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Article: Differences in the growth of microorganisms depends on the type of semi-solid enteral nutritional supplements.

Omotani, Sachiko / Murakami, Kanaha / Naka, Arisa / Hatsuda, Yasutoshi / Myotoku, Michiaki

Journal of pharmaceutical health care and sciences

2023 Volume 9, Issue 1, Page(s) 27

Abstract: Background: Enteral nutritional supplements are used in many medical facilities and home care, but require appropriate management because they are nutrient-rich products. Recently, infection control methods for Ready To Hang (RTH) preparations, which ... ...

Abstract	Background: Enteral nutritional supplements are used in many medical facilities and home care, but require appropriate management because they are nutrient-rich products. Recently, infection control methods for Ready To Hang (RTH) preparations, which are widely used and are expected to reduce the risk of infection, have not been established in Japan and are dependent on caregivers. Therefore, we evaluated the difference in the growth of microorganisms depending on the type of enteral nutrients following contamination with microorganisms. Methods: Nine types of enteral nutrition were used. Escherichia coli (E. coli) W3110, Serratia marcescens (S. marcescens) NBRC3046, and Candida albicans (C. albicans) IFM61197 were used as test bacteria. The bacterial solution was added to the enteral nutritional supplement, adjusted, and the number of bacteria was measured at 0, 4, 8, and 24 h after the addition of the bacterial solution at 25 °C and in the dark. Results: E. coli and S. marcescens grew in RACOL Conclusion: Because the viscosity and calorie content vary among enteral nutrition preparations in which growth was observed, we found that pH had the greatest effect on the differences in bacterial growth. Nonetheless, C. albicans growth occurred in all nine types of enteral nutrients, indicating that unlike bacteria, its growth was independent of pH. If semi-solid enteral nutrients are contaminated with microorganisms for any reason, microorganisms will grow, so appropriate infection control is necessary to prevent infection.
Language	English
Publishing date	2023-09-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2809913-8
ISSN	2055-0294
ISSN	2055-0294
DOI	10.1186/s40780-023-00297-8
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Article ; Online: Effect of Central Venous Nutrition Infusion, Intravenous Fat Emulsion, and Therapeutic Agents on the Particle Size of Fat Emulsion for Simultaneous Administration of Three Drugs.

Onishi, Mika / Koyama, Yoshihito / Hagika, Akemi / Omotani, Sachiko / Hatsuda, Yasutoshi / Maezaki, Naoyoshi / Myotoku, Michiaki

Annals of nutrition & metabolism

2022 Volume 78, Issue 6, Page(s) 307–315

Abstract: Background: In Japan, therapeutic agents are often administered through the side tube of a central venous line or mixed with a total parenteral nutrition (TPN) infusion. This is expected to result in the mixture of three drugs in the infusion line: the ... ...

Abstract	Background: In Japan, therapeutic agents are often administered through the side tube of a central venous line or mixed with a total parenteral nutrition (TPN) infusion. This is expected to result in the mixture of three drugs in the infusion line: the infusion product for TPN, the fat emulsion, and the therapeutic agent. Therefore, we investigated whether various therapeutic agents affect the particle size of the fat emulsion. Methods: In model of administration A, the TPN infusion formulation was administered through the main tube, and the fat emulsion and therapeutic agents were simultaneously administered through the side tube; 21 therapeutic agents were used. In model of administration B, the TPN infusion formulation mixed with therapeutic agents was administered through the main tube, and the fat emulsion was simultaneously administered through the side tube; 20 therapeutic agents were used. The number of fine particles for each particle size range in the mixed solution was measured over time using a light-shielding automatic fine-particle measuring device. Results: In model A, the number of fine particles in the fat emulsion changed rapidly for five therapeutic agents and slowly for two therapeutic agents. In model B, this change occurred drastically for five therapeutic agents and slowly for one therapeutic agent. Conclusions: Some therapeutic agents may contribute to fat particle aggregation. Therefore, these therapeutic agents should not be concurrently administered with fat emulsions.
MeSH term(s)	Humans ; Fat Emulsions, Intravenous ; Particle Size ; Pharmaceutical Preparations ; Japan
Chemical Substances	Fat Emulsions, Intravenous ; Pharmaceutical Preparations
Language	English
Publishing date	2022-08-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	392341-1
ISSN	1421-9697 ; 0250-6807 ; 1018-9688
ISSN (online)	1421-9697
ISSN	0250-6807 ; 1018-9688
DOI	10.1159/000526329
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Article ; Online: Impact of Different Attitudes toward Face-to-Face and Online Classes on Learning Outcomes in Japan.

Aoe, Mai / Esaki, Seiji / Ikejiri, Masahiro / Ito, Takuya / Nagai, Katsuhito / Hatsuda, Yasutoshi / Hirokawa, Yoshimi / Yasuhara, Tomohisa / Kenzaka, Takehiko / Nishinaka, Toru

Pharmacy (Basel, Switzerland)

2023 Volume 11, Issue 1

Abstract: During the coronavirus disease 2019 (COVID-19) pandemic, online-based learning has become mainstream in many countries, and its learning outcomes have been evaluated. However, various studies have shown that online-based learning needs to be optimized in ...

Abstract	During the coronavirus disease 2019 (COVID-19) pandemic, online-based learning has become mainstream in many countries, and its learning outcomes have been evaluated. However, various studies have shown that online-based learning needs to be optimized in the future, and the number of reports for this purpose is currently not sufficient. The purpose in this study was to determine the relationship between academic performance and attitudes toward face-to-face and remote formats among Japanese pharmacy students enrolled in a course designed for knowledge acquisition. A combination of face-to-face and remote formats was used in a practice course for sixth-year pharmacy students, designed to improve academic performance through knowledge acquisition. To evaluate learning outcomes, we used a questionnaire that was administered to the course participants and the results of examinations conducted before and after the course. Online-oriented and face-to-face-oriented groups differed in their attitudes toward the ease of asking questions of faculty and communicating with the faculty members and classmates in each format. In a knowledge acquisition course for Japanese pharmacy students, the study revealed that the same academic outcomes were achieved, regardless of the students' own perceptions of their aptitude for face-to-face or remote learning style.
Language	English
Publishing date	2023-01-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2737194-3
ISSN	2226-4787 ; 2226-4787
ISSN (online)	2226-4787
ISSN	2226-4787
DOI	10.3390/pharmacy11010016
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Article ; Online: Microbial growth and importance of flushing inside closed-type infusion devices during administration of lipid emulsion

Omotani, Sachiko / Hatsuda, Yasutoshi / Katsui, Yasuhiro / Asao, Ayumi / Toujou, Hiroyuki / Ihara, Keigo / Tani, Katsuji / Myotoku, Michiaki

International journal of medical sciences

2021 Volume 18, Issue 14, Page(s) 3106–3111

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Equipment Contamination/prevention & control ; Escherichia coli/growth & development ; Escherichia coli/isolation & purification ; Fat Emulsions, Intravenous/administration & dosage ; Infusions, Intravenous/instrumentation ; Parenteral Nutrition, Total/instrumentation ; Parenteral Nutrition, Total/methods
Chemical Substances	Fat Emulsions, Intravenous
Language	English
Publishing date	2021-06-26
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2151424-0
ISSN	1449-1907 ; 1449-1907
ISSN (online)	1449-1907
ISSN	1449-1907
DOI	10.7150/ijms.60200
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Article ; Online: Effects of concurrent and staggered dosing of semi-solid enteral nutrients on pharmacokinetic behavior of antiepileptic drugs after oral administration in rats.

Nagai, Katsuhito / Ryuno, Yoshikazu / Iwanami, Yoshihito / Omotani, Sachiko / Fukuno, Shuhei / Hatsuda, Yasutoshi / Konishi, Hiroki / Myotoku, Michiaki

PloS one

2021 Volume 16, Issue 11, Page(s) e0259400

Abstract: Background: The use of enteral nutrients plays a highly important role in accurate nutrition management, but limited information is currently available on the cautionary points of semi-solid enteral nutrients.: Aim: In this study, we examined whether ...

Abstract	Background: The use of enteral nutrients plays a highly important role in accurate nutrition management, but limited information is currently available on the cautionary points of semi-solid enteral nutrients. Aim: In this study, we examined whether the pharmacokinetic profiles of sodium valproate (SVA), levetiracetam (LEV), and carbamazepine (CBZ) are affected by altering the dosing time of RACOL®-NF Semi Solid for Enteral Use (RASS), a prescribed semi-solid formula. We also investigated whether the pharmacokinetic interaction observed in this study can be avoided by staggered dosing of the chemical drug and semi-solid enteral nutrient. Methods: The plasma concentration of SVA, LEV and CBZ after oral administration was measured by LC-MS/MS method. Results: There was no difference in pharmacokinetic characteristics of SVA and LEV when the dosing time of RASS was altered. On the other hand, the plasma concentration of CBZ after oral administration at all sampling points decreased with the extension of the dosing time of RASS, which was consistent with the Cmax and AUC. However, no significant difference was observed in the pharmacokinetic profiles or parameters of CBZ between the short-term and long-term RASS dosing groups by prolonging the administered interval of CBZ and RASS for 2 hr. Conclusion: We concluded that the pharmacokinetic profiles of CBZ, but not SVA and LEV, after its oral administration are affected by the dosing time of RASS, but staggered administration of CBZ and RASS prevented their interaction.
MeSH term(s)	Administration, Oral ; Animals ; Anticonvulsants/blood ; Anticonvulsants/chemistry ; Anticonvulsants/pharmacokinetics ; Area Under Curve ; Carbamazepine/blood ; Carbamazepine/chemistry ; Carbamazepine/pharmacokinetics ; Chromatography, High Pressure Liquid ; Drug Compounding/methods ; Half-Life ; Levetiracetam/blood ; Levetiracetam/chemistry ; Levetiracetam/pharmacokinetics ; Nutrients/chemistry ; ROC Curve ; Rats ; Rats, Sprague-Dawley ; Tandem Mass Spectrometry ; Valproic Acid/blood ; Valproic Acid/chemistry ; Valproic Acid/pharmacokinetics
Chemical Substances	Anticonvulsants ; Carbamazepine (33CM23913M) ; Levetiracetam (44YRR34555) ; Valproic Acid (614OI1Z5WI)
Language	English
Publishing date	2021-11-09
Publishing country	United States
Document type	Journal Article
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0259400
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Article ; Online: Bacterial contamination of lightproof covers for high-calorie infusion solutions in wards.

Hosomi, Kengo / Takasu, Yuko / Hisai, Yumiko / Komaki, Sachiko / Otsuki, Hiroaki / Okimoto, Kyoko / Omotani, Sachiko / Hatsuda, Yasutoshi / Myotoku, Michiaki

International journal of medical sciences

2021 Volume 18, Issue 16, Page(s) 3708–3711

Abstract: Deterioration of drugs due to light exposure is one of the major concerns, especially regarding protection of high-calorie infusion solutions, lightproof covers are used in hospitals. In the absence of any set standards regarding their usage, they are ... ...

Abstract	Deterioration of drugs due to light exposure is one of the major concerns, especially regarding protection of high-calorie infusion solutions, lightproof covers are used in hospitals. In the absence of any set standards regarding their usage, they are often reused. This study aimed to investigate bacterial contamination of lightproof covers used in hospital wards. For this, lightproof covers which had been used or stored in wards were collected and bacterial cultures were carried out from them. Examination of the cultures revealed that bacteria were present in the used lightproof covers. The bacterial species detected in the used lightproof covers were
MeSH term(s)	Bacillus/isolation & purification ; Cross Infection/prevention & control ; Drug Packaging/instrumentation ; Drug Storage ; Equipment Contamination ; Equipment and Supplies, Hospital/microbiology ; Glucose Solution, Hypertonic/radiation effects ; Glucose Solution, Hypertonic/therapeutic use ; Hospitals ; Humans ; Japan ; Light/adverse effects ; Methicillin-Resistant Staphylococcus aureus/isolation & purification ; Microbial Sensitivity Tests ; Parenteral Nutrition Solutions/radiation effects ; Parenteral Nutrition Solutions/therapeutic use ; Staphylococcus aureus/isolation & purification
Chemical Substances	Glucose Solution, Hypertonic ; Parenteral Nutrition Solutions
Language	English
Publishing date	2021-09-23
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2151424-0
ISSN	1449-1907 ; 1449-1907
ISSN (online)	1449-1907
ISSN	1449-1907
DOI	10.7150/ijms.62193
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Article ; Online: Visualization of cross-resistance between antimicrobial agents by asymmetric multidimensional scaling.

Hatsuda, Yasutoshi / Maki, Syou / Ishizaka, Toshihiko / Omotani, Sachiko / Koizumi, Naonori / Yasui, Yukako / Saito, Takako / Myotoku, Michiaki / Okada, Akinori / Imaizumi, Tadashi

Journal of clinical pharmacy and therapeutics

2021 Volume 47, Issue 3, Page(s) 345–359

Abstract: What is known and objective: In our previous studies, we developed a cross-resistance rate (CRR) correlation diagram (CRR diagram) that visually captures the magnitude of CRRs between antimicrobials using scatter plots. We used asymmetric ... ...

Abstract	What is known and objective: In our previous studies, we developed a cross-resistance rate (CRR) correlation diagram (CRR diagram) that visually captures the magnitude of CRRs between antimicrobials using scatter plots. We used asymmetric multidimensional scaling (MDS) to transform cross-resistance similarities between antimicrobials into a 2-dimensional map and attempted to visually express them. We also explored the antibiograms of Pseudomonas aeruginosa before and after the transfer to newly built hospitals, and we determined by the CRR diagram that the CRRs among β-lactam antimicrobials other than carbapenems decreased substantially with the facility transfer. The present study tests whether the analysis of CRRs by asymmetric MDS can be used as new visual information that is easy for healthcare professionals to understand. Method: We tested the impact of changes in the nosocomial environment due to institutional transfers on CRRs among antimicrobials in asymmetric MDS, as well as contrasted the asymmetric MDS map and CRR diagram. Results and discussion: In the asymmetric MDS map, antimicrobial groups with the same mechanism of action were displayed close together, and antimicrobial groups with different mechanisms of action were displayed separately. The asymmetric MDS map drawn solely for antimicrobials belonging to the group with the same mechanism of action showed similarities to the CRR diagram. Also, the distance of each antimicrobial to other antimicrobials shown in the asymmetric MDS map was negatively correlated with the CRRs for them against that antimicrobial. What is new and conclusion: The asymmetric MDS map expresses the dissimilarity as distances between agents, and there are no meanings or units on the ordinate and abscissa axes of the output map. In contrast, the CRR diagram expresses the antimicrobials' resistance status as values, such as resistance rate and CRR. By analysing the CRRs in the asymmetric MDS, it is feasible to visually recognize cross-resistance similarities between antimicrobial groups as distances. The use of the asymmetric MDS combined with the CRR diagram allows us to visually understand the resistance and cross-resistance status of each antimicrobial agent as a 2-dimensional map, as well as to understand the trends and characteristics of the data by means of quantitative values.
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Anti-Infective Agents/pharmacology ; Humans ; Microbial Sensitivity Tests ; Multidimensional Scaling Analysis ; Pseudomonas aeruginosa
Chemical Substances	Anti-Bacterial Agents ; Anti-Infective Agents
Language	English
Publishing date	2021-11-24
Publishing country	England
Document type	Journal Article
ZDB-ID	639006-7
ISSN	1365-2710 ; 0269-4727
ISSN (online)	1365-2710
ISSN	0269-4727
DOI	10.1111/jcpt.13564
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Article ; Online: Enhanced anti-cancer activity by menthol in HepG2 cells exposed to paclitaxel and vincristine: possible involvement of CYP3A4 downregulation.

Nagai, Katsuhito / Fukuno, Shuhei / Omachi, Anna / Omotani, Sachiko / Hatsuda, Yasutoshi / Myotoku, Michiaki / Konishi, Hiroki

Drug metabolism and personalized therapy

2019 Volume 34, Issue 1

Abstract: Background Menthol is widely used as a constituent of functional foods and chemical drugs. In the present study, we investigated changes in the expression of cytochrome P450 isoform CYP3A4mRNA after treating human hepatocellular carcinoma HepG2 cells ... ...

Abstract	Background Menthol is widely used as a constituent of functional foods and chemical drugs. In the present study, we investigated changes in the expression of cytochrome P450 isoform CYP3A4mRNA after treating human hepatocellular carcinoma HepG2 cells with menthol. We also examined the effects of pretreatment with menthol on the cytotoxic activity of paclitaxel (PAC) and vincristine (VIN), which are substrates of CYP3A4, in the cells. Methods HepG2 cells were maintained in Dulbecco's Modified Eagle's Medium. Expression of CYP3A4 was examined by the real-time polymerase chain reaction. Survival rate of HepG2 cells was evaluated by the MTT assay. Results The gene expression level of CYP3A4 in HepG2 cells was significantly reduced by treatment with menthol for 1 day. The viability of HepG2 cells was not affected by treatment with menthol alone once a day for two consecutive days. The degree of reduction in cell viability by PAC or VIN in HepG2 cells was significantly increased by menthol treatment for 24 h prior to exposure to these anti-cancer drugs. Conclusions These results demonstrate that menthol enhanced the anti-tumor effects of PAC and VIN through the downregulation of CYP3A4 in HepG2 cells without exerting cytotoxic activity.
MeSH term(s)	Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Cytochrome P-450 CYP3A/genetics ; Cytochrome P-450 CYP3A/metabolism ; Down-Regulation/drug effects ; Down-Regulation/genetics ; Drug Screening Assays, Antitumor ; Gene Expression Profiling ; Hep G2 Cells ; Humans ; Menthol/pharmacology ; Paclitaxel/pharmacology ; RNA, Messenger/antagonists & inhibitors ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Vincristine/pharmacology
Chemical Substances	Antineoplastic Agents ; RNA, Messenger ; Menthol (1490-04-6) ; Vincristine (5J49Q6B70F) ; Cytochrome P-450 CYP3A (EC 1.14.14.1) ; CYP3A4 protein, human (EC 1.14.14.55) ; Paclitaxel (P88XT4IS4D)
Language	English
Publishing date	2019-03-06
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2822040-7
ISSN	2363-8915 ; 2363-8907
ISSN (online)	2363-8915
ISSN	2363-8907
DOI	10.1515/dmpt-2018-0029
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Article ; Online: Enhanced Understanding of the Levels of Palliative Care in Pharmacy Students Through Participating in Clinical Training in Hospitals.

Myotoku, Michiaki / Omotani, Sachiko / Hatsuda, Yasutoshi / Konishi, Hiroki / Hirotani, Yoshihiko

Journal of pharmacy practice

2017 Volume 30, Issue 3, Page(s) 313–317

Abstract: Objective: A palliative care knowledge survey was conducted involving pharmacy students to examine their perceived usefulness and the educational effect of clinical training in hospitals.: Methods: A questionnaire sheet was distributed to fifth-year ... ...

Abstract	Objective: A palliative care knowledge survey was conducted involving pharmacy students to examine their perceived usefulness and the educational effect of clinical training in hospitals. Methods: A questionnaire sheet was distributed to fifth-year pharmacy students before and after clinical training. The questionnaire consisted of questions to clarify the details of palliative care-related training in hospitals and students' knowledge of such care. The respondents were divided into 2 groups: those who participated in palliative care team (PCT) rounds (group A: 57) and those who did not (group B: 57). Results: The mean total correct answer rate markedly increased after training in group A, from 37.9 to 47.1% (P < .01). Such an increase was also observed in the domains of philosophy and pain in this group ( P < .01). In contrast, group B did not show differences in the mean correct answer rate between before and after training; there was no significant increase in the rate in any domain. Conclusion: Pharmacy students' knowledge was enhanced by participating in the PCT, confirming the usefulness of such participation during training as part of palliative care education.
Language	English
Publishing date	2017-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	1027474-1
ISSN	1531-1937 ; 0897-1900
ISSN (online)	1531-1937
ISSN	0897-1900
DOI	10.1177/0897190016637528
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Article: Drug-induced lung disease adverse effect with Ledipasvir Acetonate/Sofosbuvir.

Omotani, Sachiko / Ishizaka, Toshihiko / Inoue, Miki / Nishida, Koji / Yasui, Yukako / Hatsuda, Yasutoshi / Mukai, Junji / Myotoku, Michiaki

Journal of pharmaceutical health care and sciences

2020 Volume 6, Page(s) 6

Abstract: Background: Interferon and ribavirin have been used as therapeutic agents for chronic hepatitis C infection or C-compensated cirrhosis in the conventional treatment. Hepatitis C virus (HCV) -specific direct-acting antiviral agents that directly inhibit ... ...

Abstract	Background: Interferon and ribavirin have been used as therapeutic agents for chronic hepatitis C infection or C-compensated cirrhosis in the conventional treatment. Hepatitis C virus (HCV) -specific direct-acting antiviral agents that directly inhibit the growth process of HCV have been approved since 2011. However, in the early post-marketing vigilance phase of ledipasvir acetonate/sofosbuvir (LDV/SOF), there were reports of interstitial lung disease in 4 out of 32,700 cases with death in 1 case; the onset mechanism is unknown. Case presentation: Treatment for hepatitis C was deemed to be necessary, and the patient was referred to our hospital. Oral administration of LDV/SOF was started. On day 8 of administration, a fever of 38-39 °C and coughing were observed followed by the gradual appearance of shortness of breath. As there was no improvement, the patient visited her primary care physician on day 16 of administration and the patient was brought urgently to our hospital on the same day. Blood tests and imaging tests were conducted at our hospital on the day of emergency transport; inflammatory response markers showed abnormal values, and sialylated carbohydrate antigen Krebs von den Lungen-6 was within the normal value range at 303 U/mL. Because the possibility of infection was low based on results of imaging and bronchoalveolar lavage, drug-induced lung disease was suspected, LDV/SOF administration was discontinued, and steroid administration was started. Following steroid pulse therapy, treatment with oral prednisolone tablets was gradually tapered. The patient's symptoms were relieved and she was discharged. Conclusions: The patient's medication history in this case indicated that there were no drugs taken before or after administration of LDV/SOF until the adverse reaction occurred, and there were no supplements or dietary supplements taken. Therefore, LDV/SOF has been proposed as the cause of the suspected adverse effect. Pharmacists should try to collect adverse effect reports to identify adverse effects early.
Language	English
Publishing date	2020-04-02
Publishing country	England
Document type	Case Reports
ZDB-ID	2809913-8
ISSN	2055-0294
ISSN	2055-0294
DOI	10.1186/s40780-020-00162-y
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