LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 9 of total 9

Search options

  1. Article ; Online: Adding eye protection to universal masking reduces COVID-19 among frontline emergency clinicians to the level of community spread.

    Hawkins, Edward S / Fertel, Baruch S / Muir, McKinsey R / Meldon, Stephen W / Delgado, Fernando J / Smalley, Courtney M

    The American journal of emergency medicine

    2020  Volume 46, Page(s) 792–793

    MeSH term(s) COVID-19/epidemiology ; COVID-19/transmission ; Disease Transmission, Infectious/prevention & control ; Emergency Service, Hospital/organization & administration ; Humans ; Masks ; Pandemics ; Physicians ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-08-27
    Publishing country United States
    Document type Letter
    ZDB-ID 605890-5
    ISSN 1532-8171 ; 0735-6757
    ISSN (online) 1532-8171
    ISSN 0735-6757
    DOI 10.1016/j.ajem.2020.08.064
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: Angiotensin-Converting Enzyme Inhibitors Versus Angiotensin II Receptor Blockers: A Comparison of Outcomes in Patients With COVID-19.

    Kalra, Ankur / Hawkins, Edward S / Nowacki, Amy S / Jain, Vardhmaan / Milinovich, Alex / Saef, Joshua / Thomas, George / Gebreselassie, Surafel K / Karnik, Sadashiva S / Jehi, Lara / Young, James B / Svensson, Lars G / Chung, Mina K / Mehta, Neil

    Circulation. Cardiovascular quality and outcomes

    2020  Volume 13, Issue 10, Page(s) e007115

    MeSH term(s) Aged ; Angiotensin Receptor Antagonists/therapeutic use ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/therapy ; Coronavirus Infections/virology ; Female ; Hospitalization/statistics & numerical data ; Humans ; Hypertension/complications ; Hypertension/drug therapy ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/therapy ; Pneumonia, Viral/virology ; Respiration, Artificial/statistics & numerical data ; Retrospective Studies ; SARS-CoV-2
    Chemical Substances Angiotensin Receptor Antagonists ; Angiotensin-Converting Enzyme Inhibitors
    Keywords covid19
    Language English
    Publishing date 2020-08-28
    Publishing country United States
    Document type Comparative Study ; Letter ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2483197-9
    ISSN 1941-7705 ; 1941-7713
    ISSN (online) 1941-7705
    ISSN 1941-7713
    DOI 10.1161/CIRCOUTCOMES.120.007115
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article: Adding eye protection to universal masking reduces COVID-19 among frontline emergency clinicians to the level of community spread

    Hawkins, Edward S / Fertel, Baruch S / Muir, McKinsey R / Meldon, Stephen W / Delgado, Fernando J / Smalley, Courtney M

    Am. j. emerg. med

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #731687
    Database COVID19

    Kategorien

  4. Article ; Online: Adding eye protection to universal masking reduces COVID-19 among frontline emergency clinicians to the level of community spread

    Hawkins, Edward S. / Fertel, Baruch S. / Muir, McKinsey R. / Meldon, Stephen W. / Delgado, Fernando J. / Smalley, Courtney M.

    The American Journal of Emergency Medicine ; ISSN 0735-6757

    2020  

    Keywords Emergency Medicine ; General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    DOI 10.1016/j.ajem.2020.08.064
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

  5. Article: Angiotensin-Converting Enzyme Inhibitors Versus Angiotensin II Receptor Blockers: A Comparison of Outcomes in Patients With COVID-19

    Kalra, Ankur / Hawkins, Edward S / Nowacki, Amy S / Jain, Vardhmaan / Milinovich, Alex / Saef, Joshua / Thomas, George / Gebreselassie, Surafel K / Karnik, Sadashiva S / Jehi, Lara / Young, James B / Svensson, Lars G / Chung, Mina K / Mehta, Neil

    Circ Cardiovasc Qual Outcomes

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #884931
    Database COVID19

    Kategorien

  6. Article ; Online: Angiotensin-Converting Enzyme Inhibitors Versus Angiotensin II Receptor Blockers ; A Comparison of Outcomes in Patients With COVID-19

    Kalra, Ankur / Hawkins, Edward S. / Nowacki, Amy S. / Jain, Vardhmaan / Milinovich, Alex / Saef, Joshua / Thomas, George / Gebreselassie, Surafel K. / Karnik, Sadashiva S. / Jehi, Lara / Young, James B. / Svensson, Lars G. / Chung, Mina K. / Mehta, Neil

    Circulation: Cardiovascular Quality and Outcomes

    2020  Volume 13, Issue 10

    Keywords Cardiology and Cardiovascular Medicine ; covid19
    Language English
    Publisher Ovid Technologies (Wolters Kluwer Health)
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2483197-9
    ISSN 1941-7705 ; 1941-7713
    ISSN (online) 1941-7705
    ISSN 1941-7713
    DOI 10.1161/circoutcomes.120.007115
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

  7. Article ; Online: SARS-CoV-2 and ACE2: The biology and clinical data settling the ARB and ACEI controversy.

    Chung, Mina K / Karnik, Sadashiva / Saef, Joshua / Bergmann, Cornelia / Barnard, John / Lederman, Michael M / Tilton, John / Cheng, Feixiong / Harding, Clifford V / Young, James B / Mehta, Neil / Cameron, Scott J / McCrae, Keith R / Schmaier, Alvin H / Smith, Jonathan D / Kalra, Ankur / Gebreselassie, Surafel K / Thomas, George / Hawkins, Edward S /
    Svensson, Lars G

    EBioMedicine

    2020  Volume 58, Page(s) 102907

    Abstract: Background: SARS-CoV-2 enters cells by binding of its spike protein to angiotensin-converting enzyme 2 (ACE2). Angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs) have been reported to increase ACE2 expression in ... ...

    Abstract Background: SARS-CoV-2 enters cells by binding of its spike protein to angiotensin-converting enzyme 2 (ACE2). Angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs) have been reported to increase ACE2 expression in animal models, and worse outcomes are reported in patients with co-morbidities commonly treated with these agents, leading to controversy during the COVID-19 pandemic over whether these drugs might be helpful or harmful.
    Methods: Animal, in vitro and clinical data relevant to the biology of the renin-angiotensin system (RAS), its interaction with the kallikrein-kinin system (KKS) and SARS-CoV-2, and clinical studies were reviewed.
    Findings and interpretation: SARS-CoV-2 hijacks ACE2to invade and damage cells, downregulating ACE2, reducing its protective effects and exacerbating injurious Ang II effects. However, retrospective observational studies do not show higher risk of infection with ACEI or ARB use. Nevertheless, study of the RAS and KKS in the setting of coronaviral infection may yield therapeutic targets.
    MeSH term(s) Angiotensin Receptor Antagonists/pharmacology ; Angiotensin Receptor Antagonists/therapeutic use ; Angiotensin-Converting Enzyme 2 ; Angiotensin-Converting Enzyme Inhibitors/pharmacology ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Animals ; Betacoronavirus/pathogenicity ; COVID-19 ; Coronavirus Infections/drug therapy ; Coronavirus Infections/metabolism ; Coronavirus Infections/pathology ; Coronavirus Infections/virology ; Humans ; Kallikrein-Kinin System/drug effects ; Pandemics ; Peptidyl-Dipeptidase A/genetics ; Peptidyl-Dipeptidase A/metabolism ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/metabolism ; Pneumonia, Viral/pathology ; Pneumonia, Viral/virology ; Renin-Angiotensin System/drug effects ; SARS-CoV-2
    Chemical Substances Angiotensin Receptor Antagonists ; Angiotensin-Converting Enzyme Inhibitors ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
    Keywords covid19
    Language English
    Publishing date 2020-08-06
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2020.102907
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article: SARS-CoV-2 and ACE2: The biology and clinical data settling the ARB and ACEI controversy

    Chung, Mina K / Karnik, Sadashiva / Saef, Joshua / Bergmann, Cornelia / Barnard, John / Lederman, Michael M / Tilton, John / Cheng, Feixiong / Harding, Clifford V / Young, James B / Mehta, Neil / Cameron, Scott J / McCrae, Keith R / Schmaier, Alvin H / Smith, Jonathan D / Kalra, Ankur / Gebreselassie, Surafel K / Thomas, George / Hawkins, Edward S /
    Svensson, Lars G

    EBioMedicine

    Abstract: BACKGROUND: SARS-CoV-2 enters cells by binding of its spike protein to angiotensin-converting enzyme 2 (ACE2). Angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs) have been reported to increase ACE2 expression in ... ...

    Abstract BACKGROUND: SARS-CoV-2 enters cells by binding of its spike protein to angiotensin-converting enzyme 2 (ACE2). Angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs) have been reported to increase ACE2 expression in animal models, and worse outcomes are reported in patients with co-morbidities commonly treated with these agents, leading to controversy during the COVID-19 pandemic over whether these drugs might be helpful or harmful. METHODS: Animal, in vitro and clinical data relevant to the biology of the renin-angiotensin system (RAS), its interaction with the kallikrein-kinin system (KKS) and SARS-CoV-2, and clinical studies were reviewed. FINDINGS AND INTERPRETATION: SARS-CoV-2 hijacks ACE2to invade and damage cells, downregulating ACE2, reducing its protective effects and exacerbating injurious Ang II effects. However, retrospective observational studies do not show higher risk of infection with ACEI or ARB use. Nevertheless, study of the RAS and KKS in the setting of coronaviral infection may yield therapeutic targets.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #704827
    Database COVID19

    Kategorien

  9. Article ; Online: SARS-CoV-2 and ACE2

    Chung, Mina K. / Karnik, Sadashiva / Saef, Joshua / Bergmann, Cornelia / Barnard, John / Lederman, Michael M. / Tilton, John / Cheng, Feixiong / Harding, Clifford V. / Young, James B. / Mehta, Neil / Cameron, Scott J. / McCrae, Keith R. / Schmaier, Alvin H. / Smith, Jonathan D. / Kalra, Ankur / Gebreselassie, Surafel K. / Thomas, George / Hawkins, Edward S. /
    Svensson, Lars G.

    EBioMedicine

    The biology and clinical data settling the ARB and ACEI controversy

    2020  Volume 58, Page(s) 102907

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2020.102907
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

To top