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  1. Article ; Online: A case of tracheal stenosis due to anaplastic thyroid carcinoma treated using the stent-in-stent method.

    Sakaguchi, Tadashi / Ohi, Maki / Nishii, Yoichi / Hataji, Osamu

    Thoracic cancer

    2023  Volume 15, Issue 4, Page(s) 350–352

    Abstract: Tracheal AERO stent collapse is a rare complication compared to bronchial AERO stent collapse due to differences in the nitinol framework thickness. A 58-year-old man with a bulky anaplastic thyroid carcinoma was referred to our hospital due to ... ...

    Abstract Tracheal AERO stent collapse is a rare complication compared to bronchial AERO stent collapse due to differences in the nitinol framework thickness. A 58-year-old man with a bulky anaplastic thyroid carcinoma was referred to our hospital due to exacerbation of tracheal stenosis despite the administration of lenvatinib. His tracheal stenosis exhibited a severe extrinsic compression pattern with a length of 8 cm. Because tracheotomy was inappropriate, we placed an 18 × 80 mm AERO stent. Five months later, he was readmitted with severe dyspnea due to collapse of the distal portion of the stent caused by tumor growth. Because stent removal was difficult, we placed an additional AERO stent (18 × 60 mm) to cover the collapsed portion. The additional stent successfully expanded the collapse and improved his dyspnea. To our knowledge, this is the first case where a tracheal AERO stent collapse due to a poor prognosis tumor was treated with the stent-in-stent method.
    MeSH term(s) Male ; Humans ; Middle Aged ; Tracheal Stenosis/etiology ; Tracheal Stenosis/surgery ; Tracheal Stenosis/pathology ; Thyroid Carcinoma, Anaplastic/complications ; Stents/adverse effects ; Thyroid Neoplasms/complications ; Thyroid Neoplasms/surgery ; Dyspnea
    Language English
    Publishing date 2023-12-27
    Publishing country Singapore
    Document type Case Reports
    ZDB-ID 2625856-0
    ISSN 1759-7714 ; 1759-7706
    ISSN (online) 1759-7714
    ISSN 1759-7706
    DOI 10.1111/1759-7714.15185
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  2. Article ; Online: Krebs von den Lungen-6 levels at admission predicts exercise-induced hypoxemia before and after discharge in patients with COVID-19.

    Morikawa, Keisuke / Tabira, Kazuyuki / Takemura, Hiroyuki / Inaba, Shogo / Suzuki, Yuta / Hataji, Osamu

    Respiratory investigation

    2024  Volume 62, Issue 3, Page(s) 369–374

    Abstract: Background: There are no reports of exercise-induced hypoxemia in patients with coronavirus disease 2019 (COVID-19). Additionally, the predictive factors and prevalence of exercise-induced hypoxemia are unknown. This study investigated the incidence and ...

    Abstract Background: There are no reports of exercise-induced hypoxemia in patients with coronavirus disease 2019 (COVID-19). Additionally, the predictive factors and prevalence of exercise-induced hypoxemia are unknown. This study investigated the incidence and predictive factors of exercise-induced hypoxemia before and after discharge in patients with COVID-19.
    Methods: We enrolled 77 patients diagnosed with COVID-19 who were hospitalized between November 2020 and October 2021 and who underwent a 6-min walk test before and after discharge. Based on the test results, we classified patients into exercise-induced and non-exercise-induced hypoxemia groups and investigated the predictive factors of exercise-induced hypoxemia using logistic regression analysis.
    Results: The incidences of exercise-induced hypoxemia in patients with COVID-19 were 37.7% and 19.5% before and after discharge, respectively. At admission, the Krebs von den Lungen-6 levels was the associated factor for exercise-induced hypoxemia in patients with COVID-19 before and after discharge, with cut-off values of 314 U/mL and 367 U/mL, respectively. Age and lactate dehydrogenase levels were the associated factors for exercise-induced hypoxemia in patients with COVID-19 before discharge, with cut-off values of 61 years and 492 U/L, respectively.
    Conclusions: Some patients with COVID-19 may continue to experience exercise-induced hypoxemia after discharge. Age, lactate dehydrogenase, and Krebs von den Lungen-6 levels at admission could serve as predictive markers of exercise-induced hypoxemia before and after discharge in these patients.
    MeSH term(s) Humans ; COVID-19/complications ; Patient Discharge ; Hypoxia/etiology ; Lactate Dehydrogenases ; Mucin-1 ; Biomarkers
    Chemical Substances Lactate Dehydrogenases (EC 1.1.-) ; Mucin-1 ; Biomarkers
    Language English
    Publishing date 2024-03-01
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2660821-2
    ISSN 2212-5353 ; 2212-5345
    ISSN (online) 2212-5353
    ISSN 2212-5345
    DOI 10.1016/j.resinv.2024.02.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Leveraging Microbiome Composition Variability for Precision Medicine in Idiopathic Pulmonary Fibrosis.

    Fujimoto, Hajime / D'Alessandro-Gabazza, Corina N / Yasuma, Taro / Gabazza, Esteban C / Hataji, Osamu / Kobayashi, Tetsu

    American journal of respiratory and critical care medicine

    2024  

    Language English
    Publishing date 2024-01-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202310-1899LE
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  4. Article ; Online: Refractory response to entrectinib for ROS-1 rearranged NSCLC with concurrent de novo TP53 mutation showing good response to CNS lesion, but poor duration of response: A case report.

    Ito, Kentaro / Nishio, Miho / Fujiwara, Kentaro / Nishii, Yoichi / Ushiro, Kengo / Yasui, Hiroki / Hataji, Osamu

    Thoracic cancer

    2023  Volume 14, Issue 25, Page(s) 2622–2626

    Abstract: Entrectinib, a ROS-1 inhibitor, has been shown to be effective for patients with ROS-1 fused NSCLC, and has been established as the standard of care for this population. Entrectinib has been shown to achieve a better response to brain metastasis due to ... ...

    Abstract Entrectinib, a ROS-1 inhibitor, has been shown to be effective for patients with ROS-1 fused NSCLC, and has been established as the standard of care for this population. Entrectinib has been shown to achieve a better response to brain metastasis due to the characteristic of the drug having a weak interaction with P-glycoprotein and, even in prospective studies, the intracranial response is higher. Patients have been known to acquire resistance to molecularly targeted drugs such as EGF-TKIs or ALK-TKIs during targeted therapy. Similarly, the mechanisms of resistance to entrectinib have been reported, but information about the effects of TP53 mutation with entrectinib are still limited. Here, we experienced a case of a patient with ROS-1 fusion and concurrent TP53 mutation who was treated with entrectinib, resulting in a response to brain metastasis but rapid resistance to entrectinib. Our case demonstrates both the intracranial activity of entrectinib and the potential for resistance to entrectinib due to TP53 mutation.
    MeSH term(s) Humans ; Reactive Oxygen Species ; Prospective Studies ; Carcinoma, Non-Small-Cell Lung/pathology ; Brain Neoplasms/drug therapy ; Mutation ; Lung Neoplasms/pathology ; Protein Kinase Inhibitors/therapeutic use ; Tumor Suppressor Protein p53/genetics
    Chemical Substances entrectinib (L5ORF0AN1I) ; Reactive Oxygen Species ; Protein Kinase Inhibitors ; TP53 protein, human ; Tumor Suppressor Protein p53
    Language English
    Publishing date 2023-08-06
    Publishing country Singapore
    Document type Case Reports
    ZDB-ID 2625856-0
    ISSN 1759-7714 ; 1759-7706
    ISSN (online) 1759-7714
    ISSN 1759-7706
    DOI 10.1111/1759-7714.15044
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  5. Article ; Online: Physical Activity Using a Wearable Device as an Alternative to Performance Status in Patients With Advanced Lung Cancer.

    Ito, Kentaro / Suzuki, Yuta / Sakaguchi, Tadashi / Fujiwara, Kentaro / Nishii, Yoichi / Yasui, Hiroki / Taguchi, Osamu / Hataji, Osamu

    JAMA oncology

    2024  Volume 10, Issue 5, Page(s) 648–651

    Abstract: Importance: The Eastern Cooperative Oncology Group Performance Status (ECOG PS) is extensively used to guide treatment decisions in patients with advanced lung cancer. However, its assessment is subjective, potentially leading to discordance among ... ...

    Abstract Importance: The Eastern Cooperative Oncology Group Performance Status (ECOG PS) is extensively used to guide treatment decisions in patients with advanced lung cancer. However, its assessment is subjective, potentially leading to discordance among observers.
    Objective: To investigate the association between measured physical activity and ECOG PS, as well as the potential prognostic value of physical activity measurements in patients with advanced lung cancer.
    Design, setting, and participants: This single-institution, prospective observational study enrolled 119 patients with advanced lung cancer scheduled to receive systemic therapy as outpatients at Matsusaka Municipal Hospital in Mie, Japan. Participants wore the wearable device amuelink (Sony) for up to 14 days to measure physical activity, including metabolic equivalent tasks, distance walked, and number of steps taken. ECOG PS was assessed at enrollment, which took place from December 2021 to August 2022.
    Main outcomes and measures: The primary end point was estimating the area under the curve (AUC) for classification into ECOG PS of 2 or higher using physical activity measurements. An analysis of the association with survival was also conducted.
    Results: Among the 119 patients (median [range] age, 72 (32-88) years; 71 [59.7%] male), mean distance walked (MDW) had the highest diagnostic value for classifying an ECOG PS of 2 or greater, with an AUC of 0.818 (95% CI, 0.703-0.934). Moreover, MDW was also associated with 6-month survival, with an AUC of 0.806 (95% CI, 0.694-0.918). Survival curves significantly diverged based on the MDW threshold, indicating a potential association with survival outcome (hazard ratio, 0.17; 95% CI, 0.05-0.57).
    Conclusions and relevance: The cohort study suggests that MDW, as measured by a wearable device, was associated with ECOG PS and may serve as a predictor of health status alongside ECOG PS categories. It demonstrates the potential of objectively measured physical activity in complementing subjective ECOG PS assessments in patients with advanced lung cancer. Further research is needed to confirm the prognostic value of physical activity measurements.
    MeSH term(s) Humans ; Male ; Female ; Aged ; Lung Neoplasms ; Middle Aged ; Wearable Electronic Devices ; Exercise ; Aged, 80 and over ; Prospective Studies ; Adult ; Prognosis
    Language English
    Publishing date 2024-03-28
    Publishing country United States
    Document type Journal Article ; Observational Study ; Comment
    ISSN 2374-2445
    ISSN (online) 2374-2445
    DOI 10.1001/jamaoncol.2024.0023
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  6. Article: Osimertinib therapy as first-line treatment before acquiring T790M mutation: from AURA1 trial.

    Ito, Kentaro / Hataji, Osamu

    Journal of thoracic disease

    2018  Volume 10, Issue Suppl 26, Page(s) S3071–S3077

    Language English
    Publishing date 2018-02-22
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2573571-8
    ISSN 2077-6624 ; 2072-1439
    ISSN (online) 2077-6624
    ISSN 2072-1439
    DOI 10.21037/jtd.2018.07.52
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  7. Article ; Online: An oldest-old non-small cell lung cancer patient with abscopal effect in a single lesion.

    Sakaguchi, Tadashi / Ito, Kentaro / Fujiwara, Kentaro / Nishii, Yoichi / Ochiai, Satoru / Nomoto, Yoshihito / Hataji, Osamu

    Thoracic cancer

    2022  Volume 13, Issue 15, Page(s) 2267–2270

    Abstract: The abscopal effect without concomitant immunotherapy is a rare event, including among cases of lung cancer. Furthermore, the occurrence of limited abscopal effect for only a single lesion in the metastatic organ consistent with the irradiated organ ... ...

    Abstract The abscopal effect without concomitant immunotherapy is a rare event, including among cases of lung cancer. Furthermore, the occurrence of limited abscopal effect for only a single lesion in the metastatic organ consistent with the irradiated organ would be an even more rare event. A 94-year-old man was diagnosed with advanced lung cancer with osteolytic bone metastases in his right iliac bone, and the right side of his axial vertebrae. After palliative radiation therapy to the right iliac lesion for pain relief without other anticancer therapy, the axial vertebral osteolytic lesion disappeared despite no reduction in the other lesions. This case furthers our understanding of the pathogenesis of the abscopal effect.
    MeSH term(s) Aged, 80 and over ; Bone Neoplasms/secondary ; Carcinoma, Non-Small-Cell Lung/complications ; Carcinoma, Non-Small-Cell Lung/pathology ; Carcinoma, Non-Small-Cell Lung/radiotherapy ; Humans ; Immunotherapy ; Lung Neoplasms/complications ; Lung Neoplasms/pathology ; Lung Neoplasms/radiotherapy ; Male
    Language English
    Publishing date 2022-06-27
    Publishing country Singapore
    Document type Case Reports
    ZDB-ID 2625856-0
    ISSN 1759-7714 ; 1759-7706
    ISSN (online) 1759-7714
    ISSN 1759-7706
    DOI 10.1111/1759-7714.14551
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  8. Article ; Online: Epoprostenol and Treprostinil: Differential Effects on Regulatory T-Cell Generation in Patients with Pulmonary Arterial Hypertension.

    Yasuma, Taro / Fujimoto, Hajime / D'Alessandro-Gabazza, Corina N / Gabazza, Esteban C / Hataji, Osamu / Kobayashi, Tetsu

    American journal of respiratory and critical care medicine

    2023  Volume 208, Issue 11, Page(s) 1248

    MeSH term(s) Humans ; Epoprostenol/therapeutic use ; Epoprostenol/pharmacology ; Pulmonary Arterial Hypertension/drug therapy ; T-Lymphocytes, Regulatory ; Familial Primary Pulmonary Hypertension/drug therapy ; Antihypertensive Agents/therapeutic use ; Antihypertensive Agents/pharmacology ; Treatment Outcome
    Chemical Substances treprostinil (RUM6K67ESG) ; Epoprostenol (DCR9Z582X0) ; Antihypertensive Agents
    Language English
    Publishing date 2023-09-27
    Publishing country United States
    Document type Letter
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202308-1347LE
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  9. Article ; Online: Risk factors for disease progression in fibrotic hypersensitivity pneumonitis.

    Fujimoto, Hajime / Yasuma, Taro / D'Alessandro-Gabazza, Corina N / Gabazza, Esteban C / Hataji, Osamu / Kobayashi, Tetsu

    The European respiratory journal

    2023  Volume 61, Issue 1

    MeSH term(s) Humans ; Prevalence ; Disease Progression ; Alveolitis, Extrinsic Allergic ; Lung Diseases, Interstitial ; Risk Factors
    Language English
    Publishing date 2023-01-27
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.01706-2022
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  10. Article: Physical Activity Estimated by the Wearable Device in Lung Disease Patients: Exploratory Analyses of Prospective Observational Study.

    Ito, Kentaro / Esumi, Maki / Esumi, Seiya / Suzuki, Yuta / Sakaguchi, Tadashi / Fujiwara, Kentaro / Nishii, Yoichi / Yasui, Hiroki / Taguchi, Osamu / Hataji, Osamu

    Journal of clinical medicine

    2023  Volume 12, Issue 13

    Abstract: Background. ...

    Abstract Background.
    Language English
    Publishing date 2023-06-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12134424
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