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  1. AU="Havva Keskin"
  2. AU="Gomis, Susantha"
  3. AU="Castro, Vanda"
  4. AU="Josiah, S M"
  5. AU="Yanjun Guo"
  6. AU="Klapp, Sabine H L"
  7. AU="Cipolat, Lauriane"
  8. AU="Rhee, Hwanseok"
  9. AU="El-Khatabi, K"
  10. AU="Lee, Seung Hee"
  11. AU=Torres Antoni
  12. AU="Baldacini, Mathieu"
  13. AU="Stahl, Alexander"
  14. AU="Karimbumkara, Seena Narayanan"
  15. AU="Welz Mirosław"
  16. AU="Jintao Ding"
  17. AU="Mei-Fang Chen"

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  1. Artikel ; Online: The Status of Iron Stores in the Women with Beta Thalassemia Minor

    Tahsin KARAASLAN / Havva KESKİN / Kenan ÇADIRCI / Günçağ DİNÇOL

    Bezmiâlem Science, Vol 9, Iss 4, Pp 387-

    2021  Band 393

    Abstract: Objective:Patients with beta-thalassemia minor are often exposed to unnecessary iron replacement therapies due to hypochrome microcytic change in erythrocyte morphology. However, in these patients, ineffective erythropoiesis may increase iron absorption ... ...

    Abstract Objective:Patients with beta-thalassemia minor are often exposed to unnecessary iron replacement therapies due to hypochrome microcytic change in erythrocyte morphology. However, in these patients, ineffective erythropoiesis may increase iron absorption in the intestines and excessive iron accumulation in the body. In this study, retrospectively, we aimed to show the iron storage status in our patients with beta-thalassemia minor with both biochemical parameters and bone marrow examinations.Methods:Fifteen beta-thalassemia minor patients, who underwent bone marrow aspiration and biopsy for any reason in our hospital but had no additional diagnosis except thalassemia, were detected from the hospital records. Their related laboratory values were examined retrospectively. The pathological materials were reevaluated for erythroblast, and sideroblast.Results:The median age was 43 [interqurtile range (IQR): 27-54] years and the median ferritin values was 24 (IQR: 14.1-84.8) ng/mL. The ferritin values was 15 ng/mL in four cases. Sideroblast values were under the normal limit in all but one case. The median sideroblast value was 6% (IQR: 1.5-15.0%). Transferrin saturation was less than 20% in only one case. There was a moderate positive correlation between ferritin and sideroblast (r=+0.598; p=0.032) while there was not any positive or negative significant correlation between other parameters.Conclusion:In this study, where iron storage status was examined both biochemically and histopathologically, 66% of cases with iron deficiency could have been overlooked if the iron status of the patients was evaluated only by the serum iron panel. The examination of bone marrow aspiration with prussian blue is a gold standard method for determining iron storage status.
    Schlagwörter thalassemia minor ; ferritin ; sideroblast ; iron stores ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 616
    Sprache Englisch
    Erscheinungsdatum 2021-10-01T00:00:00Z
    Verlag Galenos Publishing House
    Dokumenttyp Artikel ; Online
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  2. Artikel ; Online: Can Dehydroepiandrosterone-Sulphate be a New Diagnostic Parameter in Idiopathic Hypogonadotropic Hypogonadism?

    Kenan ÇADIRCI / Havva KESKİN / Muharrem BAYRAK / Ayşe ÇARLIOĞLU / Şenay CEYLAN ARIKAN

    Bezmiâlem Science, Vol 10, Iss 5, Pp 628-

    2022  Band 632

    Abstract: Objective:Dehydroepiandrosterone (DHEA) and its sulfate derivative DHEA-sulfate (DHEA-s) are major androgen hormones which are synthesis from the adrenal origin. The purpose of this study was to investigate DHEA-s levels in male patients with idiopathic ... ...

    Abstract Objective:Dehydroepiandrosterone (DHEA) and its sulfate derivative DHEA-sulfate (DHEA-s) are major androgen hormones which are synthesis from the adrenal origin. The purpose of this study was to investigate DHEA-s levels in male patients with idiopathic hypogonadotropic hypogonadism (IHH) and to determine whether DHEA-s level are a useful marker for diagnosis of IHH.Methods:A total of 91 subjects, 31 males with IHH (mean age 19.7±2.6 years) and 60 healthy males (mean age 20.7±2.6 years), were enrolled in this study. The patients with IHH were selected from the subjects who had not yet started treatment for hypogonadism and who had no additional disease, while the healthy control group consisted entirely from individuals admitted to the same hospital outpatient clinic for routine check-ups. Both groups’ blood sampling, anthropometric measures, and physical examination were undertaken.Results:Mean DHEA-s level was 133.4±56.5 μg/dL in the IHH group and 433.3±160.3 μg/dL in the control group (p=0.000). The low DHEA-s level in patients with IHH was independent of age, cortisol, and adrenocorticotropic hormone (ACTH) at multivariate logistic regression analysis. The ROC analysis showed that DHEA-s ≤38.2 μg/dL supports a diagnosis of IHH with 100% specificity and 100% sensitivity. DHEA-s was as predictive as total testosterone which is used in the diagnosis of patients with IHH.Conclusion:DHEA-s level was significantly lower in the males with IHH compared to controls. Therefore, DHEA-s may be a potential predictive marker for diagnosis of IHH.
    Schlagwörter dehydroepiandrosterone ; dehydroepiandrosterone-sulphate ; idiopathic hypogonadotropic hypogonadism ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2022-10-01T00:00:00Z
    Verlag Galenos Publishing House
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Colorectal cancer in the Linxian China Nutrition Intervention Trial

    Havva Keskin / Shao-Ming Wang / Arash Etemadi / Jin-Hu Fan / Sanford M Dawsey / Christian C Abnet / You-Lin Qiao / Philip R Taylor

    PLoS ONE, Vol 16, Iss 9, p e

    Risk factors and intervention results.

    2021  Band 0255322

    Abstract: Background Colorectal cancer (CRC) is among the most common cancers in economically developed countries and developing world. While dietary factors are associated with risk of CRC in the West and urban China, little is known about risk or protective ... ...

    Abstract Background Colorectal cancer (CRC) is among the most common cancers in economically developed countries and developing world. While dietary factors are associated with risk of CRC in the West and urban China, little is known about risk or protective factors in rural China. Methods The Linxian General Population Nutrition Intervention Trial (NIT) cohort was established over 30 years ago to test whether daily multivitamin/mineral supplements could reduce the incidence and mortality of esophageal/gastric cardia cancer. The cohort included a total of 29,553 healthy participants 40-69 years old who were randomly assigned to supplements or placebos via a 24 fractional factorial study design. We examined risk factors for the development of CRC as well as the effects of four different nutritional factors (Factor A: retinol, zinc; B: riboflavin, niacin; C: ascorbic acid, molybdenum; D: selenium, alpha-tocopherol, beta-carotene,) on CRC incidence following 5.25 years of supplementation in this randomized, placebo-controlled intervention trial. Results CRC risk increased with age and height as well as piped water usage, family history of CRC, and consumption of foods cooked in oil, eggs, and fresh fruits. No effect on CRC was seen for any of these four intervention factors tested in both genders, but CRC was reduced 37% in females who received Factor D (selenium/alpha-tocopherol/beta-carotene) (RR = 0.63, 95% CI = 0.43-0.92, P = 0.016) compared to females who did not receive Factor D. Conclusions In this undernourished rural Chinese population, CRC risk factors in this Chinese cohort showed both similarities and differences compared to Western and urban Asian Chinese populations. Intervention results suggested a potential benefit for women supplemented with selenium/alpha-tocopherol/beta-carotene.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2021-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
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  4. Artikel: Rad52 Inverse Strand Exchange Drives RNA-Templated DNA Double-Strand Break Repair

    Mazina, Olga M / Alexander V. Mazin / Francesca Storici / Havva Keskin / Kritika Hanamshet

    Molecular cell. 2017 July 06, v. 67, no. 1

    2017  

    Abstract: RNA can serve as a template for DNA double-strand break repair in yeast cells, and Rad52, a member of the homologous recombination pathway, emerged as an important player in this process. However, the exact mechanism of how Rad52 contributes to RNA- ... ...

    Abstract RNA can serve as a template for DNA double-strand break repair in yeast cells, and Rad52, a member of the homologous recombination pathway, emerged as an important player in this process. However, the exact mechanism of how Rad52 contributes to RNA-dependent DSB repair remained unknown. Here, we report an unanticipated activity of yeast and human Rad52: inverse strand exchange, in which Rad52 forms a complex with dsDNA and promotes strand exchange with homologous ssRNA or ssDNA. We show that in eukaryotes, inverse strand exchange between homologous dsDNA and RNA is a distinctive activity of Rad52; neither Rad51 recombinase nor the yeast Rad52 paralog Rad59 has this activity. In accord with our in vitro results, our experiments in budding yeast provide evidence that Rad52 inverse strand exchange plays an important role in RNA-templated DSB repair in vivo.
    Schlagwörter DNA repair ; eukaryotic cells ; homologous recombination ; humans ; RNA ; single-stranded DNA ; yeasts
    Sprache Englisch
    Erscheinungsverlauf 2017-0706
    Umfang p. 19-29.e3.
    Erscheinungsort Elsevier Inc.
    Dokumenttyp Artikel
    ZDB-ID 1415236-8
    ISSN 1097-4164 ; 1097-2765
    ISSN (online) 1097-4164
    ISSN 1097-2765
    DOI 10.1016/j.molcel.2017.05.019
    Datenquelle NAL Katalog (AGRICOLA)

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  5. Artikel ; Online: Ribonucleotide incorporation in yeast genomic DNA shows preference for cytosine and guanosine preceded by deoxyadenosine

    Sathya Balachander / Alli L. Gombolay / Taehwan Yang / Penghao Xu / Gary Newnam / Havva Keskin / Waleed M. M. El-Sayed / Anton V. Bryksin / Sijia Tao / Nicole E. Bowen / Raymond F. Schinazi / Baek Kim / Kyung Duk Koh / Fredrik O. Vannberg / Francesca Storici

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Band 14

    Abstract: Ribonucleoside monophosphates are incorporated by DNA polymerases into double-stranded DNA. Here, the authors use ribose-seq and Ribose-Map techniques to reveal that signatures and patterns of ribonucleotide incorporation in yeast mitochondrial and ... ...

    Abstract Ribonucleoside monophosphates are incorporated by DNA polymerases into double-stranded DNA. Here, the authors use ribose-seq and Ribose-Map techniques to reveal that signatures and patterns of ribonucleotide incorporation in yeast mitochondrial and nuclear DNA show preference for cytosine and guanosine preceded by deoxyadenosine.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2020-05-01T00:00:00Z
    Verlag Nature Publishing Group
    Dokumenttyp Artikel ; Online
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  6. Artikel ; Online: Ribonucleotide incorporation in yeast genomic DNA shows preference for cytosine and guanosine preceded by deoxyadenosine

    Sathya Balachander / Alli L. Gombolay / Taehwan Yang / Penghao Xu / Gary Newnam / Havva Keskin / Waleed M. M. El-Sayed / Anton V. Bryksin / Sijia Tao / Nicole E. Bowen / Raymond F. Schinazi / Baek Kim / Kyung Duk Koh / Fredrik O. Vannberg / Francesca Storici

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Band 14

    Abstract: Ribonucleoside monophosphates are incorporated by DNA polymerases into double-stranded DNA. Here, the authors use ribose-seq and Ribose-Map techniques to reveal that signatures and patterns of ribonucleotide incorporation in yeast mitochondrial and ... ...

    Abstract Ribonucleoside monophosphates are incorporated by DNA polymerases into double-stranded DNA. Here, the authors use ribose-seq and Ribose-Map techniques to reveal that signatures and patterns of ribonucleotide incorporation in yeast mitochondrial and nuclear DNA show preference for cytosine and guanosine preceded by deoxyadenosine.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2020-05-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Association of Glomerular Filtration Rate with Inflammation in Polycystic Ovary Syndrome

    Ilay Ozturk Gozukara / Kerem Han Gozukara / Suna Kabil Kucur / Eda Ulku Karakılıc / Havva Keskin / Derya Akdeniz / Ayse Nur Aksoy

    International Journal of Fertility and Sterility, Vol 9, Iss 2, Pp 176-

    2015  Band 182

    Abstract: Background: We aimed to estimate the glomerular filtration rate (GFR) in women with polycystic ovary syndrome (PCOS) and to determine the relationship between GFR with C-reactive protein (CRP) and uric acid. Materials and Methods: In this cross-sectional ...

    Abstract Background: We aimed to estimate the glomerular filtration rate (GFR) in women with polycystic ovary syndrome (PCOS) and to determine the relationship between GFR with C-reactive protein (CRP) and uric acid. Materials and Methods: In this cross-sectional study, one-hundred and forty PCOS women and 60 healthy subjects were evaluated. The study was carried out at Endocrinology Outpatient Clinic, Erzurum Training and Research Hospital, Erzurum, Turkey, from December 2010 to January 2011. GFRs were estimated by Modification of Diet in Renal Disease (MDRD) formula. CRP, urinary albumin excretion (UAE) and uric acid levels were also measured. Results: GFRs were significantly higher in PCOS group than control (135.24 ± 25.62 vs. 114.92 ± 24.07 ml/min per 1.73 m2). CRP levels were significantly higher in PCOS patients (4.4 ± 3.4 vs. 2.12 ± 1.5 mg/l). The PCOS group had significantly higher serum uric acid levels (4.36 ± 1.3 mg/dl vs. 3.2 ± 0.73 mg/dl). There was also significantly higher proteinuria level in PCOS patients. Conclusion: Even though PCOS patients had higher GFR, serum uric acid and UAE values than control patients, the renal function was within normal limits. Increased GFR in PCOS women positively correlates with elevated serum CRP and uric acid.
    Schlagwörter CRP ; Glomerular Filtration Rate ; Polycystic Ovary Syndrome ; Uric Acid ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2015-07-01T00:00:00Z
    Verlag Royan Institute (ACECR), Tehran
    Dokumenttyp Artikel ; Online
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  8. Artikel ; Online: C-reactive protein level and obesity as cardiovascular risk factors in polycystic ovary syndrome

    Eda Ülkü Uludağ / İlay Gözükara / Suna Kabil Kucur / Havva Keskin / Halime Kılıç / Zeynep Kamalak / Ayşe Kargılı / Şenay Arıkan Durmaz

    Dicle Medical Journal, Vol 40, Iss 3, Pp 426-

    2013  Band 431

    Abstract: Objective: To investigate the role of C-reactive protein(CRP) level elevation and obesity for the increased cardiovasculardisease risk in polycystic ovary syndrome(PCOS).Methods: A hundred and nine patients with PCOS and 30age matched healthy volunteers ... ...

    Abstract Objective: To investigate the role of C-reactive protein(CRP) level elevation and obesity for the increased cardiovasculardisease risk in polycystic ovary syndrome(PCOS).Methods: A hundred and nine patients with PCOS and 30age matched healthy volunteers with regular menstrualcycle are involved in the study. PCOS group is furthersubdivided into three subgroups according to the bodymass index (BMI). Subgroups included 54 with BMI<25,22 with BMI 25-30, and 33 with BMI>30. Blood samplesfor glucose, insulin, uric acid, and CRP were collected inthe morning after overnight fasting (12 hours). Homeostasismodel assessment-insulin resistance (HOMA-IR)was calculated. Results: Fasting blood glucose, insulin,and HOMA-IR was significantly higher in PCOS group(p=0.02, p=0.01 and p=0.02). CRP level was higher insubgroup with BMI>30. High CRP level in PCOS wasfound to be independent from BMI (p<0.001). HOMA-IRand insulin level was higher in the subgroup with BMI>30.When compared with the control group high insulin levelwas the only to be statistically significant in obese PCOSpatients (p=0.005). HOMA-IR was higher in PCOS subgroupwith BMI>30 when compared with controls and thePCOS subgroup with BMI<25 (p<0.001, p= 0.003).Conclusion: Obesity, hyperinsulinemia, and high CRPlevels are seemed to be related and potentiating eachother in PCOS. Struggling with obesity is one of the mostimportant issues for preventive medicine.Key words: PCOS, CRP, obesity, cardiovascular risk
    Schlagwörter PCOS ; CRP ; obesity ; cardiovascular risk ; Medicine ; R ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2013-09-01T00:00:00Z
    Verlag Dicle University Medical School
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: Association of Glomerular Filtration Rate with Inflammation in Polycystic Ovary Syndrome

    Ilay Ozturk Gozukara / Kerem Han Gozukara / Suna Kabil Kucur / Eda Ulku Karakılıc / Havva Keskin / Derya Akdeniz / Ayse Nur Aksoy / Ayse Carlıoglu

    International Journal of Fertility & Sterility, Vol 9, Iss 2, Pp 176-

    2015  Band 182

    Abstract: Background: We aimed to estimate the glomerular filtration rate (GFR) in women with polycystic ovary syndrome (PCOS) and to determine the relationship between GFR with C-reactive protein (CRP) and uric acid. Materials and Methods: In this cross-sectional ...

    Abstract Background: We aimed to estimate the glomerular filtration rate (GFR) in women with polycystic ovary syndrome (PCOS) and to determine the relationship between GFR with C-reactive protein (CRP) and uric acid. Materials and Methods: In this cross-sectional study, one-hundred and forty PCOS women and 60 healthy subjects were evaluated. The study was carried out at Endocrinology Outpatient Clinic, Erzurum Training and Research Hospital, Erzurum, Turkey, from December 2010 to January 2011. GFRs were estimated by Modification of Diet in Renal Disease (MDRD) formula. CRP, urinary albumin excretion (UAE) and uric acid levels were also measured. Results: GFRs were significantly higher in PCOS group than control (135.24 ± 25.62 vs. 114.92 ± 24.07 ml/min per 1.73 m2). CRP levels were significantly higher in PCOS patients (4.4 ± 3.4 vs. 2.12 ± 1.5 mg/l). The PCOS group had significantly higher serum uric acid levels (4.36 ± 1.3 mg/dl vs. 3.2 ± 0.73 mg/dl). There was also significantly higher proteinuria level in PCOS patients. Conclusion: Even though PCOS patients had higher GFR, serum uric acid and UAE values than control patients, the renal function was within normal limits. Increased GFR in PCOS women positively correlates with elevated serum CRP and uric acid.
    Schlagwörter CRP ; Glomerular Filtration Rate ; Polycystic Ovary Syndrome ; Uric Acid ; Medicine (General) ; R5-920 ; Medicine ; R
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2015-08-01T00:00:00Z
    Dokumenttyp Artikel ; Online
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  10. Artikel ; Online: Association of Glomerular Filtration Rate with Inflammation in Polycystic Ovary Syndrome

    Ilay Ozturk Gozukara / Kerem Han Gozukara / Suna Kabil Kucur / Eda Ulku Karakılıc / Havva Keskin / Derya Akdeniz / Ayse Nur Aksoy / Ayse Carlıoglu

    International Journal of Fertility and Sterility, Vol 9, Iss 2, Pp 176-

    2015  Band 182

    Abstract: Background We aimed to estimate the glomerular filtration rate (GFR) in women with polycystic ovary syndrome (PCOS) and to determine the relationship between GFR with C-reactive protein (CRP) and uric acid. Materials and Methods In this cross-sectional ... ...

    Abstract Background We aimed to estimate the glomerular filtration rate (GFR) in women with polycystic ovary syndrome (PCOS) and to determine the relationship between GFR with C-reactive protein (CRP) and uric acid. Materials and Methods In this cross-sectional study, one-hundred and forty PCOS women and 60 healthy subjects were evaluated. The study was carried out at Endocrinol- ogy Outpatient Clinic, Erzurum Training and Research Hospital, Erzurum, Turkey, from December 2010 to January 2011. GFRs were estimated by Modification of Diet in Renal Disease (MDRD) formula. CRP, urinary albumin excretion (UAE) and uric acid levels were also measured. Results GFRs were significantly higher in PCOS group than control (135.24 ± 25.62 vs. 114.92 ± 24.07 ml/min per 1.73 m2). CRP levels were significantly higher in PCOS patients (4.4 ± 3.4 vs. 2.12 ± 1.5 mg/l). The PCOS group had significantly higher serum uric acid levels (4.36 ± 1.3 mg/dl vs. 3.2 ± 0.73 mg/dl). There was also significantly higher proteinuria level in PCOS patients. Conclusion Even though PCOS patients had higher GFR, serum uric acid and UAE val- ues than control patients, the renal function was within normal limits. Increased GFR in PCOS women positively correlates with elevated serum CRP and uric acid.
    Schlagwörter crp ; glomerular filtration rate ; polycystic ovary syndrome ; uric acid ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2015-07-01T00:00:00Z
    Verlag Royan Institute (ACECR), Tehran
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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