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  1. Book ; Online ; E-Book: Hepatitis C / Volume 1 /

    Hatzakis, Angelos

    2021  

    Author's details Angelos Hatzakis, editor
    Keywords Medical microbiology ; Virology ; Health promotion ; Hepatitis C ; Epidemiologia ; Medicina preventiva ; Terapèutica
    Subject code 616.01
    Language English
    Size 1 online resource (267 pages)
    Publisher Springer
    Publishing place Cham, Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 3-030-64649-1 ; 3-030-64648-3 ; 978-3-030-64649-3 ; 978-3-030-64648-6
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online ; E-Book: Hepatitis C

    Hatzakis, Angelos

    care and treatment

    2021  

    Abstract: This volume provides the reader with a detailed overview of the current state-of-the art approach of Hepatitis C management. It reviews the course of action in handling of chronic Hepatitis C patients with various HCV genotypes and treats special cases ... ...

    Author's details Angelos Hatzakis, editor
    Abstract This volume provides the reader with a detailed overview of the current state-of-the art approach of Hepatitis C management. It reviews the course of action in handling of chronic Hepatitis C patients with various HCV genotypes and treats special cases such as acute hepatitis, transplant and renal patients as well as people who inject drugs. The two volume work on Hepatitis C introduces to the topic by reviewing virology, diagnosis, epidemiology, prevention, management and elimination of HCV. The book provides a valuable source at full length for researchers and clinicians working on Hepatitis C.
    Keywords Virology ; Health promotion ; Medical microbiology ; Hepatitis C ; Virologia ; Diagnòstic microbiològic
    Subject code 616.3623
    Language English
    Size 1 online resource (VI, 219 p. 27 illus., 24 illus. in color.)
    Edition 1st ed. 2021.
    Publisher Springer
    Publishing place Cham, Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 3-030-67762-1 ; 3-030-67761-3 ; 978-3-030-67762-6 ; 978-3-030-67761-9
    DOI 10.1007/978-3-030-67762-6
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Conference proceedings: The state of hepatitis B and C in Mediterranean and Balkan countries

    Hatzakis, Angelos

    report from a summit conference

    (Journal of viral hepatitis ; 20, Suppl. 2)

    2013  

    Author's details guest ed. A. Hatzakis
    Series title Journal of viral hepatitis ; 20, Suppl. 2
    Collection
    Language English
    Size 20 S.
    Publisher Wiley-Blackwell
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT017722642
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Zs A 4119 -20,Suppl.2- not available for loan Zeitschriften-Lesesaal

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  4. Article ; Online: Estimating the number of people who inject drugs using repeated respondent-driven sampling (RDS) in a community-based program: implications for the burden of hepatitis C and HIV infections and harm reduction coverage.

    Roussos, Sotirios / Paraskevis, Dimitrios / Malliori, Meni / Hatzakis, Angelos / Sypsa, Vana

    AIDS and behavior

    2022  Volume 27, Issue 2, Page(s) 424–430

    Abstract: Estimates of the population size of people who inject drugs (PWID) are essential for efficient program planning and for monitoring key targets. Existing estimates in Greece are based on the capture-recapture method applied to drug treatment sources. We ... ...

    Abstract Estimates of the population size of people who inject drugs (PWID) are essential for efficient program planning and for monitoring key targets. Existing estimates in Greece are based on the capture-recapture method applied to drug treatment sources. We aimed to obtain estimates based on data collected from a community-based program addressing PWID in Athens, Greece. The program was implemented in 2012-2013 to increase diagnosis and treatment for HIV among PWID during an HIV outbreak. Five Responden-Driven Sampling (RDS) rounds were used to recruit participants. A unique code was used to identify participants among rounds. Capture-recapture was applied to estimate the population size in 2013 (PWID with injection in the past 12 months; active PWID with injection in the past 30 days). Log-linear models were applied. In 2013, the estimated number of active PWID in Athens was 4,117 [95% confidence interval (CI): 3,728-4,507] (vs. 1,956 [95% CI: 1,525-2,565] the existing population size estimate). Based on this estimate, the coverage of needle and syringe programs in 2013 was 103 syringes/PWID/year (vs. 216 based on the existing estimate). The population prevalence of injecting drug use in Athens (past 12 months) was 0.222% (95% CI: 0.200-0.245). The inclusion of data from community-based programs in the estimation of the PWID population size resulted in 2.1-fold higher estimates, compared to the official estimates obtained from drug treatment data, and indicates the need for re-evaluation of necessary resources for harm reduction and elimination of HIV and hepatitis C in PWID.
    MeSH term(s) Humans ; HIV Infections/epidemiology ; HIV Infections/prevention & control ; HIV Infections/diagnosis ; Substance Abuse, Intravenous/complications ; Substance Abuse, Intravenous/epidemiology ; Harm Reduction ; Drug Users ; Surveys and Questionnaires ; Hepatitis C/epidemiology ; Hepatitis C/prevention & control ; Hepacivirus ; Prevalence
    Language English
    Publishing date 2022-08-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1339885-4
    ISSN 1573-3254 ; 1090-7165
    ISSN (online) 1573-3254
    ISSN 1090-7165
    DOI 10.1007/s10461-022-03777-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6451: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Reactivation of Varicella Zoster Virus after Vaccination for SARS-CoV-2.

    Psichogiou, Mina / Samarkos, Michael / Mikos, Nikolaos / Hatzakis, Angelos

    Vaccines

    2021  Volume 9, Issue 6

    Abstract: Seven immunocompetent patients aged > 50 years old presented with herpes zoster (HZ) infection in a median of 9 days (range 7-20) after vaccination against SARS-CoV-2. The occurrence of HZ within the time window 1-21 days after vaccination defined for ... ...

    Abstract Seven immunocompetent patients aged > 50 years old presented with herpes zoster (HZ) infection in a median of 9 days (range 7-20) after vaccination against SARS-CoV-2. The occurrence of HZ within the time window 1-21 days after vaccination defined for increased risk and the reported T cell-mediated immunity involvement suggest that COVID-19 vaccination is a probable cause of HZ. These cases support the importance of continuing assessment of vaccine safety during the ongoing massive vaccination for the COVID-19 pandemic and encourage reporting and communication of any vaccination-associated adverse event.
    Language English
    Publishing date 2021-06-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines9060572
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Global molecular epidemiology of HIV-1: the chameleon challenge.

    Paraskevis, Dimitrios / Hatzakis, Angelos

    The Lancet. Infectious diseases

    2018  Volume 19, Issue 2, Page(s) 114–115

    MeSH term(s) HIV Seropositivity ; HIV-1/genetics ; Humans ; Molecular Epidemiology ; Surveys and Questionnaires
    Language English
    Publishing date 2018-11-30
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(18)30687-X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5743: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Trends in COVID-19 Vaccination Intent, Determinants and Reasons for Vaccine Hesitancy: Results from Repeated Cross-Sectional Surveys in the Adult General Population of Greece during November 2020-June 2021.

    Sypsa, Vana / Roussos, Sotirios / Engeli, Vasiliki / Paraskevis, Dimitrios / Tsiodras, Sotirios / Hatzakis, Angelos

    Vaccines

    2022  Volume 10, Issue 3

    Abstract: Vaccine hesitancy is a major barrier to achieving large-scale COVID-19 vaccination. We report trends in vaccination intention and associated determinants from surveys in the adult general population in Greece. Four cross-sectional phone surveys were ... ...

    Abstract Vaccine hesitancy is a major barrier to achieving large-scale COVID-19 vaccination. We report trends in vaccination intention and associated determinants from surveys in the adult general population in Greece. Four cross-sectional phone surveys were conducted in November 2020 and February, April and May 2021 on nationally representative samples of adults in Greece. Multinomial logistic regression was used on the combined data of the surveys to evaluate independent predictors of vaccination unwillingness/uncertainty. Vaccination intention increased from 67.6% in November 2020 to 84.8% in May 2021. Individuals aged 65 years or older were more willing to be vaccinated (May 2021: 92.9% vs. 79.5% in 18−39 years, p < 0.001) but between age-groups differences decreased over time. Vaccination intention increased substantially in both men and women, though earlier among men, and was higher in individuals with prograduate education (May 2021: 91.3% vs. 84.0% up to junior high). From multivariable analysis, unwillingness and/or uncertainty to be vaccinated was associated with younger age, female gender (in particular in the April 2021 survey), lower educational level and living with a child ≤12 years old. Among those with vaccine hesitancy, concerns about vaccine effectiveness declined over time (21.6% in November 2020 vs. 9.6% in May 2021, p = 0.014) and were reported more often by men; safety concerns remained stable over time (66.3% in November 2020 vs. 62.1% in May 2021, p = 0.658) and were reported more often by women. In conclusion, vaccination intention increased substantially over time. Tailored communication is needed to address vaccine hesitancy and concerns regarding vaccine safety.
    Language English
    Publishing date 2022-03-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines10030470
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: HIV RNA/DNA Levels at Diagnosis Can Predict Immune Reconstitution: A Longitudinal Analysis.

    Basoulis, Dimitrios / Pantazis, Nikos / Paraskevis, Dimitrios / Iliopoulos, Panos / Papadopoulou, Martha / Akinosoglou, Karolina / Hatzakis, Angelos / Daikos, George L / Psichogiou, Mina

    Microorganisms

    2023  Volume 11, Issue 6

    Abstract: Background: HIV DNA mirrors the number of infected cells and the size of the HIV viral reservoir. The aim of this study was to evaluate the effect of pre-cART HIV DNA levels as a predictive marker of immune reconstitution and on the post-cART CD4 counts ...

    Abstract Background: HIV DNA mirrors the number of infected cells and the size of the HIV viral reservoir. The aim of this study was to evaluate the effect of pre-cART HIV DNA levels as a predictive marker of immune reconstitution and on the post-cART CD4 counts trends.
    Methods: HIV DNA was isolated from PBMCs and quantified by real-time PCR. Immune reconstitution was assessed up to four years. Piecewise-linear mixed models were used to describe CD4 count changes.
    Results: 148 people living with HIV (PLWH) were included. The highest rate of immune reconstitution was observed during the first trimester. There was a trend showing that high HIV RNA level resulted in greater increase in CD4 count, especially during the first trimester of cART (difference above vs. below median 15.1 cells/μL/month; 95% CI -1.4-31.5;
    Conclusions: In successfully treated PLWH, pre-cART HIV DNA and HIV RNA levels are predictors of immune reconstitution.
    Language English
    Publishing date 2023-06-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11061510
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Assessment of mRNA Vaccine Immunogenicity in Solid Organ Transplant Recipients.

    Tsoutsoura, Paraskevi / Xagas, Efstathios / Roussos, Sotirios / Hatzakis, Angelos / Gourzi, Polyxeni / Boletis, Ioannis N / Marinaki, Smaragdi

    Medicina (Kaunas, Lithuania)

    2023  Volume 59, Issue 6

    Abstract: Background and Objectives: ...

    Abstract Background and Objectives:
    MeSH term(s) Humans ; 2019-nCoV Vaccine mRNA-1273 ; Antibodies, Viral ; BNT162 Vaccine ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Drug-Related Side Effects and Adverse Reactions ; Immunogenicity, Vaccine ; Organ Transplantation/adverse effects ; RNA, Messenger ; SARS-CoV-2
    Chemical Substances 2019-nCoV Vaccine mRNA-1273 (EPK39PL4R4) ; Antibodies, Viral ; BNT162 Vaccine ; COVID-19 Vaccines ; RNA, Messenger
    Language English
    Publishing date 2023-06-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59061075
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6270: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Molecular epidemiology of HIV among people who inject drugs after the HIV-outbreak in Athens, Greece: Evidence for a 'slow burn' outbreak.

    Kostaki, Evangelia Georgia / Roussos, Sotirios / Kefala, Anastasia Maria / Limnaios, Stefanos / Psichogiou, Mina / Papachristou, Eleni / Nikolopoulos, Georgios / Flountzi, Eleni / Friedman, Samuel R / Lagiou, Pagona / Hatzakis, Angelos / Sypsa, Vana / Magiorkinis, Gkikas / Beloukas, Apostolos / Paraskevis, Dimitrios

    Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases

    2024  Volume 121, Page(s) 105597

    Abstract: Background: New diagnoses of HIV-1 infection among people who inject drugs (PWID) in Athens, Greece, saw a significant increase in 2011 and a subsequent decline after 2013. Despite this, ongoing HIV-1 transmission persisted from 2014 to 2020 within this ...

    Abstract Background: New diagnoses of HIV-1 infection among people who inject drugs (PWID) in Athens, Greece, saw a significant increase in 2011 and a subsequent decline after 2013. Despite this, ongoing HIV-1 transmission persisted from 2014 to 2020 within this population. Our objective was to estimate the time of infection for PWID in Athens following the HIV-1 outbreak, explore the patterns of HIV-1 dispersal over time, and determine the duration from infection to diagnosis.
    Methods: Time from HIV-1 infection to diagnosis was estimated for 844 individuals infected within 4 PWID-specific clusters and for 8 PWID infected with sub-subtype A6 diagnosed during 2010-2019. Phylogeny reconstruction was performed using the maximum-likelihood method. HIV-1 infection dates were based on molecular clock calculations.
    Results: In total 86 of 92 (93.5%) sequences from PWID diagnosed during 2016-2019 were either related to the previously identified PWID-specific clusters (n = 81) or belonged to a new A6 cluster (n = 5). The median time between infection and diagnosis was 0.42 years during the outbreak period and 0.70 years during 2016-2019 (p < 0.001). The proportion of clustered sequences from PWID was very low at 5.3% during the pre-outbreak period (1998-2009), saw an increase to 41.7% one year before the outbreak in 2010, and consistently remained high during the whole period after 2011, spanning the post-outbreak period (2016-2019) with a range from 92.9% to 100%.
    Conclusions: The substantial proportion of clustered infections (93.5%) during 2016-2019 implies a persistent 'slow burn' HIV outbreak among PWID in Athens, suggesting that the outbreak was not successfully eliminated. The consistently high proportion of clustered sequences since the onset of the outbreak suggests the persistence of ongoing HIV-1 transmission attributed to injection practices. Our findings underscore the importance of targeted interventions among PWID, considering the ongoing transmission rate and prolonged time from infection to diagnosis.
    Language English
    Publishing date 2024-04-23
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2037068-4
    ISSN 1567-7257 ; 1567-1348
    ISSN (online) 1567-7257
    ISSN 1567-1348
    DOI 10.1016/j.meegid.2024.105597
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5645: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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