosuppression gut microbiota ; cyclophosphamide ; gut health ; prostate cancer ; nummularic acid ; docking ; apoptosis ; BAX ; p53 ; echimidine ; echimidine isomers ; hepatotoxicity ; Echium plantagineum L. ; rat hepatocytes primary culture ; Fragaria indica ; α-glucosidase ; α-amylase ; antioxidant ; bioactives ; antidiabetic ; diabetes ; antibacterial activity ; total phenolic contents ; total flavonoid contents ; DPPH ; ABTS ; antidiabetic enzymes ; HPLC-UV ; GC-MS ; endogenous hydrogen sulfide ; breast cancer ; signaling pathway ; tumor growth ; Michael products ; anti-inflammatory ; analgesic ; carrageenan ; COX-2 ; 5-LOX ; Pleurospermum candollei ; natural compounds ; thrombolytic ; antibacterial ; pharmaceuticals ; berbamine ; bergapten ; carveol ; paclitaxel ; ELISA ; Western blot ; n/a
    Language English
    Size 1 electronic resource (232 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English
    HBZ-ID HT030376394
    ISBN 9783036569543 ; 3036569545
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: The Role of Calmodulin Binding Transcription Activator in Plants under Different Stressors: Physiological, Biochemical, Molecular Mechanisms of

    Zaman, Shah / Hassan, Syed Shams Ul / Ding, Zhaotang

    Bioengineering (Basel, Switzerland)

    2022  Volume 9, Issue 12

    Abstract: Low temperatures have a negative effect on plant development. Plants that are exposed to cold temperatures undergo a cascade of physiological, biochemical, and molecular changes that activate several genes, transcription factors, and regulatory pathways. ...

    Abstract Low temperatures have a negative effect on plant development. Plants that are exposed to cold temperatures undergo a cascade of physiological, biochemical, and molecular changes that activate several genes, transcription factors, and regulatory pathways. In this review, the physiological, biochemical, and molecular mechanisms of
    Language English
    Publishing date 2022-12-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2746191-9
    ISSN 2306-5354
    ISSN 2306-5354
    DOI 10.3390/bioengineering9120759
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Quantitative Real-Time Analysis of Differentially Expressed Genes in Peripheral Blood Samples of Hypertension Patients.

    Ali, Fawad / Khan, Arifullah / Muhammad, Syed Aun / Hassan, Syed Shams Ul

    Genes

    2022  Volume 13, Issue 2

    Abstract: Hypertension (HTN) is considered one of the most important and well-established reasons for cardiovascular abnormalities, strokes, and premature mortality globally. This study was designed to explore possible differentially expressed genes (DEGs) that ... ...

    Abstract Hypertension (HTN) is considered one of the most important and well-established reasons for cardiovascular abnormalities, strokes, and premature mortality globally. This study was designed to explore possible differentially expressed genes (DEGs) that contribute to the pathophysiology of hypertension. To identify the DEGs of HTN, we investigated 22 publicly available cDNA Affymetrix datasets using an integrated system-level framework. Gene Ontology (GO), pathway enrichment, and transcriptional factors were analyzed to reveal biological information. From 50 DEGs, we ranked 7 hypertension-related genes (
    MeSH term(s) Gene Ontology ; Humans ; Hypertension/genetics ; Kruppel-Like Transcription Factors/genetics ; Real-Time Polymerase Chain Reaction ; Signal Transduction/genetics ; Transcription Factors/genetics
    Chemical Substances KLF7 protein, human ; Kruppel-Like Transcription Factors ; Transcription Factors
    Language English
    Publishing date 2022-01-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes13020187
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Quantitative Real-Time Analysis of Differentially Expressed Genes in Peripheral Blood Samples of Hypertension Patients

    Ali, Fawad / Khan, Arifullah / Muhammad, Syed Aun / Hassan, Syed Shams ul

    Genes. 2022 Jan. 21, v. 13, no. 2

    2022  

    Abstract: Hypertension (HTN) is considered one of the most important and well-established reasons for cardiovascular abnormalities, strokes, and premature mortality globally. This study was designed to explore possible differentially expressed genes (DEGs) that ... ...

    Abstract Hypertension (HTN) is considered one of the most important and well-established reasons for cardiovascular abnormalities, strokes, and premature mortality globally. This study was designed to explore possible differentially expressed genes (DEGs) that contribute to the pathophysiology of hypertension. To identify the DEGs of HTN, we investigated 22 publicly available cDNA Affymetrix datasets using an integrated system-level framework. Gene Ontology (GO), pathway enrichment, and transcriptional factors were analyzed to reveal biological information. From 50 DEGs, we ranked 7 hypertension-related genes (p-value < 0.05): ADM, ANGPTL4, USP8, EDN, NFIL3, MSR1, and CEBPD. The enriched terms revealed significant functional roles of HIF-1-α transcription; endothelin; GPCR-binding ligand; and signaling pathways of EGF, PIk3, and ARF6. SP1 (66.7%), KLF7 (33.3%), and STAT1 (16.7%) are transcriptional factors associated with the regulatory mechanism. The expression profiles of these DEGs as verified by qPCR showed 3-times higher fold changes (2−ΔΔCt) in ADM, ANGPTL4, USP8, and EDN1 genes compared to control, while CEBPD, MSR1 and NFIL3 were downregulated. The aberrant expression of these genes is associated with the pathophysiological development and cardiovascular abnormalities. This study will help to modulate the therapeutic strategies of hypertension.
    Keywords blood ; data collection ; gene expression regulation ; gene ontology ; hypertension ; ligands ; mortality ; pathophysiology ; therapeutics ; transcription (genetics)
    Language English
    Dates of publication 2022-0121
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2527218-4
    ISSN 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes13020187
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Natural Products for Chronic Diseases: A Ray of Hope.

    Hassan, Syed Shams Ul / Abdel-Daim, Mohamed M / Behl, Tapan / Bungau, Simona

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 17

    Abstract: This Special Issue includes many high advanced quality papers that focus on natural products with their potent pharmacological potential targeting various areas of diseases [ ... ]. ...

    Abstract This Special Issue includes many high advanced quality papers that focus on natural products with their potent pharmacological potential targeting various areas of diseases [...].
    MeSH term(s) Biological Products/pharmacology ; Biological Products/therapeutic use ; Chronic Disease ; Humans
    Chemical Substances Biological Products
    Language English
    Publishing date 2022-08-30
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27175573
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 81: Show issues

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  6. Article: Toxicity evaluation induced by single and 28-days repeated exposure of withametelin and daturaolone in Sprague Dawley rats.

    Baig, Muhammad Waleed / Majid, Muhammad / Nasir, Bakht / Hassan, Syed Shams Ul / Bungau, Simona / Haq, Ihsan-Ul

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 999078

    Abstract: Safe preclinical dose determination is predictive of human toxicity and can have a profound impact on the overall progress of the compound in early drug discovery process. In this respect, current study sought to investigate for the first time the acute ... ...

    Abstract Safe preclinical dose determination is predictive of human toxicity and can have a profound impact on the overall progress of the compound in early drug discovery process. In this respect, current study sought to investigate for the first time the acute and subacute oral toxicity of two pharmacologically active natural compounds i.e., withametelin and daturaolone in Sprague Dawley rats following OECD guideline 420 and 407, respectively. As per acute toxicity studies, withametelin and daturaolone were characterized as Globally Harmonized System (GHS) category 4 and 5 compounds, respectively. Sub-acute daily dose of withametelin was 5, 2.5, and 1.25 mg/kg but, for daturaolone, it was 10, 5, and 2.5 mg/kg. High dose (5 and 2.5 mg/kg) withametelin groups showed dose dependent changes in the general, hematological, biochemical and histopathological parameters in both sexes, the most prominent being hyperthyroidism while no toxicity was observed at lower doses (1.25 and 0.75 mg/kg), No Observable Adverse Effect Level (NOAEL) being 1.25 mg/kg. Daturaolone was comparatively safer and showed dose dependent significant changes in hepatic enzyme (Alanine Transaminase), bilirubin, creatinine, and glucose levels while histological changes in testes were also observed. Lower doses (5, 2.5, and 1.25 mg/kg) of daturaolone showed no significant toxic effects and 5 mg/kg was declared as its NOAEL. Depending upon our findings, starting effective oral dose levels of 1.25 mg/kg/day for withametelin and 5 mg/kg/day for daturaolone are proposed for repeated dose (up to 28 days) preclinical pharmacological evaluation models. Long term studies with more behavioral, biochemical, histopathological and hormonal parameters are proposed to strengthen the findings.
    Language English
    Publishing date 2022-09-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.999078
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Pharmacological basis of bergapten in gastrointestinal diseases focusing on H

    Aslam, Huma / Khan, Arif-Ullah / Qazi, Neelum Gul / Ali, Fawad / Hassan, Syed Shams Ul / Bungau, Simona

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 1005154

    Abstract: Aim and objectives: ...

    Abstract Aim and objectives:
    Language English
    Publishing date 2022-11-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.1005154
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Genome-wide Meta-analysis Reveals New Gene Signatures and Potential Drug Targets of Hypertension.

    Ali, Fawad / Khan, Arifullah / Muhammad, Syed Aun / Abbas, Syed Qamar / Hassan, Syed Shams Ul / Bungau, Simona

    ACS omega

    2022  Volume 7, Issue 26, Page(s) 22754–22772

    Abstract: The prevalence of hypertension reported around the world is increasing and is an important public health challenge. This study was designed to explore the disease's genetic variations and to identify new hypertension-related genes and target proteins. We ...

    Abstract The prevalence of hypertension reported around the world is increasing and is an important public health challenge. This study was designed to explore the disease's genetic variations and to identify new hypertension-related genes and target proteins. We analyzed 22 publicly available Affymetrix cDNA datasets of hypertension using an integrated system-level framework involving differential expression genetic (DEG) analysis, data mining, gene enrichment, protein-protein interaction, microRNA analysis, toxicogenomics, gene regulation, molecular docking, and simulation studies. We found potential DEGs after screening out the extracellular proteins. We studied the functional role of seven shortlisted DEGs (ADM, EDN1, ANGPTL4, NFIL3, MSR1, CEBPD, and USP8) in hypertension after disease gene curation analysis. The expression profiling and cluster analysis showed significant variations and enriched GO terms. hsa-miR-365a-3p, hsa-miR-2052, hsa-miR-3065-3p, hsa-miR-603, hsa-miR-7113-3p, hsa-miR-3923, and hsa-miR-524-5p were identified as hypertension-associated miRNA targets for each gene using computational algorithms. We found functional interactions of source DEGs with target and important gene signatures including EGFR, AGT, AVP, APOE, RHOA, SRC, APOB, STAT3, UBC, LPL, APOA1, and AKT1 associated with the disease. These DEGs are mainly involved in fatty acid metabolism, myometrial pathways, MAPK, and G-alpha signaling pathways linked with hypertension pathogenesis. We predicted significantly disordered regions of 71.2, 48.8, and 45.4% representing the mutation in the sequence of NFIL3, USP8, and ADM, respectively. Regulation of gene expression was performed to find upregulated genes. Molecular docking analysis was used to evaluate Food and Drug Administration-approved medicines against the four DEGs that were overexpressed. For each elevated target protein, the three best drug candidates were chosen. Furthermore, molecular dynamics (MD) simulation using the target's active sites for 100 ns was used to validate these 12 complexes after docking. This investigation establishes the worth of systems genetics for finding four possible genes as potential drug targets for hypertension. These network-based approaches are significant for finding genetic variant data, which will advance the understanding of how to hasten the identification of drug targets and improve the understanding regarding the treatment of hypertension.
    Language English
    Publishing date 2022-06-20
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.2c02277
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Separation of Mandelic Acid by a Reactive Extraction Method Using Tertiary Amine in Different Organic Diluents.

    Kiriş, Barış / Aşçı, Yavuz Selim / Zahoor, Muhammad / Hassan, Syed Shams Ul / Bungau, Simona

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 18

    Abstract: Mandelic acid is a valuable chemical that is commonly used in the synthesis of various drugs, in antibacterial products, and as a skin care agent in cosmetics. As it is an important chemical, various methods are used to synthesize and extract this ... ...

    Abstract Mandelic acid is a valuable chemical that is commonly used in the synthesis of various drugs, in antibacterial products, and as a skin care agent in cosmetics. As it is an important chemical, various methods are used to synthesize and extract this compound. However, the yields of the used processes is not significant. A dilute aqueous solution is obtained when using several production methods, such as a fermentation, etc. In this study, the reactive extraction of mandelic acid from aqueous solutions using tri-n-octylamine extractant at 298.15 K was investigated. Dimethyl phthalate (DMP), methyl isobutyl ketone (MIBK), 2-octanone, 1-octanol, n-pentane, octyl acetate, and toluene were used as diluents. The batch extraction results of the mandelic acid experiments were obtained for the development of a process design. Calculations of the loading factor (Z), distribution coefficient (D), and extraction efficiency (E%) were based on the experimental data. The highest separation yield was obtained as 98.13% for 0.458 mol.L
    MeSH term(s) 1-Octanol ; Amines/chemistry ; Anti-Bacterial Agents ; Mandelic Acids ; Toluene ; Water/chemistry
    Chemical Substances Amines ; Anti-Bacterial Agents ; Mandelic Acids ; Water (059QF0KO0R) ; Toluene (3FPU23BG52) ; tri-N-octylamine (I40965UY86) ; mandelic acid (NH496X0UJX) ; 1-Octanol (NV1779205D)
    Language English
    Publishing date 2022-09-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27185986
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  10. Article ; Online: RETRACTED: Akter et al. Potential Role of Natural Products to Combat Radiotherapy and Their Future Perspectives.

    Akter, Rokeya / Najda, Agnieszka / Rahman, Md Habibur / Shah, Muddaser / Wesołowska, Sylwia / Hassan, Syed Shams Ul / Mubin, Sidra / Bibi, Parveen / Saeeda, Saeeda

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 24

    Abstract: This published review [ ... ]. ...

    Abstract This published review [...].
    Language English
    Publishing date 2023-12-14
    Publishing country Switzerland
    Document type Retraction of Publication
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28248091
    Database MEDical Literature Analysis and Retrieval System OnLINE

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