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  1. Article ; Online: Damaging Alleles Affecting Multiple CARD14 Domains Are Associated with Palmoplantar Pustulosis.

    Niaouris, Athanasios / Hernández-Cordero, Ariana / Haddad, Salma / Hassi, Niina Karoliina / Benzian-Olsson, Natashia / Bugarin Diz, Carmen / Burden, A David / Cooper, Hywel L / Griffiths, Christopher E M / Parslew, Richard / Pink, Andrew E / Reynolds, Nick J / Wahie, Shyamal / Warren, Richard B / Wright, Andrew / Simpson, Michael / Baum, Patrick / Visvanathan, Sudha / Barker, Jonathan N /
    Smith, Catherine H / Capon, Francesca

    The Journal of investigative dermatology

    2022  Volume 143, Issue 3, Page(s) 504–508.e5

    MeSH term(s) Humans ; Alleles ; Psoriasis/genetics ; Exanthema ; Guanylate Cyclase ; Membrane Proteins ; CARD Signaling Adaptor Proteins
    Chemical Substances CARD14 protein, human (EC 4.6.1.-) ; Guanylate Cyclase (EC 4.6.1.2) ; Membrane Proteins ; CARD Signaling Adaptor Proteins
    Language English
    Publishing date 2022-09-27
    Publishing country United States
    Document type Research Support, Non-U.S. Gov't ; Letter
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1016/j.jid.2022.07.031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: Single-cell analysis implicates T

    McCluskey, Daniel / Benzian-Olsson, Natashia / Mahil, Satveer K / Hassi, Niina Karoliina / Wohnhaas, Christian T / Burden, A David / Griffiths, Christopher E M / Ingram, John R / Levell, Nick J / Parslew, Richard / Pink, Andrew E / Reynolds, Nick J / Warren, Richard B / Visvanathan, Sudha / Baum, Patrick / Barker, Jonathan N / Smith, Catherine H / Capon, Francesca

    The Journal of allergy and clinical immunology

    2022  Volume 150, Issue 4, Page(s) 882–893

    Abstract: Background: Palmoplantar pustulosis (PPP) is a severe inflammatory skin disorder characterized by eruptions of painful, neutrophil-filled pustules on the palms and soles. Although PPP has a profound effect on quality of life, it remains poorly ... ...

    Abstract Background: Palmoplantar pustulosis (PPP) is a severe inflammatory skin disorder characterized by eruptions of painful, neutrophil-filled pustules on the palms and soles. Although PPP has a profound effect on quality of life, it remains poorly understood and notoriously difficult to treat.
    Objective: We sought to investigate the immune pathways that underlie the pathogenesis of PPP.
    Methods: We applied bulk and single-cell RNA sequencing (RNA-Seq) methods to the analysis of skin biopsy samples and peripheral blood mononuclear cells. We validated our results by flow cytometry and immune fluorescence microscopy RESULTS: Bulk RNA-Seq of patient skin detected an unexpected signature of T-cell activation, with a significant overexpression of several T
    Conclusions: PPP is associated with complex T-cell activation patterns and may explain why biologic drugs that target individual T helper cell populations have shown limited therapeutic efficacy.
    MeSH term(s) Biological Products ; Cell Plasticity ; Chronic Disease ; Humans ; Leukocytes, Mononuclear/pathology ; Psoriasis ; Quality of Life ; Single-Cell Analysis ; Skin Diseases, Vesiculobullous
    Chemical Substances Biological Products
    Language English
    Publishing date 2022-05-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2022.04.027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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