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Book ; Online ; Thesis: Assoziation der Autoimmunthyreoiditis mit depressiven Störungen

Haust, Merle

Association of autoimmune thyroiditis with depressive disorders

2012

Abstract: Ziel: Schilddrüsenerkrankungen sind häufig mit psychiatrischen Erkrankungen assoziiert. Ziel dieser Studie war die Erfassung sowohl der Prävalenz als auch der Zusammenhänge zwischen der Autoimmunthyreoiditis (AIT) und affektiven Störungen. Methoden: ... ...

Title variant	Association of autoimmune thyroiditis with depressive disorders
Author's details	vorgelegt von Merle Haust
Abstract	Ziel: Schilddrüsenerkrankungen sind häufig mit psychiatrischen Erkrankungen assoziiert. Ziel dieser Studie war die Erfassung sowohl der Prävalenz als auch der Zusammenhänge zwischen der Autoimmunthyreoiditis (AIT) und affektiven Störungen. Methoden: Insgesamt wurden 71 konsekutive ambulante Patienten prospektiv und nicht selektiert mit einer psychiatrischen Erkrankung (52 Patienten mit Depressionen bzw. Depression bei bipolarer Störung und 19 Patienten mit einer Schizophrenie) untersucht. Neben den Schilddrüsenparametern TSH, fT3 und fT4 wurden auch Antikörper gegen die thyreoidale Peroxidase (TPO-Ak) und Thyreoglobulinantikörper bestimmt. Bei erhöhten TPO-Ak-Titern (cut-off >60 U/ml) wurde zusätzlich eine Sonographie der Schilddrüse zur Sicherung der Diagnose einer AIT durchgeführt ...
Language	German
Size	Online-Ressource (PDF-Datei: 100 S., 1.626 KB), Ill., graph. Darst
Document type	Book ; Online ; Thesis
Thesis / German Habilitation thesis	Univ., Diss.--Göttingen, 2012
Database	Former special subject collection: coastal and deep sea fishing

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Article ; Online: Association between autoimmune thyroiditis and depressive disorder in psychiatric outpatients.

Degner, Detlef / Haust, Merle / Meller, Johannes / Rüther, Eckart / Reulbach, Udo

European archives of psychiatry and clinical neuroscience

2014 Volume 265, Issue 1, Page(s) 67–72

Abstract: Thyroid diseases are often associated with psychiatric disorders. The prevalence of autoimmune thyroiditis in the general population is estimated to be at about 5-14 %. A clinical study was conducted to evaluate the association between autoimmune ... ...

Abstract	Thyroid diseases are often associated with psychiatric disorders. The prevalence of autoimmune thyroiditis in the general population is estimated to be at about 5-14 %. A clinical study was conducted to evaluate the association between autoimmune thyroiditis and depression in psychiatric outpatients. Fifty-two patients with depression and nineteen patients with schizophrenia (serving as control group), attending a psychiatric outpatient unit, were included. In addition to the measurement of thyroid-stimulating hormone (TSH), free triiodothyronine, free thyroxine, antithyroid peroxidase (anti-TPO) antibodies, and anti-thyroglobulin antibodies, ultrasound examination of the thyroid gland was performed. The proportion of pathologically increased anti-TPO levels in patients with depression was high. Furthermore, the distribution of pathologically increased anti-TPO levels was significantly (χ (2) = 5.5; p = 0.019) different between patients with depression (32.7 %) and patients with schizophrenia (5.3 %). In a gender- and age-adjusted logistic regression, the odds ratio of uni- or bipolar patients with depression for an autoimmune thyroiditis was ten times higher (95 % CI = 1.2-85.3) when compared with schizophrenia patients. TSH basal level did not differ between patients with depression and patients with schizophrenia. Our study demonstrates a strong association between anti-TPO levels, which are considered to be of diagnostic value for autoimmune thyroiditis (in combination with a hypoechoic thyroid in ultrasonography) with uni- or bipolar depression. It should be noted that the routinely measured TSH level is not sufficient in itself to diagnose this relevant autoimmune comorbidity.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Autoantibodies/blood ; Bipolar Disorder/blood ; Bipolar Disorder/complications ; Depressive Disorder/blood ; Depressive Disorder/complications ; Female ; Humans ; Male ; Middle Aged ; Schizophrenia/blood ; Schizophrenia/complications ; Thyroiditis, Autoimmune/blood ; Thyroiditis, Autoimmune/complications ; Thyrotropin/blood ; Thyroxine/blood ; Triiodothyronine/blood ; Young Adult
Chemical Substances	Autoantibodies ; anti-thyroglobulin ; Triiodothyronine (06LU7C9H1V) ; Thyrotropin (9002-71-5) ; Thyroxine (Q51BO43MG4)
Language	English
Publishing date	2014-09-06
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1045583-8
ISSN	1433-8491 ; 0175-758X ; 0940-1334
ISSN (online)	1433-8491
ISSN	0175-758X ; 0940-1334
DOI	10.1007/s00406-014-0529-1
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Article ; Online: Fixed solar urticaria with delayed onset.

Wessendorf, Ulf / Hanneken, Sandra / Haust, Merle / Neumann, Norbert J

Journal of the American Academy of Dermatology

2009 Volume 60, Issue 4, Page(s) 695–697

Abstract: Fixed solar urticaria (FSU) is an extremely rare type of solar urticaria characterized by urticarial wheals appearing frequently confined to fixed areas of the skin. After a few minutes of exposure to sunlight or other sources of radiation, urticarial ... ...

Abstract	Fixed solar urticaria (FSU) is an extremely rare type of solar urticaria characterized by urticarial wheals appearing frequently confined to fixed areas of the skin. After a few minutes of exposure to sunlight or other sources of radiation, urticarial lesions can usually be induced exclusively in the same localization. We report a case of delayed onset FSU occurring 6 hours after exposure to ultraviolet A and B light.
MeSH term(s)	Adult ; Humans ; Male ; Time Factors ; Ultraviolet Rays/adverse effects ; Urticaria/etiology ; Urticaria/pathology
Language	English
Publishing date	2009-04
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	603641-7
ISSN	1097-6787 ; 0190-9622
ISSN (online)	1097-6787
ISSN	0190-9622
DOI	10.1016/j.jaad.2008.08.044
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Article ; Online: Updated analysis of standardized photoprovocation in patients with cutaneous lupus erythematosus.

Ruland, Vincent / Haust, Merle / Stilling, Roman M / Metze, Dieter / Amler, Susanne / Ruzicka, Thomas / Kuhn, Annegret

Arthritis care & research

2013 Volume 65, Issue 5, Page(s) 767–776

Abstract: Objective: To determine the frequency and reproducibility of standardized photoprovocation in patients with cutaneous lupus erythematosus (CLE) and report our long-term experience.: Methods: Photoprovocation using a standardized protocol was ... ...

Abstract	Objective: To determine the frequency and reproducibility of standardized photoprovocation in patients with cutaneous lupus erythematosus (CLE) and report our long-term experience. Methods: Photoprovocation using a standardized protocol was evaluated retrospectively in 566 patients. A diagnosis of CLE was clinically and/or histologically confirmed in 431 patients, and 315 patients with polymorphic light eruption (PLE) were additionally included as controls. Data were statistically analyzed using an SPSS database. Results: A total of 61.7% of the 431 CLE patients exhibited a positive photoprovocation, with a significantly longer latency period for the development of skin lesions after ultraviolet (UV) A and/or UVB irradiation than PLE patients (P < 0.001). The frequency of positive photoprovocation varied among the CLE subtypes, and intermittent CLE was the most photosensitive disease entity (74.8%). Subsequent photoprovocation in 35 patients demonstrated that CLE patients with an initial positive result exhibited a significantly higher frequency of a positive photoprovocation at a later time point (P = 0.013). However, an initial positive photoprovocation did not definitively predict a positive reaction at a later time point. Moreover, patient history of photosensitivity was not a predictor for the photoprovocation outcome. Conclusion: Standardized photoprovocation is a useful tool to reproducibly induce skin lesions and objectively evaluate photosensitivity in patients with CLE. These data further suggest that the reaction to UV light may change during the course of this heterogeneous disease and that photosensitivity should not be excluded in patients with a negative history of photosensitivity.
MeSH term(s)	Adult ; Female ; Humans ; Lupus Erythematosus, Cutaneous/diagnosis ; Lupus Erythematosus, Cutaneous/epidemiology ; Male ; Middle Aged ; Photosensitivity Disorders/diagnosis ; Photosensitivity Disorders/epidemiology ; Population Surveillance/methods ; Retrospective Studies ; Ultraviolet Rays ; Young Adult
Language	English
Publishing date	2013-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	645059-3
ISSN	2151-4658 ; 0893-7524 ; 2151-464X
ISSN (online)	2151-4658
ISSN	0893-7524 ; 2151-464X
DOI	10.1002/acr.21867
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Book ; Online ; Thesis: Assoziation der Autoimmunthyreoiditis mit depressiven Störungen

Haust, Merle [Verfasser] / Degner, Detlef [Akademischer Betreuer] / Rüther, Eckart [Akademischer Betreuer] / Meller, Johannes [Akademischer Betreuer]

2012

Author's details	Merle Haust. Gutachter: Eckart Rüther ; Johannes Meller. Betreuer: Detlef Degner
Keywords	Medizin, Gesundheit ; Medicine, Health
Subject code	sg610
Language	German
Publisher	Niedersächsische Staats- und Universitätsbibliothek Göttingen
Publishing place	Göttingen
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

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Article ; Online: Photoprotective effects of a broad-spectrum sunscreen in ultraviolet-induced cutaneous lupus erythematosus: a randomized, vehicle-controlled, double-blind study.

Kuhn, Annegret / Gensch, Kristina / Haust, Merle / Meuth, Anna-Maria / Boyer, France / Dupuy, Patrick / Lehmann, Percy / Metze, Dieter / Ruzicka, Thomas

Journal of the American Academy of Dermatology

2011 Volume 64, Issue 1, Page(s) 37–48

Abstract: Objective: We sought to assess if the exclusive use of a broad-spectrum sunscreen can prevent skin lesions in patients with different subtypes of cutaneous lupus erythematosus (CLE) induced by ultraviolet (UV) irradiation under standardized conditions.!# ...

Abstract	Objective: We sought to assess if the exclusive use of a broad-spectrum sunscreen can prevent skin lesions in patients with different subtypes of cutaneous lupus erythematosus (CLE) induced by ultraviolet (UV) irradiation under standardized conditions. Methods: A total of 25 patients with a medical history of photosensitive CLE were included in this monocentric, randomized, vehicle-controlled, double-blind, intraindividual study. The test product and its vehicle were applied 15 minutes before UVA and UVB irradiation of uninvolved skin areas on the upper aspect of the back in a random order, and standardized phototesting was performed daily for 3 consecutive days. Results: Characteristic skin lesions were induced by UVA and UVB irradiation in 16 patients with CLE in the untreated area, and 14 patients showed a positive test result in the vehicle-treated area. In contrast, no eruptions compatible with CLE were observed in the sunscreen-treated area in any of the 25 patients. This resulted in significant differences (P < .001) between UV-irradiated sunscreen-treated versus vehicle-treated areas, and between UV-irradiated sunscreen-treated versus untreated areas. Furthermore, a significant difference (P < .05) was observed concerning the age of disease onset and the patient history of photosensitivity. Patients who were younger than 40 years at onset of CLE reported photosensitivity significantly more often than patients with a higher age of disease onset. None of the patients showed any adverse events from application of the test product or the vehicle. Limitations: Data resulting from standardized experimental phototesting might not be transferable to a clinical setting. Conclusion: These results indicate clearly that the use of a highly protective broad-spectrum sunscreen can prevent skin lesions in photosensitive patients with different subtypes of CLE.
MeSH term(s)	Adult ; Confidence Intervals ; Double-Blind Method ; Female ; Humans ; Lupus Erythematosus, Cutaneous/immunology ; Lupus Erythematosus, Cutaneous/pathology ; Male ; Middle Aged ; Photosensitivity Disorders/immunology ; Photosensitivity Disorders/pathology ; Photosensitivity Disorders/prevention & control ; Reference Values ; Risk Assessment ; Sunscreening Agents/pharmacology ; Ultraviolet Rays/adverse effects
Chemical Substances	Sunscreening Agents
Language	English
Publishing date	2011-01
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	603641-7
ISSN	1097-6787 ; 0190-9622
ISSN (online)	1097-6787
ISSN	0190-9622
DOI	10.1016/j.jaad.2009.12.053
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Article ; Online: A database analysis of cutaneous lupus erythematosus with the EUSCLE Core Set Questionnaire.

Meuth, Anna Maria / Amler, Suzanne / Haust, Merle / Bein, Dennis / Sauerland, Cristina / Köpcke, Wolfgang / Bonsmann, Gisela / Nyberg, Filippa / Kuhn, Annegret

Acta dermato-venereologica

2010 Volume 90, Issue 4, Page(s) 386–394

Abstract: The aim of this study was to determine whether the Core Set Questionnaire developed recently by the European Society of Cutaneous Lupus Erythematosus (EUSCLE) is a useful tool to evaluate clinical features and therapeutic strategies in cutaneous lupus ... ...

Abstract	The aim of this study was to determine whether the Core Set Questionnaire developed recently by the European Society of Cutaneous Lupus Erythematosus (EUSCLE) is a useful tool to evaluate clinical features and therapeutic strategies in cutaneous lupus erythematosus. Disease characteristics were analysed in 50 patients with different subtypes of cutaneous lupus erythematosus from two European centres (Germany and Sweden). Mean age at onset of disease was 42.0 +/- 13.3 years (range: 7-69 years) and this differed significantly between the cutaneous lupus erythematosus subtypes. Moreover, 22 (44.0%) of the patients with cutaneous lupus erythematosus fulfilled four or more of the American College of Rheumatology (ACR) criteria; however, only 7 (14.0%) had severe systemic organ manifestations, such as kidney involvement. The analysis of serological features, such as antinuclear antibodies, revealed further significant differences between the cutaneous lupus erythematosus subtypes. In conclusion, the EUSCLE Core Set Questionnaire provides a useful tool for standardized collection and statistical analysis of data on cutaneous lupus erythematosus in clinical practice.
MeSH term(s)	Adolescent ; Adult ; Aged ; Child ; Databases as Topic ; Feasibility Studies ; Female ; Germany ; Humans ; Lupus Erythematosus, Cutaneous/classification ; Lupus Erythematosus, Cutaneous/complications ; Lupus Erythematosus, Cutaneous/diagnosis ; Lupus Erythematosus, Cutaneous/therapy ; Male ; Middle Aged ; Predictive Value of Tests ; Reproducibility of Results ; Retrospective Studies ; Severity of Illness Index ; Surveys and Questionnaires ; Sweden ; Treatment Outcome ; Young Adult
Language	English
Publishing date	2010-07
Publishing country	Sweden
Document type	Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't ; Validation Studies
ZDB-ID	80007-7
ISSN	1651-2057 ; 0001-5555
ISSN (online)	1651-2057
ISSN	0001-5555
DOI	10.2340/00015555-0879
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Article ; Online: Effect of bosentan on skin fibrosis in patients with systemic sclerosis: a prospective, open-label, non-comparative trial.

Kuhn, Annegret / Haust, Merle / Ruland, Vincent / Weber, Ramona / Verde, Pablo / Felder, Gerd / Ohmann, Christian / Gensch, Kristina / Ruzicka, Thomas

Rheumatology (Oxford, England)

2010 Volume 49, Issue 7, Page(s) 1336–1345

Abstract: Objectives: To assess the effect of the ET-receptor antagonist bosentan on skin fibrosis and functionality in patients with SSc.: Methods: In this prospective, open-label, non-comparative trial, a total of 10 patients with SSc received 62.5 mg of ... ...

Abstract	Objectives: To assess the effect of the ET-receptor antagonist bosentan on skin fibrosis and functionality in patients with SSc. Methods: In this prospective, open-label, non-comparative trial, a total of 10 patients with SSc received 62.5 mg of bosentan twice daily for 4 weeks and then 125 mg twice daily for 20 weeks. The primary endpoint was skin thickening as measured by the modified Rodnan skin score (mRSS). Further assessments included 20 MHz ultrasound, examination of digital ulcers (DUs) and evaluation of hand function by examining patients' fist closure. Furthermore, patients with SSc used the UK SSc Functional Score (UKFS), the modified scleroderma HAQ (SHAQ) and its visual analogue scale (VAS) to rate their disability related to specific organ systems. Results: The mean change from baseline mRSS (the primary endpoint) was 6.4 at Week 24 of bosentan treatment, which was statistically significant (P < 0.001). Patients with both diffuse and limited SSc exhibited a statistically significant mean difference in the mRSS. Moreover, there was a significant healing of DUs noted between baseline and at Week 24 of bosentan treatment (P < 0.001); however, the 20 MHz ultrasound and the fist closure evaluation revealed no significant differences. There were also no statistically significant changes between baseline and Week 24 in the UKFS, the modified SHAQ and its VAS. Conclusion: In addition to the well-known effect of bosentan in prevention of DUs, the results of this study demonstrate that bosentan may also be effective at reducing skin fibrosis in patients with SSc.
MeSH term(s)	Aged ; Endothelin Receptor Antagonists ; Female ; Fibrosis/drug therapy ; Humans ; Male ; Middle Aged ; Receptors, Endothelin/therapeutic use ; Scleroderma, Systemic/drug therapy ; Skin Ulcer/drug therapy ; Statistics as Topic ; Sulfonamides/therapeutic use ; Treatment Outcome
Chemical Substances	Endothelin Receptor Antagonists ; Receptors, Endothelin ; Sulfonamides ; bosentan (Q326023R30)
Language	English
Publishing date	2010-07
Publishing country	England
Document type	Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1464822-2
ISSN	1462-0332 ; 1462-0324
ISSN (online)	1462-0332
ISSN	1462-0324
DOI	10.1093/rheumatology/keq077
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Article ; Online: Anti-annexin 1 antibodies: a new diagnostic marker in the serum of patients with discoid lupus erythematosus.

Kretz, Cosima C / Norpo, Maria / Abeler-Dörner, Lucie / Linke, Björn / Haust, Merle / Edler, Lutz / Krammer, Peter H / Kuhn, Annegret

Experimental dermatology

2010 Volume 19, Issue 10, Page(s) 919–921

Abstract: Annexin 1 is an anti-inflammatory molecule and has also been described to be a common target of autoantibodies. In this study, we determined whether antibodies against annexin 1 can be detected in sera of patients with cutaneous lupus erythematosus (CLE). ...

Abstract	Annexin 1 is an anti-inflammatory molecule and has also been described to be a common target of autoantibodies. In this study, we determined whether antibodies against annexin 1 can be detected in sera of patients with cutaneous lupus erythematosus (CLE). Levels of anti-annexin 1 antibodies were evaluated by a new established enzyme-linked immunosorbent assay and found to be significantly higher in sera of patients with CLE when compared to normal healthy donors (NHD). Moreover, the percentage of sera positively tested for anti-annexin 1 antibodies was elevated in patients with CLE when compared to NHD. In particular, the percentage of positive sera for anti-annexin 1 antibodies was significantly higher in patients with discoid lupus erythematosus (DLE); however, disease activity did not correlate with the antibody levels. The results of this study indicate that anti-annexin 1 antibodies in sera of patients with DLE might be a valuable aid in the diagnosis of this subtype.
MeSH term(s)	Adult ; Annexin A1/blood ; Autoantibodies/blood ; Biomarkers/blood ; Female ; Humans ; Lupus Erythematosus, Discoid/blood ; Lupus Erythematosus, Discoid/diagnosis ; Male ; Middle Aged ; Young Adult
Chemical Substances	Annexin A1 ; Autoantibodies ; Biomarkers
Language	English
Publishing date	2010-10
Publishing country	Denmark
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	1130936-2
ISSN	1600-0625 ; 0906-6705
ISSN (online)	1600-0625
ISSN	0906-6705
DOI	10.1111/j.1600-0625.2010.01145.x
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Article: Carbamazepin-Intoxikation nach Interaktion mit Erythromycin und Metronidazol

Degner, Detlef / Grohmann, Renate / Rüther, Eckart / Reulbach, Udo / Haust, Merle

Psychopharmakotherapie

2006 Volume 13, Issue 4, Page(s) 169

Language	German
Document type	Article
ZDB-ID	1196510-1
ISSN	0944-6877 ; 0946-5146
Database	Current Contents Medicine

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