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  1. Article ; Online: Critical Amino Acid Residues Regulating TRPA1 Zn

    Matsubara, Masaki / Muraki, Yukiko / Suzuki, Hiroka / Hatano, Noriyuki / Muraki, Katsuhiko

    The Journal of biological chemistry

    2024  , Page(s) 107302

    Abstract: Cellular zinc ions ( ... ...

    Abstract Cellular zinc ions (Zn
    Language English
    Publishing date 2024-04-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1016/j.jbc.2024.107302
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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.108: Show issues Location:
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  2. Article ; Online: Potent Activation of Human but Not Mouse TRPA1 by JT010.

    Matsubara, Masaki / Muraki, Yukiko / Hatano, Noriyuki / Suzuki, Hiroka / Muraki, Katsuhiko

    International journal of molecular sciences

    2022  Volume 23, Issue 22

    Abstract: Transient receptor potential (TRP) ankyrin repeat 1 (TRPA1), which is involved in inflammatory pain sensation, is activated by endogenous factors, such as intracellular ... ...

    Abstract Transient receptor potential (TRP) ankyrin repeat 1 (TRPA1), which is involved in inflammatory pain sensation, is activated by endogenous factors, such as intracellular Zn
    MeSH term(s) Humans ; Transient Receptor Potential Channels/genetics ; Calcium Channels/genetics ; TRPA1 Cation Channel/genetics ; Cysteine ; Calcium/metabolism ; Methionine
    Chemical Substances Transient Receptor Potential Channels ; Calcium Channels ; TRPA1 Cation Channel ; JT010 ; Cysteine (K848JZ4886) ; Calcium (SY7Q814VUP) ; Methionine (AE28F7PNPL) ; TRPA1 protein, human
    Language English
    Publishing date 2022-11-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms232214297
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  3. Article ; Online: HIF-1α Dependent Upregulation of ZIP8, ZIP14, and TRPA1 Modify Intracellular Zn

    Hatano, Noriyuki / Matsubara, Masaki / Suzuki, Hiroka / Muraki, Yukiko / Muraki, Katsuhiko

    International journal of molecular sciences

    2021  Volume 22, Issue 12

    Abstract: Intracellular free zinc ([ ... ...

    Abstract Intracellular free zinc ([Zn
    MeSH term(s) Cation Transport Proteins/genetics ; Cation Transport Proteins/metabolism ; Fibroblasts/metabolism ; Fibroblasts/pathology ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Inflammation/genetics ; Inflammation/pathology ; Intracellular Space/metabolism ; Synoviocytes/metabolism ; Synoviocytes/pathology ; TRPA1 Cation Channel/genetics ; TRPA1 Cation Channel/metabolism ; Up-Regulation/genetics ; Zinc/metabolism
    Chemical Substances Cation Transport Proteins ; Hypoxia-Inducible Factor 1, alpha Subunit ; SLC39A14 protein, human ; SLC39A8 protein, human ; TRPA1 Cation Channel ; TRPA1 protein, human ; Zinc (J41CSQ7QDS)
    Language English
    Publishing date 2021-06-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22126349
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  4. Article ; Online: The inflammatory regulation of TRPA1 expression in human A549 lung epithelial cells.

    Luostarinen, Samu / Hämäläinen, Mari / Hatano, Noriyuki / Muraki, Katsuhiko / Moilanen, Eeva

    Pulmonary pharmacology & therapeutics

    2021  Volume 70, Page(s) 102059

    Abstract: Transient receptor potential ankyrin-1 (TRPA1) is an ion channel mediating pain and cough signals in sensory neurons. We and others have shown that TRPA1 is also expressed in some non-neuronal cells and supports inflammatory responses. To address the ... ...

    Abstract Transient receptor potential ankyrin-1 (TRPA1) is an ion channel mediating pain and cough signals in sensory neurons. We and others have shown that TRPA1 is also expressed in some non-neuronal cells and supports inflammatory responses. To address the pathogenesis and to uncover potential targets for pharmacotherapy in inflammatory lung diseases, we set out to study the expression of TRPA1 in human A549 lung epithelial cells under inflammatory conditions. TRPA1 expression was determined by RT-qPCR and Western blotting at a mRNA and protein level, respectively and its function was studied by Fluo 3-AM intracellular Ca
    MeSH term(s) A549 Cells ; Cytokines ; Epithelial Cells ; Gene Expression ; Humans ; Lung ; TRPA1 Cation Channel/genetics ; Tumor Necrosis Factor-alpha
    Chemical Substances Cytokines ; TRPA1 Cation Channel ; TRPA1 protein, human ; Tumor Necrosis Factor-alpha
    Language English
    Publishing date 2021-07-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1399707-5
    ISSN 1522-9629 ; 1094-5539
    ISSN (online) 1522-9629
    ISSN 1094-5539
    DOI 10.1016/j.pupt.2021.102059
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2389: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: PIEZO1 Channel Is a Potential Regulator of Synovial Sarcoma Cell-Viability.

    Suzuki, Takahisa / Muraki, Yukiko / Hatano, Noriyuki / Suzuki, Hiroka / Muraki, Katsuhiko

    International journal of molecular sciences

    2018  Volume 19, Issue 5

    Abstract: Detection of mechanical stress is essential for diverse biological functions including touch, audition, and maintenance of vascular myogenic tone. PIEZO1, a mechano-sensing cation channel, is widely expressed in neuronal and non-neuronal cells and is ... ...

    Abstract Detection of mechanical stress is essential for diverse biological functions including touch, audition, and maintenance of vascular myogenic tone. PIEZO1, a mechano-sensing cation channel, is widely expressed in neuronal and non-neuronal cells and is expected to be involved in important biological functions. Here, we examined the possibility that PIEZO1 is involved in the regulation of synovial sarcoma cell-viability. Application of a PIEZO1 agonist Yoda1 effectively induced Ca
    MeSH term(s) Action Potentials/drug effects ; Cell Line, Tumor ; Cell Survival/genetics ; Gene Knockdown Techniques ; Humans ; Ion Channel Gating/drug effects ; Ion Channels/genetics ; Ion Channels/metabolism ; Mechanotransduction, Cellular ; Sarcoma, Synovial/genetics ; Sarcoma, Synovial/metabolism ; Stress, Mechanical
    Chemical Substances Ion Channels ; PIEZO1 protein, human
    Language English
    Publishing date 2018-05-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms19051452
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  6. Article ; Online: Recent advances in therapeutic strategies that focus on the regulation of ion channel expression.

    Ohya, Susumu / Kito, Hiroaki / Hatano, Noriyuki / Muraki, Katsuhiko

    Pharmacology & therapeutics

    2016  Volume 160, Page(s) 11–43

    Abstract: A number of different ion channel types are involved in cell signaling networks, and homeostatic regulatory mechanisms contribute to the control of ion channel expression. Profiling of global gene expression using microarray technology has recently ... ...

    Abstract A number of different ion channel types are involved in cell signaling networks, and homeostatic regulatory mechanisms contribute to the control of ion channel expression. Profiling of global gene expression using microarray technology has recently provided novel insights into the molecular mechanisms underlying the homeostatic and pathological control of ion channel expression. It has demonstrated that the dysregulation of ion channel expression is associated with the pathogenesis of neural, cardiovascular, and immune diseases as well as cancers. In addition to the transcriptional, translational, and post-translational regulation of ion channels, potentially important evidence on the mechanisms controlling ion channel expression has recently been accumulated. The regulation of alternative pre-mRNA splicing is therefore a novel therapeutic strategy for the treatment of dominant-negative splicing disorders. Epigenetic modification plays a key role in various pathological conditions through the regulation of pluripotency genes. Inhibitors of pre-mRNA splicing and histone deacetyalase/methyltransferase have potential as potent therapeutic drugs for cancers and autoimmune and inflammatory diseases. Moreover, membrane-anchoring proteins, lysosomal and proteasomal degradation-related molecules, auxiliary subunits, and pharmacological agents alter the protein folding, membrane trafficking, and post-translational modifications of ion channels, and are linked to expression-defect channelopathies. In this review, we focused on recent insights into the transcriptional, spliceosomal, epigenetic, and proteasomal regulation of ion channel expression: Ca(2+) channels (TRPC/TRPV/TRPM/TRPA/Orai), K(+) channels (voltage-gated, KV/Ca(2+)-activated, KCa/two-pore domain, K2P/inward-rectifier, Kir), and Ca(2+)-activated Cl(-) channels (TMEM16A/TMEM16B). Furthermore, this review highlights expression of these ion channels in expression-defect channelopathies.
    MeSH term(s) Epigenesis, Genetic/drug effects ; Epigenesis, Genetic/genetics ; Humans ; Ion Channels/drug effects ; Ion Channels/genetics ; Pharmaceutical Preparations/administration & dosage ; Proteasome Endopeptidase Complex/drug effects ; Proteasome Endopeptidase Complex/genetics ; RNA Precursors/metabolism ; Signal Transduction/drug effects ; Signal Transduction/genetics ; Transcription, Genetic/drug effects ; Transcription, Genetic/genetics
    Chemical Substances Ion Channels ; Pharmaceutical Preparations ; RNA Precursors ; Proteasome Endopeptidase Complex (EC 3.4.25.1)
    Language English
    Publishing date 2016-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 194735-7
    ISSN 1879-016X ; 0163-7258
    ISSN (online) 1879-016X
    ISSN 0163-7258
    DOI 10.1016/j.pharmthera.2016.02.001
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1183: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Castration Induces Down-Regulation of A-Type K

    Ohya, Susumu / Ito, Katsunori / Hatano, Noriyuki / Ohno, Akitoshi / Muraki, Katsuhiko / Imaizumi, Yuji

    International journal of molecular sciences

    2019  Volume 20, Issue 17

    Abstract: ... A-type ... ...

    Abstract A-type K
    MeSH term(s) Animals ; Blotting, Western ; Castration/adverse effects ; Down-Regulation ; Electrophysiology ; Kv Channel-Interacting Proteins/genetics ; Kv Channel-Interacting Proteins/metabolism ; Male ; Methyltestosterone/pharmacology ; Muscle, Smooth/drug effects ; Muscle, Smooth/metabolism ; Rats ; Rats, Wistar ; Testosterone/metabolism ; Vas Deferens/drug effects ; Vas Deferens/metabolism
    Chemical Substances Kv Channel-Interacting Proteins ; Testosterone (3XMK78S47O) ; Methyltestosterone (V9EFU16ZIF)
    Language English
    Publishing date 2019-08-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms20174073
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  8. Article ; Online: ATP increases [Ca

    Hatano, Noriyuki / Ohya, Susumu / Imaizumi, Yuji / Clark, Robert B / Belke, Darrell / Giles, Wayne R

    Experimental physiology

    2018  Volume 103, Issue 5, Page(s) 666–682

    Abstract: New findings: What is the central question of this study? Although electrophysiological and biophysical characteristics of heart fibroblasts have been studied in detail, their responses to prominent paracrine agents in the myocardium have not been ... ...

    Abstract New findings: What is the central question of this study? Although electrophysiological and biophysical characteristics of heart fibroblasts have been studied in detail, their responses to prominent paracrine agents in the myocardium have not been addressed adequately. Our experiments characterize changes in cellular electrophysiology and intracellular calcium in response to ATP. What is the main finding and its importance? In rat ventricular fibroblasts maintained in cell culture, we find that ATP activates a specific subset of Ca
    Abstract: Effects of ATP on enzymatically isolated rat ventricular fibroblasts maintained in short-term (36-72 h) cell culture were examined. Immunocytochemical staining of these cells revealed that a fibroblast, as opposed to a myofibroblast, phenotype was predominant. ATP, ADP or uridine 5'-triphosphate (UTP) all produced large increases in [Ca
    MeSH term(s) Adenosine Triphosphate/metabolism ; Animals ; Calcium/metabolism ; Cells, Cultured ; Chlorides/metabolism ; Fibroblasts/drug effects ; Fibroblasts/metabolism ; Heart Ventricles/drug effects ; Heart Ventricles/metabolism ; Male ; Purinergic P2Y Receptor Antagonists/pharmacology ; Rats ; Rats, Sprague-Dawley ; Signal Transduction/drug effects ; Signal Transduction/physiology ; Type C Phospholipases/metabolism
    Chemical Substances Chlorides ; Purinergic P2Y Receptor Antagonists ; Adenosine Triphosphate (8L70Q75FXE) ; Type C Phospholipases (EC 3.1.4.-) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2018-04-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1016295-1
    ISSN 1469-445X ; 0958-0670
    ISSN (online) 1469-445X
    ISSN 0958-0670
    DOI 10.1113/EP086822
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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.102: Show issues Location:
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  9. Article: TRPV4 partially participates in proliferation of human brain capillary endothelial cells

    Hatano, Noriyuki / Suzuki, Hiroka / Itoh, Yuka / Muraki, Katsuhiko

    Life sciences. 2013 Mar. 12, v. 92, no. 4-5

    2013  

    Abstract: AIMS: The vanilloid type 4 transient receptor potential channel (TRPV4) is a potential environmental sensor to multiple stimuli in many types of cells. In this study, we show that TRPV4 activated by 4α-phorbol 12,13-didecanoate (4αPDD) and hypo-osmotic ... ...

    Abstract AIMS: The vanilloid type 4 transient receptor potential channel (TRPV4) is a potential environmental sensor to multiple stimuli in many types of cells. In this study, we show that TRPV4 activated by 4α-phorbol 12,13-didecanoate (4αPDD) and hypo-osmotic stimulation (HOS) is a regulator of intracellular calcium ([Ca²⁺]ᵢ) in human brain capillary endothelial cells (HBCEs), and its activation can partially regulate cell proliferation of HBCEs. MAIN METHODS: The expression of TRPV4 in HBCEs was analyzed at the mRNA and protein levels. The function of TRPV4 in HBCEs was evaluated using a TRPV4 agonist, 4αPDD, and HOS while measuring [Ca²⁺]ᵢ and membrane currents. KEY FINDINGS: Analysis of the mRNA transcripts of the TRPV subfamily revealed that TRPV2 and TRPV4 were expressed in HBCEs. Immunoreactivity to the TRPV4 protein was also detected in HBCEs, which were positively stained by von Willebrand factor and CD31. When 4αPDD was applied, [Ca²⁺]ᵢ in HBCEs was elevated in a concentration-dependent manner. In addition, exposure of HBCEs to HOS at 228mOsm induced an elevation of [Ca²⁺]ᵢ. Application of 4αPDD also activated non-selective cation currents (NSCCs). Pretreatment of HBCEs with short interference RNA targeting TRPV4 (siRNA) significantly reduced the 4αPDD-induced elevation of [Ca²⁺]ᵢ. When HBCEs were treated for 24h with concentrations of 4αPDD between 0.3 and 3μM, the cell proliferation was potentiated in a concentration-dependent manner. The potentiation was partially inhibited in HBCEs treated with siRNA. SIGNIFICANCE: These data suggest that endogenous TRPV4, which functions as a regulator of [Ca²⁺]ᵢ in HBCEs, partially controls cell proliferation.
    Keywords RNA interference ; agonists ; blood coagulation factors ; brain ; calcium ; cell proliferation ; endothelial cells ; humans ; messenger RNA ; small interfering RNA
    Language English
    Dates of publication 2013-0312
    Size p. 317-324.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 3378-9
    ISSN 1879-0631 ; 0024-3205
    ISSN (online) 1879-0631
    ISSN 0024-3205
    DOI 10.1016/j.lfs.2013.01.002
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 73/732: Show issues

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  10. Article ; Online: PIEZO1 and TRPV4, which Are Distinct Mechano-Sensors in the Osteoblastic MC3T3-E1 Cells, Modify Cell-Proliferation.

    Yoneda, Maki / Suzuki, Hiroka / Hatano, Noriyuki / Nakano, Sayumi / Muraki, Yukiko / Miyazawa, Ken / Goto, Shigemi / Muraki, Katsuhiko

    International journal of molecular sciences

    2019  Volume 20, Issue 19

    Abstract: Mechanical-loading and unloading can modify osteoblast functioning. ... ...

    Abstract Mechanical-loading and unloading can modify osteoblast functioning. Ca
    MeSH term(s) Animals ; Cell Line ; Cell Proliferation ; Gene Expression Regulation ; Gene Knockdown Techniques ; Humans ; Ion Channels/genetics ; Ion Channels/metabolism ; Mechanotransduction, Cellular ; Membrane Potentials ; Mice ; Osteoblasts/metabolism ; Stress, Mechanical ; TRPV Cation Channels/genetics ; TRPV Cation Channels/metabolism
    Chemical Substances Ion Channels ; Piezo1 protein, mouse ; TRPV Cation Channels ; Trpv4 protein, mouse
    Language English
    Publishing date 2019-10-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms20194960
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