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  1. Article ; Online: Chronic Ethanol Intake Impairs Niacin Nutritional Status in Mice.

    Mizutani, Amane / Goto, Chihiro / Fujigaki, Hidetsugu / Yamamoto, Yasuko / Saito, Kuniaki / Hatayama, Sho / Fukuwatari, Tsutomu

    Journal of nutritional science and vitaminology

    2024  Volume 70, Issue 1, Page(s) 1–8

    Abstract: Niacin is involved in many biological reactions relating energy metabolism, redox reactions, DNA repair and longevity. Since niacin deficiency has been reported in alcoholic patients, and niacin coenzyme NAD is used as substrate to dehydrogenate ethanol ... ...

    Abstract Niacin is involved in many biological reactions relating energy metabolism, redox reactions, DNA repair and longevity. Since niacin deficiency has been reported in alcoholic patients, and niacin coenzyme NAD is used as substrate to dehydrogenate ethanol in the liver, ethanol consumption can be a factor to impair niacin nutritional status. We have recently established the niacin insufficient model mice using kynurenine 3-monooxygenase knock out (KMO
    MeSH term(s) Humans ; Mice ; Animals ; Niacin/metabolism ; Nutritional Status ; NAD/metabolism ; Alcoholism ; Niacinamide ; Body Weight
    Chemical Substances Niacin (2679MF687A) ; NAD (0U46U6E8UK) ; Niacinamide (25X51I8RD4)
    Language English
    Publishing date 2024-02-22
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 191366-9
    ISSN 1881-7742 ; 0301-4800
    ISSN (online) 1881-7742
    ISSN 0301-4800
    DOI 10.3177/jnsv.70.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Establishment of Model Mice to Evaluate Low Niacin Nutritional Status.

    Mizutani, Amane / Sato, Miu / Fujigaki, Hidetsugu / Yamamoto, Yasuko / Saito, Kuniaki / Hatayama, Sho / Fukuwatari, Tsutomu

    Journal of nutritional science and vitaminology

    2023  Volume 69, Issue 5, Page(s) 305–313

    Abstract: Niacin is involved in many biological reactions relating energy metabolism, redox reactions, DNA repair and longevity, and low NAD levels with aging and feeding high fat diets develop and progress age-related diseases. Although recent findings suggest ... ...

    Abstract Niacin is involved in many biological reactions relating energy metabolism, redox reactions, DNA repair and longevity, and low NAD levels with aging and feeding high fat diets develop and progress age-related diseases. Although recent findings suggest the requirement of niacin insufficient animal model to further study, appropriate animal models have not been established yet because niacin is biosynthesized from tryptophan via tryptophan-nicotinamide pathway. To establish model mice to evaluate niacin nutritional status, we used kynurenine 3-monooxygenase knock out (KMO
    MeSH term(s) Mice ; Animals ; Niacin/metabolism ; Nutritional Status ; Tryptophan/metabolism ; NAD/metabolism ; Niacinamide
    Chemical Substances Niacin (2679MF687A) ; Tryptophan (8DUH1N11BX) ; NAD (0U46U6E8UK) ; Niacinamide (25X51I8RD4)
    Language English
    Publishing date 2023-11-08
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 191366-9
    ISSN 1881-7742 ; 0301-4800
    ISSN (online) 1881-7742
    ISSN 0301-4800
    DOI 10.3177/jnsv.69.305
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Effects of B-Group Vitamin Administration on Daily Change in Urine 2-Oxo Acids in Young Japanese Women.

    Hirai, Maho / Hatayama, Sho / Kimata, Motoki / Shibata, Katsumi / Fukuwatari, Tsutomu

    Journal of nutritional science and vitaminology

    2021  Volume 67, Issue 1, Page(s) 63–67

    Abstract: B-group vitamins are required in amino acid catabolism, and recent findings suggest that urine 2-oxo acids, catabolites of amino acid, could be functional biomarkers indicating the nutritional status of B-group vitamins. To clarify the relationship ... ...

    Abstract B-group vitamins are required in amino acid catabolism, and recent findings suggest that urine 2-oxo acids, catabolites of amino acid, could be functional biomarkers indicating the nutritional status of B-group vitamins. To clarify the relationship between B-group vitamins and urine 2-oxo acids, we investigated the effects of B-group vitamin administration on daily changes in urinary amounts of 2-oxo acids in humans. Twenty-nine young Japanese women collected 24-h urine samples for 8 d, and took B-group vitamins for 7 d beginning on the second day of urine collection. The participants were divided into three groups on the basis of the amounts of total branched-chain 2-oxo acids, 2-oxoglutaric acid, 2-oxoadipic acid, and pyruvic acid excreted in urine. In the upper tertile, but not the middle and lower tertiles, each urine 2-oxo acid decreased from the first day of vitamin administration, and completely decreased to a normal level on the second day of administration. These results indicate that administration of B-group vitamins immediately affects 2-oxo acid metabolism in some young Japanese women. Thus, urinary 2-oxo acids could be useful and functional biomarkers for B-group vitamin status.
    MeSH term(s) Biomarkers ; Female ; Humans ; Japan ; Keto Acids ; Nutritional Status ; Vitamin B Complex
    Chemical Substances Biomarkers ; Keto Acids ; Vitamin B Complex (12001-76-2)
    Language English
    Publishing date 2021-02-25
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 191366-9
    ISSN 1881-7742 ; 0301-4800
    ISSN (online) 1881-7742
    ISSN 0301-4800
    DOI 10.3177/jnsv.67.63
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Variation of the Tensile Properties of Basalt-Fiber-Reinforced Polybutylene Succinate Matrix Composites during Microbial Degradation.

    Rova, Lovisa / Kurita, Hiroki / Kudo, Shinji / Hatayama, Sho / Kanno, Teruyoshi / Gallet-Pandellé, Alia / Narita, Fumio

    Polymers

    2023  Volume 15, Issue 7

    Abstract: Little is known about how the strength of biodegradable polymers changes during decomposition. This study investigated the changes in the tensile properties of polybutylene succinate (PBS) and basalt-fiber (BF)-reinforced PBS (PBS-BF) composite sheets ... ...

    Abstract Little is known about how the strength of biodegradable polymers changes during decomposition. This study investigated the changes in the tensile properties of polybutylene succinate (PBS) and basalt-fiber (BF)-reinforced PBS (PBS-BF) composite sheets during degradation in bacterial solutions. Seven days after the start of the experiment, the elongation at break of the PBS specimens decreased significantly, and the PBS-BF composite specimens were characterized by barely any change in ultimate tensile strength (UTS) after immersion in the bacteria-free medium for 7 and 56 days. Meanwhile, when immersed in the bacterial solution, the UTS of the PBS-BF composite specimens showed a tendency to decrease after 7 days. After 56 days, the UTS decreased to about half of its value immediately after fabrication. The degradation of the material was attributed to infiltration of the bacterial solution into structurally weak areas, causing decomposition throughout the material.
    Language English
    Publishing date 2023-04-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym15071796
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Vibrio parahaemolyticus induces inflammation-associated fluid accumulation via activation of the cystic fibrosis transmembrane conductance regulator.

    Iba, Hitomi / Shimohata, Takaaki / Kido, Junko / Hatayama, Sho / Uebanso, Takashi / Mawatari, Kazuaki / Takahashi, Akira

    The journal of medical investigation : JMI

    2021  Volume 68, Issue 1.2, Page(s) 59–70

    Abstract: Vibrio parahaemolyticus is a foodborne bacterium that causes acute gastroenteritis through the consumption of contaminated, raw, or undercooked seafood. Cystic fibrosis transmembrane conductance regulator (CFTR) is a well-characterized chloride channel ... ...

    Abstract Vibrio parahaemolyticus is a foodborne bacterium that causes acute gastroenteritis through the consumption of contaminated, raw, or undercooked seafood. Cystic fibrosis transmembrane conductance regulator (CFTR) is a well-characterized chloride channel that regulates several other ion channels and transporters to maintain water homeostasis in the gut lumen. Also, CFTR is a main target of bacterial infection-associated diarrhea. Hence, the aim of this study was to clarify the contribution of CFTR in V. parahaemolyticus-induced diarrhea in a mouse model of intestinal loop fluid accumulation, with CFTR inhibitors and a CFTR knockout model. The results indicated that CFTR plays a critical role in fluid accumulation in response to V. parahaemolyticus infection. We also investigated the inflammatory association in CFTR-mediated V. parahaemolyticus-induced fluid secretion with cyclooxygenase inhibitors and found that fluid accumulation was decreased by inhibition of cyclooxygenase 2 produced by neutrophils. These findings suggest that V. parahaemolyticus-inducing infiltration and activation of neutrophils also participated in CFTR mediated fluid secretion. This study reveals an important relationship between V. parahaemolyticus-induced diarrhea and inflammation in a mouse model. J. Med. Invest. 68 : 59-70, February, 2021.
    MeSH term(s) Animals ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Diarrhea/etiology ; Gastroenteritis ; Inflammation ; Mice ; Vibrio parahaemolyticus
    Chemical Substances Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6)
    Language English
    Publishing date 2021-05-14
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1435233-3
    ISSN 1349-6867 ; 1343-1420
    ISSN (online) 1349-6867
    ISSN 1343-1420
    DOI 10.2152/jmi.68.59
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  6. Article ; Online: Type III Secretion Effector VopQ of Vibrio parahaemolyticus Modulates Central Carbon Metabolism in Epithelial Cells.

    Nguyen, Anh Quoc / Shimohata, Takaaki / Hatayama, Sho / Tentaku, Aya / Kido, Junko / Bui, Thi Mai Huong / Uebanso, Takashi / Mawatari, Kazuaki / Takahashi, Akira

    mSphere

    2020  Volume 5, Issue 2

    Abstract: ... Vibrio ... ...

    Abstract Vibrio parahaemolyticus
    MeSH term(s) Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Caco-2 Cells ; Carbon/metabolism ; Cell Death ; Cell Line ; Epithelial Cells/metabolism ; Gene Expression Regulation, Bacterial ; Host-Pathogen Interactions ; Humans ; Metabolomics ; Type III Secretion Systems/genetics ; Type III Secretion Systems/metabolism ; Vibrio parahaemolyticus/genetics ; Vibrio parahaemolyticus/metabolism ; Virulence Factors
    Chemical Substances Bacterial Proteins ; Type III Secretion Systems ; Virulence Factors ; Carbon (7440-44-0)
    Language English
    Publishing date 2020-03-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2379-5042
    ISSN (online) 2379-5042
    DOI 10.1128/mSphere.00960-19
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Cellular Tight Junctions Prevent Effective

    Hatayama, Sho / Shimohata, Takaaki / Amano, Sachie / Kido, Junko / Nguyen, Anh Q / Sato, Yuri / Kanda, Yuna / Tentaku, Aya / Fukushima, Shiho / Nakahashi, Mutsumi / Uebanso, Takashi / Mawatari, Kazuaki / Takahashi, Akira

    Frontiers in cellular and infection microbiology

    2018  Volume 8, Page(s) 15

    Abstract: Campylobacter ... ...

    Abstract Campylobacter jejuni
    MeSH term(s) Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Calcium/metabolism ; Campylobacter Infections/metabolism ; Campylobacter Infections/microbiology ; Campylobacter jejuni/pathogenicity ; Campylobacter jejuni/physiology ; Cell Line ; Electrophysiological Phenomena ; Heat-Shock Proteins/genetics ; Heat-Shock Proteins/metabolism ; Host-Pathogen Interactions ; Humans ; Intestinal Mucosa/metabolism ; Intestinal Mucosa/microbiology ; Membrane Lipids/metabolism ; Membrane Microdomains ; Tight Junctions/metabolism ; Virulence ; Virulence Factors
    Chemical Substances Bacterial Proteins ; CapA protein, bacteria ; Heat-Shock Proteins ; Membrane Lipids ; Virulence Factors ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2018-01-30
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2018.00015
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  8. Article ; Online: Host cellular unfolded protein response signaling regulates Campylobacter jejuni invasion.

    Tentaku, Aya / Shimohata, Takaaki / Hatayama, Sho / Kido, Junko / Nguyen, Anh Quoc / Kanda, Yuna / Fukushima, Shiho / Uebanso, Takashi / Iwata, Taketoshi / Mawatari, Kazuaki / Harada, Nagakatsu / Takahashi, Akira

    PloS one

    2018  Volume 13, Issue 10, Page(s) e0205865

    Abstract: Campylobacter jejuni is a major cause of bacterial foodborne illness in humans worldwide. Bacterial entry into a host eukaryotic cell involves the initial steps of adherence and invasion, which generally activate several cell-signaling pathways that ... ...

    Abstract Campylobacter jejuni is a major cause of bacterial foodborne illness in humans worldwide. Bacterial entry into a host eukaryotic cell involves the initial steps of adherence and invasion, which generally activate several cell-signaling pathways that induce the activation of innate defense systems, which leads to the release of proinflammatory cytokines and induction of apoptosis. Recent studies have reported that the unfolded protein response (UPR), a system to clear unfolded proteins from the endoplasmic reticulum (ER), also participates in the activation of cellular defense mechanisms in response to bacterial infection. However, no study has yet investigated the role of UPR in C. jejuni infection. Hence, the aim of this study was to deduce the role of UPR signaling via induction of ER stress in the process of C. jejuni infection. The results suggest that C. jejuni infection suppresses global protein translation. Also, 12 h of C. jejuni infection induced activation of the eIF2α pathway and expression of the transcription factor CHOP. Interestingly, bacterial invasion was facilitated by knockdown of UPR-associated signaling factors and treatment with the ER stress inducers, thapsigargin and tunicamycin, decreased the invasive ability of C. jejuni. An investigation into the mechanism of UPR-mediated inhibition of C. jejuni invasion showed that UPR signaling did not affect bacterial adhesion to or survival in the host cells. Further, Salmonella Enteritidis or FITC-dextran intake were not regulated by UPR signaling. These results indicated that the effect of UPR on intracellular intake was specifically found in C. jejuni infection. These findings are the first to describe the role of UPR in C. jejuni infection and revealed the participation of a new signaling pathway in C. jejuni invasion. UPR signaling is involved in defense against the early step of C. jejuni invasion and thus presents a potential therapeutic target for the treatment of C. jejuni infection.
    MeSH term(s) Caco-2 Cells ; Campylobacter Infections/microbiology ; Campylobacter Infections/pathology ; Campylobacter jejuni/metabolism ; Endoplasmic Reticulum/metabolism ; Endoplasmic Reticulum Stress ; Eukaryotic Initiation Factor-2/metabolism ; Green Fluorescent Proteins/metabolism ; HeLa Cells ; Humans ; Nalidixic Acid/pharmacology ; Signal Transduction ; Thapsigargin/pharmacology ; Transcription Factor CHOP/metabolism ; Tunicamycin/pharmacology ; Unfolded Protein Response
    Chemical Substances Eukaryotic Initiation Factor-2 ; Tunicamycin (11089-65-9) ; Transcription Factor CHOP (147336-12-7) ; Green Fluorescent Proteins (147336-22-9) ; Nalidixic Acid (3B91HWA56M) ; Thapsigargin (67526-95-8)
    Language English
    Publishing date 2018-10-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0205865
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  9. Article ; Online: Cystic Fibrosis Transmembrane Conductance Regulator Reduces Microtubule-Dependent Campylobacter jejuni Invasion.

    Kido, Junko / Shimohata, Takaaki / Amano, Sachie / Hatayama, Sho / Nguyen, Anh Quoc / Sato, Yuri / Kanda, Yuna / Tentaku, Aya / Fukushima, Shiho / Nakahashi, Mutsumi / Uebanso, Takashi / Mawatari, Kazuaki / Takahashi, Akira

    Infection and immunity

    2017  Volume 85, Issue 10

    Abstract: ... ...

    Abstract Campylobacter
    MeSH term(s) Bacterial Adhesion ; Bacterial Load ; Biological Transport ; Campylobacter Infections/microbiology ; Campylobacter jejuni/pathogenicity ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Cystic Fibrosis Transmembrane Conductance Regulator/physiology ; Epithelial Cells/metabolism ; Epithelial Cells/microbiology ; HEK293 Cells ; Humans ; Microtubules/physiology ; Molecular Motor Proteins/metabolism ; Mutation
    Chemical Substances Molecular Motor Proteins ; Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6)
    Language English
    Publishing date 2017-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218698-6
    ISSN 1098-5522 ; 0019-9567
    ISSN (online) 1098-5522
    ISSN 0019-9567
    DOI 10.1128/IAI.00311-17
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  10. Article ; Online: Bacterial Contamination of Hemodialysis Devices in Hospital Dialysis Wards.

    Shimohata, Takaaki / Mawatari, Kazuaki / Uebanso, Takashi / Honjo, Airi / Tsunedomi, Akari / Hatayama, Sho / Sato, Yuri / Kido, Junko / Nishisaka, Risa / Yoshimoto, Ayumi / Yamashita, Tomoko / Amano, Sachie / Maetani-Yasui, Miki / Iba, Hitomi / Harada, Yumi / Nakahashi, Mutsumi / Yasui-Yamada, Sonoko / Hamada, Yasuhiro / Nakagawa, Tadahiko /
    Sogabe, Masahiro / Emoto, Takahiro / Akutagawa, Masatake / Okahisa, Toshiya / Kinouchi, Yohsuke / Takahashi, Akira

    The journal of medical investigation : JMI

    2019  Volume 66, Issue 1.2, Page(s) 148–152

    Abstract: Chronic care patients undergoing hemodialysis for treatment of end-stage renal failure experience higher rates of bloodstream-associated infection due to the patients' compromised immune system and management of the bloodstream through catheters. ... ...

    Abstract Chronic care patients undergoing hemodialysis for treatment of end-stage renal failure experience higher rates of bloodstream-associated infection due to the patients' compromised immune system and management of the bloodstream through catheters. Staphylococcus species are acommon cause of hemodialysis catheterrelated bloodstream infections. We investigated environmental bacterial contamination of dialysis wards and contamination of hemodialysis devices to determine the source of bacteria for these infections. All bacterial samples were collected by the swab method and the agarose stamp method. And which bacterium were identified by BBL CRYSTAL Kit or 16s rRNA sequences. In our data, bacterial cell number of hemodialysis device was lower than environment of patient surrounds. But Staphylococcus spp. were found predominantly on the hemodialysis device (46.8%), especially on areas frequently touched by healthcare-workers (such as Touch screen). Among Staphylococcus spp., Staphylococcus epidermidis was most frequently observed (42.1% of Staphylococcus spp.), and more surprising, 48.2% of the Staphylococcus spp. indicated high resistance for methicillin. Our finding suggests that hemodialysis device highly contaminated with bloodstream infection associated bacteria. This study can be used as a source to assess the risk of contamination-related infection and to develop the cleaning system for the better prevention for bloodstream infections in patients with hemodialysis. J. Med. Invest. 66 : 148-152, February, 2019.
    MeSH term(s) Bacteremia/etiology ; Bacterial Load ; Equipment Contamination ; Humans ; Renal Dialysis/adverse effects ; Renal Dialysis/instrumentation
    Language English
    Publishing date 2019-05-07
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1435233-3
    ISSN 1349-6867 ; 1343-1420
    ISSN (online) 1349-6867
    ISSN 1343-1420
    DOI 10.2152/jmi.66.148
    Database MEDical Literature Analysis and Retrieval System OnLINE

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