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Article: Prevalence and Risk Factors for Trichomonas Vaginalis Infection Among Women: a Population-Based Controlled Study in Saudi Arabia.

Hawash, Yousry A / Ismail, Khadiga A / Jaafer, Najwa F / Ahmed, Gaber / Alpakistany, Tareq A / Khalifa, Osama M

2022 Volume 68, Issue 6

Abstract: Background: Information on Trichomonas vaginalis (T. vaginalis) infection in Saudi Arabia is scarce. The aim of study was to assess the burden and risk factors of T. vaginalis infection for a cohort of women living in Saudi Arabia.: Methods: Women ... ...

Abstract	Background: Information on Trichomonas vaginalis (T. vaginalis) infection in Saudi Arabia is scarce. The aim of study was to assess the burden and risk factors of T. vaginalis infection for a cohort of women living in Saudi Arabia. Methods: Women aged ≥ 18 years who were seeking medical care at the King Faisal Medical Complex Gynecology Clinic in Taif city, Western Saudi Arabia, were enrolled in a non-randomized case-control study between June 2018 and May 2019. Participants were interviewed using a standard questionnaire for a number of sociodemographic and clinical characteristics. Vaginal swabs obtained from each participant were screened for T. vaginalis infection with direct wet mount smear microscopy, the OSOM Trichomonas rapid test 'OSOM Trich' (Genzyme Diagnostics, Cambridge, MA, USA) and a published nested PCR. Results: Over the study period, 155 women were recruited: 79 with symptoms of vaginitis (i.e. cases) and 76 with no symptoms (i.e. controls). The T. vaginalis infection was detected in ~20% (16/79) of cases and ~9% (7/76) of the controls by the nested PCR. Using the PCR test results as a gold standard, the wet mount microscopy's sensitivity, specificity, negative predictive value, and positive predictive value were 69.5%, 100%, 94.9%, and 100%, respectively, whereas the OSOM Trich's were 86.9%, 100%, 97.7%, and 100%, respectively. The main high-risk factors included age between 30 and 39 years (~35%), marriage for 10 - 30 years (~62%), non-education (~41%), urban residence (~29%), and employment (~36%). Highly significant differences were observed concerning infection distribution among cases for the presence of lower abdominal pain (~64%) and abnormal vaginal discharge (38%) as presenting symptoms (χ2 = 20.42; p < 0.001 and χ2 = 5.63; p = 0.017, respectively). Conclusions: The burden of infection with T. vaginalis is unexpectedly high in the population studied. Regular screening for T. vaginalis infection, particularly in high-risk women, is required.
MeSH term(s)	Adult ; Case-Control Studies ; Female ; Humans ; Prevalence ; Risk Factors ; Saudi Arabia/epidemiology ; Sensitivity and Specificity ; Trichomonas Vaginitis/diagnosis ; Trichomonas Vaginitis/epidemiology ; Trichomonas vaginalis
Language	English
Publishing date	2022-06-13
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1307629-2
ISSN	1433-6510 ; 0941-2131
ISSN	1433-6510 ; 0941-2131
DOI	10.7754/Clin.Lab.2021.210913
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Article: Effect of COVID-19 Pandemic on Neonatal Sepsis.

Mahmoud, Ahmed M / Alpakistany, Tariq A / Ismail, Khadiga A / Hawash, Yousry A / Jaafar, Najwa / Mohamed, Medhat M / Sami, Rokayya / Khalifa, Osama M

Clinical laboratory

2022 Volume 68, Issue 5

Abstract: Background: There is a sudden rise in infectious diseases, with special concern to the most recent SARS-CoV 2 outbreak. A retrospective study was conducted to study the effect of this outbreak on neonatal sepsis as a global issue that poses a challenge ... ...

Abstract	Background: There is a sudden rise in infectious diseases, with special concern to the most recent SARS-CoV 2 outbreak. A retrospective study was conducted to study the effect of this outbreak on neonatal sepsis as a global issue that poses a challenge for pediatric management and to identify its risk factors, microbial profile, and mortality rate at King Faisal Medical Complex, Taif, KSA, a COVID-19-tertiary care segregation hospital. Methods: This research included 111 neonates with a culture-proven diagnosis of neonatal sepsis (4 and 62 cases during 2019 and 2020, respectively). Results: During 2019 early onset sepsis (EOS) occurred in 6/49 (12.2%) while in 2020 22/62 (35.5%), and during 2019 late onset sepsis (LOS) occurred in 43/49 (87.7%) while in 2020 40/62 (64.5%). Premature rupture of membrane was the major neonatal risk factor for EOS during 2019 and 2020 with proportions of 4 (66.7%), 20 (90.9%); respectively. As regards LOS, the peripherally inserted central catheters and peripheral lines were the top neonatal risk factors. In the two-year outbreak, the most prevalent causative organism for EOS neonates was Escherichia coli and for LOS neonates it was Klebsiella. There was non-significant change in the mortality rate of neonatal sepsis between 2019 and 2020. However, the mortality rate was higher in EOS 9/22 (40.9%) in 2020 in comparison to 2/6 (33.3%) in 2019. Conclusions: Neonatal sepsis remains a major health problem causing serious morbidity and mortality, and health care policy makers have to implement EOS preventive measures.
MeSH term(s)	COVID-19/epidemiology ; Child ; Escherichia coli ; Humans ; Infant, Newborn ; Intensive Care Units, Neonatal ; Neonatal Sepsis/diagnosis ; Neonatal Sepsis/epidemiology ; Pandemics ; Retrospective Studies ; Sepsis/diagnosis ; Sepsis/epidemiology
Language	English
Publishing date	2022-05-10
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1307629-2
ISSN	1433-6510 ; 0941-2131
ISSN	1433-6510 ; 0941-2131
DOI	10.7754/Clin.Lab.2021.210711
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Article ; Online: High Frequency of Enteric Protozoan, Viral, and Bacterial Potential Pathogens in Community-Acquired Acute Diarrheal Episodes: Evidence Based on Results of Luminex Gastrointestinal Pathogen Panel Assay.

Hawash, Yousry A / Ismail, Khadiga A / Almehmadi, Mazen

The Korean journal of parasitology

2017 Volume 55, Issue 5, Page(s) 513–521

Abstract: Infectious diarrhea is endemic in most developing countries. We aimed to investigate the protozoan, viral, and bacterial causes of acute diarrhea in Taif, Saudi Arabia. A cross-sectional prospective 1-year study was conducted on 163 diarrheal patients of ...

Abstract	Infectious diarrhea is endemic in most developing countries. We aimed to investigate the protozoan, viral, and bacterial causes of acute diarrhea in Taif, Saudi Arabia. A cross-sectional prospective 1-year study was conducted on 163 diarrheal patients of various ages. Stool samples were collected, 1 per patient, and tested for 3 protozoa, 3 viruses, and 9 bacteria with the Luminex Gastrointestinal Pathogen Panel. Overall, 53.4% (87/163) of samples were positives (20.8% protozoa, 19.6% viruses, 2.8% bacteria, and 9.8% mixed). Rotavirus (19.6%), Giardia duodenalis (16.5%), and Cryptosporidium spp. (8.5%) were the mostly detected pathogens. Adenovirus 40/41 (4.2%), Salmonella (3%), Shiga toxin-producing Escherichia coli (3%), and Entamoeba histolytica (2.4%) were also detected. Norovirus GI/II, Vibrio cholerae, Yersinia enterocolitica, and Clostridium difficile toxin A/B were not detected in any patients. All pathogens were involved in coinfections except E. histolytica. Giardia (5.5%) and rotavirus (3%) were the most commonly detected in co-infections. Enterotoxigenic E. coli (2.4%), Campylobacter spp. (2.4%), E. coli 0157 (1.8%), and Shigella spp. (1.2%) were detected in patients only as co-infections. Infections were more in children 0-4 years, less in adults <40 years, and least >40 years, with statistically significant differences in risk across age groups observed with rotavirus (P<0.001), Giardia (P=0.006), and Cryptosporidium (P=0.036) infections. Lastly, infections were not significantly more in the spring. This report demonstrates the high burden of various enteropathogens in the setting. Further studies are needed to define the impact of these findings on the clinical course of the disease.
Language	English
Publishing date	2017-10
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	286875-1
ISSN	1738-0006 ; 0023-4001
ISSN (online)	1738-0006
ISSN	0023-4001
DOI	10.3347/kjp.2017.55.5.513
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Article: LYMPHO-PROLIFERATIVE RESPONSES TO VARIOUS FASCIOLA HEPATICA WORM'S ANTIGENS: AN IN VITRO STUDY.

Sharaf, Osama F / Amir, Elamir M / Hawash, Yousry A

Journal of the Egyptian Society of Parasitology

2016 Volume 46, Issue 1, Page(s) 217–222

Abstract: Fascioliasis is an important zoonotic disease with approximately 2-4 million people infected worldwide and a further 180 million at risk of infection. F. hepatica can survive within the bile ducts for many years through its ability to suppress the host ... ...

Abstract	Fascioliasis is an important zoonotic disease with approximately 2-4 million people infected worldwide and a further 180 million at risk of infection. F. hepatica can survive within the bile ducts for many years through its ability to suppress the host immunity with Fasciola cathepsin L1 cysteine protease and Glutathione S transferase playing an important role. The aim of the present study is to investigate the in vitro lympho-proliferative responses of hepatic hilar lymphocytes (HLN) of infected sheep in response to different F. hepatica antigens. The suppressive effects of Fasciola excretory/secretory (ES) and tegument (TEG) and their fractions were also investigated. Our results showed that both ES and TEG had significant suppressive effects on lympho-proliferation, up to 74% and 92%, respectively. When these antigens were fractionated, fraction 3 (MW of >10000-30000) of both ES (64%) and TEG (59%) in addition to fraction 4 (MW of ≤ 10000) of TEG (38%) inherited the suppressive effects. Identification of the potential molecule(s) with such suppressive effects on lymphocytes in TEG fraction 4 could reveal vaccine candidates.
MeSH term(s)	Animals ; Antigens, Helminth/physiology ; Cell Proliferation ; Fasciola hepatica/physiology ; Fascioliasis/immunology ; Fascioliasis/parasitology ; Fascioliasis/veterinary ; Helminth Proteins/immunology ; Helminth Proteins/physiology ; Lymphocytes/physiology ; Sheep ; Sheep Diseases/immunology ; Sheep Diseases/parasitology
Chemical Substances	Antigens, Helminth ; Helminth Proteins
Language	English
Publishing date	2016-01-21
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	645058-1
ISSN	1110-0583 ; 0253-5890
ISSN	1110-0583 ; 0253-5890
DOI	10.12816/0026167
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Article ; Online: Prevalence, toxin gene profile, genotypes and antibiotic susceptibility of

Saber, Taisir / Hawash, Yousry A / Ismail, Khadiga A / Khalifa, Amany S / Alsharif, Khalaf F / Alghamdi, Saleh A / Saber, Tamer / Eed, Emad M

Indian journal of medical microbiology

2020 Volume 38, Issue 2, Page(s) 176–182

Abstract: Purpose: Clostridium difficile (C. difficile) is an important causative agent of nosocomial diarrhoea and has become a major worldwide public health concern. The current study was conducted to determine the prevalence of C. difficile infection (CDI) ... ...

Abstract	Purpose: Clostridium difficile (C. difficile) is an important causative agent of nosocomial diarrhoea and has become a major worldwide public health concern. The current study was conducted to determine the prevalence of C. difficile infection (CDI) amongst patients with nosocomial diarrhoea in a large tertiary care hospital in Taif, Saudi Arabia, and to define molecular characteristics and antimicrobial sensitivity profiles of C. difficile strains isolated from those patients. Materials and methods: Stool specimens were collected from 456 patients and were cultured for C. difficile isolation. The isolates were subjected to multiplex polymerase chain reaction (PCR) for detecting genes encoding the toxins (toxin A, toxin B and binary toxin [CDT]), genotyping by PCR ribotyping method and antimicrobial sensitivity testing using E test strips. Results: Seventy-four C. difficile strains were recovered, of which 44 (59.5%) were A Conclusion: Further larger studies are required for an accurate understanding of CDI epidemiology in Saudi Arabia.
MeSH term(s)	ADP Ribose Transferases/genetics ; Adult ; Aged ; Bacterial Proteins/genetics ; Bacterial Toxins/genetics ; Clostridioides difficile/drug effects ; Clostridioides difficile/genetics ; Clostridioides difficile/isolation & purification ; Clostridium Infections/epidemiology ; Clostridium Infections/microbiology ; Cross-Sectional Studies ; Drug Resistance, Bacterial ; Drug Resistance, Multiple, Bacterial ; Enterotoxins/genetics ; Female ; Genotype ; Humans ; Male ; Microbial Sensitivity Tests ; Middle Aged ; Prevalence ; Ribotyping ; Saudi Arabia/epidemiology ; Tertiary Care Centers ; Young Adult
Chemical Substances	Bacterial Proteins ; Bacterial Toxins ; Enterotoxins ; tcdA protein, Clostridium difficile ; toxB protein, Clostridium difficile ; ADP Ribose Transferases (EC 2.4.2.-) ; actin-specific ADP-ribosyltransferase, Clostridium (EC 2.4.2.31)
Language	English
Publishing date	2020-09-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	1038798-5
ISSN	1998-3646 ; 0255-0857
ISSN (online)	1998-3646
ISSN	0255-0857
DOI	10.4103/ijmm.IJMM_20_300
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Article ; Online: Dientamoeba fragilis Infection in Patients with Digestive and Non-Digestive Symptoms: A Case-Control Study.

Hawash, Yousry A / Ismail, Khadiga A / Saber, Taisir / Eed, Emad M / Khalifa, Amany S / Alsharif, Khalaf F / Alghamdi, Saleh A

The Korean journal of parasitology

2020 Volume 58, Issue 2, Page(s) 129–134

Abstract: In most developing countries, Dientamoeba fragilis infection is an obscure protozoan infection. We aimed to determine a frequency and clinical importance of D. fragilis infection in Taif, Saudi Arabia. A 1-year case control study included patients with ... ...

Abstract	In most developing countries, Dientamoeba fragilis infection is an obscure protozoan infection. We aimed to determine a frequency and clinical importance of D. fragilis infection in Taif, Saudi Arabia. A 1-year case control study included patients with gastrointestinal (cases, n=114) or non-gastrointestinal symptoms (controls, n=90). The fecal samples were examined with the classical parasitological methods for intestinal protozoa, and by real time PCR for D. fragilis. The infection by D. fragilis was detected in 5.8% by PCR and in 4.4% patients by microscopy. The infection was identified more in control group (n=9) than in cases (n=3); a sole infection in 11 patients and mixed with Giardia in 1 patient. The other enteric parasites detected were Blastocystis sp. (8.3%), Giardia sp. (5.3%), Cryptosporidium sp. (2.9%), Entamoeba histolytica (1.4%), Entamoeba coli (0.9%) and Hymenolepis nana (0.4%). Our results tend to reinforce the need to increase awareness of D. fragilis infection in Saudi Arabia.
MeSH term(s)	Asymptomatic Diseases ; Case-Control Studies ; Dientamoeba/isolation & purification ; Dientamoebiasis/epidemiology ; Dientamoebiasis/parasitology ; Digestive System Diseases ; Humans ; Polymerase Chain Reaction ; Saudi Arabia/epidemiology
Language	English
Publishing date	2020-04-30
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	286875-1
ISSN	1738-0006 ; 0023-4001
ISSN (online)	1738-0006
ISSN	0023-4001
DOI	10.3347/kjp.2020.58.2.129
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Article ; Online: Diagnosis, Treatment and Clinical Features of Cutaneous Leishmaniasis in Saudi Arabia.

Hawash, Yousry A / Ismail, Khadiga A / Abdel-Wahab, Maha M / Khalifa, Mahmoud

The Korean journal of parasitology

2018 Volume 56, Issue 3, Page(s) 229–236

Abstract: Cutaneous leishmaniasis (CL) has been one of the most common parasitic diseases in Saudi Arabia. This study exhibits the clinical features, diagnosis, cytokine profile and treatment of CL patients in Al-Taif province. Ninety CL suspects at a tertiary ... ...

Abstract	Cutaneous leishmaniasis (CL) has been one of the most common parasitic diseases in Saudi Arabia. This study exhibits the clinical features, diagnosis, cytokine profile and treatment of CL patients in Al-Taif province. Ninety CL suspects at a tertiary care general hospital were enrolled in one-year study. Patients were interviewed, clinically-examined, and subjected to laboratory tests: skin scraping smear microscopy, OligoC-TesT commercial PCR (Coris BioConcept) and kinetoplast DNA (kDNA) PCR for Leishmania diagnosis. Interferon-gamma (RayBio; Human IFN-γ) and nitric oxide (NO) levels in patients' sera were evaluated before treatment with sodium stibogluconate (pentostam) with 20-day intramuscular drug regimen. Positive rates of microscopy, commercial PCR and kDNA PCR were 74.4%, 95.5% and 100%, respectively. Patients came to hospital mostly in winter (45.0%). CL was frequently exhibited in Saudi patients (78.8%), male gender (70.7%), age <20 years (50.0%), rural-dwellers (75.5%) and patients with travel history (86.6%). Lesion was mostly single ulcer (93.3%), occurred in the face (67.7%). Upon pentostam treatment, 85.1% of ulcers showed rapid healing signs. Levels of IFN-γ and NO were significantly higher in the healing than the non-healing cases (P<0.001). The kDNA PCR proved more sensitive than microscopy and OligoC-TesT commercial PCR. Our results open perspectives for IFN-γ use as a biomarker predicting treatment response.
MeSH term(s)	Adolescent ; Adult ; Age Factors ; Child ; Child, Preschool ; DNA, Protozoan ; Female ; Humans ; Interferon-gamma/blood ; Leishmania/genetics ; Leishmania/isolation & purification ; Leishmania/ultrastructure ; Leishmaniasis, Cutaneous/diagnosis ; Leishmaniasis, Cutaneous/drug therapy ; Leishmaniasis, Cutaneous/epidemiology ; Leishmaniasis, Cutaneous/parasitology ; Male ; Microscopy ; Middle Aged ; Nitric Oxide/blood ; Prevalence ; Saudi Arabia/epidemiology ; Sex Factors ; Young Adult
Chemical Substances	DNA, Protozoan ; Nitric Oxide (31C4KY9ESH) ; Interferon-gamma (82115-62-6)
Language	English
Publishing date	2018-06-30
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	286875-1
ISSN	1738-0006 ; 0023-4001
ISSN (online)	1738-0006
ISSN	0023-4001
DOI	10.3347/kjp.2018.56.3.229
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Article ; Online: Association of toll-like receptors 2, 4, 9 and 10 genes polymorphisms and

Eed, Emad M / Hawash, Yousry A / Khalifa, Amany S / Alsharif, Khalaf F / Alghamdi, Saleh A / Almalki, Abdulraheem A / Almehmadi, Mazen M / Ismail, Khadiga A / Taha, Azza A / Saber, Taisir

Indian journal of medical microbiology

2020 Volume 38, Issue 1, Page(s) 94–100

Abstract: Purpose: Helicobacter pylori is one of the most prevalent human pathogens worldwide. However, the outcomes of H. pylori infection are markedly variable from asymptomatic mild lesion to malignant transformation. Many factors are suggested to influence ... ...

Abstract	Purpose: Helicobacter pylori is one of the most prevalent human pathogens worldwide. However, the outcomes of H. pylori infection are markedly variable from asymptomatic mild lesion to malignant transformation. Many factors are suggested to influence these infection outcomes, including host immunity and genetic susceptibility. Toll-like receptors (TLRs) can recognise different microbial components and play an essential role in the mucosal immune response against H. pylori infection. Materials and methods: The association between the common single nucleotide polymorphisms (SNPs) in the genes of TLR2, 4, 9 and 10 and H. pylori-related gastric diseases were investigated by molecular methods after the confirmation of H. pylori infection. The study included 210 patients in three groups; chronic gastritis (n = 90), peptic ulcer disease (PUD) (n = 75) and gastric carcinoma (n = 45). Results: The results showed a significant association between TLR4 SNPs (rs 4986790 and rs 4986791) and the presence of H. pylori infection, especially in chronic gastritis patient group. Furthermore, TLR9-rs352140 TT genotype was more prevalent among chronic gastritis patient group. TLR10-rs 10004195 TT genotype was found to be less prevalent among H. pylori-related chronic gastritis and PUD and was suspected to have a protective effect. TLR2 SNPs (rs3804099 and rs3804100) showed no significant statistical difference between H. pylori-infected patients and the controls. Conclusion: TLR genes polymorphisms may play a role in H. pylori infection susceptibility and may influence its outcomes; however, the ethnic and other factors may modify this effect.
MeSH term(s)	Adult ; Biopsy ; Case-Control Studies ; Female ; Genetic Predisposition to Disease ; Genotyping Techniques ; Helicobacter Infections/epidemiology ; Helicobacter Infections/genetics ; Helicobacter pylori/isolation & purification ; Humans ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Saudi Arabia/epidemiology ; Stomach Diseases/genetics ; Stomach Diseases/microbiology ; Toll-Like Receptor 10/genetics ; Toll-Like Receptor 2/genetics ; Toll-Like Receptor 4/genetics ; Toll-Like Receptor 9/genetics ; Toll-Like Receptors/genetics ; Young Adult
Chemical Substances	TLR10 protein, human ; TLR2 protein, human ; TLR4 protein, human ; TLR9 protein, human ; Toll-Like Receptor 10 ; Toll-Like Receptor 2 ; Toll-Like Receptor 4 ; Toll-Like Receptor 9 ; Toll-Like Receptors
Language	English
Publishing date	2020-07-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	1038798-5
ISSN	1998-3646 ; 0255-0857
ISSN (online)	1998-3646
ISSN	0255-0857
DOI	10.4103/ijmm.IJMM_20_164
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Article ; Online: Microsporidia infection in patients with autoimmune diseases.

Ismail, Khadiga Ahmed / Hawash, Yousry A / Saber, Taisir / Eed, Emad M / Khalifa, Amany S / Alsharif, Khalaf F / Alghamdi, Saleh A / Khalifa, Ahmed M / Khalifa, Osama Mahmoud / Althubiti, Hatem K / Alsofyani, Gala M

Indian journal of medical microbiology

2020 Volume 38, Issue 3 & 4, Page(s) 409–414

Abstract: Purpose: Microsporidium is a spore-forming intracellular parasite that affects a wide range of hosts including humans. The tumor necrosis factor alpha (TNF-α) plays a key role in the immunity to infection with microsporidia. Recently, the TNF-α ... ...

Abstract	Purpose: Microsporidium is a spore-forming intracellular parasite that affects a wide range of hosts including humans. The tumor necrosis factor alpha (TNF-α) plays a key role in the immunity to infection with microsporidia. Recently, the TNF-α antagonists have proven successful in treating variable autoimmune diseases. In the current study, we aimed to investigate the impact of using TNF-α antagonists as a therapeutic regimen in the prevalence of infections with microsporidia. Materials and methods: Diarrheal patients with distinct autoimmune diseases (n = 100) were assigned to the study. Patients taking anti-TNF-α medications (n = 60) were allocated to Group 1A and those undergoing non-TNF-α inhibitor treatment (n = 40) to Group 1B. Furthermore, patients with diarrhea without autoimmune disorders (n = 20) were allocated as controls. Stool specimens, 3 per patient, were collected and microscopically examined for microsporidia spores. A microsporidia-specific stool polymerase chain reaction was used to confirm the microscopic findings. Results: Microsporidia infection was identified in 28.3% (17/60), 10% (4/40), and in 5% (1/20) of patients in Group 1A, Group 1B, and in the control group, respectively. Overall, infection was significantly high in cases compared to the controls and in patients receiving TNF-α antagonists compared to patients not given TNF-α inhibitors (P < 0.05). Finally, infection was significantly higher in cases treated with TNF-α antagonists for ≥2 months compared to cases treated for <2 months of duration (P < 0.05). Conclusion: There was a significant increase in microsporidia infection in autoimmune disease patients undergoing treatment with TNF-α antagonists, and the duration of treatment is one of the risk factors. The study highlights the importance of microsporidia testing in immunocompromised patients, particularly those undergoing treatment with anti-TNF-α drugs and emphasises the need for awareness among clinicians regarding this opportunistic parasite.
MeSH term(s)	Autoimmune Diseases/complications ; Case-Control Studies ; Diarrhea/etiology ; Feces/microbiology ; Female ; Humans ; Male ; Microsporidia/isolation & purification ; Microsporidiosis/complications ; Microsporidiosis/drug therapy ; Microsporidiosis/immunology ; Polymerase Chain Reaction ; Prospective Studies ; Tumor Necrosis Factor-alpha/antagonists & inhibitors ; Tumor Necrosis Factor-alpha/physiology
Chemical Substances	Tumor Necrosis Factor-alpha
Language	English
Publishing date	2020-11-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	1038798-5
ISSN	1998-3646 ; 0255-0857
ISSN (online)	1998-3646
ISSN	0255-0857
DOI	10.4103/ijmm.IJMM_20_325
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Article: Prevalence of Intestinal Protozoa among Saudi Patients with Chronic Renal Failure: A Case-Control Study.

Hawash, Yousry A / Dorgham, Laila Sh / Amir, El-Amir M / Sharaf, Osama F

Journal of tropical medicine

2015 Volume 2015, Page(s) 563478

Abstract: It has been hypothesized that chronic renal failure (CRF) predisposes patients to infection with intestinal protozoa. We tested this hypothesis with a matched case-control study to determine the prevalence of these protozoa and their diarrhea associated ... ...

Abstract	It has been hypothesized that chronic renal failure (CRF) predisposes patients to infection with intestinal protozoa. We tested this hypothesis with a matched case-control study to determine the prevalence of these protozoa and their diarrhea associated symptoms among 50 patients with CRF (cases) from Taif, western Saudi Arabia. Fifty diarrheal patients without CRF were recruited in the study as controls. Participants were interviewed by a structured questionnaire and stool samples were collected. Samples were thoroughly examined with microscopy and three coproantigens detection kits. Enteric protozoa were detected in 21 cases and 14 controls. Blastocystis spp. were the most predominant parasite (16% in cases versus 8% in controls), followed by Giardia duodenalis (10% in cases versus 12% in controls) and Cryptosporidium spp. (10% in cases versus 6% in controls). Cyclospora cayetanensis was identified in two cases, while Entamoeba histolytica was described in one case and one control. Intestinal parasitism was positively associated with the male gender, urban residence, and travel history. Clinical symptoms of nausea/vomiting and abdominal pain were significantly varied between the parasitized cases and controls (P value ≤ 0.05). Given the results, we recommend screening all diarrheal feces for intestinal protozoa in the study's population, particularly those with CRF.
Language	English
Publishing date	2015-09-28
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2546526-0
ISSN	1687-9694 ; 1687-9686
ISSN (online)	1687-9694
ISSN	1687-9686
DOI	10.1155/2015/563478
Database	MEDical Literature Analysis and Retrieval System OnLINE

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