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  1. Article ; Online: Disseminated Intravascular Coagulation Associated with Large Deletion of Immunoglobulin Heavy Chain

    Abbas Khalili / Amir Hosein Yadegari / Samaneh Delavari / Reza Yazdani / Hassan Abolhassani

    Iranian Journal of Allergy, Asthma and Immunology, Vol 20, Iss

    2021  Volume 6

    Abstract: Although the majority of monogenic defects underlying primary immunodeficiency are microlesions, large lesions like large deletions are rare and constitute less than 10% of these patients. The immunoglobulin heavy chain (IGH) locus is one of the common ... ...

    Abstract Although the majority of monogenic defects underlying primary immunodeficiency are microlesions, large lesions like large deletions are rare and constitute less than 10% of these patients. The immunoglobulin heavy chain (IGH) locus is one of the common regions for such genetic alterations. This study describes a rare case of autosomal recessive agammaglobulinemia with a homozygous large deletion in chromosome 14q32.33 (106067756-106237742) immunoglobulin heavy chain clusters with an unusual and severe skin infection and disseminated intravascular coagulopathy.
    Keywords Agammaglobulinemia ; Disseminated intravascular coagulation ; Immunoglobulin mu-chain ; Primary immunodeficiency diseases ; Medicine ; R
    Language English
    Publishing date 2021-12-01T00:00:00Z
    Publisher Tehran University of Medical Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Evaluation of MicroRNA-125b-5p and Transcription Factors BLIMP1 and IRF4 Expression in Unsolved Common Variable Immunodeficiency Patients

    Zahra Hamidi Esfahani / Reza Yazdani / Sepideh Shahkarami / Fateme Babaha / Hassan Abolhassani / Maryam Sadr / Ali Akbar Pourfathollah / Asghar Aghamohammadi

    Iranian Journal of Allergy, Asthma and Immunology, Vol 20, Iss

    2021  Volume 6

    Abstract: Common variable immunodeficiency (CVID) is the most prevalent form of symptomatic primary humoral immunodeficiencies characterized by failure in the final differentiation of B lymphocytes. The majority of CVID cases have no identified genetic defect, and ...

    Abstract Common variable immunodeficiency (CVID) is the most prevalent form of symptomatic primary humoral immunodeficiencies characterized by failure in the final differentiation of B lymphocytes. The majority of CVID cases have no identified genetic defect, and epigenetic alteration could be involved in the pathogenesis of CVID. Hence, we aimed to evaluate the expression of hsa-miR-125b-5p -and, B lymphocyte-induced maturation protein-1(BLIMP-1) and interferon regulatory protein-4 (IRF-4) in a group of CVID patients with no definitive genetic diagnosis in comparison with healthy individuals. Ten CVID patients (all known genes excluded) and 10 age and sex-matched healthy controls participated in the study. B lymphocytes were isolated and expression of miR-125b-5p, IRF4, and BLIMP1 were evaluated by real-time polymerase chain reaction (RT-PCR). Moreover, B cell subsets were analyzed by flow cytometry. The results showed that the relative expression of miR-125b-5p in CVID patients was increased while it was decreased for the BLIMP1 and IRF4 transcription factors compared with the healthy controls. Although a reduction was observed in switched and non-switched memory B cells among all high-miR patients, these subsets were decreased in patients with normal miR expression (71.0% and 85.0%, respectively). Our results suggest that overexpression of miR-125b-5p affects the terminal differentiation of B cells in a selected group of CVID patients by downregulating the BLIMP-1 gene and more intensively for the IRF-4 gene expressions.
    Keywords Common Variable Immunodeficiency ; Epigenesis ; MicroRNAs ; Primary immunodeficiency diseases ; Medicine ; R
    Subject code 610 ; 616
    Language English
    Publishing date 2021-12-01T00:00:00Z
    Publisher Tehran University of Medical Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Vitamin D Deficiency among Female Nurses of Children’s Medical Center Hospital and Its Related Factors

    Hamid Rajebi / Ahmad Khodadad / Golshan Fahimi / Hassan Abolhassani

    Acta Medica Iranica, Vol 54, Iss

    2016  Volume 2

    Abstract: Vitamin D deficiency is one of the most preventable challenges worldwide. The aim of this study was to determine the prevalence of vitamin D deficiency among female nurses working at Children’s Medical Center Hospital in Tehran, Iran, due to the risk ... ...

    Abstract Vitamin D deficiency is one of the most preventable challenges worldwide. The aim of this study was to determine the prevalence of vitamin D deficiency among female nurses working at Children’s Medical Center Hospital in Tehran, Iran, due to the risk factor of being a notably long period indoors and the fact that their health status may have consequences on the process of patients’ treatment. A total of 114 female nurses who were at least 20 years old entered the study voluntarily, and a questionnaire was applied to collect information on lifestyle and other factors associated with vitamin D deficiency. A sample of blood was taken to measure 25-hydroxyvitamin D (25-OHD) and cut off value to indicate deficiency was considered below 10ng/ml, and the amounts of 10-29ng/ml were declared insufficient. The mean of 25-OHD was 11.7±9.3ng/ml. A total of 79 subjects (69.3%) had a deficient level of vitamin D, 28 subjects (24.6%) had an insufficient level and only 7 subjects (6.1%) had sufficient level of vitamin D. The deficiency was more noticeable in the age group of 26-35 years old. Prevalence of vitamin D deficiency had a significant correlation with younger subjects (P<0.001). There was no significant association among other factors such as body mass index (BMI), health status complications, regular exercise, and duration of sun exposure. High prevalence of vitamin D deficiency in the study population leads to emphasise the need to screen health care workers for vitamin D levels.
    Keywords Vitamin D deficiency ; Prevalence ; Nurse ; Medicine (General) ; R5-920
    Subject code 360
    Language English
    Publishing date 2016-03-01T00:00:00Z
    Publisher Tehran University of Medical Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Generation of a human induced pluripotent stem cell line (PHAi003) from a primary immunodeficient patient with CD70 mutation

    Jonathan Arias-Fuenzalida / Jingwei Yu / Hassan Abolhassani / Likun Du / Joaquin Custodio / Qiang Pan-Hammarström

    Stem Cell Research, Vol 41, Iss , Pp - (2019)

    2019  

    Abstract: Primary immunodeficiency (PID) comprises a heterogeneous group of over 330 genetic disorders, caused mainly by single-gene mutations, such as CD70. We generated human induced pluripotent stem cell lines, PHAi003-A and PHAi003-B, from a PID patient ... ...

    Abstract Primary immunodeficiency (PID) comprises a heterogeneous group of over 330 genetic disorders, caused mainly by single-gene mutations, such as CD70. We generated human induced pluripotent stem cell lines, PHAi003-A and PHAi003-B, from a PID patient carrying the homozygous frameshift CD70 mutation c.250delT. The CD70 c.250delT genotype results in a complete loss of expression variant. This patient is one of the five CD70 deficient individuals described to date, and presented hypogammaglobulinemia, EBV associated Hodgkin's lymphoma and susceptibility to other viral infections. The PHAi003-A and PHAi003-B lines are a unique resource for PID modeling and studying CD70-mediated immunity in human cells.
    Keywords Biology (General) ; QH301-705.5
    Language English
    Publishing date 2019-12-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Dystonia in Ataxia Telangiectasia

    Majid Zaki-Dizaji / Mohammad Tajdini / Fatemeh Kiaee / Hossein Shojaaldini / Reza Shervin Badv / Hassan Abolhassani / Asghar Aghamohammadi

    Oman Medical Journal, Vol 35, Iss 1, Pp e93-e

    A Case Report with Novel Mutations

    2020  Volume 93

    Abstract: Ataxia telangiectasia (A-T) is a common, genetically inherited cause of early childhoodonset ataxia that is classically characterized by progressive cerebellar malfunction, oculocutaneous telangiectasia, genome instability, and immunodeficiency. There is ...

    Abstract Ataxia telangiectasia (A-T) is a common, genetically inherited cause of early childhoodonset ataxia that is classically characterized by progressive cerebellar malfunction, oculocutaneous telangiectasia, genome instability, and immunodeficiency. There is vast phenotype variation in patients with A-T and recently, dystonia, an extrapyramidal movement disorder. Here, we report the case of a 10-year-old girl who had experienced repeated diarrhea and mild gait ataxia since the age of two years. At age seven, ataxia and ocular telangiectasia were evident and immunoglobulin level assessment showed hyper IgM immune phenotype, thus a diagnosis of A-T was made based on clinical and laboratory findings, and she was started on intravenous immunoglobulin therapy. Generalized dystonia appeared when she was 10-years-old. Molecular analysis revealed two heterozygous mutations, c.6259delG and c.6658C>T, in the ATM gene of which one (c.6259delG) is novel. Dystonia can be part of the clinical picture in the A-T disorder and may even mask ataxia. This should be considered as a major feature mainly in variant A-T, which may occur without general ataxia and may be misdiagnosed in adults with primary dystonia.
    Keywords ataxia telangiectasia ; dystonia ; mutation ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher Oman Medical Specialty Board
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Establishment of national primary immunodeficiency network, requisite of health organization and final stage of polio eradication

    Asghar Aghamohammadi / Mohammadreza Shaghaghi / Hassan Abolhassani / Reza Yazdani / Seyed Mohsen Zahraie / Mohammad Mehdi Goya / Susan Mahmoudi / Nima Rezaei / Shohreh Shahmahmoodi

    Tehran University Medical Journal, Vol 78, Iss 1, Pp 1-

    review article

    2020  Volume 8

    Abstract: Primary immunodeficiency diseases (PIDs) is a diverse group of diseases, characterized by a defect in the immune system. These patients are susceptible to recurrent respiratory infections, gastrointestinal problems, autoimmune diseases, and malignancies. ...

    Abstract Primary immunodeficiency diseases (PIDs) is a diverse group of diseases, characterized by a defect in the immune system. These patients are susceptible to recurrent respiratory infections, gastrointestinal problems, autoimmune diseases, and malignancies. In most cases, patients with primary immunodeficiency disorders have genetic defects and are monogenic disorders that follow a simple Mendelian inheritance, however, some PIDs recognize a more complex polygenic origin. Overall, almost 70 to 90 percent of patients with primary immunodeficiency are undiagnosed. Given that these patients are exposing to respiratory infectious agents and some live-attenuated vaccines, thus they have a high risk to some clinical complications. The administration of oral polio vaccine in patients with PIDs especially can increase the possibility of acute flaccid paralysis. These patients will excrete the poliovirus for a long time through their feces, even though they are not paralyzed. Long-term virus proliferation in the vaccinated individuals causes a mutation in the poliovirus and creates a vaccine-derived polioviruses (VDPVs), which is a major challenge to the final stages of the worldwide eradication of polio. To increase the diagnosis and identification of patients with immunodeficiency and carrying out a national plan for screening patients with immunodeficiency from the fecal excretion of the poliovirus, a possible polio epidemic can be prevented during post-eradication. Development of laboratory facilities in provincial and city centers, improvement of communications among physicians regarding medical consultation and establishment of referring systems for patients by national network lead to improve status of diagnosis and treatment of patients with primary immunodefiicencies. In this context, launching and activating the national network of immunodeficiency diseases is essential for improving the health of children and reducing the cost of the health system of the country. A national network of immunodeficiency can lead to ...
    Keywords child ; poliovirus ; primary immunodeficiency diseases ; review ; screening ; vaccines ; Medicine (General) ; R5-920
    Subject code 610
    Language Persian
    Publishing date 2020-03-01T00:00:00Z
    Publisher Tehran University of Medical Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Ectopic Decidual Reaction Mimicking Irritable Bowel Syndrome

    Soraya Salehgargari / Behrokh Sahebdel / Ali Zare / Hassan Abolhassani

    Acta Medica Iranica, Vol 52, Iss

    A Case Report

    2014  Volume 1

    Abstract: Ectopic decidualization with gross involvement of the peritoneum is one of the rare findings in pregnant women particularly when ectopic decidualization disseminated as an asymptomatic intra-abdominal nodule. We present here a case of an ectopic ... ...

    Abstract Ectopic decidualization with gross involvement of the peritoneum is one of the rare findings in pregnant women particularly when ectopic decidualization disseminated as an asymptomatic intra-abdominal nodule. We present here a case of an ectopic decidualization in a 33-year-old pregnant woman with symptoms of irritable bowel syndrome during pregnancy.
    Keywords Ectopic decidualization ; Irritable bowel syndrome ; Pregnancy ; Medicine (General) ; R5-920
    Language English
    Publishing date 2014-01-01T00:00:00Z
    Publisher Tehran University of Medical Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Heterologous inactivated virus/mRNA vaccination response to BF.7, BQ.1.1, and XBB.1

    Fanglei Zuo / Rui Sun / Hassan Abolhassani / Likun Du / Yating Wang / Stelios Vlachiotis / Federico Bertoglio / Maren Schubert / Nima Rezaei / Zahra Chavoshzadeh / Concetta Guerra / Andrea Cavalli / Juni Andréll / Makiko Kumagai-Braesch / Yintong Xue / Yunlong Cao / Michael Hust / Davide F. Robbiani / Xiaoliang Sunney Xie /
    Lennart Hammarström / Harold Marcotte / Qiang Pan-Hammarström

    The Lancet Regional Health. Western Pacific, Vol 33, Iss , Pp 100762- (2023)

    2023  

    Keywords Public aspects of medicine ; RA1-1270
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: The Approach to Children with Recurrent Infections

    Payam Mohammadinejad / Hassan Abolhassani / Asghar Aghamohammadi / Nima Rezaei

    Iranian Journal Of Allergy, Asthma and Immunology, Vol 11, Iss 2, Pp 89-

    2012  Volume 109

    Abstract: Recurrent and chronic infections in children are one of the most common reasons for physicians' visits that make a diagnostic challenge to pediatricians. Although the majority of referred children with recurrent infections are normal, underlying causes ... ...

    Abstract Recurrent and chronic infections in children are one of the most common reasons for physicians' visits that make a diagnostic challenge to pediatricians. Although the majority of referred children with recurrent infections are normal, underlying causes of recurrent infection such as atopy, anatomical and functional defects, and primary or secondary immunodeficiency must be considered in evaluation of children with this complaint.Although primary immunodeficiency diseases (PIDs) were originally felt to be rare, it has became clear that they are much more common than routinely appreciated. Early and accurate detection of PIDs in children is essential to institute early lifesaving care and optimized treatments.Therefore in the approach to children with recurrent infections, careful medical history taking and physical examination with more attention to warning PIDs signs and symptoms are essential to distinguish those children with underlying PIDs from those who are normal or having other underlying disorders. If indicated, appropriate laboratory studies including simple screening and advanced tests must be performed.
    Keywords Approach ; Diagnosis ; Primary immunodeficiency diseases ; Recurrent infections infections ; Immunologic diseases. Allergy ; RC581-607 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Allergy and Immunology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Subject code 610
    Language English
    Publishing date 2012-06-01T00:00:00Z
    Publisher Tehran University of Medical Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: The Approach to Children with Recurrent Infections

    Asghar Aghamohammadi / Hassan Abolhassani / Payam Mohammadinejad / Nima Rezaei

    Iranian Journal of Allergy, Asthma and Immunology, Vol 11, Iss

    2012  Volume 2

    Abstract: Recurrent and chronic infections in children are one of the most common reasons for physicians' visits that make a diagnostic challenge to pediatricians. Although the majority of referred children with recurrent infections are normal, underlying causes ... ...

    Abstract Recurrent and chronic infections in children are one of the most common reasons for physicians' visits that make a diagnostic challenge to pediatricians. Although the majority of referred children with recurrent infections are normal, underlying causes of recurrent infection such as atopy, anatomical and functional defects, and primary or secondary immunodeficiency must be considered in evaluation of children with this complaint. Although primary immunodeficiency diseases (PIDs) were originally felt to be rare, it has became clear that they are much more common than routinely appreciated. Early and accurate detection of PIDs in children is essential to institute early lifesaving care and optimized treatments. Therefore in the approach to children with recurrent infections, careful medical history taking and physical examination with more attention to warning PIDs signs and symptoms are essential to distinguish those children with underlying PIDs from those who are normal or having other underlying disorders. If indicated, appropriate laboratory studies including simple screening and advanced tests must be performed.
    Keywords Approach ; Diagnosis ; Primary immunodeficiency diseases ; Recurrent infections ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2012-06-01T00:00:00Z
    Publisher Tehran University of Medical Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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