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Article ; Online: Cellular Respiration in Thymic Fragments from Mice.

Alshamsi, Mariam / Hassane, Maya / Almarzooqi, Farida / Souid, Abdul-Kader

Frontiers in bioscience (Landmark edition)

2022 Volume 27, Issue 8, Page(s) 230

Abstract: Background: This report aims to detail the use of the phosphorescence oxygen analyzer for : Methods: Thymic fragments from mice were placed in glass vials containing phosphate-buffered saline, bovine albumin, and Pd(II) meso-tetra (sulfophenyl) ... ...

Abstract	Background: This report aims to detail the use of the phosphorescence oxygen analyzer for Methods: Thymic fragments from mice were placed in glass vials containing phosphate-buffered saline, bovine albumin, and Pd(II) meso-tetra (sulfophenyl) tetrabenzoporphyrin. The vials were sealed from air, and the cellular oxygen consumption was monitored as function of time. Results: The decline of dissolved oxygen concentration with time (d[O2]/d Conclusions: Thymocyte respiration can serve as a surrogate biomarker for studying the mode-of-action and the cytotoxicity of immunotoxins and immunosuppressants.
MeSH term(s)	Animals ; Cattle ; Cell Respiration ; Immunosuppressive Agents/pharmacology ; Mice ; Oxygen ; Oxygen Consumption/physiology ; Sirolimus/pharmacology
Chemical Substances	Immunosuppressive Agents ; Oxygen (S88TT14065) ; Sirolimus (W36ZG6FT64)
Language	English
Publishing date	2022-08-30
Publishing country	Singapore
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2704569-9
ISSN	2768-6698 ; 2768-6698
ISSN (online)	2768-6698
ISSN	2768-6698
DOI	10.31083/j.fbl2708230
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Article ; Online: Ozanimod-mediated remission in experimental autoimmune encephalomyelitis is associated with enhanced activity of CNS CD27

Kamyan, Doua / Hassane, Maya / Alnaqbi, Alanood / Souid, Abdul-Kader / Rasbi, Zakeya Al / Tahrawi, Abeer Al / Shamsi, Mariam Al

Frontiers in immunology

2024 Volume 15, Page(s) 1230735

Abstract: Background: Ozanimod (RPC1063) is an immunomodulator that has been recently approved by the FDA (2020) for the treatment of relapsing-remitting multiple sclerosis (RRMS). It is a selective agonist of the sphingosine-1-phophate receptors 1 and 5, ... ...

Abstract	Background: Ozanimod (RPC1063) is an immunomodulator that has been recently approved by the FDA (2020) for the treatment of relapsing-remitting multiple sclerosis (RRMS). It is a selective agonist of the sphingosine-1-phophate receptors 1 and 5, expressed on naïve and central memory T and B cells, as well as natural killer (NK) cells, and is involved in lymphocyte trafficking. Oral administration of ozanimod was reported to result in rapid and reversible reduction in circulating lymphocytes in multiple sclerosis (MS) patients, however, only minimal effect on NK cells was observed. In this study, we sought to investigate the effect of ozanimod on NK cells and assess whether they play any role in ozanimod-induced remission in experimental autoimmune encephalomyelitis (EAE), the animal model of MS. Methods: Active EAE induction was done in C57BL/6 female mice, followed by daily oral treatment with ozanimod (0.6mg/kg) starting at disease onset (score 1). Flow cytometry of blood and CNS was performed 24 hours after the last oral dose of ozanimod treatment in diseased mice. Histological analysis of lumbar spinal cord was performed for evaluating the level of inflammation and demyelination. Depletion of peripheral NK cells was done using anti-NK1.1 mouse antibody (mAb) at day 5 post-EAE induction. Results: Ozanimod was effective in reducing the clinical severity of EAE and reducing the percentage of autoreactive CD4 Conclusion: The current study demonstrated that ozanimod treatment significantly improved clinical symptoms in EAE mice. Ozanimod and anti-NK1.1 mAb appear to function in opposition to one another. Collectively, our data suggest that ozanimod-mediated remission is associated with an increased percentage of total NK cells and CD27
MeSH term(s)	Humans ; Female ; Mice ; Animals ; Encephalomyelitis, Autoimmune, Experimental ; CD8-Positive T-Lymphocytes ; Mice, Inbred C57BL ; Multiple Sclerosis ; Killer Cells, Natural ; Indans ; Oxadiazoles
Chemical Substances	ozanimod (Z80293URPV) ; Indans ; Oxadiazoles
Language	English
Publishing date	2024-03-12
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2024.1230735
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Article ; Online: "Universal Flu Vaccine": Can NK Cell-mediated ADCC Tip the Scales?

Hassane, Maya / Paget, Christophe

EBioMedicine

2016 Volume 8, Page(s) 18–19

Language	English
Publishing date	2016-06-03
Publishing country	Netherlands
Document type	Journal Article ; Comment
ZDB-ID	2851331-9
ISSN	2352-3964
ISSN (online)	2352-3964
DOI	10.1016/j.ebiom.2016.05.042
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Article: Thymic Program Directing the Functional Development of γδT17 Cells.

Jouan, Youenn / Patin, Emmanuel C / Hassane, Maya / Si-Tahar, Mustapha / Baranek, Thomas / Paget, Christophe

Frontiers in immunology

2018 Volume 9, Page(s) 981

Abstract: γδT cells comprise a unique T cell sublineage endowed with a wide functional repertoire, which allow them to play important-sometimes opposite-roles in many immune responses associated with infection, cancer, and inflammatory processes. This is largely ... ...

Abstract	γδT cells comprise a unique T cell sublineage endowed with a wide functional repertoire, which allow them to play important-sometimes opposite-roles in many immune responses associated with infection, cancer, and inflammatory processes. This is largely dependent on the existence of pre-programmed discrete functional subsets that differentiate within the thymus at specific temporal windows of life. Since they represent a major early source of interleukin-17A in many models of immune responses, the γδT17 cell population has recently gained considerable interest. Thus, a better dissection of the developmental program of this effector γδT subset appears critical in understanding their associated immune functions. Several recent reports have provided new exciting insights into the developmental mechanisms that control γδT cell lineage commitment and differentiation. Here, we review the importance of thymic cues and intrinsic factors that shape the developmental program of γδT17 cells. We also discuss the potential future areas of research in γδT17 cell development especially in regards to the recently provided data from deep RNA sequencing technology. Pursuing our understanding into this complex mechanism will undoubtedly provide important clues into the biology of this particular T cell sublineage.
MeSH term(s)	Animals ; Cell Differentiation ; Cell Lineage ; Cytokines/immunology ; High-Throughput Nucleotide Sequencing ; Humans ; Immunity, Innate ; Interleukin-17/genetics ; Interleukin-17/immunology ; Intraepithelial Lymphocytes/immunology ; Mice ; Thymus Gland/cytology ; Thymus Gland/immunology
Chemical Substances	Cytokines ; IL17A protein, human ; Interleukin-17
Language	English
Publishing date	2018-05-08
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2606827-8
ISSN	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2018.00981
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Article ; Online: Pathogenesis of Tobacco-Associated Lung Adenocarcinoma Is Closely Coupled with Changes in the Gut and Lung Microbiomes.

Finnicum, Casey T / Rahal, Zahraa / Hassane, Maya / Treekitkarnmongkol, Warapen / Sinjab, Ansam / Morris, Rhiannon / Liu, Yuejiang / Tang, Elizabeth L / Viet, Sarah / Petersen, Jason L / Lorenzi, Philip L / Tan, Lin / Petrosino, Joseph / Hoffman, Kristi L / Fujimoto, Junya / Moghaddam, Seyed Javad / Kadara, Humam

International journal of molecular sciences

2022 Volume 23, Issue 18

Abstract: Microbial dysbiosis has emerged as a modulator of oncogenesis and response to therapy, particularly in lung cancer. Here, we investigate the evolution of the gut and lung microbiomes following exposure to a tobacco carcinogen. We performed 16S rRNA-Seq ... ...

Abstract	Microbial dysbiosis has emerged as a modulator of oncogenesis and response to therapy, particularly in lung cancer. Here, we investigate the evolution of the gut and lung microbiomes following exposure to a tobacco carcinogen. We performed 16S rRNA-Seq of fecal and lung samples collected prior to and at several timepoints following (nicotine-specific nitrosamine ketone/NNK) exposure in
MeSH term(s)	Adenocarcinoma/genetics ; Adenocarcinoma of Lung ; Animals ; Butyrates ; Carcinogens ; Dysbiosis/microbiology ; Growth Inhibitors ; Humans ; Ketones ; Lung/pathology ; Lung Neoplasms/metabolism ; Mice ; Microbiota ; Nicotine ; Nitrosamines ; Propionates ; RNA, Ribosomal, 16S/genetics ; Receptors, G-Protein-Coupled ; Nicotiana/genetics
Chemical Substances	Butyrates ; Carcinogens ; GPRC5A protein, human ; Growth Inhibitors ; Ketones ; Nitrosamines ; Propionates ; RNA, Ribosomal, 16S ; Receptors, G-Protein-Coupled ; Nicotine (6M3C89ZY6R)
Language	English
Publishing date	2022-09-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms231810930
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Article ; Online: Chronic Exposure to Waterpipe Smoke Elicits Immunomodulatory and Carcinogenic Effects in the Lung.

Hassane, Maya / Rahal, Zahraa / Karaoghlanian, Nareg / Zhang, Jiexin / Sinjab, Ansam / Wong, Justin W / Lu, Wei / Scheet, Paul / Lee, J Jack / Raso, Maria Gabriela / Solis, Luisa M / Fujimoto, Junya / Chami, Hassan / Shihadeh, Alan L / Kadara, Humam

Cancer prevention research (Philadelphia, Pa.)

2022 Volume 15, Issue 7, Page(s) 423–434

Abstract: Effects of waterpipe smoking on lung pathobiology and carcinogenesis remain sparse despite the worldwide emergence of this tobacco vector. To address this gap, we investigated the effects of chronic waterpipe smoke (WPS) exposure on lung pathobiology, ... ...

Abstract	Effects of waterpipe smoking on lung pathobiology and carcinogenesis remain sparse despite the worldwide emergence of this tobacco vector. To address this gap, we investigated the effects of chronic waterpipe smoke (WPS) exposure on lung pathobiology, host immunity, and tumorigenesis using an experimental animal model that is prone to tobacco carcinogens and an exploratory observational analysis of human waterpipe smokers and nonsmokers. Mice exhibited elevated incidence of lung tumors following heavy WPS exposure (5 days/week for 20 weeks) compared to littermates with light WPS (once/week for 20 weeks) or control air. Lungs of mice exposed to heavy WPS showed augmented CD8+ and CD4+ T cell counts along with elevated protumor immune phenotypes including increased IL17A in T/B cells, PD-L1 on tumor and immune cells, and the proinflammatory cytokine IL1β in myeloid cells. RNA-sequencing (RNA-seq) analysis showed reduced antitumor immune gene signatures in animals exposed to heavy WPS relative to control air. We also performed RNA-seq analysis of airway epithelia from bronchial brushings of cancer-free waterpipe smokers and nonsmokers undergoing diagnostic bronchoscopy. Transcriptomes of normal airway cells in waterpipe smokers, relative to waterpipe nonsmokers, harbored gene programs that were associated with poor clinical outcomes in patients with lung adenocarcinoma, alluding to a WPS-associated molecular injury, like that established in response to cigarette smoking. Our findings support the notion that WPS exhibits carcinogenic effects and constitutes a possible risk factor for lung cancer as well as warrant future studies that can guide evidence-based policies for mitigating waterpipe smoking. Prevention relevance: Potential carcinogenic effects of waterpipe smoking are very poorly understood despite its emergence as a socially acceptable form of smoking. Our work highlights carcinogenic effects of waterpipe smoking in the lung and, thus, accentuate the need for inclusion of individuals with exclusive waterpipe smoking in prevention and smoking cessation studies.
MeSH term(s)	Animals ; Carcinogens/toxicity ; Lung ; Mice ; Neoplasms ; Tobacco Products/adverse effects ; Water Pipe Smoking/adverse effects
Chemical Substances	Carcinogens
Language	English
Publishing date	2022-04-25
Publishing country	United States
Document type	Journal Article ; Observational Study ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2434717-6
ISSN	1940-6215 ; 1940-6207
ISSN (online)	1940-6215
ISSN	1940-6207
DOI	10.1158/1940-6207.CAPR-21-0610
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Article: Genome-Wide and Phenotypic Evaluation of Stem Cell Progenitors Derived From

Daouk, Reem / Hassane, Maya / Bahmad, Hisham F / Sinjab, Ansam / Fujimoto, Junya / Abou-Kheir, Wassim / Kadara, Humam

Frontiers in oncology

2019 Volume 9, Page(s) 207

Abstract: Lung adenocarcinomas (LUADs) with somatic mutations in ... ...

Abstract	Lung adenocarcinomas (LUADs) with somatic mutations in the
Language	English
Publishing date	2019-04-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2019.00207
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Article ; Online: Type I IFN Receptor Signaling Controls IL7-Dependent Accumulation and Activity of Protumoral IL17A-Producing γδT Cells in Breast Cancer.

Patin, Emmanuel C / Soulard, Daphnée / Fleury, Sébastien / Hassane, Maya / Dombrowicz, David / Faveeuw, Christelle / Trottein, François / Paget, Christophe

Cancer research

2017 Volume 78, Issue 1, Page(s) 195–204

Abstract: The protumoral activity of γδT17 cells has recently emerged in a wide variety of solid malignancies, including breast cancer. These cells exert their detrimental functions by promoting tumor growth, angiogenesis, and subsequent metastasis development. ... ...

Abstract	The protumoral activity of γδT17 cells has recently emerged in a wide variety of solid malignancies, including breast cancer. These cells exert their detrimental functions by promoting tumor growth, angiogenesis, and subsequent metastasis development. However, the intratumoral factors that regulate the biology of γδT17cells within the tumor microenvironment are less well understood. Here, using two experimental models of breast cancer, we reinforced the concept that tumor-infiltrating γδT17 cells are endowed with protumoral functions, which promote tumor progression and metastasis development. More importantly, we demonstrated a critical role for type I IFN signaling in controlling the preferential accumulation in the tumor bed of a peculiar subset of γδT17 cells displaying a CD27
MeSH term(s)	Animals ; Breast Neoplasms/immunology ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Female ; Interleukin-17/genetics ; Interleukin-17/metabolism ; Interleukin-7/metabolism ; Lymphocytes, Tumor-Infiltrating/metabolism ; Lymphocytes, Tumor-Infiltrating/pathology ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Receptor, Interferon alpha-beta/genetics ; Receptor, Interferon alpha-beta/immunology ; Receptor, Interferon alpha-beta/metabolism ; Receptors, Antigen, T-Cell, gamma-delta/metabolism ; Signal Transduction ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/metabolism ; Tumor Necrosis Factor Receptor Superfamily, Member 7/genetics ; Tumor Necrosis Factor Receptor Superfamily, Member 7/metabolism
Chemical Substances	Ifnar1 protein, mouse ; Il17a protein, mouse ; Interleukin-17 ; Interleukin-7 ; Receptors, Antigen, T-Cell, gamma-delta ; Tumor Necrosis Factor Receptor Superfamily, Member 7 ; Receptor, Interferon alpha-beta (156986-95-7)
Language	English
Publishing date	2017-10-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1432-1
ISSN	1538-7445 ; 0008-5472
ISSN (online)	1538-7445
ISSN	0008-5472
DOI	10.1158/0008-5472.CAN-17-1416
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Article ; Online: Interleukin-7 protects against bacterial respiratory infection by promoting IL-17A-producing innate T-cell response.

Hassane, Maya / Jouan, Youenn / Creusat, Florent / Soulard, Daphnée / Boisseau, Chloé / Gonzalez, Loïc / Patin, Emmanuel C / Heuzé-Vourc'h, Nathalie / Sirard, Jean-Claude / Faveeuw, Christelle / Trottein, François / Si-Tahar, Mustapha / Baranek, Thomas / Paget, Christophe

Mucosal immunology

2019 Volume 13, Issue 1, Page(s) 128–139

Abstract: Interleukin-7 (IL-7) is a critical cytokine in B- and T-lymphocyte development and maturation. Recent evidence suggests that IL-7 is a preferential homeostatic and survival factor for ... ...

Abstract	Interleukin-7 (IL-7) is a critical cytokine in B- and T-lymphocyte development and maturation. Recent evidence suggests that IL-7 is a preferential homeostatic and survival factor for RORγt
MeSH term(s)	Animals ; Antibodies, Blocking/metabolism ; Cells, Cultured ; Galactosylceramides/immunology ; Humans ; Immunity, Innate ; Immunotherapy/methods ; Interleukin-17/metabolism ; Interleukin-7/administration & dosage ; Interleukin-7/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Natural Killer T-Cells/immunology ; Natural Killer T-Cells/metabolism ; Neutrophils/immunology ; Nuclear Receptor Subfamily 1, Group F, Member 3/metabolism ; Pneumococcal Infections/immunology ; Respiratory Tract Infections/immunology ; Streptococcus pneumoniae/physiology
Chemical Substances	Antibodies, Blocking ; Galactosylceramides ; Interleukin-17 ; Interleukin-7 ; Nuclear Receptor Subfamily 1, Group F, Member 3 ; alpha-galactosylceramide
Language	English
Publishing date	2019-10-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2411370-0
ISSN	1935-3456 ; 1933-0219
ISSN (online)	1935-3456
ISSN	1933-0219
DOI	10.1038/s41385-019-0212-y
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Article ; Online: Exogenous Activation of Invariant Natural Killer T Cells by α-Galactosylceramide Reduces Pneumococcal Outgrowth and Dissemination Postinfluenza.

Barthelemy, Adeline / Ivanov, Stoyan / Hassane, Maya / Fontaine, Josette / Heurtault, Béatrice / Frisch, Benoit / Faveeuw, Christelle / Paget, Christophe / Trottein, François

mBio

2016 Volume 7, Issue 6

Abstract: Influenza A virus infection can predispose to potentially devastating secondary bacterial infections. Invariant natural killer T (iNKT) cells are unconventional, lipid-reactive T lymphocytes that exert potent immunostimulatory functions. Using a mouse ... ...

Abstract	Influenza A virus infection can predispose to potentially devastating secondary bacterial infections. Invariant natural killer T (iNKT) cells are unconventional, lipid-reactive T lymphocytes that exert potent immunostimulatory functions. Using a mouse model of postinfluenza invasive secondary pneumococcal infection, we sought to establish whether α-galactosylceramide (α-GalCer [a potent iNKT cell agonist that is currently in clinical development]) could limit bacterial superinfection. Our results highlighted the presence of a critical time window during which α-GalCer treatment can trigger iNKT cell activation and influence resistance to postinfluenza secondary pneumococcal infection. Intranasal treatment with α-GalCer during the acute phase (on day 7) of influenza virus H3N2 and H1N1 infection failed to activate (gamma interferon [IFN-γ] and interleukin-17A [IL-17A]) iNKT cells; this effect was associated with a strongly reduced number of conventional CD103 Importance: Despite the application of vaccination programs and antiviral drugs, influenza A virus (IAV) infection is responsible for widespread morbidity and mortality (500,000 deaths/year). Influenza infections can also result in sporadic pandemics that can be devastating: the 1918 pandemic led to the death of 50 million people. Severe bacterial infections are commonly associated with influenza and are significant contributors to the excess morbidity and mortality of influenza. Today's treatments of secondary bacterial (pneumococcal) infections are still not effective enough, and antibiotic resistance is a major issue. Hence, there is an urgent need for novel therapies. In the present study, we set out to evaluate the efficacy of α-galactosylceramide (α-GalCer)-a potent agonist of invariant NKT cells that is currently in clinical development-in a mouse model of postinfluenza, highly invasive pneumococcal pneumonia. Our data indicate that treatment with α-GalCer reduces susceptibility to superinfections and, when combined with the corticosteroid dexamethasone, reduces viral-bacterial pneumonia.
MeSH term(s)	Administration, Intranasal ; Animals ; Disease Models, Animal ; Galactosylceramides/metabolism ; Lymphocyte Activation/drug effects ; Mice ; Natural Killer T-Cells/drug effects ; Natural Killer T-Cells/immunology ; Orthomyxoviridae Infections/complications ; Pneumococcal Infections/immunology ; Pneumococcal Infections/prevention & control ; Time Factors ; Treatment Outcome
Chemical Substances	Galactosylceramides ; alpha-galactosylceramide
Language	English
Publishing date	2016-11-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2557172-2
ISSN	2150-7511 ; 2161-2129
ISSN (online)	2150-7511
ISSN	2161-2129
DOI	10.1128/mBio.01440-16
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